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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 15 Documents
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Search results for , issue "Vol. 9 No. 4 (2024)" : 15 Documents clear
Successful Combination Therapy with Phototherapy and Topical Corticosteroid in a Rare Case : 57 Years Old Male Patient with Lichen Amyloidosis Sambodo, Shelly Lavenia; Mawardi, Prasetyadi; Tansil, Ivana; Dewi, Ayu Kusuma; Utama, Rahmat Firdaus Dwi; Octarica, Stella Gracia; Adjie, Sugih Primas
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.745

Abstract

Background: : Lichen Amyloidosis (LA) is one of the most common forms of primary localized cutaneous amyloidosis, with clinical manifestations of itchy blackish brown hyperkeratotic papules. The most predilection site is the upper extensor of the legs. This case report aims to improve the clinician’s knowledge regarding clinical features and supporting examinations to the provision of appropriate therapy in LA. Case Report: A 57 years old farmer presented to dermatology and venereology outpatient clinic of Dr. Moewardi general hospital with itchy black spots on nearly all over his body since 2 years ago. Dermatology examination obtained generalized papules and scaly hyperpigmented patches. Dermoscopy revealed a scar-like center with a whitish color in the center. Histopathological examination showed an amorphous eosinophilic (amyloid) in the dermis. Congo red examination demonstrated a reddish-orange amyloid. We treated the patient with oral cetirizine 10 mg/day, desoximetasone 0.25% cream applied twice a day in the morning and in the evening, Carmed® cream 20% cream applied twice a day in the afternoon and night, phototherapy 350 MJ/cm2 twice a week. We observed for 14 weeks. The lesion and itching started improving in week 8. Result: Lichen amyloidosis is resulted from amyloid deposits in the papillary dermis which are derived from degradation of basal keratinocytes. The diagnosis is based on history taking, clinical examination, dermoscopy and skin biopsy. The combination of phototherapy and topical corticosteroid can be an option for LA therapy, especially for the symptom of pruritus. Conclusion: Lichen Amyloidosis is the most common type of primary localized cutaneous amyloidosis, presents as blackish brown hyperkeratotic papules. The combined therapy of topical corticosteroids and phototherapy can significantly improve pruritus and skin lesions.
Effectiveness of Erythropoetin Alpha and Eryhtropoetin Beta in Patients With End-Stage Kidney Disease with Anemia Undergoing Hemodialysis: A Meta-Analysis Study Sunur, Vincentius William; Sulistio, Timothy; Adisyahputra, Vega; Safira, Vita; Adiwinoto, Ronald Pratama; Setyawan, Yuswanto
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.749

Abstract

Background and Objectives: One of the causes of anemia in ESRD (End Stage Renal Disease) is due to lack of erythropoietin (EPO) production. The use of short-lived ESA preparations such as Erytrhopoietin alpha and Erytrhopoietin beta still differs in opinion about the effectiveness between the two ESA agents. So the purpose of this study is to review the findings from various studies to provide a better understanding of the effectiveness of the use of ESA. Method The results of the study sought were the effectiveness of erythropoietin alpha and erythropoietin beta which were assessed by the hemoglobin levels in the study. This study uses a meta-analysis design in accordance with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Data search using PUBMED, ResearchGate, and ScienceDirect databases Results A total of 458 studies were identified through database sources. After adjusting for inclusion and exclusion criteria, there were 6 studies to be reviewed in a meta-analysis with a total of 220 patients given erythropoietin alpha therapy and 227 patients given erythropoietin beta therapy. The results of the meta-analysis showed that there was no significant difference in the erythropoietin alpha and erythropoietin beta groups after 1 month of therapy (P = 0.20, MD = 0.16, 95% CI [ -0.57, 1.17], I2 = 0% [P = 0.56]), nor after 3 months of therapy (P = 0.19, MD = -0.27, 95% CI [-0.68, 0.13], I2 = 0%, [P = 0.58]) Conclusions There was no significant difference between the effectiveness of erythropoetin alpha and erythropoetin beta in increasing patients' hemoglobin levels. These two ESA agents are effective in increasing hemoglobin levels in ESRD patients.
Mobile Health Assisted Self Monitoring in Heart Failure Patients To Ensure Quality of Life: A Scoping Review Indriany, Finna; Siregar, Kemal N.; Purwowiyoto, Budhi Setianto
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.751

Abstract

Background: Heart failure leads to reduced quality of life, high hospitalization rates, mortality rates, and treatment costs where out-of-hospital self-monitoring can help with management and prevention of hospitalization and digital apps can help with this. The purpose of this review was getting all information of the studies regarding self-monitoring assisted by mobile health or digital application for heart failure patients.Subjects and Method: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols for a Scoping Review (PRISMA-ScR), literature searches were developed by searching the databases: PubMed.gov, ScienceDirect, SpringerLink, Google Scholar. Following the eligibility criteria, articles that included were analyzed to get the result.Results: Mostly the studies were conducted in 2016 and 2017 (20% each, n=5), less studies in 2018, 2019, 2020, and increased again in 2021 (16%, n=4). The studies were done 57% in USA (n=13), both Australia and Canada were 9% (n=2), and other countries. The designs of the studies were mostly RCT (74%, n=17). Sample size was variative mostly less than 50 participants (39%, n=9). There were 65% of the studies measured the daily body weight (n=15), others used vital signs 57%, medication adherence 39%, and other items. QoL was the most in the outcome (61%, n=14). Main findings mostly showed positive impact on self-monitoring with digital application.Conclusion: Using mobile apps for heart failure patients’ self-monitoring created the positive impacts in the expected outcomes, mostly for quality of life.
Combination of Acupuncture and Hypnotherapy on Blood Pressure Reduction Prasetya, Hanung; Kusumawati, Heni Nur
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.779

Abstract

Background: Hypertension is "the silent killer" the number 2 highest cause of death in Indonesia. One of the non-pharmacological therapies that can be used to reduce hypertension is acupuncture and hypnotherapy. This study aims to analyze the effectiveness of the combination of acupuncture and hypnotherapy (hypnotherapy) on lowering blood pressure. Subjects and Method: The Randomized Controlled Trial (RCT) research was conducted at three clinics, namely Klinki Dr. Singgih, Kusuma Husada Clinic, and Griya Sehat Sinergi from March to September 2023. A total of 160 hypertensive patients were divided into four groups: (1) Acupuncture intervention group (n= 40); (2) Hypnotherapy intervention group (n= 40); (3) Hypnopunk intervention group (n= 40); and (4) The control group was given standard care (n=40). The dependent variable is hypertension. The independent variable was hypnopuncture. The difference in the mean decrease in blood pressure of systole and diastole in each group was analyzed using the ANOVA test. Results: The mean systole blood pressure was lower in the hypnopuncture group (Mean = 145.43; SD= 3.39) than the acupuncture group (Mean= 154.55; SD= 7.42), hypnotherapy group (Mean= 150.95; SD= 11.92), as well as the control group (Mean= 177.22; SD= 7.87), and this result was statistically significant (p <0.001). The average diastole blood pressure was lower in the hypnopuncture group (Mean = 86.47; SD= 1.57) than the acupuncture group (Mean= 87.25; SD= 10.34), hypnotherapy group (Mean= 87.25; SD= 2.89), as well as the control group (Mean= 95.03; SD= 2.90), and this result was statistically significant (p <0.001). Conclusion: Hypnopuncture is effective in lowering systole and diastole blood pressure levels in hypertensive patients.
Evaluating Compliance with Traditional Herbal Treatments in Type 2 Diabetes Mellitus Patients Mufidah, Naili Zahrotun; Murti, Bhisma; Tamtomo, Didik Gunawan
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.783

Abstract

Background: The management of diabetes mellitus is often faced with the challenge of adherence to antidiabetic herbs. Poor adherence to diabetes medication increases the risk of complications and death. This study aims to analyze the determinants related to treatment adherence in Type 2 DM patients. Subject and Method: The cross-sectional study was carried out at UPF Yankestrad Dr. Sardjito Tawangmangu Hospital. A total of 201 adult patients with Type 2 DM were selected in this study. The dependent variable is treatment adherence in Type 2 DM patients. The independent variables were education, knowledge, access to health services, family support, income, and side effects of treatment. Data was collected using questionnaires. Data were analyzed by double linearregression. Result: There was a statistically significant positive association between knowledge and medication adherence (b = 0.19; 95% CI = 0.12 to 0.26; p&lt;0.001); access to healthcare (b = 0.37; 95% CI = 0.26 to 0.47 p&lt;0.001); family support (b = 0.29; 95% CI = 0.20 to 0.39; p&lt;0.001); income (b = 0.15; 95% CI = 0.01 to 0.29; p= 0.030); and there was a negative and statistically significant association between adverse events and medication adherence (b = -0.33; 95% CI = -0.49 up to -0.18; p&lt;0.001). The model fit between the independent variables included in the linear multiple regression analysis model together was able to explain the variation in treatment adherence by 67.12% (Adj R-squared= 67.12%). Conclusion: Treatment adherence in Type 2 DM patients is positively related to knowledge, access to services, family support, and income. The independent variables included in the linear multiple regression analysis model together were able to explain the variation of treatment adherence by 67.12% (Adj R-squared = 67.12%).
Correlation between Troponin I and Serum Sodium and Potassium Levels in Acute Coronary Syndrome Rahma, Hadiyatur; Loesnihari, Ricke; Siregar, Dewi Indah Sari
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.794

Abstract

Background: Acute Coronary Syndrome covers a spectrum of conditions that include patients who have recently changed symptoms or clinical signs, with or without changes in the 12-lead electro­cardiogram, and with or without acute elevations in cardiac troponin (Tn) concentrations. Advances in technology have refined troponin testing and increased its accuracy in detecting and measuring cardiomyocyte injury, high sensitivity, and can detect small myocardial necrosis that is not detected on an electrocardiogram or CKMB examination. This study aims to analyze the correlation between troponin I and sodium and potassium levels in acute coronary syndrome. Subjects and Method: This study was an analytical observational research with a cross-sectional design, involving 40 patients with acute coronary syndrome who visited the Integrated Heart Center Emergency Department. The independent variable is acute coronary syndrome, while the dependent variables are troponin I, sodium, and potassium. The study was conducted at H.Adam Malik Hospital in Medan from February to March 2024. Patients were interviewed for medical history, and then blood samples were taken for troponin I examination and serum electrolyte (sodium and potassium) examination. Data were analyzed using the Spearman correlation test. Results: 40 study subjects, most of the study subjects over 55 years, mostly male (72.5%), with a smoking history of 67.5%, and a family history of hypertension of 52.5%. The median troponin I level was 6.09 ng/ml (range 0.12-15), the median sodium level was 143.5 mmol/L (range 130-155), and the mean potassium level was 4.19 mmol/L (SD= 0.52). There was a weak and non-significant positive correla­tion between troponin I and sodium (r= 0.129, p= 0.429), as well as a weak and non-significant positive correlation between troponin I and potassium (r= 0.059, p= 0.717). Conclusion: There was no correlation between troponin I and sodium, as well as troponin I and potassium.
The Effect of Turmeric-based Vaginal Liquid Soap with Different Concentrations on the Incidence of Vaginal Discharge and PH : Experimental Test on Santriwati of Darussholah II Islamic Boarding School North Pontianak Lutfiawaliah, Delvia; Fatmasari, Diyah; Arwani
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.795

Abstract

Background: As many as 90% of Indonesian women have the potential to experience vaginal discharge because of Indonesia's tropical climate. Hot and humid weather causes mold to easily develop and cause vaginal discharge in women. For this reason, there needs to be an innovation that can be used as one of the efforts to overcome vaginal discharge in general. The purpose of this study is to prove the potential of turmeric-based vaginal soap that is able to overcome vaginal discharge. Subjects and Method: This was a quasi experiment study. The study was conducted at the Darussholah II Islamic Boarding School, North Pontianak, Indonesia from November to December 2023. The sample was divided into 3 groups: (1) , namely groups 1, 2 and 3 with 5%, 10%, and 15% turmeric liquid soap interventions. The dependent variables studied were vaginal discharge and vaginal ph, and the independent variable was Vaginal Turmeric Soap. The analysis technique uses Wilcoxon bivariate analysis. Results: The average value of 5% soap whiteness reduction was 0.96+0.20, 10% was 0.88+0.33 and 15% was 0.92+0.27 with a p value of 0.585. The average value of the pH reduction of 5% soap was 0.60 + 0.57, 10% soap was 0.52 + 0.65, and 15% soap was 0.48 + 0.65 with a p value of 0.904. At a dose of 5%, the reduction in vaginal discharge and pH was the highest compared to other groups. And the results of the analysis showed that the administration of 5%, 10%, and 15% doses did not have a significant difference in changes in vaginal discharge and pH. Conclusion: A 5% dose of turmeric-based vaginal soap was more effective at treating vaginal discharge and lowering vaginal pH, compared to other groups in this study. It is hoped that young women will be more selective in choosing soap in maintaining pH and vaginal discharge, especially if used for a long period of time.
The Effect of Using a Dynamic Wrist Splint on Wrist Pain in Stroke Patients Rachmat, Nur; Kuncoro, Bambang; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.796

Abstract

Background: Hand movement function in hemiplegic stroke patients is impaired due to contractures and spasticity. Pain in the wrist joint often occurs when moved. This research aims to determine how dynamic wrist splints can reduce wrist pain in stroke patients. Subjects and Method: This was a quasi-expe­rimental study. The subjects were 20 hemiplegic stroke patients in Colomadu Karanganyar. The research was carried out in July – September 2023. The dependent variable was wrist pain. The independent variable was the use of a dynamic wrist splint. measurement the degree of pain using the Visual Analog Scale which is used to determine the level of pain felt by the sufferer. Data normality test using Shapiro-Wilk. The statistical test used in this research is wilxocon. Results: The ages of subjects ranged from 30 to 62 years. Wrist pain was reduced after the use of a dynamic wrist splint compared to levels before its use. Conclusion: There is an influence of dynamic wrist splints on wrist pain in stroke patients.
Clinical Outcomes Comparison in Administration of Secretome vs Hyaluronic Acid in Patients with Knee Osteoarthritis Kellgren-Lawrence Grade I-III Aryana, I Gusti Ngurah Wien; Suyasa, I Ketut; Dharmayuda, Cokorda Gde Oka; Febyan; Gunawan, Dary
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.798

Abstract

Background: The prevalence of OA in Indonesia is predicted to reach more than 20% of the population aged over 60 years in 2050, with a high risk of disability. So far, early treatment of osteoarthritis in the form of administering hyaluronic acid has not been completely satisfactory and tends to be progressive until ending in more invasive operative therapy. This study aimed to compare the clinical outcomes between secretome injection and hyaluronic acid in patients with Kellgren-Lawrence grade I-III knee osteoarthritis. Subjects and Method: This was a single-blind experimental study. This study was conducted in the orthopedic polyclinic at General Hospital Prof. Dr. I.G.N.G. Ngoerah Bali. A total sample of 36 knee osteoarthritis patients was selected using permuted block sampling with randomization. The sample was divided into two groups, (1) secretome (intervention group) and (2) hyaluronic acid (control group). The independent variables were secretome injection and hyaluronic acid injection. The dependent variable was pain. Pain was measured using Western Ontario and McMaster University (WOMAC), Knee Osteoarthritis Outcome Score (KOOS), Visual Analog Score (VAS), and Patient-Reported Outcome Measure (PROM). Results: Based on gender, there are more women than men and the right foot is more affected at 58.3%. Functional score parameters in each secretome and hyluronic acid group were compared between the 3rd and 6th months of follow-up. Pain in the hyaluronic acid group was lower than in the secretome group. Conclusion: Hyaluronic acid has better effect in pain reduction than secretome. Further studies could explore the underlying mechanisms and potential long-term effects to better understand these differences in pain outcomes.
Effect of Moringa Leaf Infusion (Moringa oleifera) on Reducing Blood Glucose and Total Cholesterol Levels in Mice (Mus musculus) with Diabetic Ulcers Napitupulu, Helen Debora; Siahaan, Jekson Martiar; Simangunsong, Batara
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.799

Abstract

Background: Diabetes mellitus is a chronic disease in the form of metabolic disorders, which is characterized by blood glucose levels (KGD) that exceed normal limits and are accompanied by impaired metabolism of carbohydrates, lipids, and proteins, as a result of abnormalities in insulin secretion. Diabetics are known to have slow wound healing. Moringa oleifera leaves or moringa plants contain flavonoid compounds, which can decrease glucose absorption. This study aims to determine the effect of moringa leaf infusion on blood sugar levels, glucose tolerance, cholesterol levels, body weight, and wound healing speed in mouse model animals. Subject and Method: This study is experimental using a posttest only controlled group design, using 25 male mice (Mus musculus) divided into 5 groups. The study was conducted at the Phytochemistry and Animal House Laboratory, Faculty of Medicine, Methodist University Indonesia from March to May 2022. The bound variables were body weight measured using a scale, current blood glucose levels and blood glucose levels with glucose loading measured with strips and glucometers, total cholesterol levels measured using strips and cholesterol measuring devices, and the length of mice wounds measured using a ruler. The free variable is the variation in the dose of moringa leaf infusion. The data were analyzed using the Anova and Kruskal-Wallis tests. Results: The administration of moringa leaf infusion had a significant effect on the reduction of the levels of each variable, namely a dose of 10% in body weight, a dose of 30% in KGD, 20% in KGD with glucose loading, 20% in cholesterol, and 20% in wound closure, which was proven based on the results of statistical tests. Conclusion: Moringa leaf infusion can lower blood sugar levels, blood sugar levels by glucose depletion, cholesterol levels, body weight, and accelerate wound healing in sucrose-induced mice, high fat diet, and PTU.

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