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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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FORMULASI GEL EKSTRAK ETANOL DAUN SIRIH CINA SERTA AKTIVITASNYA TERHADAP PERTUMBUHAN BAKTERI PENYEBAB JERAWAT Propionibacterium acne DAN Staphylococcus aureus Ulfah Ayu Ninsih; Andi Tenri Bunga Lambogo; Ernawati Ernawati; Mutiara Imaniar; A. Hasrawati
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.784

Abstract

Pepper elder  is a weed plant whose leaves contain anti-bacterial compounds such as flavonoids, tannins, triterpenoids, and saponins that can be used as acne treatment therapy. Pepper elder leaves can be made into anti-acne gel preparations by formulating the right gelling agent. This study aims to obtain a gel with good physical stability from variations in the gelling agent base and its activity against acne-causing bacteria. Formulation of Pepper elder leaf extract gel is made with variations in the base of Na.CMC, Carbopol, and HPMC, further stability evaluation includes organoleptic, homogentias, pH, viscosity, scattering power, and testing of antibacterial activity against the growth of Propionibacterium acne and Staphylococcus aureus. The results obtained from the stability test obtained by the Carbopol base and HPMC have good standards for organoleptics, homogenity, pH, viscosity, and scattering power. Antibacterial testing showed clear zone diameters formed against Propionibaceterium acne in naCMC, Carbopol, and HPMC variations of 17.7 mm, 16.3 mm, and 21.3 mm and staphylococcus aureus of 13.3 mm, 15.3 mm, and 14.3 mm, respectively. Based on the results obtained, HPMC gel has the best gel stability and can all formulas inhibit the growth of acne-causing bacteria Propionibacterium acne and Staphylococcus aureus evidenced by the diameter of the bland zone formed into the strong category.
IDENTIFIKASI KUALITATIF FENOLIK DAN PENAPISAN AKTIVITAS PEREDAMAN RADIKAL DPPH MENGGUNAKAN KLT PADA EKSTRAK BATANG Pluchea indica L. Ni Putu Ermi Hikmawanti; Agustin Yumita; Jihan Esa Siregar
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.812

Abstract

Pluchea indica L. (beluntas) from the Asteraceae is a plant known to be rich in phenolics. Studies on the phenolic content of P. indica stems have not been explored much. The purpose of this study is to qualitatively identify the presence of phenolic compounds and to screen for the radical scavenging ability of DPPH in P. indica stem extracts using the TLC method. Extraction was carried out with the ultrasonic directly and sequentially using 50% ethanol as solvent. Separation was carried out on a silica gel plate GF254 with ethyl acetate: water: formic acid: toluene (20:2:2:1) as the mobile phase. Gallic acid and chlorogenic acid were used as comparisons. Identification of the presence of phenolic using FeCl3 5% as a spray reagent, while screening for radical scavenging activity using DPPH 0.1 mM as a spray reagent. The results showed that the 50% ethanol extracts of P. indica stems, both obtained from direct and stratified extraction, indicated the presence of phenolic compounds as antioxidants. The phenolic compounds detected were identical to gallic acid and chlorogenic acid, respectively, at hRf values of 89.4 and 55.3. The development of phenolic utilization from P. indica stems as a source of antioxidants still needs to be studied.
UJI EFEK NEFROPROTEKTIF EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) PADA TIKUS JANTAN YANG DIINDUKSI GENTAMISIN Irma Santi; Aulia Wati; Mauriska Dwiyanti Sjamsuddin
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.788

Abstract

Nephroprotective is an attempt to protect the kidneys from damage. The research aimed tc determine the effect of nephroprotective and determine the effective dosage of ethanol extract of Anredera cordifolia (Ten.) Steenis leaf as the nephroprotective. The research used 15 male rats divided into 5 groups. Group 1 (normal) was no treatment; group 2 (negative control) was induced by gentamicin; and groups 3, 4 and 5 (test group) were provided ethanol extract of Anredera cordlfolia Ten.) Steenis leaves sequentially at the doses of 100 mg/KgBW, 150 mg/KgBW and 200 mg/KgBW. The extract was orally given once a day for 8 days; every 1 hour after the treatment, all the test rats were intraperitoneally induced by gentamicin of 80 mg/KgBW except for the normal group. The measurement of creatinine content was conducted on day 1 and 9. Based on the results of the measurement of final creatinine content, the ethanoi exiract of the Madeira-vine leaf obtained had the effect as nephroprotective. From the results of the difference in creatinine content, the analysis was conducted by One-Way ANOVA followed by the LSD test. In conclusion, the ethanol extract of Madeira-vine leaf of the doses of 100 mg/KgBW, 150 mg/KgBW and 200 mg/KgBW had relatively the same nephroprotective effect.
EFEK ANTINEFROTOKSISITAS EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) DENGAN PARAMETER KADAR UREUM TIKUS PUTIH Sukmawati, Sukmawati; Rahmawati, Rahmawati; Isyanda A., Kenanga
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i2.795

Abstract

Nephrotoxicity caused by chemical compounds such as drugs. This condition can cause an increase in urea levels. Antioxidants used to inhibit nephrotoxicity by protect and repair cells. One of the plants as antioxidant is the pandan wangi leaf (Pandanus amaryllifolius Roxb.) which contains phenolic to absorb and neutralize free radicals or decompose peroxides. This study aimed to examine the antinephrotoxicity effect of the ethanolic extract of pandan wangi leaf (Pandanus amaryllifolius Roxb.) on kidney damage with parameters of urea level in rats. Eighteen male Wistar rats were divided into 6 groups. Group 1 as a naive group, group 2 as a negative control by Gentamicin, group 3 as a positive control by amino acid supplement, and groups 4, 5, and 6 were given ethanol extract of pandan wangi leaves at a dose by 125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW respectively. Nephrotoxicity condition was induced by Gentamicin 100 mg/kgBW (ip) for seven days. The blood samples were taken and measured the serum creatinine levels on days 0, 8th and 21st by Human Analyzer. The results study showed that ethanol extract of pandan wangi leaves at 125 mg/kgBW have the effect as antinephrotoxicity based on decreased ureum levels.
GAMBARAN KARAKTERISASI DARI EKSTRAK ETANOL LIMBAH RAMBUT JAGUNG MANIS (Zea mays L.) Sholicha, Yuyun Nikmatus; Sari, Fita; Aryantini, Dyah
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i2.719

Abstract

Traditional plants in Indonesia, have a variety of benefits to overcome various diseases. For example, sweet corn hair waste (Zea mays L), was the residue from corn which is usually used for culinary purposes. Corn silk in previous studies was thought to have pharmacological activity as anti-inflammatory, antidiabetic, and antihypertensive. This study aims to determine the characterization of the ethanol extract of sweet corn hair waste in a hilly area of Kediri, East Java. Characterization to determine the content of active compounds in the ethanol extract of sweet corn hair waste and to ensure the quality of corn hair waste extract when it will be used as raw material for traditional medicine. Characterization includes specific parameters such as screening for metabolites in plant extracts using Thin Layer Chromatography (TLC) and non-specific parameters including determination of water content and specific gravity. The sample used was ethanol extract of sweet corn hair waste (EELRJM) obtained from the hilly area of Kediri, East Java. The results of the specific parameters of the secondary metabolite compound test by TLC indicated that EELRJM contains quercetin compounds of the flavonoid group. Non-specific parameters resulted that the water content of EELRJM did not meet the requirements of the extract monograph because it was suspected that there was an influence on the weather including rainfall.
UJI EFEK ANTIRHEUMATOID ARTRITIS EKSTRAK n-BUTANOL DAUN PETAI CINA (Leucaena leucocephala (Lam.) de Wit) PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND`S ADJUVANT Sitti Amirah; Safriani Rahman; Rahmatia S Hi Amin
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.763

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation. The research animed to determine the effect of n-butanol extract of Leucaena leucocephala leaves and the effective dose as antirheumatoid arthritis. It used 15 male rats divided into 5 groups: group I (negative control) was given Na-CMC; group II (positive control) was given a suspension of Methylprednisolone; group III, IV dan V were give the extraxt with doses of 83,3 mg/kgBW, 166,6 mg/kgBW and 333,2 mg/kgBW. The treatment was started by inducing Complete Freund`s Adjuvant intraplantary of 0,1 mL and let it remain until day 16. The therapy was conduction for 14 days orally and the foot volume measurements and observation of the arthritis index were performed on day 17 and 31st. In conclusion, the n-butanol extract of Leucaena leucocephala  leaves had the effect as antirheumatoid
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN BODY LOTION EKSTRAK ETANOL DAUN KEMANGI (Ocimum cannum Sims.) DENGAN METODE DPPH (1,1 – diphenyl-2- picrylhydrazyl) Ambari, Yani; Saputri, Arlin Oscardini; Nurrosyidah, Iif Hanifa
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i2.678

Abstract

Basil leaves (Ocimum cannum Sims.) Are known to contain alkaloids, flavonoids, saponins, tannins, polyphenols, and triterpenoids. One of the compounds contained in the basil leaves (Ocimum cannum Sims.) Is a flavonoid which has antioxidant activity. Compounds that have antioxidant activity are known to prevent premature aging. This study aims to determine that the ethanol extract of basil leaves (Ocimum cannum Sims.) Can be formulated into Body Lotion with good physical stability or stable and to determine the antioxidant activity of Body Lotion ethanol extract of basil leaves (Ocimum cannum Sims.). The ethanol extract of basil leaves (Ocimum cannum Sims.) Was obtained by remaseration method using ethanol 96% with a yield percentage of 7.09%. Body lotion ethanol extract of basil leaves (Ocimum cannum Sims.) Is made in 3 formulas, which contain extracts F1 (0.5%), F2 (1%), and F3 (1.5). Body lotion preparations were also tested for physical stability using the cycling test which included organoleptic, homogeneity, pH, dispersal, and adhesion tests. Then proceed to the determination of antioxidant activity carried out by the DPPH free radical reduction method by calculating the IC50 value. The results showed that the ethanol extract of basil leaves (Ocimum cannum Sims.) Has antioxidant activity with IC50 value of 7.05 ppm with AAI value of 14.1 and body lotion preparations can be made. The results of the body lotion antioxidant activity test of basil leaves ethanol extract (Ocimum cannum Sims.) Showed that, F3 had the strongest antioxidant activity namely IC50 18.36 ppm with AAI value of 11.9 then followed by F2 namely IC50 25.2 ppm with AAI value 3.9, and F1, namely IC50 90.5 ppm with AAI value of 14.1. Based on the research results obtained, it can be concluded that the higher the concentration of ethanol extract of basil leaves (Ocimum cannum Sims.) Added, the antioxidant activity of the body lotion will be stronger.
AKTIVITAS ANTIOKSIDAN EKSTRAK FERMENTAT ISOLAT FUNGI ENDOFIT BIJI BUAH KENARI (Canarium indicum L.) SECARA KLT-AUTOGRAFI Naim, Nurul Khatimah; Herwin, Herwin; Fitriana, Fitriana; Nurung, Ayyub Harly
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i2.794

Abstract

Walnut seeds (Canarium indicum L.) contain tannin, flavonoids, carotenoids which is potentially fungtioning as antioxidants. The research aimed to examine the antioxidant activity of fermentate extract of walnut seeds endophytic fungi by autography-TLC. The result of the endophytic fungi isolation in Walnut seeds (Canarium indicum L.) obtained 5 isolates with characteristics. The test result of screening free antiradical activity obtained that isolate 4th was active as an antioxidant indicated by the presence of brown spots with the addition of 1,1-diphenyl-2-picrylhydrazyl 0.004%. Isolate 4th was fermented using Maltosa Yeast Broth (MYB) medium to obtain fermentate supernatant and mycelia. The Fermentate of supernantant of isolate 4th was extracted to obtained supernantant of ethyl acetate extract. Based on the result of free antiradical activity test of ethyl acetate fermentate extract isolate 4th by autography-TLC using ethyl acetate: methanol: water eluent (6:2:1), obtained Rf 0.78 value active as free antiradical by spraying 1,1diphenyl-2-picrylhydrazil 0.004%.
PERBANDINGAN MEDICATION ERROR PADA PERESEPAN ELEKTRONIK DAN PERESEPAN MANUAL PADA TAHAP PRESCRIBING DI APOTEK KOTA PALU Mukaddas, Alwiyah; Faustine, Ingrid; Nofriyanti, Nofriyanti
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i2.700

Abstract

 Prescribing drugs is now growing, as evidenced by the existence of electronic prescribing that have been applied in several hospitals and pharmacies. The development of this prescribing method does not rule out the possibility of increasing the incidence of medication errors in prescribing. So, it is necessary to identify the prescribing that has been implemented, especially in drugstore at Palu City. The purpose of this study was to look at the comparison of medication errors at the prescribing stage which included aspects of prescribing completeness and therapeutic errors in electronic prescribing at Drugstore X and manual prescribing at Drugstore Y in Palu city in 2018. This type of research is a descriptive study with retrospective data collection. Samples taken in the form of secondary data are prescribing using purposive sampling method. The results obtained in this study are, the prevalence of medication error at the prescribing stage of electronic prescribing in drugstore at Palu City includes data,  patient's body weight is 2%, doctor's license 100%, doctor's telephone number 100%, doctor's initial 100%, dosage form 97% and 90% strength of the drug. While the prevalence of medication error at the prescribing stage of manual prescribing in Drugstore Palu City is data, the patient's age is 2%, the patient's body weight is 99.1%, the patient's sex is 100%, the doctor's license is 91.6%, the doctor's telephone number is 80% , initial doctor 42.7%, 88% dosage form and 65% drug strength. Based on these results, it can be concluded that the use of electronic prescribing is better than manual prescribing.
SAMPUL AS-SYIFAA JURNAL FARMASI 13.2 As-Syifaa Jurnal Farmasi, Sampul
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i2.811

Abstract

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