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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
Sulih hormon (HRT): sebuah persimpangan antara harapan dan realitas BAZIAD, A.
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 3, July 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Menelaah dampak publikasi penelitian WHI dan penggunaan pengobatan alternatif/komplementari terhadap perempuan menopause. Rancangan/rumusan data: Kajian pustaka. Hasil: Pada tahun 2002, dunia dibikin heboh oleh hasil penelitian WHI pada pemberian sulih hormon estrogen ekuin konjugasi + medroksi progesteronasetat terhadap perempuan menopause, yang menyimpulkan bahwa ternyata sulih hormon tidak dapat mencegah jantung koroner dan meningkatkan kejadian kanker payudara. Setelah dilakukan analisis mendalam, penelitian WHI tersebut banyak sekali kelemahannya. Akibat pemberitaan yang luas di media massa, perempuan menopause takut menggunakan sulih hormon dan para dokter tidak mau meresepkan sulih hormon lagi. Namun pada tahun 2004, keluar penelitian WHI yang lain di mana perempuan menopause yang tidak memiliki rahim diberikan estrogen saja, yang hasilnya justru sangat bermanfaat, yaitu dapat mencegah penyakit jantung koroner dan ditemukan penurunan kejadian kanker payudara. Namun demikian dampak dari penelitian WHI masih saja belum dapat memulihkan kepercayaan pasien maupun dokter. Kebanyakan pasien lebih mempercayai menggunakan obat-obat alternatif/ komplementari, dan bahkan para dokter pun ikut juga menyarankannya, meskipun data keamanan dan efektivitas obat-obat tersebut masih diragukan kebenarannya. IMS mengeluarkan rekomendasi, bahwa sulih hormon masih tetap merupakan pilihan utama dan penggunaan obatobat alternatif/komplementari masih harus menunggu terlebih dahulu penelitian jangka panjang. Timbul kerancuan di kalangan pasien maupun dokter tentang arti dari hormon alami dan bioidentical hormon. Kesimpulan: Dampak dari hasil penelitian dari WHI telah menghilangkan harapan dan kepercayaan perempuan menopause dan dokter terhadap sulih hormon, meskipun kenyataannya sulih hormon masih merupakan pilihan utama untuk dapat meningkatkan kualitas hidup. Perlu diberikan informasi yang cukup tentang sulih hormon, pengobatan alternatif/ komplementari dan arti dari hormon alami dan bioidentical hormon. [Maj Obstet Ginekol Indones 2008; 32-3: 161-6] Kata kunci: WHI, perempuan menopause, hormon alami, bioidentical hormon.
Gynecology Cancer in Relationship with Obesity Rauw, Gracia M R G; Laihad, Bismarck J; Affandi, Biran
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (67.324 KB) | DOI: 10.32771/inajog.v4i1.68

Abstract

Objective: To know the relationship between obesity and gynecology cancer. Method: This study use case control study design for 250 gynecology patients (125 controls and 125 cases) in Prof. Dr. R. D. Kandou Manado Hospital from 1 July to 30 November 2015. The data was collected by measuring Body Mass Index (BMI) and filing out selfadministered questioners. Result: From the 250 subjects, the study group (125 subjects), 72 subjects have obesity (57.6%) and 97 subjects have multiple parities (77.6%) with 58 subjects diagnosed with cervical cancer (46.4%). In the control group (125 subjects), 71 subjects have normal weight (56.8%) and 67 subjects have multiple parities (53.6%) with 64 subjects diagnosed with ovarium cysts (51.2%). Using multivariate logistic regression, the overweight and obese subjects have 7 folds higher risk to develop gynecology cancer compared to those with normal or underweight subjects. Those with multiple parities and grande multipara subjects have 3 folds higher risk to develop gynecology cancer compared with those who are nullipara and primipara. Conclusion: A significant correlation is found between obesity and gynecology cancer using multivariate logistic regression analysis (p=0.000, OR=6.9 (95% CI = 3.62-13.13). [Indones J Obstet Gynecol 2016; 1: 23-30] Keywords: gynecology cancer, multiple parities, obesity
Obstetric Risk Factors and Anal Incontinence among Women with Previous History of Vaginal Delivery Nurdin, Azizah; Irianta, Trika; Tahir, Mardiah; Chalid, Maisuri T.
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.381 KB) | DOI: 10.32771/inajog.v6i1.759

Abstract

Objective: To investigate the obstetric risk factors of the analincontinence in mothers with previous history of vaginaldelivery.Methods: The was a case-control study conducted in the Obstetricsand Gynecology Department of Dr.Wahidin Sudirohusodo Hospital,Faculty of Medicine, Universitas Hasanuddin, Makassar, during theperiod of February 2015 through January 2016. The researchinstruments were used to evaluate obstetric risk factors and theanal incontinence was the self-administered questionnaire and FecalIncontinence Severity Index. The data were analyzed statisticallyusing the Chi-square test with the significant value of p<0.05.Results: A total of 300 subjects were recruited in this study. Theresearch results indicated that the parity of  3, the assisted vaginaldelivery history (vacuum extraction), and the prolong secondstage of labor had a significant correlation with the anal incontinencewith p value=0.026, OR (95% CI) = 1.8 (1.07-3.03), p=0.018with OR (95% CI) =3.65 (1.2-10.7) and p=0.006 with OR (95% CI)= 2.9 (1.2-6.7).The history of episiotomy and the delivery of thebaby  4000 gram had no correlation with the anal incontinence.Conclusion: Parity, vacuum delivery and prolong second stage oflabor have an association with anal incontinence among womenwho has history of vaginal delivery.Keywords: anal incontinence, obstetric risk factors, vaginal delivery
High Level of Tumor Necrosis Factor (TNF)-α is a Risk Factor for Preeclampsia Anom, I.G.N.
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To define that elevated TNF-α serum level was the risk factor of preeclampsia in pregnancy. Method: This research is a case-control study. From 56 pregnant women, there are 28 women with preeclampsia and the other 28 women with normal pregnancy. Then the serum level of TNF-α was obtained at Prodia’s clinical Laboratory Denpasar. Data’s normality test was done with Kolmogorov-Smirnov, then an analysis of data was done with Independent Sample Test, predictive value a = 0.05. To define the role of TNF-α level in preeclampsia, Chi-Square test was chosen. Result: From this research we found the average level of TNF-α in preeclampsia (6.64 ± 7.64 pg/ml) was higher than in normal pregnancy (2.42 ± 1.77 pg/ml). Analysis with t-independent test shows that the t-value was 2.85 and p-value was 0.006, which means that the average level of TNF-α between the two group was significantly different (with predictive value, p
Perbandingan ekspresi p53, Bcl-2, dan indeks apoptosis trofoblas pada preeklampsia/eklampsia dan kehamilan normal KEMAN, K.
Indonesian Journal of Obstetrics and Gynecology Volume. 33, No. 3, July 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Membuktikan bahwa, jumlah sel trofoblas yang mengalami apoptosis pada sampel jaringan trofoblas yang berasal dari kehamilan dengan preeklampsia/eklampsia lebih tinggi apabila dibandingkan dengan kehamilan normal. Tempat: Bagian Obstetri dan Ginekologi RSU Dr. Saiful Anwar Malang, dan Lab Biomedik FKUB Malang. Bahan dan cara kerja: Penelitian ini merupakan studi laboratorium secara potong lintang; dengan teknik imunohistokimia untuk pengamatan ekspresi protein Bcl-2 dan p53, dan teknik DNA-terfragmentasi (TUNEL) untuk menghitung indeks apoptosis. Sampel jaringan trofoblas berasal dari biopsi jaringan plasenta preeklampsia/eklampsia, dibandingkan dengan persalinan normal (n = 20). Variabel bebas: p53, Bcl-2, apoptosis. Variabel tergantung: preeklampsia/eklampsia. Analisa statistik menggunakan Independent t test (p ≤ 0,05). Hasil: Terdapat perbedaan yang signifikan jumlah sel-sel trofoblas yang mengalami apoptosis pada kelompok kehamilan normal (4,70± 1,829), dibandingkan dengan kelompok preeklampsia/eklampsia (4,70± 1,829), (t test; p≤0,000). Terdapat perbedaan yang signifikan ekspresi protein Bcl-2 pada jaringan trofoblas kelompok kehamilan normal (20,30±5,774), dibandingkan kelompok preeklampsia/eklampsia (9,90± 1,912) (t test; p≤0,000). Terdapat perbedaan yang bermakna ekspresi protein p53 pada jaringan trofoblas kelompok kehamilan normal (8,20 ±2,898), dibandingkan dengan kelompok preeklampsia/preeklampsia (22,70±4,990) (t test; p≤0,000). Kesimpulan: Jumlah sel trofoblas yang mengalami apoptosis pada jaringan trofoblas preeklampsia/eklampsia lebih tinggi daripada kehamilan normal. [Maj Obstet Ginekol Indones 2009; 33-3: 151-9] Kata kunci: trofoblas, indeks apoptosis, p53, Bcl-2, preeklampsia, eklampsia
Heme Oxygenase1 Level in Normotensive Pregnancy and Preeclampsia with Severe Features Homenta, Christian; Wantania, John J; Kaeng, Juneke J
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.884 KB) | DOI: 10.32771/inajog.v4i3.433

Abstract

Objective: To understand the relationship of heme oxygenase-1 (HO-1) level between normotensive pregnancy and preeclampsia with severe features. Method: The cross sectional study was conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital Manado. The subjects consisted of 26 pregnant women with normal blood pressure and 26 women with severe features of preeclampsia. We took the patients’ history, general physical examination, and laboratory assessment. The blood samples were taken from normotensive women more than 20 weeks of pregnancy and preeclamptic women with severe features more than 20 weeks of pregnancy. The data obtained was processed using SPSS 20.0 software. We did the nonparametric Mann-Whitney test to analyze the relationship between heme oxygenase-1 (HO-1) level in normotensive pregnancy and preeclampsia with severe features. Result: The level of heme oxygenase-1 (HO-1) in normotensive pregnant women was at 3.24 (SD 0.58) ng/ml (95% CI 3.00-3.47), and the level of heme oxygenase-1 (HO-1) of preeclamptic women with severe features was 3.92 (SD 0.73) ng/ml (95% CI 3.62-4.21). The result of Mann-Whitney test showed p value of 0.001 which meant that there was significant difference in the level of heme oxygenase- 1 (HO-1) between normotensive women and pre-eclamptic women with severe features. Conclusion: There was the relationship between the level of heme oxygenase-1 (HO-1) and the incidence of preeclampsia with severe features. Keywords: heme oxygenase-1 (HO-1), normotensive pregnancy, preeclampsia with severe features
Tampilan integrin ανβ3 endometrium pada wanita infertil dengan penyakit radang panggul subklinik SURJANA, E.; AFRIANA, N.; HESTIANTORO, A.; INDARTI, J.; KUSUMAH, F.; PRATAMA, G.
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 2, April 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Tujuan: Diketahuinya tampilan integrin ανβ3 pada wanita infertil dengan penyakit radang panggul (PRP). Rancangan/rumusan data: Penelitian bersifat klinis retrospektif. Bahan dan cara kerja: Penelitian dilakukan pada 52 orang pasien infertilitas dengan penyakit radang panggul subklinik yang datang ke klinik Yasmin RSCM. Dilakukan biopsi endometrium pada hari ke 20- 24 siklus haid. Hasil biopsi dianalisa dengan pemeriksaan imunositokimia di Makmal terpadu RSCM-FKUI. Hasil pewarnaan dievaluasi untuk mendapatkan HSCORE. Hasil: Didapatkan 26 sampel (50%) dengan intensitas lemah, 16 sampel (30,7%) dengan intensitas sedang, 5 sampel (9,6%) dengan intensitas kuat dan 3 sampel (5,7%) dengan intensitas sangat kuat. Kesimpulan: Intensitas tampilan integrin endometrium yang rendah pada 50% pasien infertilitas dengan penyakit radang panggul subklinik, menunjukkan kemungkinan adanya kaitan sebab-akibat antara penyakit radang panggul dan kejadian infertilitas. [Maj Obstet Ginekol Indones 2006; 30-2:116-9] Kata kunci: integrin ανβ3, reseptivitas endometrium, hidrosalping, imunositokimia.
The Rate of Asymptomatic Bacteriuria is Similar in Term and Preterm Delivery Amelia, Riska
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 1, January 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objectives: To show the prevalence of asymptomatic bacteriuria in pregnant women and to find its correlation with preterm labor. Methods: This research was performed in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. A total of 78 subjects joined this research. The first group consisted of 39 subjects that were having preterm delivery and the second group consisted of 39 subjects that were having term delivery. Urine analysis and culture were done in both groups. The subject was being considered to have asymptomatic bacteriuria if the urine culture showed a minimum of 100,000 bacteria/ml without any symptoms or signs of urinary tract infection. The number was then analyzed to reveal the correlation of asymptomatic bacteriuria with preterm delivery. Results: There were a significantly higher number of preterm deliveries in subjects whose age ranged between 15-19 year-old (28.20% vs 12.8%; p=0.033). While on the contrary, there was a significantly lower number of preterm delivery in subjects whose age ranged between 30-34 year-old (25.6% vs 5.12%; p=0.020).The incidence number of asymptomatic bacteriuria among all subjects is 21.79%. There was no significant difference of asymptomatic bacteriuria between preterm and a term delivery (23.07% vs 20.51%; p=0.784). Conclusions: There was no significant difference of asymptomatic bacteriuria between the subject with preterm delivery and term delivery, but the incidence of asymptomatic bacteriuria in pregnant women in this study was quite high, reaching eight times higher than those stated in other study. Thus, routine urine culture screening policy in early pregnancy still cannot be omitted, considering that asymptomatic bacteriuria can lead to pyelonephritis which can cause maternal and fetal morbidity. [Indones J Obstet Gynecol; 37-1: 8-11] Keywords: asymptomatic bacteriuria, urine analysis, urine culture, preterm delivery
Correlation of Inhibin A Serum Level with Preeclampsia Pratama, Dian
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: The purpose of this research is to analyze the difference of Inhibin A serum level between preeclampsia patients with normal pregnant patients and to analyze the relation between Inhibin A serum level with preeclampsia. Method: Comparison of average Inhibin A serum level of the preeclampsia group with normal pregnancy was analyzed by using Mann-Whitney test, and the correlation between Inhibin A serum level and preeclampsia was using biserial point correlation test. Samples were obtained from blood of patient suffered preeclampsia and also normal pregnancy, each containing 17 samples according inclusion and exclusion criterias. Patients came to Hasan Sadikin Hospital and two satellite hospitals in August to November 2010. Result: Characteristic test in two groups of study showed that both groups were homogeny and could compared. Mean level of Inhibin A serum was higher in preeclampsia (1268.08 pg/ml) than normal pregnancy (911.12 pg/ml) (p = 0.042) there was a strong positive correlation between Inhibin A serum level with preeclampsia (r pbi = 0.354; p = 0.027). Conclusion: From this research, we can conclude that Inhibin A serum level in preeclampsia is higher than normal. There is a positive correlation of Inhibin A serum level with preeclampsia. [Indones J Obstet Gynecol 2011; 35-1: 36-9] Keywords: inhibin A serum, normal pregnancy, preeclampsia
Comparison of Estrogen β Receptor Expression and the Addition of Various Dose of Geistein to HUVEC Endothel Cell which Exposed to Oxidative Stress Handayani, Vera
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 1, January 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To compare β estrogen receptor on HUVEC endothelial for each Genistein dose addition with β-estradiol physiologic dose. Methode: Experimental study performed in Physiology Laboratorium, Medical Faculty of Brawijaya University Malang, HUVEC culture exposed by glucose as a dysfunction endothelial model. Endothel collected from female newborn umbilicus was cultured to make a confluent culture. The culture was divided into 7 groups: 1. HUVEC without treatment, 2. HUVEC + glucose 33 mM, 3. HUVEC + glucose 33 mM + 17β estradiol , 4. HUVEC + glucose 33 mM+ Genistein 2.5 μm. 5. HUVEC + Glucose 33 mM + Genistein 5 μm, 6. HUVEC + Glucose 33 mM + Genistein 7,5 μm, 7. HUVEC + Glucose 33 mM + Genistein 10 μm. Culture then was incubated in 37°C and stained with immunohistochemistry, using primary antibody of β estrogen receptor. The expression was observed on the -15, 30, 60, 120 and 240th minute. The datas from observation result was analysed with ANOVA test and correlation test. Result: Estrogen receptor comparison between group 1 was significantly different with group 2, 3, 6, 7 and not significantly different with groups 4, 5. Estrogen receptor between group 2 was significantly different with group 4, 5 but not significantly different with groups 3, 6, 7. Estrogen receptor comparison between group 3 was significantly different with group 4, 5 and not significantly different with groups 6, 7. Estrogen receptor comparison between group 4 was significantly different with group 6, 7 and not significantly different with groups 5. Estrogen receptor comparison between group 5 was significantly different with group 6, 7. Estrogen receptor comparison between group 6 was not significantly different with group 7. Isoflavon Genistein dose increase on 30, 60 dan 120 minutes will reduce β estrogen receptor expression on endothelial HUVEC and on 15 and 240 minutes shows that there was no significant correlation with β estrogen receptor expression on endothel HUVEC. Conclusion: There was significant expression distinction of ERβ in glucose induced HUVEC exposed by 17β estradiol compared with those exposed by Genistein but not in Genistein dose 7.5 and 10 μm. The lower of Isoflavon Genistein dose in the -30, 60 dan 120 minute will cause expression of β estrogen receptor in HUVEC endothelial cell that tends to be higher. [Indones J Obstet Gynecol 2010; 34-1:24-30] Keywords: β estrogen receptor, HUVEC, genistein, estradiol.

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