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Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 244 Documents
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Polyclinic Geriatrics, Rumah Sakit Haji Medan, Risk Factors for Isolated Systolic Hypertension in the Elderly Zahrah, Nadianty Az; Nasution, Huwainan Nisa
Buletin Farmatera Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i2.9740

Abstract

ABSTRACTIntroduction: Hypertension is a manifestation of hemodynamic balance disorders in the cardiovascular system. Isolated systolic hypertension was defined as systolic blood pressure ?140 mmHg and diastolic blood pressure ?90 mmHg. Objective: The purpose of this study was to analyze the effect of family history, obesity, smoking, physical activity and consumption of salt and fat on the incidence of isolated systolic hypertension in the elderly at the Geriatrics Clinic of Haji Hospital Medan. Method: The design of this study was an analytic observasional study with a case control approach using a questionnaire from patients at the Geriatrics Polyclinic, Haji Hospital Medan. The sampling technique used was purposive sampling. Results: From 90 samples, it was found that there was an effect of family history (p-value=0,003; OR=3,62; CI 95% = 1,51-8,65), smoking (p-value=0,035; OR=2,47; CI 95% = 1,05-5,76), physical activity (p-value=0,010; OR=3,07; CI 95% = 1,28-7,36), and consumption of salt and fat (p-value=0,033; OR=2,53; CI 95% = 1,07-5,98) on the incidence of isolated systolic hypertension in the elderly and there is no effect of obesity on the incidence of isolated systolic hypertension (p-value=0,827; OR=1,10; CI 95% = 0,46-2,59). The results of multivariate analysis showed that the most dominant variable influencing the incidence of isolated systolic hypertension was family history (p-value = 0,023; Exp ? =0,347). Conclusion: There is an effect of family history, smoking, physical activity, and consumption of salt and fat on the incidence of isolated systolic hypertension in the elderly and there is no influence of obesity with the incidence of isolated systolic hypertension in the elderly. The most dominant variable influencing the incidence of isolated systolic hypertension in the elderly is family history.Keyword : Elderly, Isolated Systolic Hypertension, Risk Factors
The Relationship Between Dietary Fiber Consumption and The Incidence of Obesity in Students of The Faculty of Medicine, Universitas Sumatera Utara Binti Iqbal, Nurun Nabilah; Martineta, Meriza; M Rambe, Andrina Yunita; Siregar, Muhammad Fidel Ganis
Buletin Farmatera Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i2.8982

Abstract

Abstract. Obesity is caused by the changes in nutrient intake due to changes in diet by populations who have adopted a modern lifestyle, thus increasing the tendency of fat consumption with decreased consumption of fiber and lack of physical activity. The role of fiber in obesity includes helps indigestion and helps to reduce the occurrence of obesity. This study aims to determine the relationship between dietary fiber consumption and the incidence of obesity in students of the Faculty of Medicine, Universitas Sumatera Utara. This research is analytic observational research with a cross-sectional design. The sample was selected using a non-probability sampling technique, with a sample size of 72 people. The measuring instrument used is a questionnaire. From table 4.4 the research subjects are 72 respondents; 11 respondents are grouped in underweight nutritional status and all 11 respondents have insufficient fiber consumption. There are 29 respondents who are grouped in a normal nutritional status where 8 respondents have sufficient fiber consumption and 21 respondents have insufficient fiber consumption. A total of 12 respondents were classified as overweight, 7 of the 12 respondents have sufficient fiber consumption and 5 respondents have insufficient fiber consumption. There are 20 respondents grouped in the nutritional status of obesity, 10 respondents whose fiber consumption is sufficient, and 10 respondents whose fiber consumption is insufficient. From the results of the Spearman correlation test, a p-value of 0,049 was obtained and the RR value was -0,233. There is a weak and unidirectional relationship between dietary fiber consumption and the incidence of obesity in students of the Faculty of Medicine, Universitas Sumatera Utara.Keywords: Dietary fiber, obesity, students
Article Review: Antioxidant Activity of Some Plants Found In Garut Arboretum Asman Sadino; Hesti Renggana; Saepul Nurohman
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.10707

Abstract

Abstract: Free radicals in the form of atomic molecules do not have partners with high reactivity, free radicals can come from within the body in the form of metabolic waste products and from outside the body such as ultraviolet light, food, beverages, smoke and pollutants. The role of antioxidants is needed to reduce these free radicals. This article review aims to find out and examine scientific information from research that has been carried out regarding plants, especially in the Garut Arboretum which have antioxidant activity. The method of writing this article review uses a literature study through search engines such as Google Scholar, Pubmed, and NCBI. It is known that from 56 plant species found in the Garut Arboretum, 27 plant species have been studied to have antioxidant activity, including 15 plants with very strong antioxidant activity, 9 plants with strong antioxidant activity, and 3 plants with moderate antioxidant activity. Secondary metabolites that are responsible for antioxidant activity include flavonoids, alkaloids, saponins, and tannins.
Salivary Microflora and Its Diagnostic Importance Dina Rahmi Solihad Nasution; Zulham Yamamoto
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.12199

Abstract

Saliva as a source of DNA has several advantages over blood. These advantages include easier sample collection, the sampling process can be carried out independently by participants, and stability. The study of the normal microflora of human saliva is increasingly in demand because it is related to the oral health status of each individual. Several studies explain microflora associated with diabetes, cancer, rheumatic heart disease, and others. Other things that affect the composition of the microflora of each individual include living habits, hygiene, age, and smoking. The microflora in saliva are protozoa, bacteria, yeast, and viruses. In healthy people, the characteristics of normal oral microflora found are dominant Gram-positive cocci and rods such as Actinomycetes spp and Streptococcus spp. Protozoa commonly found in saliva are Entamoeba gingivalis and Trichomonas tenax, while from the yeast Candida albicans group, the viruses most commonly found in saliva are herpes and retrovirus. Identification of normal salivary microflora can be done through microbiological and biomolecular approaches. Identification of microflora using a biomolecular approach, currently the most commonly used markers are 16S rRNA (bacteria) and ITS rDNA (fungi).
Effect of Omega-3 Supplementation on Major Adverse Cardiovascular Events (MACE): A Systematic Review Aisy, Annesyia; Martineta, Meriza; Sari, Dina Keumala; Sitorus, Esther Reny Deswani
Buletin Farmatera Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i2.9038

Abstract

Abstract: Major adverse cardiovascular events (MACE) are the most relevant outcome in cardiovascular secondary prevention because they are the main cause of mortality and morbidity in patients with cardiovascular disease. Due to the contrasting results between studies, omega-3 supplementation is believed to have cardioprotective effects, but its significance in reducing MACE is still in question. This study aims to determine the effect of omega-3 supplementation on the prevention of MACE. A literature search was carried out on several databases from September 820, 2021. Selection of literature is done through the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart. Literature that is eligible was then assessed qualitatively. We compared the hazard ratio of each key outcome of interest, which was included in the primary and secondary end-point of each study. Among 2049 publications found from the initial literature search, 6 publications were included in this study. The analysis showed a significant reduction in cardiovascular risk in participants with a high dose of pure EPA. Studies with a lower dose of omega-3 that contains a combination of EPA and DHA did not provide similar significant results. The use of high-dose omega-3 supplementation with pure EPA content can significantly reduce
Anti-Cervical Cancer Study of a Labdane-type Diterpene Obtained from Legundi Fruit (Vitex triolia L.) Targeting the Bcl-2 Gene Humairah Medina Liza Lubis; Emni Purwoningsih; Nurfadly Nurfadly
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11728

Abstract

Abstract: The development and induction of cervical cancer carcinogenesis are linked to sexually transmitted Human Papillomavirus (HPV) infection, and can affect human genes, particularly those involved in the apoptotic process, one of which is the Bcl-2 gene. Several synthetic compounds, including pyrimidineylpiperazine, phenylpyrazole, kendomycin, and navitoclax, have been shown to be effective in inhibiting the antiapoptotic activity of Bcl-2, but it is the labdane-type diterpene content of the natural legundi fruit plant (Vitex trifolia L.) that has anticancer bioactivity, particularly in the process of genetic mutations, Apoptotic inhibition and therapeutic failure have yet to be discovered, particularly in cervical cancer. The study's goal was to investigate the mechanism of interaction (molecular docking) of labdane type-diterpene compounds with the antiapoptotic protein Bcl-2. In silico (docking molecular) research was used to determine the interaction between legundi fruit ligands and the Bcl-2 target protein in cervical cancer. The docking analysis results will then be visualized with the Discovery Studio 4.1, LigPlot+, and Ligand Scout 3.1 software. The interaction of proteins and ligands was studied to determine the number and type of bonds formed, such as hydrogen and hydrophobic bonds. The results were as follows: Gibbs energy -7.8, pKi 1.91 m, 10 hydrophobic bonds, and hydrophobic residues Leu80, Leu82, Thr83, Thr86, Ala87, Cys90, Met118, Glu121, Ser122, and Leu130. The findings presented here suggest that labdane-type diterpenes are powerful anticancer agents capable of inducing apoptosis and inhibiting the antiapoptotic action of the Bcl-2 gene, which should be investigated further in (pre)clinical studies.
Description of Types of Wounds on Living Victims Due to Persecution who Come to the Emergency Installation of Drs. H. Amri Tambunan Hospital, Deli Serdang, in 2020-2021 Abdul Gafar Parinduri; Muhammad Reza Restu Fauzi
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.12137

Abstract

Background. About 50-70% of cases that come to the Emergency Installation are cases of injury or trauma. Injuries to these patients can occur as a result of accidents, abuse, attempted suicide, disasters, and terrorist attacks. Aim: This study aims to describe the types of injuries to living victims due to abuse who came to the Emergency Installation of drs. H. Amri Tambunan Hospital, Deli Serdang from January 1, 2021 to December 31, 2021. Method: The research design is an observational study using analytical descriptive methods and a retrospective approach using the data from visum et repertum report of survivors as a result of persecution who came to the Emergency Installation of drs. H. Amri Tambunan Hospital, Deli Serdang. Results: Out of 273 survivors of abuse, 69.6% involved mechanical trauma and the majority of mechanical trauma occurred to females (52.6%) and the most common pattern of injury was abrasions (58.2%). Conclusion: Based on the results of this study, the most common type of wound encountered was mechanical trauma with a pattern of abrasions.
Perception of Pharmacists as Agents of Change About the Use of Traditional Medicines by Indonesian Society Sri Suwarni; Aris Widayati; Nurista Dida Ayuningtyas
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11424

Abstract

Abstract: Pharmacists, as one of the professional health workers, have a big responsibility related to the use of traditional medicines, especially pharmacists in the community who deal directly with consumers, starting from choosing to use, ensuring the safety of use, and providing education about traditional medicines. This study aims to explore the perception of pharmacists as agents of change (AoC) and whether they are ready to take an active role in Indonesian society in the use of traditional medicines. Exploratory observation is used to deepen knowledge and seek new ideas about a particular phenomenon with non-participatory observation steps. The results of this study show that many people still use traditional medicine because of the suggestions and beliefs of the community from generation to generation. Pharmacists have been able to play an active role as a source of information on conventional medicines in the community. The conclusion is that people have used a lot of traditional medicine for curing disease or trying to increase stamina, even with information on the efficacy and dosage of use according to hereditary information.
Sholat Dhuha May Reduce The Risk of Knee Osteoarthritis in The Elderly: Preliminary Research Elman Boy; Des Suryani; Debby Mirani Lubis; Balemun Kaisar Harahap
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11939

Abstract

Abstract: Osteoarthritis is one of the most common degenerative diseases that attack the joints and cause deformity in the elderly. The purpose of this study was to investigate the link between dhuha prayer and the risk of knee osteoarthritis (kOA). Methods: cross-sectional and purposive sampling, with inclusion criteria including Muslim women cured in the Government Binjai Senior Care, age greater than or equal to 60 years, communicative, signing informed consent, and providing complete answers to the WOMAC questionnaire to assess kOA risk. The interview form was used to count the number of rak'ahs of dhuha prayer that are usually performed every day. SPSS was used to analyze the data, and the Spearman Rank test was used. The research criteria were met by 30 of 101 prospective respondents. The respondents ages range from 60 to 85 years old, 68% are at risk of mild kOA, and there is a link between the number of rak'ahs of dhuha prayer and a lower risk of kOA. Conclusion: The more rak'ahs of dhuha prayer that are performed on a daily basis, the lower the risk of KOA.
The Relationship of Environmental Factors to the Incidence of Malaria in Different Countries: Systematic Review Muhammad Aandi Ihram; Hamzah Hasyim; Hilda Zulkifli; Didit Haryanto
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11609

Abstract

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