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Effect of Bamboo Shoot (Gigantochloa Nigrociliata) Extract on Decreased Blood Pressure and Tnf-Α in Male Wistar Rats (Rattus Norvegicus) Surati, Surati; Setyowatiningsih, Lilik; Aulia, Qurrotu A’yuni; Widiyanto, Santo Yoseph Didik; Sutrisna, EM
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.639

Background: Hypertension is a non-communicable disease based on increased pathologies such as RAS, inflammation, and oxidative stress. Bamboo shoot extract contains BSP, phenol, and flavonoids that can reduce inflammatory status, oxidative stress, and ACE. The study aims to determine the effect of bamboo shoot extract on decreased blood pressure and TNF-α in male Wistar Rats made hypertensive.Subjects and Method: This study used a True Experimental Design with the Posttest Only Control Group Design. The study was located at the Integrated Biomedical Laboratory of the Faculty of Medicine, Sultan Agung Islamic University, Semarang in April-July 2021. The study sample of 24 male Wistar Rats was randomly divided into 4 groups. The dependent variables of the study were Blood pressure and TNF-α. The independent variable was bamboo shoot extract. Blood pressure was measured by Pressure Recording Tail Cuff, and TNF-α was measured by using the ELISA method with CATALOG Number KET 9007-48 well. The data were analyzed by using the One Way Anova Test.Results: This study showed no significant difference from systolic or diastolic blood pressure results of male Wistar rats in the K1, K2, and K3 groups after the intervention. Meanwhile, the average levels of TNF-α decreased significantly in the K3 group (Mean= 1.99; SD= 1.13) compared with the control group K0 (Mean= 16.70; SD= 7.45) and it was statistically significant p<0.001.Conclusion: There is no significant effect on blood pressure in male Wistar rats that obtained bamboo shoot extract, but there is a significant effect on TNF-α levels in male wistar rats that obtained bamboo shoot extract.Keywords: bamboo shoots, hypertension, blood pressure, TNF-α, male wistar rat.Correspondence: Surati. Department of Cytohistotechnology, Study Program of Health Analyst, Health Polytechnic, Ministry of Health Semarang. Jl. Wolter Monginsidi No. 115, Pedurungan, Semarang, Central Java, Indonesia, Email: analis_surati@yahoo.com. Mobile: 085226825024.Indonesian Journal of Medicine (2023), 08(01): 121-127https://doi.org/10.26911/theijmed.2023.08.01.12

Relationship between Social Support and COVID-Related Common Mental Disorders Incidence in Pregnant Women in Banyumas, Central Java Rahman, Fadel; Wibowo, Yudhi; Riana, Purwa
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.609

Background: Social restriction and distancing were enforced, to contain the viral transmission of Coronavirus Disease-19 (COVID-19). Therefore, normal social activities are stagnant and give rise to common mental disorders (CMDs) in pregnant women, especially in the first trimester of pregnancy. The purpose of this study was to analyze the relationship of social support with COVID-related common mental disorders (CMDs) in pregnant women in Banyumas Regional General Hospital.Subjects and Method: A observational analytic study using a Cross-sectional study approach targeting pregnant women in the Banyumas Regency Central Java, from May to December 2022. The independent variable is social support. The dependent variable is common mental disorders (CMDs). The sampling technique used snowball sampling of approximately 1543 respondents. This study employed the WHO-SSQ-6 and WHO-SRQ-20 questionnaires. The data analysis technique made use of the Chi-Square test.Results: Pregnant women who have low social support have a risk of Common Mental Disorders (CMDs) and are statistically significant (PR= 1.74; 95% CI = 1.83 to 1.87; p<0.001).Conclusion: Social support has a significant correlation with COVID-related CMDs.Keywords: COVID-19, COVID-related CMDs, Pregnant women, first trimesterCorrespondence: Yudhi Wibowo, Department of Public Health and Community Medicine, Faculty of Medicine, Jenderal Soedirman University. Jl. Dr. Gumbreg No.1, South of Purwokerto, Banyumas Regency, Central Java. Email: dryudhiwibowo2005@gmail.com. Mobile: +62 811-2621-904.Indonesian Journal of Medicine (2022), 08(02): 142-149https://doi.org/10.26911/theijmed.2023.08.02.03

Clinical Demographics Characteristic of Total Knee Arthroplasty at Prof IGNG Ngoerah General Hospital, Bali, Indonesia Aryana, I Gusti Ngurah Wien; Dharmayuda, Cokorda Gde Oka; Febyan, Febyan; Dimitri, Dominicus; Limena, Shianita; Kuswara, Leonardus William
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.616

Background: Total knee arthroplasty (TKA) is a widespread surgical procedure for severe arthritis. By 2030, primary TKA would reach over 1.2 million procedures annually in the United States. In Indonesia, the prevalence of joint disease is about 19.5 million cases. This study aims to evaluate the clinical demographics characteristics of TKA in Prof. Ngoerah General Hospital, Bali, Indonesia.Subjects and Method: This is a descriptive study using a Cross-Sectional method with a total 57 adult patients undergoing TKA caused by Osteoarthritis grade III/IV in Prof IGNG Ngoerah Hospital from June 2020-June 2022. The dependent variable is the TKA procedure. Independent Variable is Age, gender, grade of knee osteoarthritis, comorbidities, and complications Data from the medical record was collected and stored in a Microsoft Office Excel 365 spreadsheet, the distributive table was analyzed and collected by using SPSS.Results: Patient characteristic is dominated by an elderly female (84.2%), with age group 61-70 (38.6%). Comorbidities in this study include hypertension (28.1%), type II diabetes (10.5%), and rheumatoid disease (1.8%). The main complication recorded in this study includes joint stiffness (3.5%), and persistent pain (5.3%).Conclusion: After Total Knee Arthroplasty was performed on 57 patients with a wide range of comorbidities, only a small number of complications occurred. This study implied that TKA could be performed even if the patient had some comorbidities as long as the patient pursued a complete pre and post-operative evaluation algorithm of the procedure.Keywords: knee arthroplasty, osteoarthritis, human and medicine, rehabilitationCorrespondence: IGN Wien Aryana, Consultant of Sports Medicine, Dept. Orthopaedic and Traumatology, Prof IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University. Jl. Diponegoro, Dauh Puri Klod. Denpasar City, Bali 80113 Email: wienaryanaortho@gmail.com. Mobile: +62811385263.Indonesian Journal of Medicine (2023), 08(02): 128-135https://doi.org/10.26911/theijmed.2023.08.02.01

Relationship between Family Support and Family Burden in Families With Cancer: Meta-Analysis Adyani, Sang Ayu Made; Jadmiko, Arief Wahyudi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.613

Background: Cancer is a chronic disease caused by abnormal cell growth with special care needs that cause a burden on the family. Family support can have a significant impact on family burden. Adequate support from family members can lighten the burden on individuals or families and improve their overall well-being. This study aimed to estimate the relationship between family support on family burden in families with cancer obtained from several previous similar studies.Subjects and Method: This research was conducted using a systematic review and meta-analysis with PICO namely, Population: family with cancer; Intervention: good family support; Comparison: Lack of family support; Outcome: family burden. By searching articles in 4 databases namely PubMed, Google Scholar, Science Direct, and ProQuest published from 2014 to 2022, entering the following keywords “Family support” OR “Supportive Family” AND “Family Burden” OR “Family depresssion” AND “Chronic Disease” AND “Cancer” AND “Multivariate Analysis”. Articles were selected using PRISMA flow and data analysis using the Review Manager 5.3 application.Results: There 9 articles using the Cross-Sectional study design with a total sample of 2,832 subjects from India, Japan, USA, Swiss, Austria, Yunani, Germany, and Mexico which have been subject to systematic review and meta-analysis. The results showed that good family support are effective in decreasing family burden, and the results are statistically significant. Families with cancer who receive good family support are decrease family burden 0.57 times than families with cancer receive lack family support (aOR= 0.57; 95% CI= 0.38 to 0.85; p= 0.006).Conclusion: Good family support are effective in decreasing family burden.Keywords: family support, family burden, chronic disease, cancer.Correspondence: Sang Ayu Made Adyani. Nursing Department, Faculty of Health, Universitas Pembangunan Nasional Veteran Jakarta. Jl. RS. Fatmawati Raya, Pd. Labu, Cilandak, Depok, West Java. Email: adyani.sangayu@upnvj.ac.id. Mobile: +62 819-3206-5946.Indonesian Journal of Medicine (2023), 08(02): 169-178https://doi.org/10.26911/theijmed.2023.08.02.06

Intrafracture Recombinant Platelet-Derived Growth Factor Improves Fracture Healing Process on Wistar Rat Aryana, I Gusti Ngurah Wien; Giri, Kadek Gede Bakta; Suyasa, I Ketut; Lestari, Anak Agung Wiradewi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.615

Background: Femoral fracture is associated with high morbidity and mortality, especially in young adults with high-energy injuries. Abnormal fracture healing presents as a significant matter in management of femoral fracture. Platelet Derived Growth Factor (PDGFBB) is proposed as potential agent in fracture healing. Up to this point, PDGF has been scientifically studied improve wound healing by enhancing fibroblast proliferation, extracellular matrix synthesis, and revascularization. This study aims to evaluate role of PDGF on fractured bone healing.Subjects and Method: This was a randomized controlled trial conducted at Animal and Biomedical Laboratory of Udayana University, from March to September 2022. 36 male and healthy Wistar Rats at 34 months old and weighs 140160 grams were selected for this study. The dependent variables were Allen score, type I and type III collagen levels. The independent variable was administration of 10 mcg PDGFBB following femoral osteotomy and intramedullary wire fixation. Type I and III collagen levels are assessed using ELISA methods. Statistical analysis is performed using independent T-test in SPSS ver 25.0 software.Results: Allen score in the PDGFBB group (Mean= 3.89; SD= 1.40) was higher than control group (Mean= 2.28; SD= 1.48), with p=0.002. Type I collagen in the PDGFBB group (Mean= 4.97; SD= 0.54) was higher than control group (Mean= 4.41; SD= 0.74), with p=0.014. Type III collagen in the PDGFBB group (Mean= 12.1; SD= 2.49) was higher than control group (Mean= 10.01; SD= 1.61), with p=0.005.Conclusion: In comparison to the nonPDGFBB group, Wistar rats that had their femurs osteotomized and joined with intramedullary wire in the PDGFBB group has higher mean of Allen score, type I and type III collagen levels.Keywords: femoral fracture, allen score, type I collagen, type III collagen, PDGFBBCorrespondence: IGN Wien Aryana, Consultant of Sports Medicine, Dept. Orthopaedic and Traumatology, Prof IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University. Jl. Diponegoro, Dauh Puri Klod. Denpasar City, Bali 80113. Email: wienaryanaortho@gmail.com. Mobile: +62811385263.Indonesian Journal of Medicine (2023), 08(02): 136141https://doi.org/10.26911/theijmed.2023.08.02.02

Correlations between Age and Hypertension on Diabetic Foot Ulcer Marsya, Vitania; Mahmuda, Iin Novita Nurhidayati; Lestari, Nining; Jatmiko, Safari Wahyu
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.622

Background: Diabetic foot ulcer is a wound located on the foot of a diabetic patient, which is related to peripheral neuropathy or arterial disease. Hypertension can be related to diabetic foot ulcer by its mechanism that caused peripheral artery disease. Age also can be the one of risk factors for diabetic foot ulcers, because aging occurs a reduction of insulin secretion, even insulin resistance. Insulin resistance occurs in macroangiopathy. The purpose of this study is to determine the correlation between age and hypertension with diabetic foot ulcers.Subjects and Method: This was a cross-sectional study conducted at Arafah Islamic Hospital Rembang, Central Java. The dependent variable is diabetic ulcers. The independent variables were age and hypertension. A sample of diabetic patients using medical records from January 2022-June 2022. Data were collected using purposive sampling and analyzed using the Chi-Square test, and regression logistic test.Results: Significant correlation was found between age (OR= 3.80; 95% CI= 1.38 to 10.57; p<0.001) and hypertension (OR= 8.12; 95% CI= 2.70 to 24.40; p<0.001) with a diabetic foot ulcer.Conclusion: There is a significant correlation between age and hypertension with diabetic foot ulcers.Keywords: age, hypertension, diabetes, diabetic foot ulcers.Correspondence: Nining Lestari. Bachelor of Medicine, Muhammadiyah University of Surakarta. Jl. A. Yani, Mendungan, Pabelan, Kartasura, Sukoharjo 57162, Central Jawa, Indonesia. Email: nl209@ums.ac.id. Mobile: +62852-2939-0353Indonesian Journal of Medicine (2023), 08(02): 179-185https://doi.org/10.26911/theijmed.2023.08.02.07

Green Synthesis of Silver Nanoparticles as a Wound Healing Agent: a Systematic Review of the Biological Activities Priambodo, Galih; Samekto, Widiastuti; Subagio, Agus; Susanto, Hardhono; Dwiantoro, Luky
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.612

Background: The implication of nanotechnology includes silver nanoparticles to medical sciences, and has a revolutionary impact on therapeutic and diagnostics management. Many studies reported that silver nanoparticle (AgNPs) application can accelerate the wound healing process. This study aimed to systematically review the biological activities of silver nanoparticles as a wound-healing agent.Subjects and Method: This article was a systematic review study conducted by searching for articles from online databases such as EBSCO, PubMed, Science Direct, and World Scientific. Populations: laboratory animals; Intervention: green synthesis of silver nanoparticles; Comparison: a standard ointment for wounds such as povidone-iodine, etc; Outcome: wound healing. The independent variable is the green synthesis of silver nanoparticles, and the dependent variable is wound healing. The inclusion criteria for this study were full articles using an experimental study, with the publication year until 2022. The data extraction was focused on the biological activities of silver nanoparticles and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews.Results: A total of 8 articles reviewed in this study were from countries: Egypt, India, Saudi Arabia, Singapore, and China. The green synthesis of AgNPs was accomplished using a natural aqueous extract from leaves such as Azadirachta indica, Tridax procumbens, the combinations of Catharanthus roseus and Azadirachta indica, Scutellaria barbata, the fungus Fusarium verticillioides, or cyanobacterial platforms (ex: Phormidium sp., Synechocystis sp, and arthrospira sp polysaccharides). All studies were animal-based experimental with wounds infected with bacteria and inflicted in regards to the experiment. All trials resulted in favor of the AgNPs ointment treated group compared to the untreated group or the standard ointment group.Conclusion: Our review suggested that all studies about the efficacy of AgNPs as wound-healing therapy showed positive results.Keywords: biological activities, silver nanoparticles, wound healing.Correspondence: Galih Priambodo. Faculty of Medicine, Universitas Diponegoro. Jl. Prof. Sudarto, Tembalang, Kec. Tembalang, Kota Semarang, Central Java. Email: g2_37@yahoo.co.id. Mobile: 085229998999.Indonesian Journal of Medicine (2023), 08(01): 100-113https://doi.org/10.26911/theijmed.2023.08.01.10

Meta-Analysis: Effectiveness of Scoliosis Brace to Reduce Scoliosis Curve Degree in Adolescent Idiopathic Scoliosis Marsim, Etanaulia; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.598

Background: Adolescent Idiopathic Scoliosis (AIS) is a disorder of the spine that is curved laterally which includes rotation of the spine so that there is humpback on the ribs, which occurs in children aged 10-18 years. The use of a brace is an attempt to modify the mechanical shape and control the development of curves in the curvature of the spine by applying certain pressure points on the body. The purpose of this study was to determine the magnitude of the effect of using the scoliosis brace to reduce the degree of scoliosis in adolescents with idiopathic scoliosis.Subjects and Method: This study was conducted using a systematic review and meta-analysis study design using PICO, population: adolescent idiopathic scoliosis, intervention: using a scoliosis brace. comparison: not using a scoliosis brace, outcome: degree of scoliosis. The articles used in this study come from 3 databases, namely Google Scholar, PubMed, and Science Direct. With keywords including "Adolescent scoliosis" OR "scoliosis" AND "scoliosis brace" OR "brace" AND "degree of scoliosis" OR "Cobb Angle" AND "randomized control trial". The articles included in this study are full paper articles with experimental studies, research subjects of adolescent patients with scoliosis, articles published in the 2011-2021 period.Results: A meta-analysis was conducted on 10 primary randomized control trials conducted from Turkey, China, Canada, Switzerland, the United States, and Hong Kong, with a total sample size of 558. The meta-analysis concluded that adolescent patients with idiopathic scoliosis who received intervention The scoliosis brace had a lower grade of scoliosis 0.27 compared to adolescents who did not use the scoliosis brace, and the difference was statistically significant (SMD= -0.27; 95% CI= -0.45 to –0.09; p= 0.003).Conclusion: The use of a scoliosis brace can reduce the degree of scoliosis in adolescents with idiopathic scoliosis.Keywords: adolescent idiopathic scoliosis, scoliosis brace, cobb angleCorespondence: Etanaulia Marsim. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: etanaulia@gmail.com. Mobile: +6285840530580.Indonesian Journal of Medicine (2023), 08(01): 12-22https://doi.org/10.26911/theijmed.2023.08.01.02

Effect of Hypnobreastfeeding on Fatigue and Motivation to Breastfeed in Post Partum Mothers Starting on Day 3 Watna, Ida; Ambarika, Rahmania; Peristiowati, Yuly
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.625

Background: Fatigue is a condition in which individuals feel tired and reduce their physical and mental abilities and will not go away with rest. Mothers with postpartum fatigue have a higher risk of stopping breastfeeding. This study aimed to analyze the effect of hypno-breastfeeding on maternal fatigue and motivation for breastfeeding post-partum mothers starting on the 3rd day in the working area of the Arjasa Health Center.Subjects and Method: Research with a Pre-Experimental design was conducted at the Arjasa Health Center, Jember, East Java in January 2023. A total of 33 mothers were selected by cluster sampling. The dependent variable is the fatigue of the postpartum mother and the motivation for breastfeeding. The independent variable is the provision of hypno-breastfeeding. Data was collected using the PFS and BMIMS questionnaires. Data were analyzed using paired sample T-test.Results: Mother's fatigue before (Mean= 51.60; SD= 16.73) was higher than after (Mean= 36.06; SD= 7.45) given hypno-breastfeeding and was statistically significant (p<0.001). Mothers' motivation in breastfeeding after being given hypno-breastfeeding treatment (Mean= 85.96; SD= 4.64) was higher than before (Mean= 68.80; SD= 14.66), and statistically significant (p<0.001).Conclusion: Hypno-breastfeeding is effective in reducing fatigue and increasing motivation in breastfeeding post-partum mothers.Keywords: hypno-breastfeeding, postpartum mothers, fatigue, breastfeeding motivation.Correspondence: Ida Watna. Master's Program of Public Health, Strada Institute of Health Sciences, Indonesia. Jl. Manila No. 37, Tosaren, Kec. Islamic Boarding School, City of Kediri, East Java 64123. Email: danandeso79@gmail.com. Mobile: +62 823-3423-6376.Indonesian Journal of Medicine (2023), 08(02): 150-156https://doi.org/10.26911/theijmed.2023.08.02.04

Epidemiological Analysis of Mental Health Disorders in Patients at Psychiatric Hospitals in the Special Region of Yogyakarta, Indonesia Rokhmayanti, Rokhmayanti; Rulianawati, Viandika; Astuti, Fardhiasih Dwi; Hastuti, Siti Kunia Widi; Rosyidah, Rosyidah; Desvita, Widea Rossi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.640

Background: Mental disorder is a condition of decreasing all psychiatric conditions that result in deviant behavior. WHO estimates that one in eight people in the world lives with a mental disorder in the world. The COVID-19 pandemic that has occurred since 2019 has had an impact and has had a major impact on the mental health of people in the world and in Indonesia. The Special Region of Yogyakarta is the province with the highest cases of mental disorders in Indonesia based on the results of the 2013 and 2018 Basic Health Research (Riskesdas) surveys. The purpose of this study was to determine the epidemiological description of mental disorders per classification in inpatients at Mental Hospitals in the Special Region of Yogyakarta in 2019-2021.Subjects and Method: This study used a quantitative descriptive method, sourced from secondary data from Mental Hospitals in the Special Region of Yogyakarta for the period 2019 - 2021. The population in this study was 4,413, with a total sample of 3,919. The inclusion criteria are data of inpatients with mental disorders recorded in the recapitulation of medical records of inpatients at the Mental Hospital for the period 2019 to 2021. Exclusion criteria are incomplete data. The sampling technique used is total sampling. The person variable consists of a classification of mental disorders, age, gender, education level, occupation, marital status, health insurance, and end of care. The instrument used in this research is a dummy table. Data from this study were analyzed descriptively by looking at the frequency and proportion of each variable studied.Results: The results showed that the highest disease classification was F20-F29 (schizophrenia, schizotypal disorder, and delusional disorder) 76.72%. Most of them were aged 25-44 years (55.60%), male (61.55%), graduated from high school or equivalent (46.54%), did not work (66.90%), and were not married (57.29%). Most of them use national health insurance (62.95%), end of treatment with doctor's approval (97.86%), and length of stay ≤ 42 days (95.1%). Most of the patients came from Sleman Regency (37.25%) and from urban areas (71.37%).Conclusion: Most patients with mental disorders are in productive age. People with mental disorders are an economic burden that must be borne by their families and the government. So there is a need for comprehensive prevention efforts to reduce the incidence of mental disorders in the community.Keywords: mental disorders, epidemiological studies, schizophreniaCorrespondence: Siti Kurnia Widi Hastuti, Faculty of Public Health Universitas Ahmad Dahlan. Jl Prof Dr Soepomo Warungboto Umbulharjo, Special Region of Yogyakarta, Indonesia. Email: kurnia.widihastuti@ikm.uad.ac.id. Mobile: +62813-2843-3256.Indonesian Journal of Medicine (2023), 08(02): 204-218https://doi.org/10.26911/theijmed.2023.08.02.10

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