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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 301 Documents
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The differences of parasitemia and lungs size in malaria-associated acute respiratory distress syndrome (MA-ARDS) and non-MA-ARDS in mice infected with Plasmodium berghei ANKA Eka Noviya Fuzianingsih; Cyuzuzo Callixte; Marselaonety La’lang; Dinda Eka Putri; Heny Arwati; Lucia Tri Suwanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.8853

Abstract

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is characterized by extensive infiltration of leukocytes, microhemorrhages, vasogenic edema, changes in lung color, and a significant increase in the weight of the lung. This study was aimed to find out the differences in parasitemia and lung size in MA-ARDSand non-MA-ARDSin mice infected with Plasmodium berghei ANKA. Sixteen male BALB/c mice were infected with P. berghei ANKA, and daily parasitemia was observed on Giemsa-stained tail blood smears. Mice were sacrificed when parasitemia reached ±20%. Simultaneously eight uninfected mice were used as negative control (NEG). The statistical analysis was done using Kruskal Wallis, Mann Whitney U tests, and Spearman correlation test. The results showed that there were significant differences in parasitemia (p=0.001), weight (p=0.001), and lung length (p=0.021) between the MA-ARDS and non-MA-ARDS groups. Comparison of NEG and MA-ARDS resulted in a significant difference in lung size (p=0.05). When non-MA-ARDScompared with NEG groups, it showed a significant difference in lung width (p=0.001). However, there was no significant difference in lung weight and length (p>0.05). Spearman correlation test showed that there was a strong correlation between parasitemia with weight (p=0.000), length (p=0.001), and lung width (p=0.017). The findings indicated that parasitemia played a role in the development of MA-ARDS in mice infected with P. berghei ANKA and influenced the size of the lung. 
The relationship between bacterial characteristics and mortality in diabetic foot ulcers' patients admitted to Dr. H. Abdul Moeloek General Hospital, Lampung Iswandi Darwis; Gusti Ngurah P Pradnya Wisnu; Sekar Mentari
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.7501

Abstract

ABSTRACT Around 25% of people with diabetes experience diabetic foot ulcers in their lives, accompanied by infections due to various types of bacteria. Infection due to Gram-negative and Gram-positive bacteria are reported to have different inflammation patterns, where the latter being reported to have a higher mortality rate. This study was an analytic observational study with a cross-sectional design to determine the relationship between bacterial characteristics and mortality in diabetic foot ulcers. Data were obtained from medical records of diabetic ulcer patients admitted to Dr. H. Abdul Moeloek General Hospital, Lampung, in 2017–2020. There were 131 diabetic foot ulcers patients identified, with the median age of the subjects was 53 years, 43.5% of the subject were male, and 56.5% were female. The mean hemoglobin was 9.3 g/dl, WBCs were 19.0 ×103/ml, and platelets were 422.1 ×103/ml. The mean length of stay in the hospital was 10.7 days. Eighteen subjects died during the hospital stay, with 15 of them were from the Gram-negative monomicrobial group. The results of the Fischer Exact test on mortality and bacterial characteristics among monomicrobial infections (p=0.688) indicate no relationship between the characteristics of the infectious pathogen and mortality in diabetic foot ulcers. Keywords: bacteria, diabetes, diabetic foot ulcers, mortalityCorrespondence: iswandi.darwis@gmail.com
Mental and behavioral disorders due to substances during the COVID-19 Pandemic: Prevalence, diagnosis, and management Era Catur Prasetya; Kharisma Sukma Nanda; Khofifah Dwi Oktaviana; Lens Hanin Herda Zhafirah; Lia Lisa Arista; M Dedi Dermawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.10444

Abstract

ABSTRACT COVID-19 (Coronavirus Disease 2019) is still a significant problem; therefore, mental health issues and COVID-19 are starting to get attention because of the increasing psychological impact and mainly because of Substance Use Disorder (SUD). Further study is required on this issue. This paper aimed to determine the prevalence, diagnosis, and treatment of SUD during the COVID-19 pandemic. This literature review is gained from scientific articles with a range of publication years from 2016 to 2021 about SUD During the COVID-19 pandemic based on Prevalence, Diagnosis, and psychotherapy of the published journal using Pubmed, Google Scholar, and SAGE Journals, and then critically reviewed. The prevalence of SUD patients during the COVID-19 pandemic has increased; however, digital psychotherapy strategies for SUD patients have been found and proved effective during the pandemic. In conclusion, the COVID-19 pandemic impacts a person's mental and behavior and could be a high-risk opportunity for substance abuse. Therefore health workers must improve health services for SUD patients to receive the health access needed even in a pandemic.Keywords: Mental Health, Substance Use Disorder, COVID-19, Prevalence, Diagnosis, ManagementCorrespondence : dedydermawan555@gmail.com
A biomechanical comparison of midshaft clavicle plate fixation between two screws and three screws on each side of the fractures Naufal Ranadi Firas; Erwin Ramawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.7626

Abstract

ABSTRACT The operative management of mid-clavicle fractures with plate and screw fixation is often performed, with either two or three screws on each side of the fracture. This research aimed to compare biomechanical stability on plate and screw fixation of the middle clavicle fracture with two screws and three screws on each fracture side. There were 12 samples of the fractured cadaveric clavicle in the middle and divided into two treatment groups. The first treatment group was given plate fixation and two screws on each side of the fracture, the second treatment group with plate fixation and three screws. Each group was given a repetitive load tensile force of 200 N, and the fracture shift was measured every ten times, 20 times, and 50 times. The statistical analysis showed a significant difference between plate fixation with two screws and three screws on the tensile force's repetition 20 times and 50 times. The lowest average displacement value after repetition of tensile forces is found in fixation with three screws. Biomechanically, the plate fixation system with three screws on each fracture side was more stable than the two screws in the middle clavicle fracture fixation.Keywords:            biomechanics, clavicle fracture, plate, screwCorrespondence:       nau.orthobaya@gmail.com
Compliance in taking medication for hypertension patients listed at Healthy Indonesia Program with a Family Approach Merry Tiyas Anggraini; Aisyah Lahdji; Hema Dewi Anggraheny
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.9640

Abstract

ABSTRACTCompliance is the main factor in determining the success of treatment of hypertension and is needed for controlling the prevention of complications so that it is included in one of the Healthy Indonesia Program with a Family Approach (PIS-PK/Program Indonesia Sehat dengan Pendekatan Keluarga) indicators. This research aims to determine the relationship between education level, economic status, and knowledge level with compliance in taking medication. This research was observational analytic with a cross-sectional approach. The respondents in this study were hypertension patients listed on PIS-PK in the Mijen District for the period January-August 2020, which included the inclusion and exclusion criteria of 45 respondents. Primary data were obtained using MMAS-8, HK-LS, and a hypertension management knowledge questionnaire. Technique sampling was used consecutively. Data analysis used the Spearman rank correlation test. In this research can be concluded education level (p= 0.025) with relation coefficient (r=0.334) and economic status (p=0.000) with relation coefficient (r=0.550), level of knowledge about hypertension (p=0.000) with relation coefficient (r = 0.545) and knowledge about hypertension management (p=0.005) with relation coefficient (r = 0.413). The higher level of education, the economic status, the level of knowledge its makes higher the compliance in taking medication for hypertension patients listed on the Healthy Indonesia Program with a Family Approach in the Mijen District.Keywords : Education, Economic, Knowledge, Compliance Correspondence : merry.tyas@unimus.ac.id
Bradycardia, renal failure, shock, and hyperkalemia (BRASH) caused by AV nodal blocker: a case report of a patient with BRASH syndrome resistant to calcium administration Sidhi Laksono; Ananta Siddhi Prawara
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.6248

Abstract

Chronic kidney disease patients commonly present in a clinical setting with hypertension may cause or affect the disease. Carvedilol, a beta-blocker that is routinely used to treat hypertension in chronic kidney disease, was proven to be safer compared to other beta-blockers. However, it may still cause AV nodal block. AV nodal block can cause bradyarrhythmia, resulting in low cardiac output and low blood supply to multiple organs, including the kidney. This condition further impaired the kidney function in regulating potassium levels and cause hyperkalemia. Hyperkalemia, in return, can also cause bradycardia, and the vicious cycle goes on and on. Previous studies reported that calcium gluconate administration might significantly improve the patient’s condition. However, in this case, calcium gluconate failed to give significant improvement even though it reduced the potassium level. We report a 53 years old male patient on carvedilol with bradyarrhythmia, chronic kidney disease, shock, and hyperkalemia (BRASH syndrome) that failed to resolve with calcium gluconate administration.
Pneumonia Degree Correlation in Children with Clean and Healthy Behavior (CHB) Tri Kartika Setyarini; Aisyah Lahdji; Isna Zalwa Noor Fajri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4269

Abstract

Abstract  Pneumonia is an acute infection that affects the lung with symptoms of cough, shortness of breath, grunting, cyanosis, rhonchi, and infiltrates in thorax imaging. Based on The Integrated Management of Sick Children in handling Acute Respiratory Tract Infection program, pneumonia is classified as severe pneumonia, pneumonia and not pneumonia. One of the risk factors of pneumonia is the low level of Clean and Healthy Behavior (CHB). The purpose of this study was to determine the degree of pneumonia in children with clean and healthy behavior (CHB). The analytic observational study with cross-sectional method. The sample was conducted children under five years old diagnosed with pneumonia in the Children's Ward of Rachma Husada Hospital Bantul with due regard to inclusion and exclusion criteria. Sampling was carried out using consecutive techniques. The data was retrieved using secondary data (medical records) and observing CHB with questionnaire. The data was analyzed using fisher’s exact test. From 32 samples in this study, the majority of samples suffered from severe pneumonia (81.3%) and the most CHB indicators were the Intermediate category (50%). The result of bivariate analysis shows there was a correlation between the degree of pneumonia in children and the family’s CHB (p=0.01). There was a correlation between the degree of pneumonia in children and the clean and healthy behavior (CHB). Keywords             : pneumonia, CHB, childrenCorrespondence   : lahdjiaa@unimus.ac.id
The effect of ginger (Zingiber officinale) extract on the neutrophil level and CAT (COPD Assessment Test) scores in workers with COPD due to dust exposure Susilo Budi Pratama; Yuliani Setyaningsih; Daru Lestyanto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.9711

Abstract

ABSTRACT  Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that does not fully return to normal and is associated with the increased inflammatory response in the airways due to exposure to noxious particles or gases. Workers are susceptible to exposure to steam, dust, gases, and fumes in the work environment. Administration of antioxidants can be beneficial in COPD patients by reducing oxidative stress to reduce the inflammatory response. Ginger contains various active ingredients that act as antioxidants. The research design is a quasi-experimental study with a pre-test and post-test approach. The research subjects were 30 subjects workers diagnosed with COPD. Subjects were divided into two groups: the control group was given standard therapy, the treatment group was given standard therapy and ginger extract. The treatment was given for one month, then the neutrophil and the COPD Assessment Test (CAT) scores were checked. The data were analyzed with an unpaired difference test. The treatment group (-5.67 +2.32) experienced more CAT decline than the control group (-0.73 +1.28) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = <0.001). The treatment group (-4.93 +4.43) experienced more neutrophil decline than the control group (0.27 +1.10) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = < 0.001). Administration of ginger extract can reduce neutrophil levels and CAT scores in COPD workers due to dust exposure. Keywords             : COPD, CAT score, neutrophil, gingerCorrespondence   : susilobudipratama@gmail.com 
The success of glaucoma therapy in diabetes mellitus and non-diabetes mellitus Nur Shani Meida; Ahmad Ikliluddin; Yunani Setyandriana; Ilma Naafisa Anthrasita
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.7665

Abstract

ABSTRACT  Glaucoma is a disease marked with damage to the optic nerve, chronic and can cause blindness. Glaucoma needs regular therapy to prevent blindness. This study was an observational study using a case-control approach. Data were analyzed using the Mann-Whitney test to determine the differences in blood sugar levels in the DM and non-DM groups and the Chi-Square test to determine differences in the success of glaucoma therapy in DM and non-DM patients. There were 66 samples of glaucoma patients in this study, consisting of 14 men (21.2%) and 52 women (78.8%). The mean age of the patients was 61.12 ± 9.17 years. The sample was divided into 2 groups, namely 34 DM patients (51.5%) and 32 non DM patients (48.5%). The Mann-Whitney test showed significant differences in blood sugar levels between the DM and non-DM groups (p <0.05). Blood sugar levels in the DM group were 202.59 ± 73.5 mg / dL and in the non-DM group was 106.19 ± 16.3 mg / dL. In conclusion, there is no difference in the success of glaucoma therapy in DM and non-DM patients. Keywords             : glaucoma, glaucoma therapy, diabetes mellitusCorrespondence        :nurshani_meida@yahoo.com
Prominent bradycardia in a COVID-19 patient receiving Remdesivir: a case report Sidhi Laksono Purwowiyoto; Grace Trifena Hosea
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 2 (2022): Journal Qanun Medika Vol 6 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i2.9379

Abstract

Remdesivir is a commonly used antiviral drug to treat COVID-19. Remdesivir has some side effects; however, whether it has any effect on cardiac is rarely reported. A 44-year-old woman with symptomatic confirmed COVID-19 was treated with intravenous remdesivir 200 mg on day one and followed with 100 mg remdesivir until day five. Three days after the treatment, she had significant bradycardia shown on the electrocardiography; however, the patient had no complaint or symptom regarding the bradycardia. Based on the discussion with the cardiology team, it was decided to cease remdesivir and replace it with oseltamivir, and the ECG showed some improvement. Remdesivir is a drug that should be used safely and cannot be taken at home, as there may be side effects left unaware. 

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