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All Journal Jurnal Pengabdian Magister Pendidikan IPA JPK: Jurnal Proteksi Kesehatan Journal of Tropical Pharmacy and Chemistry Journal Of Pharmacy
Nurdina Putri
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Journal Of Pharmacy

 1 
Penetapan Kadar Flavonoid Total Ekstrak Etanol 96% Daun Gaharu (Aquilaria malaccensis Lam) dengan Spektrofotometer UV-Vis Indriani, Lusi; Dewi Gulyla Hari; Arabella Natasya; Nurdina Putri
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Gaharu leaves (Aquilaria malaccensis Lam) are a type of plant commonly used as a raw material for pharmaceuticals, cosmetics, and perfumes due to its secondary metabolic compounds such as flavonoids, alkaloids, terpenoids, steroids, and quinones. This study aims to determine the total flavonoid content of 96% ethanol extract of gaharu leaves using UV-Vis spectrophotometry. Gaharu leaves were extracted using the Microwave-Assisted Extraction (MAE) method with 96% ethanol as the solvent. The resulting extract was then qualitatively tested and the flavonoid content was measured using UV-Vis spectrophotometry with quercetin as the standard. The results of the determination of the total flavonoid content of the 96% ethanol extract of gaharu leaves were 2.539 ± 0.005% equivalent to quercetin.
Aktivitas Antidiabetes Ekstrak Daun Gaharu (Aquilaria malaccensis Lam) Dan Daun Binahong (Anredera cordifolia) Pada Mencit Jantan Lusi Indriani; Dewi Gulyla Hari; Sari Ramadhani; Nurdina Putri; Siti Niqmatun Jannah
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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The binahong plant (Anredera cordifolia) is known to contain active compounds such as alkaloids, flavonoids, saponins, tannins, and terpenoids that have the potential to lower blood glucose levels. This study aimed to evaluate the antihyperglycemic activity and determine the optimal dose of the combination of ethanol extract of agarwood (Aquilaria malaccensis) leaves and binahong leaves in male mice. The study was conducted experimentally using a Completely Randomized Design (CRD) using 25 mice divided into five treatment groups: a negative control (0.05% NaCMC) and a positive control (metformin). The other three groups were given a combination of agarwood and binahong extracts in dosage ratios of 1:1, 2:1, and 1:2. ANOVA results showed that all extract combinations significantly reduced blood glucose levels compared to the negative control. The 1:1 dose combination showed the best effectiveness, equivalent to metformin, especially on days 3 to 7.
Cytotoxic Activity Testing The Extract of Leaves and Yellow Sirsak Fruit (Annona montana) using Method Brine Shrimp Lethality Test (BSLT) Rahmawati, Noveri; Hari, Dewi Gulyla; Tri Nova Lovena; Nurdina Putri; Rahma Dona; Rahma Cintya Faiza; Amini, Rahmi
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

The yellow sirsak plant (Annona montana) is an annonaceae family which has been used by the community as traditional medicine properties such as treating diarrhea, vitamin C deficiency and treating boils. This study aims to determine the cytotoxic activity of the larvae of Artemia salina Leach shrimp by using the BSLT method after giving extracts from the leaves and fruit of yellow sirsak (Annona montana). The results showed that the LC50 value of the n- hexane extract of yellow sirsak leaves was 45,84 µg/mL, the ethyl acetate extract of yellow sirsak leaves was 26,44 µg/mL and the ethanol extract of yellow sirsak leaves was 13,99 µg/mL. The n-hexane extract of yellow sirsak fruit was 31,46 µg/mL, the ethyl acetate extract was 40,45 µg/mL and the ethanol extract of the yellow sirsak fruit was 19,84 µg/mL. The mixture of n-hexane leaves and yellow sirsak fruit was 29,91 µg/mL, the ethyl acetate extract mixture of yellow sirsak leaves and fruit was 21,71 µg/mL and the mixture of ethanol extract and yellow sirsak fruit was 14,75 µg/mL. Based on the research results, it can be concluded that the ethanol extract of yellow sirsak leaves shows the most active cytotoxic activity with an LC50 value of 13,99 µg/mL.
Co-Authors .AH, Ahdi Dinil Haq Adriani Susanty Amini, Rahmi Arabella Natasya Dachriyanus Dira Dira Dwi Setiawan Fatma Sri Wahyuni Fitriani, Oryza Sativa Hari, Dewi Gulyla Hartini, Putri Tri Ihsan Ikhtiarudin Indriani, Lusi Lusi Indriani Miming Andika Noveri Rahmawati Nurdin, Khazanah Nurain Rahma Cintya Faiza Rahma Dona Rahmadasmi, Nola Rahmi Amini Rizqa Hasanah Sari Rahmadhani Sari Ramadhani Sinata, Novia Siti Niqmatun Jannah Tri Nova Lovena Wulandari, Desti Yulia Yesti, Yulia