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PENGARUH PRA-PERLAKUAN AIR PERASAN RIMPANG KENCUR (Kaempferia galanga L) Dan DAUN SELEDRI (Apium graveolens L) TERHADAP FARMAKOKINETIKA SEFALEKSIN PADA TIKUS JANTAN Yelfi Anwar
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 2, No 1 (2017)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.219 KB) | DOI: 10.52447/inspj.v2i1.441

Abstract

Interaksi yang terjadi antara sesama obat modern ataupun antara obat modern dengan obat tradisional serta antara obat dengan makanan, merupakan masalah yang perlu dicermati. Kemungkinan banyak pasien yang memakai suatu produk obat juga mengkonsumsi bahan-bahan alam secara bersamaan dan sementara pengetahuan tentang interaksi yang terjadi masih sedikit. Kemungkinan interaksi yang terjadi tersebut dapat menyebabkan perubahan farmakokinetika dan efek farmakologi. Penelitian ini bertujuan untuk mengamati pengaruh pengaruh pra-perlakuan air perasan rimpang kencur (Kaempferia Galanga L) dan daun seledri (Apium Graveolens L) terhadap farmakokinetika sefaleksin. Rancangan penelitian adalah paralel menggunakan tikus Wistar jantan (150-200 gram, umur 2-3 bulan) sebagai hewan uji, dengan satu kelompok kontrol (pemberian sefaleksin dengan dosis 25 mg/kg BB secara iv) dan dua kelompok pra-perlakuan masing-masing dengan air perasan rimpang kencur dan air perasan seledri (dosis 20 mg/kg BB secara p.o), pemberian dilakukan 1 jam sebelum penyutikan sefaleksin. Masing-masing kelompok terdiri dari 6 ekor hewan uji. Data yang dikumpulkan meliputi data parameter farmakokinetika yang diperoleh dari kadar sefaleksin utuh dalam darah dan urin. Cuplikan darah (0,2 ml) diambil dari vena lateralis ekor tikus pada menit-menit tertentu yaitu : 0, 2, 10, 20, 30, 60, 90, 120, 150 dan 180. Data urin diperoleh dengan pengumpulan urin selama 24 jam. Kadar sefaleksin utuh dalam darah dan urin ditetapkan secara spektrofluorometri. Dengan menggunakan analisa statistik yaitu uji students t tidak berpasangan dengan taraf kepercayaan 95% menggunakan perangkat lunak Graph PAD InStat.Hasil penelitian menunjukkan bahwa pra-perlakuan dengan air perasan rimpang kencur tidak menunjukkan perubahan parameter farmakokinetika sefaleksin (p>0,05). Pra-perlakuan dengan air perasan seledri mengakibatkan penurunan ClR dan Fel berturut-turut sebesar 49,67% dan 42,91% (p<0,05).  Interactions that occur among modern medicine or between modern medicine with traditional medicine and the medicine with food, an issue that needs to be observed. The possibility of many patients taking a drug product also consumes natural materials simultaneously and while the knowledge about the interaction that occurs is still little. The possibility of interactions that occur can cause changes in the pharmacokinetics and pharmacologic effects. This study aimed to investigate the effect of pre-treatment effect of the juice of the rhizome kencur (Kaempferia galanga L) and celery (Apium graveolens L) on the pharmacokinetics of cephalexin. The study design is parallel use male Wistar rats (150-200 g, aged 2-3 months) as test animals, with a control group (administration of cephalexin with a dose of 25 mg / kg iv) and two pre-treatment groups respectively with kencur rhizome juice and celery juice (dose of 20 mg / kg in po), granting performed 1 hour before penyutikan cephalexin. Each group consisted of 6 test animals. Data collected includes data parameters that shown pharmacokinetics of cephalexin levels intact in the blood and urine. Footage of blood (0.2 ml) were taken from the lateral tail vein of mice at a particular minute: 0, 2, 10, 20, 30, 60, 90, 120, 150 and 180. Data obtained with the urine for 24-hour urine collection , Cephalexin levels intact in the blood and urine determined spektrofluorometri. By using statistical analysis which students unpaired t test with a level of 95% using the software Graph PAD InStat. The results showed that pre-treatment with the juice of the rhizome kencur showed no change in the pharmacokinetics of cephalexin parameters (p> 0.05). Pre-treatment with celery juice resulted in a decrease in the CLR and Fel, respectively for 49.67% and 42.91% (p <0.05).
Fractionation of Citronella Oil and Identification of Compounds by Gas Chromatography-Mass Spectrometry Anwar, Yelfi; Siringoringo, Victor S
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

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Abstract

Citronella oil is one of the most important essential oils and is widely used in the pharmaceutical, cosmetic and food industries. However, the selling price of citronella oil is still low, so efforts are needed to increase its added value by isolating the active components such as citronellal, citronellol and geraniol. This study aims to isolate the active ingredients of citronella oil that have higher economic added value. Citronella oil was obtained by the process of distillation of Cymbopogon nardus (L.) Rendle leaves. The essential oil was then fractionated by a vacuum fractionation process. The essential oil fraction was identified by Gas Chromatography - Mass Spectrometry (GC-MS). Fractions obtained from the fractionation process were identified, and the results were: F1 (D-Limonene: 72.89%), F2 (Citronellal: 50.13%), F3 (Citronellal: 74.89%), F4 (Citronellal: 88.56%), F5 (Citronellal: 84.89%), F6 (Citronellal: 55.38%), F7 (Citronellol: 57.42%), F8 (Citronellol: 44.73%), F9-1 (Geraniol: 65.56%), F9-2 (Geraniol: 64.41%) and residual (Geraniol: 32.04%). Based on these results, several active compounds from citronella oil can be obtained using the vacuum distillation fractionation method.
Penyuluhan Kesehatan Tentang Cara Kerja Obat Di Sekolah Dasar (SD) Muhammadiyah 17 – Jakarta Utara Yelfi Anwar; Seftian Putra Dwijaya Marpaung; Michael Michael
BERDIKARI Vol 2, No 1 (2019): Jurnal Berdikari Vol 2 No 1
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.617 KB) | DOI: 10.52447/berdikari.v2i1.4091

Abstract

Obat adalah benda atau zat yang dapat digunakan untuk merawat penyakit, meredakan atau menghilangkan gejala, atau mengubah proses kimia dalam tubuh. Obat merupakan bahan atau paduan bahan-bahan yang dimaksudkan untuk digunakan dalam menetapkan diagnosis, mencegah, mengurangi, menghilangkan, menyembuhkan penyakit atau gejala penyakit, luka atau kelainan fisik dan psikis pada manusia atau hewan. Di Amerika Serikat, seorang medis profesional dapat memperoleh obat dari perusahaan farmasi atau apotek (yang membeli obat dari perusahaan farmasi). Apotek dapat juga menyediakan obat secara langsung kepada pasien bila obat tersebut dapat dengan aman digunakan sendiri, atau diberi kuasa dengan resep yang ditulis oleh dokter. Dalam penyuluhan kesehatan tentang cara kerja obat di dalam tubuh di Sekolah Dasar (SD) Muhammadiyah 17- Jakarta Utara dengan umlah siswa 26 orang (Kelas 3). Media yang digunakan  digunakan dalam penyuluhan ini yaitu, banner, leaflet, dan power point untuk mendukung kegiatan menjadi lebih efektif. Dari beberapa siswa sebelum kami melakukan penyuluhan, sebagian besar mereka belum mengetahui tentang cara kerja obat di dalam tubuh oleh karena itu penyuluhan ini perlu kami lakukan di Sekolah Dasar tersebut. Dari penyuluhan yang telah dilakukan, dari total 26 siswa/i diperoleh persentase siswa yang telah memahami tentang bagaimana Cara Kerja Obat di dalam tubuh sebesar 93 % dan siswa yang masih belum memahami tentang bagaimana cara kerja obat di dalam tubuh sebesar 7%. Dengan adanya persentase yang diperoleh, secara garis besar siswa/i telah memahami tentang cara kerja obat. Kata Kunci: Penyuluhan, Cara kerja obat di dalam tubuhABSTRACTIn health education about the workings of drugs in the body in the Primary School (SD) Muhammadiyah 17- North Jakarta with 26 students (Class 3). The media used in this outreach are banner, leaflet and power point to support activities more effectively. From a number of students before we did counseling, most of them did not know about the workings of drugs in the body, so we needed to do this counseling at the elementary school. From counseling that has been done, from a total of 26 students obtained the percentage of students who have understood about how the drug works in the body by 93% and students who still do not understand about how the drug works in the body by 7%. With the percentage obtained, in general students have understood about how medicine works.Keywords: Counseling How the drug works in the body
Penyuluhan Penyakit Diabetes Mellitus kepada Remaja Sekolah Menengah Atas di Jakarta Utara Yelfi Anwar; Muhammad Dimas An-Naf; Maeesa Putri Lathiifah; Lesli Tiana; Ratih Hardianti; Dewi Puspitasari; Etika Dewi Maharani; Nia Khorotun Fadillah; Fatimah Tibbiya; Lulu Najmah; Kartika Kartika; Jodi Apriadi; Setya Astuti; Alicia Alicia; Naplatul Mahmudah; Indah Mareta Dwi Editia
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 2 (2022): Vol 1 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1119.791 KB) | DOI: 10.3731/phar.soc.v1i2.15569

Abstract

Diabetes mellitus counseling is an activity to provide information and education about Diabetes Mellitus (DM) to the community and schools. The counseling was held at the Al-Khariyah High School onsite, the target participants were 11th grade science students. This counseling aims to provide knowledge and understanding of DM and its risk factors, including Body Mass Index (BMI), blood pressure, physical activity habits, frequency of fruit and vegetable consumption, family history of DM, waist circumference (central obesity) in adolescents high school students. The extension activities were carried out for 2 hours, starting with giving a pre-test questionnaire and ending with giving a post-test according to the topic of the extension, each with 10 questions, with the same types of questions. The pre-test and post-test were used to see the presentation of the increase in knowledge and understanding of the extension participants. This training was attended by 26 participants. From the results of the pre-test and post-test answers given, there is an increase in understanding and knowledge about Diabetes Mellitus and risk factors in adolescents.
FORMULATION AND PHYSICAL STABILITY EVALUATION OF ESSENTIAL OIL PARFUME Yelfi Anwar; Efa Bonita; Andrianopsyah Mas Jaya Putra
Media Bina Ilmiah Vol. 17 No. 7: Februari, 2023
Publisher : LPSDI Bina Patria

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33578/mbi.v17i7.294

Abstract

The need for essential oils will continue to increase by up to 8–10% in line with the increasing production of perfume. This shows that there is a public need for the perfume, which is increasing day by day. This research design is experimental and aims to determine a symptom or effect that arises as a result of certain treatments, to produce eau de toilette-type formulas and perfumes that have good quality and are liked by respondents. The evaluation was carried out using several tests, namely the organoleptic test, specific gravity test, fragrance resistance test, spreadability test, sensitivity test, physical stability test, pH test, and hedonic test. The results showed that organoleptically, all formulas produced a yellow color, were homogeneous and free of particles, and had a slightly pungent smell of fresh oranges. The specific gravity of all formulas met the requirements, with the largest specific gravity F2 of 0.86 at cold temperatures. The fragrance resistance test still smelled after 4 hours. The biggest spot test results were on F1, with a diameter of 49.17 mm. The sensitivity test did not show any allergic reactions or irritation of the skin during the use of the perfume, and the physical stability test of the entire formula did not show any separation or change in shape over a period of 7 weeks, both in room temperature storage and at cold temperatures. The entire formula has a liquid texture, is not sticky, and is easy to apply. The results of the evaluation of pH testing are in the range of 5–6 and have fulfilled the requirements of SNI 16-4399-1996, cosmetic preparations must have a pH according to the pH of the skin, which is in the range of 4.5–6.5. And the most preferred formula is Formula 1.
IDENTIFICATION IDENTIFICATION OF THE CHEMICAL COMPOUNDS OF CITRUS HYSTRIX ESSENTIAL OIL, CANANGA ORDORATA ESSENTIAL OIL, AND POGOSTEMON CABLIN BENTH ESSENTIAL OIL USING GAS CHROMATOGRAPHY-MASS SPECTROPHOTOMETRY (GC-MS) Yelfi Anwar; Efa Bonita; Andrianopsyah Mas Jaya Putra
BIOEDUKASI Vol 21 No 1 (2023)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v21i1.38039

Abstract

Essential oils, commonly known as etheric oils (essential oil, volatile oil), are produced by plants and can be obtained from the roots, stems, leaves, and flowers of plants. This study aims to determine the chemical components of kaffir lime (Citrus hystix) essential oil, ylang ylang (Cananga ordorata), and patchouli oil (Pogostemon cablin benth) obtained from farmers and refiners in Lembang, West Java. The composition of this essential oil was analyzed using the gas chromatography–mass spectrometry (GC–MS) method. The results of the analysis of the chemical components of the essential oil constituents of kaffir lime showed that the main components included linalyl acetate (20.59%), D-limonene (17.77%), and linalool (15.19%). In ylang-ylang oil, bioactive compounds such as sesquiterpenes, namely caryophyllene, were found in as much as 14.36%, which has anti-inflammatory, anti-bacterial, and local anesthetic properties. Identification of patchouli oil with its main component, namely patchouli alcohol, at 19.27%.
Analisa Biaya Pengobatan Pasien Rawat Inap Orang Dengan Gangguan Jiwa (ODGJ) dengan diagnosa COVID-19 di Rumah Sakit X periode Mei – Juli 2021 Oktavia Anggrainy; Piter Piter; Yelfi Anwar
Jurnal Kesehatan Vol. 11 No. 1 (2023): April : Health Journal "Love That Renews"
Publisher : Sekolah Tinggi Ilmu Kesehatan Santo Borromeus

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Abstract

Di masa pandemi Covid-19 pasien ODGJ memiliki risiko tinggi untuk terinfeksi COVID-19 dan menularkannya kepada orang sekitar dengan angka kematian meningkat. Rumah Sakit X pada maret 2020 telah membuka pelayanan rawat inap untuk pasien (ODGJ) dengan kasus suspect dan terkonfirmasi COVID -19. Penelitian ini bertujuan mengetahui gambaran pengobatan pasien rawat inap, biaya langsung medis serta melakukan perbandingan biaya riil dengan klaim penggantian biaya pelayanan pasien rawat inap COVID-19 yang dikeluarkan oleh Kementerian Kesehatan melalui KMK Nomor HK.01.07/MENKES/4344/2021 di Rumah Sakit X pada periode Mei - Juli 2021. Penelitian ini adalah penelitian farmakoekonomi dengan metode cost analysis secara retrospektif dengan rancangan cross sectional meliputi perhitungan biaya langsung medis dan tarif klaim penggantian biaya COVID-19 sesuai dengan KMK nomor HK.01.07/MENKES/4344/2021 yang diperoleh berdasarkan penelusuran rekam medik, data biaya perawatan pasien. Data yang diperoleh yaitu sebanyak 109 pasien yang memenuhi kriteria inklusi. Pengolahan data meliputi demografi pasien, rata-rata biaya langsung medis dan selisih perbedaan biaya riil dan klaim COVID-19 sesuai KMK Nomor HK.01.07/MENKES/4344/2021. Berdasarkan penelitian diketahui biaya medis langsung terbesar terdapat pada kriteria kasus konfirmasi dengan komorbid selain jiwa dengan nilai rata-rata biaya sebesar Rp 11.471.930,76, dengan biaya kamar rawat inap pada komponen biaya medis langsung sebagai penyusun terbesar Terdapat perbedaan yang signifikan antara total biaya riil pasien dengan klaim COVID-19 sesuai KMK Nomor HK.01.07/MENKES/4344/2021 (p<0,05).
Identification Chemical Compounds of Cymbopogon nardus (L.) Rendle Essential Oil Using Gas Chromatography and Mass Spectrophotometry (GC-MS) Marisa Tamara Sari; Yelfi Anwar; Andrianopsyah Mas Jaya Putra
BIOEDUKASI Vol 21 No 2 (2023)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v21i2.39692

Abstract

The fragrant Citronella oil derived from Cymbopogon nardus (L.) Rendle has many benefits, one of which is as an antibacterial. This research aims to identify the chemical compounds present in the essential oil Citronella obtained from a local distillery in Anding Village, Suliki District, Gunung Mas 50 Kota Regency, Province West Sumatra. The essential oil Citronella was identified using Gas Chromatography-Mass Spectrophotometry (GC-MS) at the BRIN (National Research and Innovation Agency) chemistry laboratory in Serpong, South Tangerang, Banten. The results showed that the essential oil Citronella met the requirements of SNI 06-3953-1995, and after being identified with GC-MS, 39 chemical compounds were found, with 3 compounds having high concentrations in the essential oil: Citronellal (24.57%), Citronellol (11.69%), and Geraniol (15.59%).
Formulasi Obat Kumur Minyak Atsiri Sereh Wangi (Cymbopogon nardus (L.) Rendle) dan Uji Aktivitas Antibakteri terhadap Streptococcus mutans Marisa Tamara Sari; Yelfi Anwar; Andrianopsyah Mas Jaya Putra
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 1 (2023): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i1.8308

Abstract

Mouthwash is a liquid, aqueous composition that is primarily used to treat oral conditions, as well as maintain oral health. The purpose of this study was to prove the antibacterial efficacy of citronella essential oil against Streptococcus mutans bacteria made in mouthwash formulations. Citronella essential oil was analyzed using GC-MS and then formulated into a mouthwash with concentrations of 1.5%, 3% and 4.5% at cold temperatures (2-8°C) and room temperature (20-25°C).The test results were evaluated, and analyzed using One Way ANOVA and Post Hoc Tukey. The GC-MS results showed that 3 main compounds were detected, namely Citronellol (11.69%), Geraniol (15.59%), and Citronellal (24.57%). The mouthwash formulation did not show any organoleptic change in physical preparation, was homogeneous, had a pH range of 4.91-5.18 at cold temperature and pH 5.02-5.23 at room temperature, had a viscosity consistency that met the standard of 0.8 -1 at cold temperature and room temperature, and no separation was found, such as the presence of precipitate in each treatment. Formula 3 is considered to have medium inhibition compared to formulas 1 and 2 with an average inhibition power at cold temperature formula 6.73 while at room temperature formula 7.35. Briefly, the formulation is stable both at cold temperature (2-8°C) and room temperature (20-25°C) with moderate inhibition at a concentration of 4.5%.
Identification of Chemical Compounds of Ylang Ylang Flower Essential Oil (Cananga Odorata) and Kaffir Lime Essential Oil (Citrus Hystrix) Using Gas Chromatography- Mass Spectrophotometry (Gc-Ms) Wibawanto, Dhea Setyalova; Anwar, Yelfi; Muryanto, Muryanto
BIOEDUKASI Vol 22 No. 2 (2024)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v22i2.47857

Abstract

Essential oils are substances that have an aroma contained in plants, these oils are usually also referred to as volatile oils and are usually in liquid form and can be isolated from plant parts such as roots, stems, leaves, flowers, fruit and seeds. This research aims to determine the chemical components of kaffir lime essential oil (Citrus hystix), ylang ylang (Cananga odorata) using the GC-MS method. The conclusion from the research results is that there is a main compound produced by kaffir lime (Citrus hystix) essential oil, namely the chemical compound D-limonane (15.15%) while the chemical compound linalool contained in kaffir lime (citrus hystrix) essential oil is only 1.04 % so that the essential oil of kaffir lime (citrus hystrix) does not meet the quality standard requirements for the chemical compound linalool of 3.5-5.5%. The main compound produced by ylang-ylang oil (Cananga odorata) is the chemical compound Linalool (17.85%). In this case, efforts need to be made to improve the quality of essential oils in order to increase added value and meet the requirements for essential oil quality standards.
Co-Authors Ade Via Jualiana Agnes Lenoera Akifah, Hana Tri Alicia Alicia Alifvia Nurcahyani Ance Tenouye Andrianopsyah Mas Jaya Putra Andrianopsyah Mas Jaya Putra Andrianopsyah Mas Jaya Putra Andrianopsyah Mas Jaya Putra Angel Maria Simatupang Angela Imelda Cahaya Atisi, Atisi Ayunda Fajarni Rahmi Ayuni, Fitri Berliano Karvenio Dasmyta, Eny Desty Andiani Dewi Puspitasari Dhea Setyalova Wibawanto Diajeng Para Mitha Diajeng Para Mitha Dias Septiana Sari Dias Septiana Sari Efa Bonita Efa Bonita Egy Octaviani Eka Kristina Eka Syafitri Puspita S Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah Epifani Januar P Etika Dewi Maharani Fathur Rahman Fatimah Tibbiya Feby Bethariya O Fikri, Muhammad Sayid Ali Firman, - Fitri Ayuni Gabriel Janiva Gabriela, Jean Grace Tandiseru Gracia Lai Gavia Wau Hallimah Vira Maulida Ikramullah, Nazwa Indah Mareta Dwi Editia Istiqomah, Fajriatul Jodi Apriadi Kartika Kartika Keysha Rayi Tifani Laila Safa Asrianti Laras Puspita Dewi Lesli Tiana Lily Suciati Lulu Najmah Madelyne Yuliana Insanie Maeesa Putri Lathiifah Maria Elisabeth Bota Benny Horang Marisa Tamara Sari Marisa Tamara Sari Maryan, Roni Maryana, Roni Michael Michael Muhammad Dimas An-Naf Muhammad Nazzal Muhyiddin Al Firmansyah Muryanto Muryanto, Muryanto Naplatul Mahmudah Nia Khorotun Fadillah Niken Diaz Tantri Ni’am, Laelatun Nonik, Nonik Novia Aditia Ningtiyas Nurul Diniah Oktavia Anggrainy Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Permatasari, Nurfebby Piter Piter Raden Roro Putri Nur Ramadhania Rafael Rafael Rahmadani, Nur Fitri Ratih Hardianti Regina Regina Regina Regina Rina Pebriani Riska Rahmadani Risty Setyati Ashari Ruminah Rusdi, Rafflis Sari, Eka Syafitri Puspita Sari, Sintya Puspita Seftian Putra Dwijaya Marpaung Sembiring, Rinawati Setya Astuti Shirly Kumala Shirly Kumala Silvy Widya Rahmi Silvy Widya Rahmi Siringoringo, Victor S Sri Dwi Wulandari Sucahyo Adi Nugroho Sucahyo Adi Nugroho Sudirman, - Surahman, Dziki Dzikrivan Syari Fatul Hayanis Syifa Alifia Indriani Syifa Alifia Indriani Victor Sahat Siringoringo Vinsensia Asahi Sulan Langit Wd Windi Pratiwi Wibawanto, Dhea Setyalova Windy Annisa Arbah Yofie Aldo Aditya Yofie Aldo Aditya Zahara Nurhazizah Zuli Astuti Salsabilla