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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal Of Vocational Health Studies Jurnal SOLMA PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Media Karya Kesehatan Poltekita: Jurnal Pengabdian Masyarakat Warta LPM Journal of Tropical Pharmacy and Chemistry
Dicki Bakhtiar Purkon
Poltekkes Kemenkes Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Acute and Sub-Acute Oral Toxicity Assessment of Marchantia paleacea Bertol. Liverwort Herb Extract in Mice on Liver and Kidney Function Purkon, Dicki Bakhtiar; Nainggolan, Aurelya Veny Kurnia; Ningsih, Padmasari Diah Ayu Kumala; Kusmiyati, Mimin; Sudaryat, Yayat; Srinati, Ine; Fadhlillah, Faizah Min; Sufa, Hafizah Ilmi; Hotimah, Alni Khusnul
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008218

Abstract

Herbaceous liverwort Marchantia paleacea Bertol. has been known as a potential source that has bioactive compounds with various pharmacological benefits, such as: antimicroorganism, antifungal, antioxidant, immunomodulator, hepatoprotector, antipyretic, diuretic, cardiotonic, and vasorelactan. However, information regarding oral acute and sub-acute toxicity data from ethanol extracts of Marchantia paleacea Bertol. liverwort herb is still very limited. Therefore, this study aimed to evaluate the acute and sub-acute toxicity of liverwort herb ethanol extract in female mice of ddY strains. The acute toxicity test method was carried out by giving ethanol extract of the liverwort herb Marchantia paleacea Bertol. (EEMP) in single doses at doses of 250, 500, 1000, and 2000 mg/kg bw orally for 14 days, while sub-acute toxicity tests were performed by administering EEMP test extracts at doses of 125, 250, 500, 1000, and 2000 mg/kg bw orally for 28 days in accordance with testing standards from BPOM (2022), Thompson-Weil, and OECD. Parameters observed include clinical symptoms (including: mortality), profile of body weight changes, biochemical analysis of serum, and histopathological analysis of vital organs (liver and kidney). Results from acute toxicity testing showed that a single dose of EEMP at the tested level did not cause significant clinical symptoms and histopathological disorders, and there were no deaths in test animals classified as mild toxic substances based on BPOM criteria ( 2000 mg/kg bw). And sub-acute toxicity tests from the 125, 250, and 2000 mg/kg bw test groups revealed a significant increase in average SGOT levels compared to the normal control group on the 28th test day (p0.05) but still within the normal range. Most other test parameter profiles show no significant changes. Some of the observed changes, particularly in the biochemical and histological parameters of the organs that occur are assumed to be transient reaction effects and are not a sign of toxicity. These findings suggest the need for further study of the potential toxic effects of the liverwort herb Marchantia paleacea Bertol. This study provides important insights in the understanding of the potential uses of the liverwort herb Marchantia paleacea Bertol. as a product of herbal ingredients (nutraseutics, supplements, and traditional medicine), and reinforces the need to understand the potential toxicity risks associated with it. 
Cost-effectiveness analysis of the use of antibiotics for typhoid fever inpatients in RSUD Bayu Asih Purwakarta Purkon, Dicki Bakhtiar; Agustin, Himeliya; Widyastiwi, Widyastiwi; Kusmiyati, Mimin; Fadhlillah, Faizah Min
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1679

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi, commonly treated with antibiotics to promote recovery and prevent complications. This study aimed to evaluate both the therapeutic effectiveness (clinical outcomes such as fever resolution and hospital stay duration) and the cost-effectiveness (economic efficiency of antibiotic use) in inpatients with typhoid fever at RSUD Bayu Asih Purwakarta (Bayu Asih District Hospital, Purwakarta) in 2023. A retrospective descriptive design was applied using 75 medical records from January to December 2023. Results showed that levofloxacin had the highest therapeutic effectiveness, reflected by the shortest hospitalization (3.5 days), whereas ceftriaxone was the most cost-effective, with an Average Cost-Effectiveness Ratio (ACER) of Rp. 194,858.78 per treatment. The Incremental Cost-Effectiveness Ratio (ICER) analysis indicated that the additional cost required for levofloxacin compared to ceftriaxone was disproportionate to the clinical benefit gained. In conclusion, while levofloxacin provides faster recovery, ceftriaxone remains the preferred option considering its superior cost-effectiveness. These findings emphasize the need to balance clinical outcomes and economic efficiency when determining antibiotic policies for typhoid management.
Co-Authors Afifah Rahmawati Agustin, Himeliya Ainun Nadhifah, Ainun Ali Hamzah Amirah Adlia Ansyirohanisa Ansyirohanisa Ansyirohanisa Ansyirohanisa Elvi Trinovani Elvi Trinovani, Elvi Faizah Min Fadhlillah Fatimah, Cucu Haerussana, Ayu Nala El Muna Hotimah, Alni Khusnul Imas Siti Nur Padilah Irmawartini Irmawartini Irvan Herdiana Irvan Herdiana Khaira Arnella Lilis Febriyanti Maigoda, Tonny Cortis Maria Immaculata Iwo Maria Immaculata Iwo Mimin Kusmiyati, Mimin Miranti, Mila Muhammad Aqil Zaelani Nainggolan, Aurelya Veny Kurnia Nandang Ahmad Waluya Natasya Khairunnisa Nelly Selvatiany Ningsih, Padmasari Diah Ayu Kumala Nizella Syahla Nizella Syahla Novani, Elvi Tri Noviapratami, Nikky Osman Syarief Pambudi, Fatimah Ayu Putri Roseno, M.H. Silviyanita Isna Septila Soemardji, Adreanus Andaja Srinati, Ine Sufa, Hafizah Ilmi Tanika Miatul Hadid Tri Widyastuti Vindi Nur Amalia Wibowo, Diki Prayugo Yayat Sudaryat Yennie Agnes Pratama Zahra Anggraeni Zahwa Ainunnisya Nur Aisyah