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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 301 Documents
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In vitro Alpha Lipoic Acid supplementation in freeze-dried human sperm: the impact on DNA fragmentation index Rezia Octarina; M. P. B. Dyah Pramesti; Agustinus Agustinus
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4374

Abstract

Freeze-drying technique is an alternative method on sperm preservation. However, this process can results in DNA damage. Adding antioxidants before freezing can reduce the detrimental effects of ROS on spermatozoa. Alpha lipoic acid (ALA) is one of the potent antioxidant that can be used to protect the sperm DNA. This study was aimed to determine the effect of ALA supplementation before freeze-drying on the DNA fragmentation index (DFI) of human spermatozoa. Nine semen samples were collected and evaluated for DFI (O1) then divided into 3 groups; freeze-drying without ALA (O2), freeze-drying with ALA 1,25 mg (O3) and freeze-drying with ALA 2,5 mg (O4).All three groups were stored at 4oC for 1 week. Sperm DFI were evaluated before and after freeze-drying. The result of this study showed a significant increase in sperm DFI in all three groups after freeze-drying (p<0,05) when compared to DFI before freeze-drying (14,67 ±3,295). However there was no significant difference between O2 (26,90 ±9,180) and O4 (29,29 ±5,524) group where the supplementation of 2,5 mg ALA did not have significant effect on protecting the DNA of freeze-dried human spermatozoa. The highest DFI was in the O3 group (44,64 ±11,717). Therefore, ALA supplementation before freeze-drying does not have a significant effect on protecting the DNA of freeze-dried human spermatozoa.
Collagen Type I and Type II Expression Evaluation on Cartilage Defect Regeneration Treated with Dwikora–Ferdiansyah–Lesmono–Purwati (DFLP) Scaffold Supplemented with Adipose–Derived Stem Cells (ASCs) or Secretome: An In-Vivo Study Adrianto Prasetyo Perbowo; Dwikora Novembri Utomo; Lukas Widhiyanto; Primadenny Ariesa Airlangga; Purwati Purwati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4377

Abstract

Abstract Cell-based therapies such as Scaffold, stem cells, and secretome, are one of the alternatives to enhance the regeneration of hyaline-like cartilage in cases of cartilage defects. This study is an in-vivo experiment using animal models, in which we apply a composite of DFLP (Dwikora-Ferdiansyah-Lesmono-Purwati) Scaffold and Adipose-Derived Stem Cells (ASCs) or Secretome to an injury model on the distal femoral trochlea of New Zealand White Rabbits. The animals were divided into four groups: (1) control (K); (2) Scaffold only (S); (3) Scaffold + ASCs (SA); (4) Scaffold + Secretome (SS). Animals were terminated in the 12th week, and an immunohistochemistry (IHC) evaluation for Collagen type I and II were done. Statistical analysis shows that collagen type I IHC between groups shows no significant difference (p = 0.546). Collagen type II IHC shows significant difference between groups (p = 0,016). The findings in this study showed that Scaffold + ASCs group and Scaffold + Secretome have better collagen type II expression compared to the control group. DFLP Scaffold composite with ASCs or Secretome shows potential for cartilage regeneration therapy by increasing type II collagen expression as in hyaline-like cartilage which may be used for regenerative therapy for cartilage defects. Keywords             : DFLP Scaffold; Adipose-Derived Stem Cells (ASCs); Secretome; Collagen Type I; Collagen Type IICorrespondence    : ianperbowo@me.com
Effects of acupressure therapy period towards blood sugar level in type 2 diabetes mellitus patients at Lumajang acupressure clinic Anung Putri Illahika; Hean Safira
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5097

Abstract

Abstract  Diabetes Mellitus is a worldwide metabolic disease and becomes a challenge for the health practitioner. Unfortunately, less than half of these diabetic individuals are aware of their conditions, and less than 1% of those receiving medical treatment achieve their therapeutic targets. Acupressure is an alternative method that is believed to be an effective way of treating diabetic patients with reducing symptoms and complications. This research aims to discover the effect of period acupressure therapy on blood sugar levels in type two diabetes mellitus patients in Lumajang Acupressure Clinic. It uses an observational analytic design with pre-test and post-test approach. It involved 36 participants who were split into two groups and contained 18 participants for each group. The first group received acupressure therapy for three weeks, while the second group received eight weeks. Both groups underwent acupressure at the San Yin Jiao (SP-6) acupoint for 20 minutes three times a week. All participants in both groups had their blood glucose checked before and after acupressure therapy. The results showed that the two groups were significantly different for the paired t-test and the independent t-test. The acupressure therapy period has an effect on decreasing blood sugar levels in type two diabetes mellitus patients at Lumajang acupressure clinic. Keywords             : Acupressure, the period of therapy, blood glucose level, type two diabetes mellitusCorrespondence   : Anungputri113@gmail.com
Medical students' perspectives about distance learning during early COVID 19 pandemic: a qualitative study Muhammad Reza Utama; Yelvi Levani; Ayu Lidya Paramita
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.5000

Abstract

Background: Medical education throughout the world has experienced major changes as a consequence of the presence of the COVID-19 pandemic. The Government of Indonesia has instructed physical distancing so that teaching and learning activities, including in the Faculty of Medicine, must be carried out at home with online methods to reduce the risk of COVID distribution. Objective: to explore undergraduate medical students’ perspectives towards distance learning during early COVID 19 pandemic at Muhammadiyah Surabaya University - Faculty of Medicine (MSU-FM), Indonesia. Methods: a qualitative study of students’ online survey responses had been done. Thematic analysis based on Unified Theory of Acceptance and Usage of Technolgy (UTAUT) constructs was done to ecplore students’ perspectives. Results: Students have a positive perspective related to performance expectancy of distance learning. This factor have been perceived as factor that support the behavior of the use of distance learning in order to increase cognitive involvement in the learning process. However, in this study, other factors conveyed by students limiting their optimal use of current distance learning platform. Conclusion: Students‘ user experiences must be developed and maintained continuously during this pandemic era. Longitudinal studies that investigate the long-term impact of various distance learning platforms‘ usage also need further study.
Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients Lelyana Sih Afgriyuspita; Heny Arwati; Hartono Kahar
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3559

Abstract

AbstractThe trend of dengue virus infection in Indonesia has changed from children to older groups. Some studies suggested that different gender might affect the different progression of dengue infection, but its mechanism was unclear. This study analyzed the difference by evaluating the daily thrombocyte count pattern. An analytic observational study with a retrospective design was conducted using the secondary data collected from medical records in Dr. Soetomo General Hospital Surabaya during 2017-2018. The samples were adult patients in the age range of 18-55 years old with DHF but without comorbidity or coinfection. The total number of samples was 40 patients. The average of thrombocyte count in both male and female patients decreased since the 3rd day of illness and reached the lowest level on the 6th day of illness then increased on the 7th day but did not reach the normal range. Although the majority of thrombocyte count in females was lower than males, there was no significant difference in thrombocyte count pattern between them. Keyword: Adult, DHF, Thrombocyte, GenderCorrespondence : heny-a@fk.unair.ac.id
Role of antioxidant to protect Leydig cells induced by reactive oxygen species: a literature review Anak Agung Istri Dalem Cinthya Riris; Reny I&#039;tishom; Siti Khaerunnisa
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4693

Abstract

The Leydig cells play crucial role in steroidogenesis and spermatogenesis. Those processes need complex communication in hormonal and testicular to maintain male reproductive function. Abnormal condition induced by reactive oxygen species reduce cell viability through lipid peroxidation and apoptotic pathway. Antioxidant ameliorate ROS elevation and prevent cell damage. Specifically, Leydig cells are vulnerable to ROS exposure and decline its function in mediating spermatogenesis. Therefore, it is needed to improve Leydig cells viability within antioxidant supplementation. This study aimed to determine the protective effect of antioxidant on Leydig cells induced by reactive oxygen species. This type of study is a literature review. Various studies have been reviewed through critical appraisal tool Olsen-Baisch Scoring for integrated review. Furthermore, this study highlighted the importance of the mechanism of antioxidant as protective agent of Leydig cells. Supplementation of antioxidant with the correct administration, dosage, and duration is potential to balance reactive oxygen species level and protect Leydig cells.    Keywords             : Leydig cell, antioxidant, reactive oxygen species, infertility
Identification of Thalassemia Carrier in Anemic Pregnant Women at Puskesmas Kertapati Palembang: Comparison of Five Erythrocyte Indices Mitayani Purwoko; Eriko Erenkwot
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4469

Abstract

Anemia is a condition that is almost always found in pregnancy. Although a program of Fe tablets has been introduced during pregnancy, the prevalence of anemia during pregnancy is still high. This situation maybe caused by another risk factor of anemia such as Thalassemia. This study was aimed to investigate the presence of carrier Thalassemia in pregnant women at the Puskesmas Kertapati, Palembang, South Sumatera using erythrocyte indices. This was a cross-sectional study with a sample size of 68 subjects, taken by purposive sampling technique. Hemoglobin level of all subjects was measured by Easy touch GCHb and confirmed by Sysmex K21. Differences of hemoglobin between Easy Touch GCHb and Sysmex K21 were analyzed by impaired t-test used SPSS program. Other data were analyzed using descriptive statistic.The mean hemoglobin levels in subjects were 10.7 g/dl. There were 68 subjects have anemia according to Easy Touch GCHb  but only 30 subjects that confirmed positive anemia by Sysmex KX 21. T-test result gavep value <0.05 that isconsidered there was a statistically significant difference between Easy Touch GCHb and Sysmex KX 21 results(p=0.001). Calculations using the England-Fraser index, Mentzer, Sirdah, and Srivastava indicate that none of the research subjects had thalassemia carrier status.
Overlapping Primary and Secondary Syphilis in Human Immunodeficiency Virus (HIV) Patient Nurul Laili Nahlia; Lita Setyowatie
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4378

Abstract

ABSTRACTCoinfection between syphilis and Human Immunodeficiency Virus (HIV) could have varied clinical manifestations. Overlapping of syphilis stages is accounted for 25% of cases, attributable to the defect of the cellular and humoral immune response. We reported 55 years old man who was sexually active since 25 years ago via genito-genital, genito-anal, genito-oral routes, had multiple sexual partners both male and female, seldom used condom, and always being the insertive. Dermatological examination revealed alopecia non-scarring, a painless solitary ulcer on the collum penis, also multiple erythematous macules, patches, and plaques all over the body. Spirochaeta sp. was found from the base of the ulcer with a darkfield microscope. Histopathology examination revealed secondary syphilis lesion. Venereal Disease Research Laboratory (VDRL) 1:16, Treponema Pallidum Haemagglutination test (TPHA) reactive, HIV Determine rapid test reactive, and CD4 (Cluster of Differentiation 4) T-cell count 111 cells/ µL. He was treated with a single dose of benzathine penicillin G 2,4 million units intramuscular and antiretroviral drugs. On sixth month evaluation, VDRL was non-reactive, and CD4 T-cell count 325 cells/µL. This case shows that overlapping clinical manifestations of primary and secondary syphilis on HIV patients could occur with a good general condition. Immediate treatment of antibiotics for syphilis and antiretroviral could improve the clinical and serological conditions.Keyword: primary syphilis, secondary syphilis, HIVCorrespondence: nurul.laili.nahlia@gmail.com
Comparison of clinical evaluation of post-operation patients of open reduction internal fixation (ORIF) plating proximal humerus using conventional methods and minimally invasive plate osteosynthesis (MIPO) in Surabaya Musa Arafah; Heri Suroto; Erwin Ramawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3119

Abstract

ABSTRACT There are several kinds of approaches in the installation of implants for proximal humerus therapy. At present, minimally invasive surgery is gaining in popularity; this is supported by increasingly good technological developments to optimal the postoperative outcome is more optimal than conventional methods. This study used an analytic retrospective design with samples of post-ORIF Plating MIPO and posted ORIF due to proximal humeral fracture. Evaluation using the instrument of VAS Score, ASES Score, and measurement of range of motion. Statistical tests showed that there was a significant difference in the VAS score at the first evaluation (p = 0.002); the last review was not significant. In ASES Score, abduction, flexion, and external rotation, there were significant differences during the first and last evaluations. Adduction, extension, and internal rotation have no significance. The method of minimally invasive plate osteosynthesis (MIPO) on proximal humeral operative fracture therapy had a better clinical outcome and operating time than post-ORIF plating with conventional methods. As well, the MIPO method on proximal humeral fracture operative therapy based on radiological features has the same union rates compared to post ORIF plating with conventional methods. The method of minimally invasive plate osteosynthesis (MIPO) in operative therapy of neer 2 and 3 proximal humeral fracture has a better clinical outcome than conventional methods.Keywords: proximal humeral fracture, Minimal Invasive Plate Osteosynthesis (MIPO), Open Reduction Internal Fixation (ORIF)Correspondence to: musa_shi911@yahoo.com   
Depression, anxiety, and stress levels in Denpasar community during the pandemic of Corona Virus Disease 2019 (COVID-19) I Gusti Ngurah Bagus Rai Mulya Hartawan; I Gede Gita Sastrawan; Rovie Hikari Parastan; Luh Seri Ani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5177

Abstract

The Government of Indonesia has started to implement a Large-Scale Social Limitation (PSBB) in cities and provinces in Indonesia to prevent the increasing of COVID-19 transmission. The Denpasar city as one of the cities that implemented a similar system. This study was aims to provide an overview of the levels of depression, anxiety, and stress in the Denpasar community during the COVID-19 pandemic. This study was an observational descriptive study with cross-sectional design. The data collection used Google forms that distributed online. There were 160 respondents participated in this study, dominated by women (56.9%), domiciled in South Denpasar (35.0%), living with family or relatives (85.6%), aged 18-25 years old (63.7%), had diploma or bachelor degree as their education background (55.0%), unmarried (66.3%), students (38.8%), and no income (44.4%). The results showed that respondents had 1-2 offspring (53.7%), did not experience layoffs (83.9%), and experienced a decrease in income (67.0%), dominant respondents experienced psychosocial disorders in the form of depression (51.2%) with a moderate degree (31.7%) and the anxiety (53.1%) with a mild degree (40.0%). Most respondents did not experience stress (53.1%). In conclusion, the characteristics of respondents' psychosocial disorders were moderate depression, mild anxiety, and did not stress.

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