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All Journal Jurnal Kesehatan Andalas Jurnal Farmasi Klinik Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Jurnal Respirasi (JR) Human Care Journal Unri Conference Series: Community Engagement Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Multidisiplin Indonesia Jurnal Riset Ilmiah
Ermayanti, Sabrina
Universitas Andalas
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Management of Resistance to Targeted Therapy in EGFR Mutational Lung Adenocarcinoma: A Case Report Armiza; Sabrina Ermayanti; Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.779

Abstract

Advances in diagnosis and treatment have enabled a targeted therapy approach to inhibit tumor progression and provide a favorable prognosis. One of the targeted therapies in non-small cell lung cancer (NSCLC) is tyrosine kinase inhibitor (TKI) in mutations epidermal growth factor receptor (EGFR). This study aimed to present a case with the management of resistance to targeted therapy in EGFR-mutated lung adenocarcinoma. Data shows median progression-free survival patients on TKI therapy at 10 to 14 months. Progressive caused by resistance to TKI and assessed using response evaluation criteria in solid tumors (RECIST) 1.1. and confirmed by repeat biopsy. Reported a male patient aged 66 years with adenocarcinoma of the right lung EGFR deletion exon 19 mutation and received afatinib therapy for 16 months. Patients experience oligo progressive in the 13th month of therapy and systemic progression 16th month.
Profil Pasien COVID-19 dengan Komorbid yang Dirawat di RSUP Dr. M. Djamil Padang Hamni Tanjung; Julizar Julizar; Sabrina Ermayanti; Deddy Herman; Liganda Endo Mahata; Syandrez Prima Putra
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 1 (2023): Maret 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i1.971

Abstract

Latar Belakang: Coronavirus Disease 2019 (COVID-19) yang disebabkan Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2) telah menjadi perhatian dunia sejak awal ditemukan hingga saat ini. Keparahan kondisi pasien COVID-19 dengan komorbid dipengaruhi dengan berbagai faktor yang dapat meningkatkan morbiditas dan mortalitas pasien COVID-19. Objektif: Penelitian ini bertujuan untuk mengetahui profil pasien COVID-19 dengan komorbid yang dirawat di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini merupakan observasional deskriptif dengan pendekatan cross-sectional. Data penelitian diambil dari data rekam medis dengan teknik pengambilan total sampling pada pasien yang dirawat pada 1 Oktober sampai 31 Desember 2020. Hasil: Penelitian ini mendapatkan dari total 144 pasien, 34% pasien COVID-19 dengan komorbid merupakan kelompok usia 50-59 tahun, 50,7% berjenis kelamin laki-laki, 59,7% memiliki riwayat pendidikan tingkat menengah dan 53,5% berstatus IMT obesitas. Komorbid terbanyak yang ditemukan adalah 29,2% hipertensi dengan 73,6% pasien memiliki lebih dari satu komorbid, sebanyak 77,1% merupakan COVID-19 derajat sedang dengan 71,5% memiliki lama rawatan 14 hari atau kurang, serta 62,5% memiliki luaran COVID-19 sembuh. Kesimpulan: Penelitian ini menemukan sebagian besar pasien COVID-19 dengan komorbid yang dirawat merupakan kelompok usia tua, dengan komorbid terbanyak hipertensi, sebagian besar memiliki lebih dari satu komorbid, mengalami derajat sakit sedang dengan lama rawatan 14 hari atau kurang, dan luaran sembuh.
Indonesian Society of Respirology (ISR) Consensus Statement on Lung Cancer Screening and Early Detection in Indonesia Sita Andarini; Elisna Syahruddin; Nathaniel Aditya; Jamal Zaini; Ferry Dwi Kurniawan; Sabrina Ermayanti; Noni Novisari Soeroso; Sri Melati Munir; Andreas Infianto; Ana Rima; Ungky Agus Setyawan; Laksmi Wulandari; Haryati Haryati; Ida Ayu Jasminarti; Arif Santoso
Jurnal Respirologi Indonesia Vol 43, No 2 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i2.455

Abstract

Lung cancer is the leading cause of mortality for all cancer globally and in Indonesia. In Indonesia, lung cancer contributes to 12.6% of death of all cancer, making it the number one cause of cancer death, and 8.6% of all cancer incidence in 2018, behind breast, cervical, and colorectal cancer. The total cases per year are expected to almost double from 30,023 in 2018 to 54,983 cases in 2040. Smoking is among the risk factors for lung cancer, after occupational/environmental risk factors, history of lung fibrosis, and family history of cancer. There was a tendency of younger smokers in Indonesia and increased lung cancer incidence and prevalence in the younger population. The median age of lung cancer in Indonesia was younger than in any country, probably due to the younger age of smoking, early onset of carcinogens, asbestos use, and environmental. Lung cancer screening is a voluntary measure to detect lung cancer in the earliest stage, to find cancer at curable disease before symptoms appear in high-risk individuals. Lung cancer early detection is strategies to find cancer earlier after symptoms appear (cough, hemoptysis, dyspnea, chest pain). Low-dose computerized tomography of the thorax (LDCT) screening has been known to reduce lung cancer mortality compared to a chest x-ray (CXR). This Indonesian Society of Respirology consensus statement was aimed to give recommendations on lung cancer screening and early diagnosis in Indonesia.
LENT Score as a Prognosis Factor for Overall Survival and Progression-Free Survival in Malignant Pleural Effusion Patients at Tertiary Hospitals in West Sumatera, Indonesia Laisa Azka; Sabrina Ermayanti; Russilawati; Irvan Medison; Deddy Herman; Fenty Anggraininy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.835

Abstract

Background: Malignant pleural effusion (MPE) has a variable survival rate and prognosis. The LENT score is one method for assessing survival rates in patients with MPE. This study aimed to investigate the LENT score as a prognostic factor for overall survival (OS) and progression-free survival (PFS) of patients with MPE at a tertiary hospital in West Sumatera. Methods: This study was an observational analytic study involving several tertiary hospitals in West Sumatera with a minimum observation period of 2 years. Data were collected from medical records. We used Kaplan Meier analysis to assess OS and PFS. Results: A total of 198 subjects met the inclusion criteria. Most MPE patients in this study were aged ≥60 years, male, smokers, pleural fluid lactate dehydrogenase value <1500, ECOG 1, serum NLR value <9, and high-risk cancer, namely lung cancer. The distribution of LENT scores for MPE patients was evenly distributed among the low, medium, and high-risk groups. Kaplan Meier analysis showed that the median OS based on LENT scores were 804 days, 275 days, and 161 days, respectively (log-rank test p = 0.000). The median PFS based on LENT scores were 715 days, 202 days, and 106 days, respectively (log-rank test p=0.000). The OS and PFS findings are longer than previous studies. Conclusion: Based on LENT scores, overall survival and progression-free survival MPE patients at tertiary hospitals in West Sumatera have a better prognosis compared to previous studies.
Correlation of the Adverse Event Following Immunization with the Severity of COVID-19 Infection in Health Care Workers in Padang Sabrina Ermayanti; Fenty Anggrainy; Kornelis Aribowo; Muhammad Bagus H.S.; Rizki Amrika; Dwi Rizki Fadhilah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 7 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i7.837

Abstract

Background: Effective countermeasures to control the current COVID-19 pandemic are the implementation of health protocols and vaccinations. The problem that must be a concern after vaccination is post-immunization co-occurrence (AEFI), including COVID-19 vaccination. Another issue that is also a concern after vaccination is the incidence of being infected with COVID-19. The purpose of this study was to determine the incidence of post-vaccination COVID-19 infection in health workers in the city of Padang and its association with the incidence of COVID-19 vaccine AEFIs. Methods: The study used a descriptive-analytic design with a retrospective cohort method. The research will be carried out in all hospitals in Padang, and sampling will be carried out for 2 months, from November to December 2021. Officers who are confirmed to have COVID-19 after vaccination and meet the inclusion criteria are healthcare workers who have received at least 2 vaccines and are willing to fill out a Google form. Results: The characteristics of health workers in Padang who were confirmed to have COVID-19 after 2 vaccinations were mostly (68.1%) early adults (26-35 years), the sex was mostly female as much as 77.3%, and most professions were workers. Paramedics (nurses or midwives) as much as 57.0%. The most comorbid obesity is as much as 3.4%. Nutritional status assessed by BMI showed that obesity (37.7%) and normal nutritional status (32.9%) had almost the same proportion. Almost all health workers with or without AEFI experience mild COVID-19, as many as 98%, and experience COVID-19 infection 28 days after vaccination. Conclusion: The incidence of AEFI is not related to the severity of post-vaccination COVID-19 infection in health workers in Padang.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
HUBUNGAN DERAJAT MEROKOK TERHADAP PENURUNAN FUNGSI PARU :SEBUAH KAJIAN LITERATUR Vildania, Nisrina; Sabri, Yessy Susanty; Ermayanti, Sabrina
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 2 (2025): SINERGI : Jurnal Riset Ilmiah, February 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i2.885

Abstract

Rokok merupakan gulungan tembakau seukuran jari kelingking yang dibungkus dengan daun nipah atau kertas. Asap rokok mengandung lebih dari 4.000 zat kimia, dengan 40 di antaranya diketahui sebagai penyebab kanker pada berbagai organ tubuh manusia. Sebanyak delapan dari sepuluh penelitian menunjukkan bahwa merokok dapat mengurangi fungsi paru, termasuk kapasitas vital paksa, volume ekspirasi paksa dalam satu detik, VEP1 / KVP, dan aliran ekspirasi paksa pada 25-75%. Studi literatur ini merupakan tinjauan naratif yang membahas berbagai literatur primer dengan desain penelitian observasional mengenai hubungan antara derajat merokok dan penurunan fungsi paru. Penulis melakukan pencarian literatur di enam basis data, yaitu PubMed NCBI, ProQuest, Google Scholar, Elsevier, ResearchGate, dan European Respiratory Journal. Dari 1.545 literatur yang ditemukan, hanya 15 literatur yang memenuhi kriteria inklusi. Sebelas dari lima belas literatur tersebut menyatakan adanya penurunan fungsi paru yang signifikan seiring dengan peningkatan derajat merokok, sementara tidak ditemukan perbedaan signifikan pada empat literatur lainnya. Kesimpulan dari studi ini adalah adanya hubungan antara derajat merokok dengan penurunan fungsi paru, dengan sebagian besar perokok mengalami penurunan fungsi paru yang signifikan. Beberapa faktor yang berhubungan dengan penurunan fungsi paru antara lain usia, jenis kelamin, aktivitas fisik, durasi merokok, serta jumlah batang rokok yang dihisap setiap harinya  
Hubungan Tingkat Keparahan Pasien COVID-19 dengan Distres Psikologis Pada Periode 1 Maret 2020 sampai 31 Desember 2021 di Rumah Sakit Universitas Andalas Liandhu Hakim, Sonya; Widya Murni, Arina; Yulistini, Yulistini; Gusya Liza, Rini; Ermayanti, Sabrina; Ashal, Taufik
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 1 (2025): Maret 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i1.1102

Abstract

Latar Belakang: Wabah COVID-19 (Coronavirus Disease 19) menimbulkan dampak jangka panjang terhadap kesehatan mental. Studi menilai kesehatan mental akibat keparahan COVID-19 masih belum dijadikan sebagai prioritas utama penatalaksanaan COVID-19. Objektif: Penelitian ini bertujuan mengetahui hubungan antara tingkat keparahan COVID-19 dengan stres pasien COVID-19. Metode: Penelitian potong lintang ini dilakukan pada periode 1 Maret 2020 Sampai 31 Desember 2021 di Rumah Sakit Universitas Andalas. Penelitian menggunakan data rekam medis pasien terkonfirmasi COVID-19 yang telah dinilai tingkat stres menggunakan DASS-21 (Depression, Anxiety, Stress Scale 21). Sebanyak 55 responden di ambil dengan teknik pengambilan sampel acak sederhana yang memenuhi kriteria inklusi dan ekslusi. Hasil: Lebih dari setengah pasien COVID-19 (54,5%) memiliki tingkat keparahan penyakit sedang dan 56,3% mengalami tingkat stres sedang. Uji Chi–square menunjukkan hasil yang signifikan dengan nilai p sebesar 0,000. Kesimpulan: Terdapat hubungan yang signifikan secara statistik antara tingkat keparahan COVID-19 dengan tingkat stres pada pasien terkonfirmasi COVID-19. Oleh sebab itu, pendekatan psikologis diperlukan untuk tata laksana pasien COVID-19 untuk mengurangi pengaruh psikis terhadap keparahan penyakit.  
HUBUNGAN OBESITAS DENGAN FUNGSI PARU PADA PEMERIKSAAN SPIROMETRI MAHASISWA PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS Octavia, Fatharani Nabila; Anggraini, Fika Tri; Yetti, Husna; Irramah, Miftah; Ermayanti, Sabrina; Hanum, Fathiya Juwita
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 3 (2025): SINERGI : Jurnal Riset Ilmiah, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i3.1068

Abstract

Background: Abnormal fat accumulation affects the compliance of the respiratory system which contributes to the process of normal lung expansion. Lung function can be evaluated through an examination using spirometry with the parameters assessed, namely FVC, FEV1, and FEV1/FVC. This study aims to determine the relationship between obesity and lungfunction in the spirometry examination of Andalas University Medical Education students. Methods: This study is an observational analytic study with a cross-sectional approach. The Number of samples in this study was 34 subjects. The sampling technique used wasconsecutive sampling from students of Medical Education at the Faculty of Medicine, AndalasUniversity, Class of 2018-2020. Evaluation of lung function was carried out using aspirometry examination with parameters assessed for FVC, FEV1, and FEV1/FVC while the evaluation of obesity was carried out using the BMI with a classification according toKemenkes RI. Data analysis was carried out using univariate and bivariate qualitative methods. Results: In this study, the majority of respondents were women (70.6%) with normal nutritional status (67.6%) followed by obesity (32.4%). The relationship between obesity and lung function was tested using fisher's exact test. The results showed that there was no relationship between obesity and lung function parameters FVC, FEV1, and FEV1/FVC on spirometry tests.
GAMBARAN FUNGSI PARU PADA MAHASISWA DAN RELAWAN LABORATORIUM DENGAN DAN TANPA RIWAYAT COVID-19 DI FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS TAHUN 2021 Dhiaulhaq, Zalva Indira; Afriwardi, Afriwardi; Ermayanti, Sabrina; Irawati, Lili; Russilawati, Russilawati; Putri, Biomechy Oktomalio
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1232

Abstract

Over the past two years, the COVID-19 pandemic has infected many individuals worldwide. Indonesia is one of the countries affected. This virus primarily infects the respiratory system. Some survivors have reported experiencing persistent symptoms after recovering from COVID-19, with some experiencing such symptoms for months. These persistent symptoms can also be referred to as long COVID-19. The purpose of this study is to determine the pulmonary function profile in medical students and laboratory volunteers with and without a history of COVID- 19 at the Faculty of Medicine, Andalas University. This is an observational study with a cross-sectional approach using a total sampling technique. The sample size is 43 COVID-19 survivors and 53 without history of COVID-19 from medical students and laboratory volunteers at the Faculty of Medicine, Andalas University. It is concluded and recommended that the respondents in this study have an average pulmonary function (FEV1, FVC, and FEV1/FVC ratio) in the normal category, with males being the majority among COVID-19 survivors and females among non-COVID-19 survivors.
Co-Authors Abdiana Abdiana Adrial Adrial, Adrial Afriani Afriani Afriani Afriani Afriani Sandra Afriwardi Afriwardi Ahmad Junaidi Amelin, Fitrisia Amellya Sucieta Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andika Chandra Putra Andreas Infianto Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Arifani, Adinda Rizky Arina Widya Murni Armiza Ashal, Taufik Dessy Mirzati Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dhiaulhaq, Zalva Indira Dian A. Juwita Dian Citra Dimas Bayu Firdaus Dolly Irfandy Duyen, Natalie Dwi Rizki Fadhilah Elisna Syahruddin Elsa Purnama Sari Elsesmita Fadhilah, Dwi Rizki Fenty Anggraini Fenty Anggraininy Fenty Anggrainy Ferry Dwi Kurniawan Fika Tri Anggraini Hamni Tanjung Hanif, Muhammad Alfin Hansen Nasif Hanum, Fathiya Juwita Haryati Haryati Haryati Haryati Hendris Utama Citra Wahyudin Herman, Deddy Husna Yetti Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Infianto, Andreas Intan, Shinta Ayu Iqbal Maulana Irvan Madison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Isnaniyah Usman Jasminarti, Ida Ayu Julizar Julizar Kornelis Aribowo Kurniawan, Ferry Dwi Laisa Azka Laksmi Wulandari Lestari, Rahmi Liandhu Hakim, Sonya Lili Irawati Lilik Sulistyowati Lim, Darren Wan-Teck Mahata, Liganda Endo Masrul Basyar Masrul Basyar Maulana Muharam Meta Zulyati Oktora Miftah Irramah Mirtha Anggraeni Mizarti, Dessy Moulid Hidayat Muhammad Bagus H.S. Muhammad Farhan Ramadhan Muhammad Zakki Al-Fajri Nathaniel Aditya Nixon, Poety Elberta Husna Noni Novisari Soeroso Nora Harminarti Novita Andayani, Novita Nurul Sari Octavia, Fatharani Nabila Oea Khairsyaf Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Putri, Biomechy Oktomalio Rahmat Akbar Rian Rizki Ananda Rini Gusya Liza, Rini Gusya Rizki Amrika Russi lawati Russilawati, Russilawati Santoso, Andintia Aisyah Sari Nikmawati Sari Nikmawati Setyawan, Ungky Agus Sita Andarini Sri Melati Munir Sri Melati Munir Sukri Rahman Sur Yastri Suyastri Suyastri Syandrez Prima Putra Vildania, Nisrina Yandra Darusman Yati Ernawati Yenita Yessy Setiawati Yessy Susanty Sabri Yogi Himawan Yori Yuliandra Yulia, Dwi Yulistini, Yulistini Zaini, Jamal