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Nuzul Gyanata Adiwisastra
Universitas Medika Suherman
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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HUBUNGAN TINGKAT PENGETAHUAN DENGAN KEPATUHAN MINUM OBAT DAN LUARAN KLINIS PASIEN HIPERTENSI DI PUSKESMAS SETU 1 KABUPATEN BEKASI TAHUN 2025 Putri, Intan Auliya; Marselina, Marselina; Dewi, Masita Sari; Adiwisastra, Nuzul Gyanata
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1534

Abstract

Hypertension is a non-communicable disease that is a major health problem in Indonesia, especially in industrial areas such as Bekasi Regency. Patient knowledge of hypertension affects adherence to treatment and the success of therapy as measured by clinical outcomes in the form of blood pressure achievement. This study aims to determine the relationship between the level of knowledge with medication adherence and clinical outcomes in hypertensive patients at the Setu 1 Community Health Center in Bekasi Regency. This study used a quantitative design with a cross-sectional approach, involving 91 respondents selected using a purposive sampling technique. The instruments used included the HK-LS questionnaire to assess knowledge, the MMAS-8 for adherence, and medical record data for clinical outcomes. The analysis results showed a significant relationship between the level of knowledge with medication adherence (p = 0.009) and clinical outcomes of blood pressure (p = 0.003). It can be concluded that the higher the patient's level of knowledge, the higher the adherence to treatment and the success of achieving target blood pressure.
TINGKAT PENGETAHUAN DAN KEPATUHAN TERHADAP KUALITAS HIDUP PASIEN TUBERKULOSIS DI PUSKESMAS CIKARANG Damayanti, Nanda; Dewi, Masita Sari; Adiwisastra, Nuzul Gyanata; Rosiana, Rosiana
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1542

Abstract

Tuberculosis (TB) remains a major public health problem in Indonesia, including Bekasi Regency, which has a high disease burden. A decline in quality of life is commonly experienced by TB patients due to clinical symptoms, social stigma, and adverse drug effects. Although patient knowledge and treatment adherence are widely believed to influence therapeutic outcomes, evidence regarding their impact on quality of life remains inconsistent and limited, particularly in the Cikarang region. This study aimed to examine the relationship between knowledge level and treatment adherence with the quality of life of pulmonary tuberculosis patients at Puskesmas Cikarang Utara. A cross-sectional design was employed involving 93 outpatient pulmonary TB patients who met the inclusion criteria, including age 17–65 years, undergoing category I/II therapy, able to communicate, and willing to participate, as well as exclusion criteria of having significant comorbid conditions. Participants were selected using purposive sampling. Data were collected using a structured knowledge questionnaire, the Morisky Medication Adherence Scale (MMAS-8), and the Short Form-36 (SF-36). Statistical analysis was performed using the Chi-Square test. The majority of respondents demonstrated good knowledge (86%), moderate to high treatment adherence (86%), and a high quality of life (55.9%). Chi-Square analysis indicated no significant association between knowledge level and quality of life (p = 0.468), nor between treatment adherence and quality of life (p = 0.962). These findings suggest that knowledge and adherence alone are insufficient determinants of quality of life among pulmonary TB patients. Therefore, improving patients’ quality of life requires comprehensive interventions. Beyond treatment adherence.
HUBUNGAN TINGKAT PENGETAHUAN DAN KEPATUHAN DENGAN KEBERHASILAN PENGOBATAN PASIEN TUBERKULOSIS DI PUSKESMAS TELAGA MURNI, CIKARANG Salamah, Hanifah Ikka; Dewi, Masita Sari; Adiwisastra, Nuzul Gyanata; Marselina, Marselina
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1549

Abstract

Tuberculosis (TB) remains a public health problem in Indonesia, with treatment success rates that have not yet reached national targets, partly influenced by patient behavioral factors. Patient knowledge and medication adherence are considered important determinants of TB treatment outcomes. This study aimed to analyze the relationship between patients’ knowledge level and medication adherence with tuberculosis treatment success at Telaga Murni Community Health Center, West Cikarang District. This quantitative study employed a correlational analytical design using a cross-sectional approach. The study sample consisted of 80 adult pulmonary TB patients selected through total sampling. Data were collected through structured interviews using a knowledge questionnaire and the Morisky Medication Adherence Scale-8 (MMAS-8), as well as medical record reviews to assess treatment success. Data were analyzed using univariate and bivariate analysis with the Chi-square test. The majority of respondents were female (58.7%), aged 17–25 years (35%), had senior high school education (50%), and were unemployed (51.2%). Most respondents received treatment observer (PMO) assistance (58.8%), were in the advanced treatment phase (58.7%), and were classified under treatment category I (97.5%). Good knowledge levels were identified in 90% of respondents, while low medication adherence was observed in 85%. Treatment success was achieved in 12.5% of respondents. Chi-square analysis showed no statistically significant relationship between knowledge level and treatment success (p = 0.827), nor between medication adherence and treatment success (p = 0.365). In conclusion, patient knowledge level and medication adherence were not significantly associated with tuberculosis treatment success, suggesting the need for broader multidisciplinary intervention strategies.
Potensi Imunomodulator Fraksi Etil Asetat Biji Jintan Hitam (Nigella sativa L.) terhadap Aktivasi Limfosit T dan Produksi IgG pada Model Tikus Jannah, Zam Zam Zainatul; Nurhakim, Deslia Putri; Ananda, Salsa Billa; Nurjanah, Nina; Putri, Felly Olivia Setya; Anwar, La Ode Muhammad; Hashim, Salma Hilmy Rusydi; Marselina, Marselina; Adiwisastra, Nuzul Gyanata
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.944

Abstract

Biji jintan hitam (Nigella sativa L.) merupakan tanaman herbal yang dikenal memiliki aktivitas sebagai imunomodulator, khususnya dalam meningkatkan fungsi sel imun dan produksi antibodi. Tujuan penelitian ini untuk mengetahui perbedaan aktivitas fraksi etil asetat biji jintan hitam pada konsentrasi 10%, 15%, dan 20% terhadap sel limfosit T (CD4+ dan CD8+) serta kadar imunoglobulin G (IgG). Metode pada penelitian ini merupakan metode kuantitatif dengan desain eksperimental dilakukan secara in vivo menggunakan 18 ekor tikus jantan yang dibagi 6 kelompok dengan 3 kelompok uji dan 3 kelompok kontrol. Analisis senyawa dilakukan dengan GC-MS, nilai sel limfosit T diukur dengan Flow Cytometry, sedangkan nilai imunoglobulin G (IgG) diukur menggunakan ELISA Reader. Hasil penelitian bahwa fraksi etil asetat biji jintan hitam mengandung 79 senyawa metabolit. Nilai sel limfosit T (CD4+ dan CD8+) menunjukkan tidak adanya perbedaan signifikan, akan tetapi kelompok 3 fraksi etil asetat konsentrasi 20% memiliki aktivitas tertinggi dengan nilai sebesar 97,06%. Data hasil penelitian dianalisis menggunakan uji statistik One-Way ANOVA. Hasil penelitian nilai imunoglobulin G (IgG) menunjukan adanya perbedaan yang signifikan dengan nilai sig. <0.05 dan aktivitas tertinggi serta fraksi yang paling baik terdapat pada kelompok 3 fraksi etil asetat konsentrasi 20% sebesar ±278,740 ng/mL. Hal ini menunjukkan bahwa fraksi etil asetat jintan hitam konsentrasi 20% berpotensi sebagai imunomodulator yang aman, serta dapat membantu meningkatkan sistem kekebalan tubuh, khususnya pada kondisi penurunan fungsi imun. Temuan ini menambah pengetahuan tentang potensi jintan hitam sebagai imunomodulator dan dapat menjadi dasar untuk penelitian selanjutnya guna mengetahui senyawa aktif serta cara kerjanya lebih jelas.
Co-Authors Aeni Kusno Ananda, Salsa Billa Anisa Arbalia Putri Antarini, Destya Antih Puspita Dewi Audrie Agustini Widiawati Awanda Pramudita Okhanza Cyto Yudha Kurniawan Damayanti, Nanda Destie Elmi Mufidah Devi Naibaho Dewi, Antih Puspita Dewi, Masita Sari Eka Ayu Riyanto Elda Nopriyanti Elsah Dwiyanti Embriana Dinar Pramestyani Evellia Priastuti Fadly Agung Fatah Feri Setiadi Hanifah Ikka Salamah Harahap, Kurnia Pebriyanti Hilmy, Salma Iftah Mahfuroh Ike Maya Permanasari Jannah, Zam Zam Zainatul La Ode Muhammad Anwar Marselina Marselina Marselina Masita Sari Dewi Masita Sari Dewi Mohammad Fadly Mohammad Haikhal Ramadani Muhammad Farhan Satya Baskoro Muslih, Hamdan Faisal Mutiah Nazwa Alaidarahman Novia Maharani Nurhakim, Deslia Putri Nurjanah, Nina Okhanza, Awanda Pramudita Pramestyani, Embriana Dinar Putri, Felly Olivia Setya Putri, Intan Auliya Retno Tri Anjani Romli, Cindy Junita Rosiana Rosiana, Rosiana Salamah, Hanifah Ikka Salma Hilmy Rusydi Hashim Salma Nabila Sharfina Maulidayanti Sri Lestari Suparmi, Ninik Ulfah, Ulyati Zuhrah Giatamah