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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal Of Vocational Health Studies Jurnal SOLMA PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Media Karya Kesehatan Poltekita: Jurnal Pengabdian Masyarakat Jurnal EduHealth Warta LPM Journal of Tropical Pharmacy and Chemistry
Dicki Bakhtiar Purkon
Poltekkes Kemenkes Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Acute and Sub-Acute Oral Toxicity Assessment of Marchantia paleacea Bertol. Liverwort Herb Extract in Mice on Liver and Kidney Function Purkon, Dicki Bakhtiar; Nainggolan, Aurelya Veny Kurnia; Ningsih, Padmasari Diah Ayu Kumala; Kusmiyati, Mimin; Sudaryat, Yayat; Srinati, Ine; Fadhlillah, Faizah Min; Sufa, Hafizah Ilmi; Hotimah, Alni Khusnul
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008218

Abstract

Herbaceous liverwort Marchantia paleacea Bertol. has been known as a potential source that has bioactive compounds with various pharmacological benefits, such as: antimicroorganism, antifungal, antioxidant, immunomodulator, hepatoprotector, antipyretic, diuretic, cardiotonic, and vasorelactan. However, information regarding oral acute and sub-acute toxicity data from ethanol extracts of Marchantia paleacea Bertol. liverwort herb is still very limited. Therefore, this study aimed to evaluate the acute and sub-acute toxicity of liverwort herb ethanol extract in female mice of ddY strains. The acute toxicity test method was carried out by giving ethanol extract of the liverwort herb Marchantia paleacea Bertol. (EEMP) in single doses at doses of 250, 500, 1000, and 2000 mg/kg bw orally for 14 days, while sub-acute toxicity tests were performed by administering EEMP test extracts at doses of 125, 250, 500, 1000, and 2000 mg/kg bw orally for 28 days in accordance with testing standards from BPOM (2022), Thompson-Weil, and OECD. Parameters observed include clinical symptoms (including: mortality), profile of body weight changes, biochemical analysis of serum, and histopathological analysis of vital organs (liver and kidney). Results from acute toxicity testing showed that a single dose of EEMP at the tested level did not cause significant clinical symptoms and histopathological disorders, and there were no deaths in test animals classified as mild toxic substances based on BPOM criteria ( 2000 mg/kg bw). And sub-acute toxicity tests from the 125, 250, and 2000 mg/kg bw test groups revealed a significant increase in average SGOT levels compared to the normal control group on the 28th test day (p0.05) but still within the normal range. Most other test parameter profiles show no significant changes. Some of the observed changes, particularly in the biochemical and histological parameters of the organs that occur are assumed to be transient reaction effects and are not a sign of toxicity. These findings suggest the need for further study of the potential toxic effects of the liverwort herb Marchantia paleacea Bertol. This study provides important insights in the understanding of the potential uses of the liverwort herb Marchantia paleacea Bertol. as a product of herbal ingredients (nutraseutics, supplements, and traditional medicine), and reinforces the need to understand the potential toxicity risks associated with it. 
Pendampingan Masyarakat Mengenai Pemanfaatan Tanaman TOGA sebagai Pemenuhan Gizi di Kecamatan Kawali Kabupaten Ciamis: Community Assistance Regarding the Use of TOGA Plants to Fulfill Nutrition in Kawali District Ciamis Regency Trinovani, Elvi; Kusmiyati, Mimin; Purkon, Dicki Bachtiar; Fatimah, Cucu
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.6976

Abstract

Fulfilling nutritional intake can be done by utilizing TOGA plants. TOGA plants have high nutritional content to support the fulfillment of daily nutritional needs. The aim of community service related to TOGA plants is to increase community understanding and access to nutritional sources needed to prevent high levels of malnutrition. The method used is Participatory Action and Learning and evaluated using pre-test and post-test methods. There was an increase in knowledge scores at the end of the training, namely an average of 15.8 points. The variation in knowledge scores on the pre-test tends to be higher than on the post-test, this shows that there is a similar perception of understanding of the material at the end of the training.
Qualitative Examination Of Amfetamine And Ephedrine In Urine In Doping Using Gas Chromatography-Mass Spectrometry Method Kusmiyati, Mimin; Trinovani , Elvi; Sudaryat , Yayat; Bakhtiar , Dicky
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.939 KB)

Abstract

Amphetamines and ephedrine are stimulant class doping drugs which have the effect of reducing fatigue and drowsiness, increasing alertness, physical strength, mental sense of competition and competitive attitude. Analysis of doping drugs in urine that has been recommended by the International Olympic Committee, including Gas Chromatography-Mass Spectrometry. Derivatization is carried out to change the polarity of the analyte, making it easier to become a gas and stable to heating. This study was conducted for qualitative analysis of amphetamine and ephedrine, using an HP5MS column containing non-polar phenyl methyl siloxane, temperature 100-250oC with a temperature increase of 10oC/minute. Then it was extracted with a mixture of diethyl ether-ethylacetate (1:1) in an alkaline medium pH 8, the organic layer was evaporated then derivatized with trifluoro-acetic acid-anhydride and ephedrine with acetic-anhydride-pyridine (3:2). The final results showed that the retention times of amphetamine and ephedrine were 10.47 and 4.9 minutes. While the derivatives are 13.34 and 5.50 minutes. Identification using mass spectrometry for each compound showed that the mass spectra matched the Ref. and the amphetamine and ephedrine structural similarity index was 96% and the detection limit for each compound was 2 ug/ml.
Cost-effectiveness analysis of the use of antibiotics for typhoid fever inpatients in RSUD Bayu Asih Purwakarta Purkon, Dicki Bakhtiar; Agustin, Himeliya; Widyastiwi, Widyastiwi; Kusmiyati, Mimin; Fadhlillah, Faizah Min
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1679

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi, commonly treated with antibiotics to promote recovery and prevent complications. This study aimed to evaluate both the therapeutic effectiveness (clinical outcomes such as fever resolution and hospital stay duration) and the cost-effectiveness (economic efficiency of antibiotic use) in inpatients with typhoid fever at RSUD Bayu Asih Purwakarta (Bayu Asih District Hospital, Purwakarta) in 2023. A retrospective descriptive design was applied using 75 medical records from January to December 2023. Results showed that levofloxacin had the highest therapeutic effectiveness, reflected by the shortest hospitalization (3.5 days), whereas ceftriaxone was the most cost-effective, with an Average Cost-Effectiveness Ratio (ACER) of Rp. 194,858.78 per treatment. The Incremental Cost-Effectiveness Ratio (ICER) analysis indicated that the additional cost required for levofloxacin compared to ceftriaxone was disproportionate to the clinical benefit gained. In conclusion, while levofloxacin provides faster recovery, ceftriaxone remains the preferred option considering its superior cost-effectiveness. These findings emphasize the need to balance clinical outcomes and economic efficiency when determining antibiotic policies for typhoid management.
Pelatihan Pembuatan Kombucha Nanas Probiotik untuk Peningkatan Pengetahuan Kader PKK dan Posyandu di Desa Tambakmekar, Kabupaten Subang Purkon, Dicki Bakhtiar; Trinovani, Elvi; Kusmiyati, Mimin; Pratama, Arvenda Rezky; Ansyirohanisa, Ansyirohanisa; Fatimah, Cucu; Syahla, Nizella; Fitria, Yefi; Al-Alifa, M. Rasya; Ulya, Cut Zidda; Septiani, Mitha Azalia; Fadhlillah, Faizah Min
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.21106

Abstract

Background: Tambakmekar Village, Jalancagak Subdistrict, Subang Regency, is one of the pineapple production centers in West Java, yet its utilization remains limited, resulting in low economic value. On the other hand, the community partners, consisting of PKK and Posyandu cadres, face health problems such as high risks of hypertension and blood glucose levels, as well as limited knowledge about probiotic functional foods. This Community Partnership Program (PKM) aimed to improve the knowledge and skills of cadres through training on the production of probiotic pineapple-based kombucha, health education, and simple health checks (blood pressure and blood glucose). Methods: The methods used included lectures, practical demonstrations, mentoring, and evaluation of knowledge using pre-test and post-test. Results: The average knowledge score of participants increased from 64.2 (pre-test) to 77.5 (post-test), representing a relative improvement of approximately 20.7%. Furthermore, participants were able to practice pineapple kombucha production independently and received an educational booklet as a reference material. The program outputs included a booklet, video documentation, and a manuscript for an academic article. Conclusions: This activity successfully enhanced the capacity of PKK and Posyandu cadres while promoting the use of local pineapple as a functional food with health benefits and potential economic value.
Co-Authors Afifah Rahmawati Agustin, Himeliya Ainun Nadhifah, Ainun Al-Alifa, M. Rasya Ali Hamzah Amirah Adlia Ansyirohanisa Ansyirohanisa Ansyirohanisa Ansyirohanisa Ansyirohanisa, Ansyirohanisa ARVENDA REZKY PRATAMA, ARVENDA REZKY Elvi Trinovani Elvi Trinovani, Elvi Faizah Min Fadhlillah Fatimah, Cucu Fitria, Yefi Haerussana, Ayu Nala El Muna Hotimah, Alni Khusnul Imas Siti Nur Padilah Irmawartini Irmawartini Irvan Herdiana Irvan Herdiana Khaira Arnella Lilis Febriyanti Maigoda, Tonny Cortis Maria Immaculata Iwo Maria Immaculata Iwo Mimin Kusmiyati, Mimin Miranti, Mila Muhammad Aqil Zaelani Nainggolan, Aurelya Veny Kurnia Nandang Ahmad Waluya Natasya Khairunnisa Nelly Selvatiany Ningsih, Padmasari Diah Ayu Kumala Nizella Syahla Nizella Syahla Novani, Elvi Tri Noviapratami, Nikky Osman Syarief Pambudi, Fatimah Ayu Putri Roseno, M.H. Septiani, Mitha Azalia Silviyanita Isna Septila Soemardji, Adreanus Andaja Srinati, Ine Sudaryat , Yayat Sufa, Hafizah Ilmi Syahla, Nizella Tanika Miatul Hadid Tri Widyastuti Trinovani , Elvi Ulya, Cut Zidda Vindi Nur Amalia Wibowo, Diki Prayugo Yayat Sudaryat Yennie Agnes Pratama Zahra Anggraeni Zahwa Ainunnisya Nur Aisyah