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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 301 Documents
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The Effect of Thespesia populnea Against Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase Receptor by Study In Silico I Made Prasetya Kurniawan; Prawesty Diah Utami; Risma Risma
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5368

Abstract

Indonesia is a country that has abundant natural resources; one of them is the Baru laut plant which is the latest breakthrough because it has an active substance that can be used as an anti-malaria medicine. It is very beneficial because there has been a case of resistance of artemisinin derivatives in Indonesia. The purpose of this study was to determine the potential of active compounds in Baru laut plants (Thespesia populnea (L.) Soland ex. Correa) against the Plasmodium falciparum enoyl acyl carrier protein reductase receptor in P. falciparum through in silico studies. This research is purely experimental using the One-Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely prediction analysis of active compound content, prediction analysis of the mechanism of action of active compound content, and prediction analysis of ADME active compound. The study results show that there are three active compounds in Baru laut plants that have antimalarial potential. The three compounds include gossypol, linoleic acid, and beta-sitosterol, have their respective potential in becoming a malaria drug. This study concludes that Baru laut plants have potential as anti-malaria drugs.
Effect of positive end-expiratory pressure value on change in end-tidal carbon dioxide as a predictor of fluid responsiveness in Patients Undergoing Passive Leg Raising Maneuver Lutfi Nur Farid; Hardiono Hardiono; Pesta Parulian Maurid Edwar
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5458

Abstract

Abstract  Identification of patients’ fluid status in the emergency room should be made before giving fluid therapy. This study aimed to determine the effect of positive end-expiratory pressure on change in end-tidal carbon dioxide during passive leg raising maneuver to predict fluid responsiveness. Thirty subjects aged 18-65 years in the resuscitation room, all on the ventilator, were divided into three groups according to their positive end-expiratory pressure value: low (0-5 cmH2O), moderate (6-10 cmH2O), and high (>10 cmH2O). Every subject underwent passive leg raising to simulate fluid administration. Values of blood pressure, heart rate, cardiac output, and end-tidal carbon dioxide were recorded before and after the maneuver. Analysis of the three groups found a significant correlation between change in end-tidal carbon dioxide with a cut-off value of 5% and 1 mmHg with fluid responsiveness of subjects in the low (p = 0.028) and moderate (p = 0.013) but not in the high positive end-expiratory pressure group (p = 0.333). In conclusion, change in end-tidal carbon dioxide in mechanically ventilated patients undergoing passive leg raising maneuvers can be used as a predictor of fluid responsiveness, but this method cannot be used on patients with high positive end-expiratory pressure (> 10 cmH2O) Keywords             : change in end tidal carbon dioxide, fluid responsiveness, positive end-expiratory pressure, passive leg raising, cardiac output surrogateCorrespondence   : lutfithe13th@gmail.com
Comparison of central vein pressure between distal, medial, and proximal lumens with water manometer method Cornellius Hendra Purnama Aria Sumantrie; Bambang Pujo Semedi; Bambang Purwanto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5356

Abstract

ABSTRACT Catheter Vein Pressure in ward-cared patients is rarely measured and considered invalid. The two catheter vein pressure postulates contradict, making confusion among health workers. Dr Russo said the distal-medial-proximal Catheter Vein Pressure has no difference but were denied by Susan S. Scott. Proof of postulate is needed as a solution to inward care. Therefore, this study aimed to compare the central vein pressure between distal, medial, and proximal lumens with the water manometer method. Forty-nine samples retrospective study were taken from the distal - medial - proximal Catheter Vein Pressure of the "zero" until fifth days. The differences are analyzed with Statistical Paired t Test with p-Value < 0.05 from SPSS ver. 26 to prove the right postulate. 49 samples were concluded to represent of population. Catheter Vein Pressure from day "zero" becomes zero difference, the fifth day 91.8% are no difference while the rest have difference of 0.2 - 1.0 cm H2O and the conclusion are no significant difference with 95% CI. The correlation scale of 0.998 and 0.999 proves that the three lumens tend to produce no differences. In conclusion, the distal - medial - proximal Catheter Vein Pressure values in this study have no significant differences and consistent from "zero" until fifth days. This is formulated as P distal = P medial = P proximal (cm H2O).Keywords      : Central Vein Pressure, Pressure, distal - medial - proximal, no differences, ward patient.Correspondence    : sumantrie_medicalgp@yahoo.com
Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review Nur Azizah AS; Lysa Veterini; Hafid Algristian; Hotimah Masdan Salim
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.6354

Abstract

Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in experimental animals indicate that serotonergic preparations are required to increase serotonin levels in the synapse opening, thereby triggering the formation of new dendrites to make depression reversible. The different results when these preparations create resistance in cases of chronic depression and actually increase the risk of uncomfortable and even fatal side effects with long-term use. This Systematic Literature Review uses the PubMed and Google Scholar databases for the period 2015-2020. A total of 322 articles at the beginning of identification and those that met the inclusion criteria in this study were six articles. The results of data extraction showed that the depression condition caused by various stressors resulted in BDNF levels in the hippocampus decreased significantly by p≤0.005. Based on the literature study, it was concluded that in depressive conditions, BDNF levels in the brain decreased.
Understanding Pacing-Induced Cardiomyopathy: a mini review Sidhi Laksono Purwowiyoto; Reynaldo Halomoan Siregar; Steven Philip Surya
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.6036

Abstract

Patients with total atrioventricular block or sinus node dysfunction will need pacemaker implantation to improve the physiologic function of the heart.  It is known that chronic pacing such as right ventricular pacing could deteriorate the cardiac function (decreased left ventricular ejection fraction) due to dyssynchrony. This condition is knows as pacing-induced cardiomyopathy (PICM). The incidence of PICM could reach 19.5% during 3 years follow-up. The right ventricle is one of the locations for implantation. Chronic right ventricular pacing may cause interventricular dyssynchrony and disrupt the contraction mechanism in the heart. These will lead to cardiac remodeling and eventually impair the left ventricular function. Therapy is needed in patients with PICM to improve the symptoms and maintain the cardiac function. This article will further highlight the definition, mechanism, risk factor, treatment and preventive strategy for patients with PICM.
Effectiveness factors analysis of near-miss incidence referral in obstetric complications at Waras Wiris Andong General Hospital on Boyolali District Edy Mustofa; Widyasih Pritasari; Arif Rahman Nurdianto; Sunarjo Sunarjo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.7197

Abstract

AbstractMaternal mortality in Indonesia is still very high, and the biggest problem is obstetric complications. It is possible that the mother who has obstetric complications is safe and recovered (near miss) or died. This research was an observational analytic epidemiological study conducted to determine the effectiveness of near-miss incidence referral in obstetric complications using a cross-sectional approach. The sampling technique used was a random sampling system with 85 respondents. The effectiveness of referral affects near-miss incidence, meaning that mothers who get referral according to procedure only have a 0.107 times greater chance of not occurring near miss. Pregnant women who had a history of the disease had a risk of 0.157 times greater for the absence of near-miss than mothers who did not have a history. Pregnant women with high risk have 0.157 times no near-miss than those with low risk. Maternal antenatal examination affects the incidence of a near miss. It was found that the mother's history of illness, the risk of pregnancy owned by the mother and the effectiveness of referrals could affect the incidence of near miss in obstetric complications. In conclusion, there is an influence between the effectiveness of the referral and the near-miss incident at the Waras Wiris Andong Regional Hospital, Boyolali RegencyKeywords: referral, effectiveness, near-miss, obstetric complication
Successful Triple Valve Surgery in an Undernourished Patient: What to Prepare? Dian Paramita Kartikasari; Esti Hindariati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.6189

Abstract

ABSTRACT  Valvular heart disease accountsfor 10% to 20% of all cardiac surgical procedures in the United States. The decision to intervene, as well as the type of intervention for a patient with severe valvular heart disease, should be based on an individual risk-benefit analysis. Once a patient is considered a candidate for cardiac surgery, a comprehensive patient evaluation of medical conditions and comorbidities helps improve operative outcomes and minimize the mortality rate. Patients with severe valvular heart disease with chronic heart failure at times, progressing to malnutrition. Patients undergoing cardiac surgery experience a systemic inflammatory response, which contributes to acute organ injury leading to a higher incidence of comorbidities and worse malnutrition. Therefore, preoperative risk and nutritional assessment are critical in performing safe cardiac surgical procedures. We report a case of a malnourished 17-year-old man with multiple valvular heart disease with optimal preparation, including good nutritional status leading to good outcome of complex cardiac surgery even in the high risk patients. Keywords             : valvular heart disease, malnutrition, perioperative assessmentCorrespondence   : dr.dianparamita@yahoo.com
Faktor-Faktor yang Memengaruhi Kejadian Plebitis di Ruang Marwah RSU Haji Surabaya Sukadiono Sukadiono; Ika Novianti; Musrifatul Uliyah; Dede Nasrullah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v3i1.9175

Abstract

Intravenous therapy is the installation of an invasive device into a vein during a patient undergoing treatment in the hospital. One of the complications of intravenous therapy 5% - 70% is the incidence of plebitis. The incidence of plebitis in government hospitals is 50.11%. In Haji Hospital Surabaya, the incidence of plebitis is a problem in patients who receive intravenous therapy in the hospital. The purpose of this study is to analyze the existence of factors that influence the incidence of plebitis. Methods: this study uses analytic design that is observational. The population was all patients who received intravenous therapy in the Marwah Room of the Hajj Hospital Surabaya. The sample of the research by probabability sampling is simple random sampling design with 82 respondents. Research variables include age, location of installation, type of fluid and duration of infusion. The instruments used were interviews and document studies. Data analysis using Linear Regression test with R Square = 0.3 and significance significance α = 0.05. Result & Discussion: The results of the study of age (0.345), and the type of infusion fluid (0.305) had no influence on the incidence of plebitis, whereas the location of infusion (0.020), and the length of day of infusion (0.000) influenced the incidence of plebitis. Conclusions from the study of the location of the installation factors and the duration of infusion installation affect the incidence of plebitis. Thus it is necessary to hold training related to how to prevent plebitis.
Prevalence and risk factors of Ascaris lumbricoides infection in children of Manusak Village, Kupang District, East Nusa Tenggara Province, Indonesia Meliance Bria; Heny Arwati; Indah Setyawati Tantular
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5191

Abstract

ABSTRACT Worm infection is one of the health problems in all tropical countries, including Indonesia. The most frequent helminthiasis is the infection caused by the Soil-Transmitted Helminth. Primary school-age children are an age group that is susceptible to helminthiasis. Worm infections can cause a serious impact if left untreated with no clean and healthy lifestyle. This study was conducted to determine the prevalence and risk factors of STH in children of Manusak Village, East Kupang Subdistrict, Kupang District, East Nusa Tenggara Province, followed by the characterization of subjects. The analytic observational design with the cross-sectional study was applied to this research. Research subjects were 130 children aged 6-12 years old. The infection was diagnosed microscopically by the Katokatz method. Ascaris lumbricoides were the only species found infecting a total of 50 children (38.4%.). The distribution of ascariasis was higher in girls (30 or 23.08%) than in boys (20 or 15.38%), in children whose parents have no formal education (41 or 31.54%), and who their professions are a farmer. Poor hygiene and sanitation such as no washing hands with soap (27 or 20.77%) as well as the habit of not wearing footwear (47 or 36.2%) and bowel habit on the open areas (35 or 26.92%)  are the risks factors causing the high incidence of A. lumbricoides in the studied area. Enlightenment to the parents regarding good personal and environmental hygiene and sanitation along with chemotherapy from the government and related agencies is needed to achieve a durable reduction of the burden of ascariasis and other STH infection. Keywords                   : Soil Transmitted Helminth, Ascaris lumbricoides, children,                                      Kupang DistrictCorrespondence        : heny-a@fk.unair.ac.id
Nephroprotective effect of virgin coconut oil in Plasmodium berghei ANKA infected Balb/c mice Syafarinah Nur Hidayah Akil; Heny Arwati; Puspa Wardhani; Priangga Adi Wiratama
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5791

Abstract

AbstractMalaria is a parasitic infectious disease caused by Plasmodium, which remains a world health problem with an estimated 219 million cases worldwide. In severe malaria infection, several organs of the body can be affected, including the kidneys. One of the pathophysiology associated with the worsening of this disease is oxidative stress. The use of antioxidants is expected to prevent this, and one product that has a high antioxidant content is virgin coconut oil (VCO). This study aimed to analyze the effect of VCO on the kidney in Plasmodium berghei ANKA-infected mice. This study was an in vivo laboratory experimental study with a randomized post-test only control group design using 35 BALB/c mice infected with P. berghei ANKA, weighing 20-30 grams. VCO with the Javara® brand is used with doses of 1, 5, and 10 ml/kg body weight (kgBW)/ day. The parameter assessed were levels of BUN, creatinine, and renal histopathological changes. The administration of VCO on the treated group shows minimal tubular necrosis and glomerulonephritis compared to the negative control group. The BUN and creatinine levels in the treated group were also lower than the negative control group. The results showed that VCO has a nephroprotective effect against P. berghei ANKA infection in mice.Keywords: malaria, kidney, virgin coconut oil

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