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All Journal Jurnal Biologi Tropis The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Pambudi, Balqis Prudena Kurnia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Effectiveness of Combination Therapy of Stereotactic Body Radiation Therapy with Lenvatinib in Advanced Hepatocellular Carcinoma Putri, Alifia Sabira; Nuriasti, Rovera; Pambudi, Balqis Prudena Kurnia; Fauzan, Naufal Revaldy; Maudina, Baiq Zaskia; Prawira, Yoga; Larasati, Anak Agung Ayu Regina; Budyono, Catarina
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025168-175

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a high mortality rate, especially in advanced stages. Treatment of advanced HCC remains a significant challenge due to limited effective therapeutic options. This study examines the effectiveness of combining Stereotactic Body Radiation Therapy (SBRT) and Lenvatinib in advanced HCC patients. SBRT is a high-precision radiation technique that allows high-dose irradiation of tumor targets with minimal damage to surrounding healthy tissues. At the same time, Lenvatinib is a multikinase inhibitor that inhibits several critical molecular pathways in angiogenesis and tumor cell proliferation. The results showed that the combination of SBRT and Lenvatinib significantly improved overall survival (OS) by reducing the risk of death by 63%, progression-free survival (PFS) reduced the risk of tumor progression by 67%, intrahepatic tumor progression-free survival (IHPFS) showed a decrease of 71%, objective remission rate (ORR) was also higher in the combination group (56.8%), and disease control rate (DCR) of 91.9% which was higher than the use of Lenvatinib alone. However, this combination therapy also carries a higher risk of side effects, including hypertension and diarrhea, which require close monitoring and dose adjustment. This study suggests combining SBRT and Lenvatinib may be a more practical approach to treating advanced HCC. However, the treatment strategy needs to be tailored to the patient's condition to minimize the risk of toxicity.
Caring for HIV Person in Dermatology Jibriel, Diaz Azhalea; Dharma, Yoga Prawira Wedha Swara; Nuriasti, Rovera; Pambudi, Balqis Prudena Kurnia; Sugiono, Muhammad Rafly Adrian; Febriana, Nanggi Qoriatul; Dwiandika, Rizki Ary; Zulkifli, Yasmin Sabrina; Larasati, A. A. A. Regina; Senna, Cantika Brilliant; Tahriani, Ridha; Arif Zuhan
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10075

Abstract

More than 90% of individuals infected with Human Immunodeficiency Virus (HIV) exhibit skin abnormalities that can serve as important clues for early diagnosis, monitoring disease progression, and assessing the effectiveness of antiretroviral therapy (ART). However, the diverse presentation of skin problems often complicates clinical management. Methods: This article is based on a literature review of various international and national publications on skin manifestations in HIV patients, as well as dermatological management guidelines. The analysis focused on the types of skin infections, non-infectious conditions, side effects of ART, and recommended treatment strategies. Results: The literature review revealed that skin problems in HIV patients include fungal infections (such as candidiasis, dermatophytosis), bacterial (CA-MRSA, syphilis), viral (HSV, VZV, HPV, molluscum contagiosum), and non-infectious conditions such as seborrheic dermatitis, psoriasis, and severe drug reactions. These skin conditions are influenced by a weakened immune system, treatment side effects, and socioeconomic factors. Treatment requires a combination of ART therapy, dermatological care tailored to the type of skin problem, and psychosocial support. Conclusion: Skin manifestations in HIV patients reflect their immune system and quality of life. Comprehensive treatment, including ART, dermatological therapy, and a psychosocial approach, has been shown to be effective in reducing morbidity and stigma. The results of this study underscore the importance of interdisciplinary collaboration to improve treatment outcomes for HIV patients with skin problems in Indonesia.
Cerebral Stroke Secondary to Decompression Ilness (DCI): Pathophysiology, Clinical Presentation, Diagnosis, and Management Khairifathiyyah, Khairifathiyyah; Aryasta, Ida Bagus Putra Bayu; Prawira, I Nyoman Dio Yudha; Untari, Lania Pradiva; Pambudi, Balqis Prudena Kurnia; Hunaifi, Ilsa
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10783

Abstract

Decompression illness (DCI) encompasses two major diving-related disorders: decompression sickness (DCS) and arterial gas embolism (AGE). Both conditions are characterized by the formation of gas bubbles that act as the primary mechanism of tissue injury, resulting in overlapping clinical manifestations and similar therapeutic approaches. This study aims to review the pathophysiology, clinical presentation, diagnosis, and management of DCI that presents with stroke-like neurological symptoms. The method used was a literature review approach based on current evidence from recent scientific publications. Findings show that DCS occurs when dissolved inert gases, such as nitrogen, become supersaturated during ascent and form bubbles within tissues and the venous circulation. AGE typically arises from pulmonary barotrauma, allowing trapped gas to enter the pulmonary veins and reach the arterial circulation, with the brain as the most vulnerable target organ. DCI is considered a medical emergency requiring definitive management with hyperbaric oxygen therapy (HBOT). Neurological manifestations of DCI often resemble conventional ischemic stroke but demonstrate distinct clinical and temporal patterns related to pressure changes. Therefore, in addition to recompression therapy, patients may require standard acute stroke management. Prognosis depends heavily on the promptness of diagnosis and treatment, as early intervention is critical to preventing permanent neurological injury.
Co-Authors Arif Zuhan Aryasta, Ida Bagus Putra Bayu Catarina Budyono, Catarina Dharma, Yoga Prawira Wedha Swara Dwiandika, Rizki Ary Fauzan, Naufal Revaldy Febriana, Nanggi Qoriatul Ilsa Hunaifi, Ilsa Jibriel, Diaz Azhalea Khairifathiyyah, Khairifathiyyah Larasati, A. A. A. Regina Larasati, Anak Agung Ayu Regina Maudina, Baiq Zaskia Nuriasti, Rovera Prawira, I Nyoman Dio Yudha Prawira, Yoga Putri, Alifia Sabira Senna, Cantika Brilliant Sugiono, Muhammad Rafly Adrian Tahriani, Ridha Untari, Lania Pradiva Zulkifli, Yasmin Sabrina