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All Journal Pharmascience JFL : Jurnal Farmasi Lampung JK Unila (Jurnal Kedokteran Universitas Lampung)
Lilik Koernia Wahidah
Universitas Tulang Bawang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) PENGGUNAAN ANTIHIPERTENSI PASIEN HIPERTENSI DI RSU AZZAHRA KALIREJO LAMPUNG TENGAH Lilik Koernia Wahidah; Novita Tri Wahyuni; Desiamti Ughfiroh
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.715

Abstract

A person is diagnosed with hypertension if there is an increase in systolic blood 140 mmHg and diastolic blood pressure 90 mmHg. Treatment of hypertension aims to reduce morbidity and mortality. Hypertensive patients receiving polypharmacy pharmacological therapy are at risk of developing DRPs. The purpose of this study was to identify the incidence of Drug Related Problems (DRPs) in the use of antihypertensives in hypertensive patients at Azzahra Kalirejo General Hospital, Central Lampung in 2021. This study was non-experimental with a retrospective descriptive design, then identified using the classification of DRPs according to Robert J. Cipolle EL. Pharmaceutical Care Practice and Medscape and Drug Interaction Chacker applications to identify drug interactions, and use the Medication Possession Ratio (MPR) formula to identify patient non-compliance. Based on the results of research at Azzahra Kalirejo General Hospital, Central Lampung, of the 135 samples that met the inclusion criteria, 80% of the samples experienced DRPs. Based on gender characteristics, there were 50.37% male and 49.62% female with 0% of patients aged <25 years, age 26-45 years 30.3%, age 46-65 years 57.8% and age > 65 years 11.8%. The most widely prescribed antihypertensive drug was furosemide as much as 42.2%, the most antihypertensive combination was a combination of two drugs as much as 57%. The most use of non antihypertensive drugs is PPI and analgesics as much as 12.8%. Cases of DRPs requiring additional therapy were 1.9%, drug therapy was not necessary 7.4% cases, inappropriate drugs 4.6% cases, doses too low and high in 0% cases, drug interactions were 77.8% with major severity 11.7%, minor 34.5% cases and moderate as many as 53.7%, patient non-compliance with DRPs occurred in 51.9% cases.  Keywords:  Antihipertensive, DRPs, Furosemide, Hypertension
POTENSI INTERAKSI OBAT PADA PERESEPAN PASIEN GERIATRI RAWAT JALAN DI PUSKESMAS SATELIT BANDAR LAMPUNG TAHUN 2021 Hijrah Hijrah; Lilik Koernia Wahidah; Ayu Herawati; Adityo Adityo
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.741

Abstract

Drug interaction is the modification of the effect of a drug due to a drug being given alongside food, drinks or other drugs so that the effectiveness or toxicity of a drug changes. Some of the drugs prescribed in geriatric patients need to be considered so that no adverse drug interactions occur. This study aims to determine the potential for drug interactions in the prescribing of outpatient geriatric patients at the Bandar Lampung City Satellite Health Center in the 2021 period. This study is a non-experimental type with a descriptive design taken retrospectively. Sampling using purposive sampling method. The instruments in this study were medical records and prescriptions of geriatric patients, using the Drugs.com and Medscape applications. The results of this study showed that out of 256 prescriptions for geriatric patients there were 138 prescriptions (53.9%) who experienced drug interactions, with 120 male sex patients (46.9%) and female sex as many as 136 patients (53,1%). Based on the age category of 56-65 there were 110 patients (43%), aged 66-75 there were 120 patients (47%), and aged 76-90 there were 26 patients (10%). Drug interaction levels were minor category 51 patients (24.1%), moderate 140 patients (66.0%), and major 21 patients (9.9%). Based on the mechanism of pharmacodynamic interactions of 183 (86.3%) and pharmacokinetic interactions of 28 (13.7%). The conclusions of this study prove drugs administered to geriatric patients can cause drug interactions. Keywords : Drug Interactions, Geriatric, Prescription
STUDI FARMAKOVIGILAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT JALAN DI DR. A. DADI TJOKRODIPO BANDAR LAMPUNG PERIODE OKTOBER–NOVEMBER 2021 Lilik Koernia Wahidah; Novita Tri Wahyuni; Dion Yongtama
JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i2.814

Abstract

Hypertension, also known as high blood pressure, is systolic pressure140 and diastolic pressure 80 mmHg. The more blood pressure is pumped by the heart and the narrower the arteries, the higher the blood pressure. This study aims to determine the occurrence of adverse drug reactions in hypertensive patients in RSD DR. A. Dadi Tjokrodipo Bandar Lampung. This research is a descriptive research with total sampling method. Collecting data by looking at the patient's medical record data. The results showed that the female sex was more dominant in suffering from hypertension, namely 20 female patients (62.5%) and 12 male patients (37.5%). The highest age characteristics were found in the age range of 46-55 years as many as 14 patients (43.75%). The most characteristic of hypertension was in the case of stage 2 hypertension with a total of 17 patients (53.12%). The highest pattern of drug use was amlodipine (37.5%). The incidence of drug interactions was 10 cases (31.25%) with minor severity. The highest incidence of ADR was in the "moderately probable" 1-4 with a total of 15 cases (46.87%). Keywords: ADR, hypertension, drug interactions, antihypertensive drugs
Gambaran Lama Rawat Inap Pada Pasien Skizofrenia dengan Terapi Kombinasi Antipsikotik dan Kombinasi Antipsikotik dengan Mood-stabilizer Di Rumah Sakit Jiwa Provinsi Lampung Dwi Aulia Ramdini; Lilik Koernia; Fitri Dwi Antari
Jurnal Kedokteran Universitas Lampung Vol 6, No 2 (2022): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila6289-93

Abstract

Skizofrenia adalah gangguan kesehatan mental kronis dan parah yang terkait dengan masalah kesehatan jangka panjang dan beban ekonomi. Antipsikotik menjadi terapi utama dalam pengobatan skizofrenia, yang biasanya diberikan secara kombinasi. Golongan mood-stabilzer merupakan salah satu terapi tambahan pada pasien skizofrenia. Penelitian ini bertujuan untuk melakukan evaluasi lama rawat inap pasien skizofrenia yang menggunakan antipsikotik risperidon-klorpromazin dan kombinasirisperidon-klorpromazin-asam valproat pada pasien rawat inap di rumah sakit jiwa Provinsi Lampung pada tahun 2018-2019. Penelitian ini adalah penelitian observasional dengan menggunakan data retrospektif dari rekam medis pasien skizofrenia, dengan teknik pengambilan purposive sampling. Data rata-rata hari lama rawat inap dianalisis dengan uji chi-square. Berdasarkan data sosiodemografi pada 71 sampel pasien skizofrenia, rentang usia terbanyak yaitu 20-29 tahun (45%), berpendidikan terakhir yaitu SMA (44%), status tidak bekerja (54%), dan status belum menikah (83%). Rata-rata lama hari rawat terapi kombinasi risperidon- klorpromazin pada fase akut psikotik adalah 4,12 hari dan pasca fase akut psikotik adalah 36,08 hari, sedangkan pada terapi kombinasi risperidon-klorpromazin-asam valproat pada fase akut adalah 3,05 hari dan pada pasca akut psikotik yaitu selama 27,62 hari. Hasil pemeriksaan enzim hati, pada terapi risperidon-klorpromazin terdapat peningkatan SGOT sebanyak 46% pasien, dan peningkatan SGPT sebesar 16% pasien. Pasien yang menerima risperidon-klorpromazin-asamvalproat juga mengalami peningkatan enzim SGPT sebanyak 62% dan SGOT 14% pasien. Hasil ini menggambarkan bahwa terdapat hubungan antara penggunaan kombinasi antipsikotik mood-stabilizer dengan lama hari rawat inap. Diperlukan monitoring fungsi hati serta kemungkinan efek samping lain dari penggunaan obat secara berkala.  Kata Kunci : Antipsikotik, Fungsi hati, Lama rawat, Mood-stabilizer, Skizofrenia
PENETAPAN NILAI SPF (SUN PROTECTION FACTOR) SEDIAAN KRIM TABIR SURYA DI KOTA BANDAR LAMPUNG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Subur Widodo; Akhmad Rokiban; Lilik Koernia Wahidah; Ikhrami Nurjannah
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.978

Abstract

Nowadays people awareness of the healthy skin importance is increasing, this is evident by the increasing cosmetic brands and there are many beauty clinics. Cosmetic products marketed should have the same efficacy as those listed on the packaging. Therefore, determining the efficacy of sunscreen preparations is very important to see the compliance of cosmetics manufacturers. The purpose of this study was to determine the suitability of the SPF product efficacy. The samples are the products which have SPF 30, the sample was tested by in vitro method using UV-Vis spectrophotometer, every 5 nm with the wavelength range 290 nm - 320 nm absorbance was measured, then analyzed with the mansur equation. Also did antioxidant activity tested with vitamin C as a control positive using the DPPH method. The principle of the DPPH method is the measurement of absorbance of DPPH radicals which are degraded due to the presence of antioxidant compounds using a UV-Vis spectrophotometer. The decrease in DPPH absorbance intensity is proportional to the increase in the concentration of antioxidant compounds expressed in IC50 (Inhibition Concentration 50). Sample 4 has an SPF value close to the value written on the packaging. Samples 2, 5, 1, 3, 6, 7 and 8 have SPF values ​​smaller than those listed on the packaging. The antioxidant activity obtained is rateable to the SPF value, sample 4 has the highest antioxidant activity followed by sample 2, sample 5, sample 1, sample 3, sample 6, and sample 7 and sample 8 have the lowest antioxidant activity. Keywords: Antioxidant , DPPH, UV-Vis spectrophotometry, SPF, Sunscreen
EVALUASI PENGGUNAAN OBAT HIPERTENSI PADA PASIEN RAWAT JALAN DI RUMAH SAKIT BHAYANGKARA POLDA LAMPUNG TAHUN 2020 Lilik Koernia Wahida; Novita Tri Wahyuni; Niluh Suastini
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.999

Abstract

ABSTRACT Hypertension is a condition in which a person experiences an increase in blood pressure above normal, which is higher than 140 mmHg systolic or 90 mmHg diastolic. Hypertension plays a very important role in causing the death of thousands of people, due to its dangerous side-effects, such as stroke, heart attack, heart failure, and kidney failure. The purpose of this study is to evaluate the use of hypertension drugs in outpatient hypertension patients at Bhayangkara Polda Hospital Lampung. Evaluation of drug use is a quality assurance process in the use of drugs in hospitals aimed at ensuring the drugs used are appropriate, safe and effective. The data collection technique in this study began with the selection process of outpatient medical records who had a primary diagnosis of hypertension. The population in this study were all patient medical records at the Bhayangkara Polda Lampung Hospital in the period of 2020, the use of hypertension drugs based on the right patient was 103 patients, which was 100% correct, the use of Antihypertensive drugs based on the right indication was 103 patients, which was 100% correct. the use of antihypertensive drugs based on the right drug was 82 patients with a percentage (79.61%) of the right drug and as many as 21 patients (20.39%) the wrong drug because the drug given was not in accordance with the standard used, the use of antihypertensive drug was based on the right dose as much as 103 patients were 100% on the right dose, because the dose given was in accordance with the range of antihypertensive drug therapy based on JNC VIII. Keywords: hypertension, drug evaluation, drug use.
Analisis Efektivitas Biaya (Cost Effectiveness Analysis) Penggunaan Antibiotik Seftriakson Dan Sefotaksim Pada Pasien Infeksi Saluran Kemih Di Rsd Dr. A. Dadi Tjokrodipo Bandar Lampung Koernia Wahidah, Lilik; Tri Wahyuni, Novita; Andinni, Aulia
JFL : Jurnal Farmasi Lampung Vol. 12 No. 2 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i2.1262

Abstract

Cost-effectiveness analysis is defined as an analysis to identify, measure and compare significant costs and their consequences of alternative interventions. Antibiotics are a group of drugs most often used to treat infectious diseases. Ceftriaxone and cefotaxime are the main options for treating UTI. Urinary Tract Infection (UTI) is a disease with conditions where there are very large numbers of microorganisms in the urine and can cause infection in the urinary tract. This study was designed to analyze the cost-effectiveness of ceftriaxone and cefotaxime treatment for inpatient urinary tract infections at dr. A. Dadi Tjokrodipo. The method used is descriptive with a retrospective pharmacoeconomic analysis approach. The sampling technique was purposive sampling and sampling 92 patient. The research results show characteristics based on sex most are female as much as 55 (60%), based on age ≥56 years in 35 patients (38%), and the highest length of hospitalization was 3 days in 45 patients (49%). The most widely used profile of antibiotic drug use in patients with urinary tract infections was cefotaxime with a total of 64 patients (70%). The average cost for each type of drug therapy from ceftriaxone is 735,117 and sefotaxime is 742,178. Ceftriaxone has the highest percentage of therapeutic effectiveness at 86% compared to cefotaxime at 71%. Antibiotics that are more cost effective are ceftriaxone compared to cefotaxime with an ACER calculation of 78.455. Keywords: Cost Effectiveness Analysis, Urinary Tract Infections, Ceftriaxone, Cefotaxime
Skizofrenia STUDI EFEK SAMPING PENGGUNAAN OBAT PADA PASIEN SKIZOFRENIA DI RUMAH SAKIT JIWA PROVINSI LAMPUNG TAHUN 2021: STUDI EFEK SAMPING PENGGUNAAN OBAT PADA PASIEN SKIZOFRENIA DI RUMAH SAKIT JIWA PROVINSI LAMPUNG TAHUN 2021 Wahidah, Lilik Koernia; Mulyani, Yuli Wahyu Tri; Wahyuni, Novita Tri; Hijrah; Rahayu, Dwi Sri
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1621

Abstract

Skizofrenia merupakan gangguan jiwa berat dengan berbagai gejala kejiwaan termasuk gejala positif waham dan halusinasi. Secara umum antipsikotik dibagi menjadi dua golongan, yaitu antipsikotik tipikal dan atipikal. Penelitian ini merupakan suatu penelitian non-eksperimental observasional dengan pengambilan data secara prospektif. Penelitian ini bertujuan untuk mengetahui efek samping penggunaan obat pada pasien skizofrenia di Rumah Sakit Jiwa Provinsi Lampung. Populasi sampel penelitian ini adalah pasien skizofrenia rawat jalan pada bulan Agustus tahun 2021 yang memenuhi kriteria inklusi sebanyak 100 pasien. Pengumpulan data menggunakan data primer dan sekunder. Data berupa obesrvasi dan wawancara terkait gejala efek samping antispikotik. Data sekunder dari rekam medik pasien berupa kelengkapan data pasien, jenis skizofrenia serta terapi antipsikotik. Hasil penelitian berdasarkan karakteristik usia terbanyak 26-35 tahun (28%) jenis kelamin laki-laki (62%) pendidikan terakhir SMA (48%) tidak bekerja (78%) riwayat merokok (41.7%) Hasil penelitian menunjukan bahwa terapi 2 kombinasi antipsikotik paling banyak risperidon-clozapin (50%) 3 kombinasi paling banyak haloperidol-clozapin-olanzapin (20.3%) 4 kombinasi risperidon-trihexyphenidyl-clozapin-chlorpromazin (31.4%). Efek samping yang terjadi pada 100 pasien paling banyak S.ekstrapiramidal yaitu hipersaliva (15%) tremor (72%) rigiditas otot (33%) bradikinesia (82%) akatisia (95%) distonia (10%) pusing (86%) lemas (31%) linglung (77%) kesulitan berjalan (37%) sesak nafas (34%) berkeringat (13%) mata kabur (37%) sedasi (13%) insomnia (93%) anoreksia (17%) dan sering buang air kecil (11%). Efek samping paling banyak terjadi adalah Syndrom ekstrapiramidal dan untuk terapi antipsikotik yang paling banyak digunakan adalah terapi kombinasi antipsikotik.
HUBUNGAN WAKTU TUNGGU OBAT DENGAN KEPUASAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT IBU DAN ANAK SANTA ANNA 2024: RELATIONSHIP BETWEEN DRUG WAITING TIME AND OUTPATIENT SATISFACTION IN HOSPITAL PHARMACY INSTALLATIONS MOTHER AND CHILD SANTA ANNA 2024 Nopiyansyah; Wahyuni, Novita Tri; Hijrah; Handayani, Kartika; Wahidah, Lilik Koernia
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.2128

Abstract

The waiting time for non-concocted drug services is the period from the patient submitting the prescription to receiving the finished drug with a minimum standar of<30 minutes, while the waiting time for concocted drugs is the period from the patient giving the prescription to the patient receiving the concoction with a period of <60 minutes. This study aims to see how long the waiting time for medication is with patient satisfaction. This study uses an observational research design with a cross sectional approach conducted at the Santa Anna Mother and Child Hospital Bandar Lampung. The sampling technique uses the Accidental sampling method with a total of 100 respondents. Data analysis in this study uses the chi-square testing technique. The results of this study were obtained by respondents of female gender (62%), male (38%), age 17-25 years (27%), 26-35 years (29%), 36-45 years (23%), 46-55 years (15%), 55-65 years (6%), diagnosis of ISPA (34%), dyspepsia (17%), February (17%), hypertension (5%), Antenatal Care (27%). The waiting time for medication is not according to the standard (19%) and the time is not according to the standard (81%), patients feel dissatisfied (20%), feel satisfied (80%). The results of the chi-square test of drug waiting time with patient satisfaction were obtained score (p= 0.000), meaning that Ho was rejected and Ha was accepted, this indicates that there is a relationship between drug waiting time and patient satisfaction. Keywords:  Drug waiting time, patient satisfaction, hospital
STUDI ANALISIS EFEK SAMPING KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2023: STUDY ANALYSIS OF SIDE EFFECTS OF CHEMOTHERAPY IN BREAST CANCER PATIENTS AT DR. H. ABDUL MOELOEK LAMPUNG PROVINCE YEAR 2023 Widiyastuti, Asih; Handayani, Kartika; Harissa, Nola; Wahidah, Lilik Koernia; Nopiyansyah
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2446

Abstract

The high mortality rate in breast cancer and with the most malignancy attacking women, therapy is needed in the treatment of breast cancer by chemotherapy. Chemotherapy works by killing rapidly dividing cancer cells. However, due to its non-selective nature, chemotherapy also affects healthy cells and causes side effects that affect the patient's quality of life. This study aims to determine the side effects of chemotherapy in breast cancer patients at Dr. H. Abdul Moeloek Hospital, Lampung Province in 2023. This type of research is a qualitative descriptive observational study with a cross-sectional design and accidental sampling data collection techniques. Data analysis was done descriptively in the form of a percentage. The sample in this study was 41 patients. The results of the study based on the characteristics of female gender were 41 patients (100%) and male patients were 0 patients (0%), the age of the diagnosed patients was in the age range of 36-45 years as many as 13 patients (31.7%), 46-55 years as many as 13 patients (31.7%), and 56-65 years as many as 13 patients (13.7%), based on the patient's occupation with the occupation of a housewife (IRT) as many as 24 patients (58.5%), treatment with the TdCar regimen (Taxane (docetaxel), Carboplatin) as many as 13 patients (26.9%) and the AC regimen (Doxorubicin, Cyclophosphamide) as many as 11 patients (21.2%). The conclusion of this study is the side effects using the Naranjo algorithm, the score obtained is between 1-4 (possible) which means that there may be an ADR. The most common side effects suffered by breast cancer chemotherapy patients at Dr. Soetomo Hospital. H. Abdul Moeloek Lampung Province in 2023 was hair loss (87.8%). Keywords: Side Effects, Breast Cancer, Chemotherapy, Cross-sectional
Co-Authors Adityo Adityo Andinni, Aulia Ayu Herawati Cahya Rizky Amaliana Desiamti Ughfiroh Deska Maharani Putri Dion Yongtama Dwi Atika DWi Aulia Ramdini Dwi Aulia Ramdini Fitri Dwi Antari Harissa, Nola Hijrah Hijrah Hijrah Hijrah Hijrah Ika Harum Saputri Ikhrami Nurjannah Kartika Handayani Miftahul Choiriah Mulyani, Yuli Wahyu Tri Niluh Suastini Nopiyansyah Novita Tri Wahyuni Novita Tri Wahyuni Rahayu, Dwi Sri Ramadhan Triyandi Ratih Anggun Komalasari Rima Indriani Rokiban, Akhmad Salsabila, Jauza Suri, Nurma Susanti, Laila Tri Wahyuni, Novita Viogenta, Pratika Wahyuni, Novita Tri Widiyastuti, Asih Widodo, Subur