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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 150 Documents
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Studi Komparasi Aktivitas Antiradikal Bebas Ekstrak Metanol Kulit Buah Pisang Ambon (Musa acuminata Colla) Muda dan Matang dengan Metode DPPH Abd. Malik; Reni Fauziah; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1062

Abstract

Ambonese banana fruit peel has antioxidant, antimicrobial, and anti-inflammatory activities. This search aims to investigate the potential of free radical scavengers based on the binding of DPPH free radicals (1,1-Diphenyl-2-picryl Hidrazil). Ambonese banana fruit peel was extracted by maceration using methanol. Free radical activity assay on sample measured by inhibition of DPPH using spectrophotometer UV-Vis at a wavelength at 516 nm. Identification by the TLC method showed that the peel extract of Ambonese banana was active as free radical scavengers where the DPPH solution changed in color from purple to yellow after being sprayed. The calculation results in IC50 values of each sample methanol extract of unripe Ambonese banana fruit peel is 11.78 µg/mL, while the methanol extract of the ripe Ambonese banana fruit peel is 151.56 µg/mL. The standard quercetin has IC50 values of 4.44 µg/mL. The result showed that the methanol extract from the Ambonese banana fruit peel (Musa acuminata Colla) has antioxidantactivity.
Uji Aktivitas Antiinflamasi Teh Cang Salak Secara In Vitro Dengan Metode Stabilisasi Membran Human Red Blood Cell Burhannuddin Burhannuddin; I Wayan Karta
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.903

Abstract

The use of natural ingredients can be an alternative as an anti-inflammatory agent with lower side effects. This study aims to determine the anti-inflammatory activity of cang salak tea in vitro using the human red blood cell membrane stabilization method. Cang salak tea is made into a drink in four formulations, namely P1, P2, P3, and P4 with a volume of 200 ml each. The four formulations were tested for phytochemicals and anti-inflammatory with red blood cell membrane stabilization method using diclofenac sodium as a positive control. The percentage value of red blood cell membrane stability for each formulation was then analyzed statistically with One-Way Anova and LSD tests to see the level of difference between formulations and their effect on cell membrane stability. The formulation of cang salak tea contains phytochemical compounds such as folinol (379,094 - 430,299 mg/100g GAE), flavonoids (5,299 - 7,959 mg/100g QE), alkaloids (24,312 - 28,472 mg/100g) and has antioxidant activity with a value of 3,996 - 6,222 ppm. The highest levels of active polyphenolic compounds were found in the P2 formulation, flavonoids in the P2 formulation, and alkaloids in the P3 formulation. The highest antioxidant activity was found in cang salak tea formulation P1 which had the lowest PPM value in the IC50 test. The percentage of red blood cell membrane stability in various formulations of cang salak tea had a significant difference with the highest value in formulation P1 (112.6 %), followed by formulation P2 (102 %), P3 (100, 2 %), and P4 (99, 7%) (P≤0.05). Based on the LSD test results of cang salak tea formulations P1, P2, and P3 were significantly different from the positive control (P≤0.05). While the P4 formulation was not significantly different from the positive control (P≥0.05). Cang salak tea formulations P1, P2, P3, and P4 were able to stabilize red blood cell membranes which showed strong anti-inflammatory activity
Aktivitas Larvasida Ekstrak Daun Bintaro (Cerbera odollam Gaertn.) Terhadap Larva Nyamuk Aedes aegypti Virsa Handayani; Rezki Amriati Syarif; Aktsar Roskiana Ahmad; Andi Afifah Amdar
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.940

Abstract

Bintaro Leaf (Cerbera odollam Gaertn) contains alkaloids, flavonoids, saponins and tannins that have the potential as larvicides. The study aimed to determine the mortality rate of Aedes aegypti mosquito larvae after administration of Bintaro leaf extract as indicated by the LC50 value. The extract was obtained by maceration method. The yield of Bintaro Leaf (Cerbera odollam Gaertn)extract was 6.03%. This study used 180 mosquito larvae (Aedes aegypti) instar III, divided into test solutions made with 4 concentrations (10,000 ppm, 1000 ppm, 100 ppm and 50 ppm), positive control using Abate and negative control using Aquadest. Observations were made after 24 hours of treatment. The results of the larvacide test showed that the Bintaro leaf extract was effective as a larvicidal as indicated by the LC50 value of 21.170 g/mL 1000 g/mL.  
Karakterisasi Senyawa Penghambat Polimerisasi Heme Dari Ekstrak Etanol Buah Pare (Momordica charantia L.) Purwaning Nugroho Widiyati; Syamsudin Syamsudin; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.937

Abstract

Malaria, which is caused by a parasitic infection of the genus Plasmodium, is still reported as a disease that contributes a high mortality rate in the world. However, there is another problem currently being faced, namely the incidence of patient resistance to antimalarial drugs on the market, causing an urgent need to develop new antimalarial drugs that are safe and inexpensive. Research on the ethanol extract of bitter melon (Momordica charantia L.) was carried out with the aim of providing information as an alternative antimalarial drug based on the mechanism of heme polymerization inhibition according to the method of Huy et. al and to identify the compound isolate fraction which is predicted to have the antimalarial activity. The ethanol extract of bitter melon (Momordica charantia L.) was prepared by maceration method using 96% pharmaceutical grade ethanol, partitioned using ethyl acetate and distilled water. Part of the partition which was soluble in ethyl acetate was fractionated using column chromatography (SiO2; i. n-hexane-ethyl acetate = 10 : 1 ~ 1 : 1; CH2Cl2-MeOH = 10 : 1 ~ 1 : 1 The results of heme polymerization inhibition test obtained isolate fraction 8.5 which had the highest activity, namely IC50 302.78 ppm and IC50 (chloroquine diphosphate as a positive control IC50 218.71 ppm).The results of identification by LCMS/MS spectroscopy showed that isolate fraction 8.5 contained several chemical compounds such as momordicoside L; momordicoside I and momordicoside F2 and quercetin The chemical compound that is predicted to play a role in inhibiting Heme polymerization is quercetin
Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase Ahmad Najib; Rais Razak; Izzatul Fikril Mujtahid
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1059

Abstract

The investigation focused on conducting an in silico screening of chemical compounds isolated from Syzygium oblanceolatum (C.B.Rob) to identify potential bioactive compounds that could act as inhibitors of α-Glucosidase. This screening involved tectoquinone as the potential inhibitor for α-Glucosidase and employed the Autodock Vina Docking process. The target enzyme, α-Glucosidase, was used as the receptor with 20 binding sites on the enzyme receptor 1LWJ and the Autodock Vina program was utilized for this purpose. The values of ∆Gbind and the lowest RMSD were determined for each of the 20 targeted binding sites on 1LWJ, representing the free energy change (∆G) resulting from the docking. The docking results demonstrated that the free energy change (∆G) for the 20 targeted binding sites ranged from -6.346 kcal/mol to -9.720 kcal/mol. The most favorable free energy change (∆G) was observed at the 16th binding site with a value of -9.720 kcal/mol, while the highest was recorded at the 18th binding site with a value of -6.346 kcal/mol.
Daun Cempaka Kuning (Michelia champaca Linn) sebagai Kandidat Penghambat Enzim α-glukosidase secara In Silico Amalia, Riyanti; Meiliana, Made Laksmi; Hamidu, La
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1183

Abstract

Diabetes Mellitus (DM) is a chronic disease that occurs worldwide and continues to increase rapidly. The purpose of this study was to determine the activity and mechanism of action of the antioxidant compounds in cempaka kuning leaves as an antidiabetic using the in silico method. This study used 8 antioxidant compounds from cempaka kuning leaves, namely octadecadienoic acid, butanoic acid, oleic acid, camphorsulfonic acid, pimaric acid, phenol, andrographolide, and benzoic acid. The α-glucosidase enzymes used in this study were obtained from the Protein Data Bank website with the PDB ID codes 3A4A and 2QMJ. Ligand-macromolecule docking using AutoDockTools (ADT) and AutoDock Vina programs. The results showed that the antioxidant compounds in cempaka kuning leaves that had the lowest ΔGbind values were pimaric acid (-8.9 kcal/mol) and andrographolide (-8.6 kcal/mol) in PDB ID 3A4A. The docking results used PDB ID 2QMJ, the compound with the smallest ΔGbind was andrographolide (-7.4 kcal/mol). The results of visualization of the interaction of the ligand with the macromolecular amino acid residue PDB ID 3A4A showed that the residues Arg315, Arg442, and Tyr158 were found in the compound with the smallest ΔGbind. In the PDB ID 2QMJ macromolecule, Asp542 residue was found in all compounds with the smallest ΔGbind. Based on these results, the compounds pimaric acid and andrographolide have potential as antidiabetic drugs compared to other compounds with a mechanism of action of inhibiting the α-glucosidase enzyme.
Antioxidant Activity Test for Button Mushroom (Agaricus bisporus) Ethanol Extract Using The FRAP Method (Ferric Reducing Antioxidant Power) Suhaenah, Asriani; Baits, Muzakkir; Ismail, Normawati
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1104

Abstract

Button mushrooms (Agaricus bisporus) are plants that contain phenols as antioxidants. Antioxidants are electron donor or reductant compounds. These compounds have a small molecular weight but are able to inhibit the development of oxidation reactions by preventing the formation of radicals. phenol is the main antioxidant component found in Agaricus bisporus extracts.  The aim of this research is to determine the antioxidant activity value of button mushroom ethanol extract (Agaricus bisporus) using the method of ferric reducing antioxidant power (FRAP). This research uses the maceration method as an extraction process using 96% ethanol. The resulting filtrate was concentrated with a vacuum rotary evaporator to produce a thick extract. Antioxidant testing was carried out using the FRAP method with a reagent solution of potassium feryricide, phosphate buffer pH 6.6 tricloroacetic acid (TCA), aquadest, and iron 3 chloride (FeCl3). Samples were analyzed using a UV-Vis spectrophotometer at a wavelength of 725 nm using quercetin as a standard solution. The results showed that the antioxidant activity value of the button mushroom ethanol extract (Agaricus bisporus) with the FRAP method was 3.847 mg QE /g extract.
Pengaruh Variasi Metode Ekstraksi Jahe dan Serai terhadap Aktivitas Antiinflamasi pada Penghambatan Denaturasi Protein Faradiba, Faradiba; Syarif, Rezki Amriati Amriati; Khaira, A Tenri Mifta; Alyanti, Tifani Kursya
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1184

Abstract

The content of secondary metabolites or chemical content in medicinal plants affects pharmacological activity. The level of chemical content is affected by the extraction method. Previous research has been conducted on the extraction of ginger and lemongrass using two methods, which include maceration and ultrasonic. The results obtained are differences in chemical content that have the potential to have anti-inflammatory activity. Ginger (Zingiber officinale) contains chemical compounds, including gingerol, shogaol, and zingeron. linalool, alpha-pinene, and sineol. Lemongrass (Cymbopogon citratus) contains citronellal, citronellol, geraniol, flavonoids, and tannins. The aim of this study was to compare the invitro anti-inflammatory activity of ginger and lemongrass extracts using two extraction methods: maceration and ultrasonic. The research method consists of two stages, i.e. extraction of samples using maceration and  ultrasonic methods. The second stage is testing the anti-inflammatory activity against BSA (Bovine Serum Albumin) denaturation of extracts from maceration and ultrasonic methods with the parameter of percentage value to be more than 20%. The results obtained from ginger and lemongrass extracts showed the percentage value of inhibition at concentrations of 10 µg/mL, 12.5 µg/mL, 17.5 µg/mL, and 20 µg/mL are all more than 20%. The ultrasonic extraction of ginger showed a more linear inhibition percentage than the results of maceration. Macerated lemongrass extract showed a more linear percentage inhibition than ultrasonic results.
Determination of Routin Compound Content of Moringa Folium (Moringa oleifera) using Several Extraction Methods Hasnaeni, Hasnaeni; Rosandy, Andi Rifki; Apridamayanti, Pratiwi; Permadi, Adi; Rumaisha, Sanda
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1106

Abstract

Extraction has been carried out from Moringa folium using the Microwave-Assisted Extraction (MAE), Ultrasound-Assisted Extraction (UAE) and Reflux Extraction (RE) methods. Moringa Folium has many uses, including as a chemopreventive agent. In this research, identification was carried out to determine the compounds in Moringa folium. Extraction uses the MAE, UAE, and Reflux methods. The of chemical compound content was determined using HPLC and standardized of rutin. The identification results showed that the Moringa folium spectra were similar to the routine spectra.
In Silico Screening Inhibitors Histamine H2 Chemical Compounds in Licorice Plants (Glycyrrhiza glabra L.) Using Autodock Vina Najib, Ahmad; Malik, Abd.; Sumartono, Sumartono
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1100

Abstract

The inquiry about on in silico screening of chemical compounds of Histamine H2 of Liquorice (Glycyrrhiza glabra L.), aimed to get the potential bioactive compounds found in plants The Liquorice (Glycyrrhiza glabra L.) as a potential inhibitor Histamine H2 with a screening in silico by Autodock Vina Docking process is carried out on enzyme Histamine H2 as receptors and 105 chemical compounds in plants Liquorice (Glycyrrhiza glabra L.) as ligands using Autodock Vina program. ∆Gbind value and lowest RMSD of each compound that has been in the docking taken the value of the free energy change (∆G) as a result of docking. Docking results showed that of the 105 chemical compounds of plant Liquorice (Glycyrrhiza glabra L.)  are all potential as inhibitors Histamine H2  with free energy change (∆G) most low at Glabrene amounted to -9.6 kcal/mol, and the highest Isotachioside amounted to -4.5 kcal/mol.

Page 13 of 15 | Total Record : 150

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