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Effectiveness of Hibiscus sabdariffa Linn for Obesity Treatment: A Systematic Review of Randomized Controlled Trials Anggraini, Suci; Kartinah, Neng Tine
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Hibiscus sabdariffa Linn. (H. sabdariffa), commonly known as Rosella plants in Indonesia, has had various uses in the food and beverage industry and traditional medicines for hundreds of years. The main compounds of H. sabdariffa have been stated to have anti-obesity effects through its biologically active compounds. This review systematically evaluates the evidence from human randomized clinical trials on the effects of H. sabdariffa extract in obesity, including decreased bodyweight, normalizing the blood lipid profile, and modulating appetite-related biomarkers.Subjects and Method: This review is based on the patient, intervention, comparison, and outcome (PICO) procedure, with the patient is people with obesity, the intervention is the administration of H. sabdariffa extract compared to control that given placebo, and the outcomes are reduced body weight and fat accumulation, normalize blood lipid profiles, and regulate biomarkers related to appetite. Articles used are limited to the publication year between 2013 and 2021. Search is done through PubMed, ScienceDirect, Wiley Online Library, Scopus, and Google Scholar with the keywords “hibiscus sabdariffa and obesity”, “hibiscus sabdariffa and lipogenesis”, “hibiscus sabdariffa and energy metabolism”, and “hibiscus sabdariffa and appetite”.Results: The search resulted in 10 studies involving 453 subjects. We proved several significant effects of H. sabdariffa extract on obese subjects. Administration of H. sabdariffa extract for several doses and several days can improve anthropometry measurement, fat accumulation, increased satiety sensation, while the appetite sensation mainly for fatty, sweet, and salty foods was decreased.Conclusion: This review suggests that the benefit of H. sabdariffa to people with obesity are associated with body weight and blood lipid profile-lowering effect; however, more high-quality clinical trials are needed.Keywords: Hibiscus sabdariffa, obesity, appetiteCorrespondence: Suci Anggraini, Masters Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia. Jl. Salemba Raya 4, Jakarta Pusat, DKI Jakarta 10430. Email: suci.angraini@ui.ac.id . Mobile: 081363397973.Indonesian Journal of Medicine (2021), 06(04): 439-451https://doi.org/10.26911/theijmed.2021.06.04.10

“TRISNA” Conceptual Model and Spiritual Approach to Build Body Image, Self-Esteem, and Quality of Life in Cervical Cancer Patients at Dr. Moewardi Hospital, Surakarta, Indonesia Adriani, Rita Benya; Handayani, Siti; Prabowo, Tri
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: The problems of cervical cancer patient’s psychological response to advanced cancer are acute crisis, struggle, anxiety, and sadness, which will interfere with their life, especially sexual relations with their partners. Sexual relations in the Javanese view are a noble, sacred bond and have the function to maintain harmony. The spiritual approach and "TRISNA" which contains the principles of Javanese teachings about sincerity should be applied by cervical cancer patients and their sexual partners. This study aimed to determine the effect of palliative sexuality treatment with a "TRISNA" and spiritual approach to body image, self-esteem, and quality of life in cervical cancer patients at Moewardi Hospital Surakarta.Subjects and Method: This study was a quasi-experimental design using 138 samples divided into three groups, namely the TRISNA, Spiritual, and control groups with a pre-test-post-test control group design conducted at Dr. Moewardi Hospital Surakarta, Central Java, in May to August 2019. The dependent variable in this study is the body image scale, self-esteem, and quality of life. The independent variables in this study are the TRISNA and spiritual approaches. The instruments used are the body image scale, self-esteem scale, and the European Organization for Research and Treatment of Cancer (EORTC) QOQ-CX24. Statistical analysis using t-test with SPSS 13 application software.Results: The results showed that sexuality with the TRISNA and spiritual approaches can improve body image (F= 137.67), self-esteem (F= 241.05), and quality of life (F= 76.95) of cervical cancer patients with a significant value for each group (p≤0.001).Conclusion: Sexuality with TRISNA's approach is the most influential in body image, self-esteem, and quality of life in cervical cancer patients in cervical patients Moewardi Hospital Surakarta.Keywords: body image scale, self-esteem, quality of life, sexuality, spiritualCorrespondence: Rita Benya Adriani, Ministry of Health of Surakarta, Health Polytechnics Surakarta, Letjend Sutoyo Street, Mojosongo, Surakarta 57127, Central Java, Indonesia. Email: benyaadriani@gmail.com. Mobile +628122617033.Indonesian Journal of Medicine (2023), 08(01): 37-46https://doi.org/10.26911/theijmed.2023.08.01.04

The Agreement of Immunoglobulin Gamma Release Assay (IGRA)/ T-SPOT Tuberculosis and Tuberculin Skin Test to Detect Latent TB Infection in Diabetes Mellitus Patients Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Saptawati, Leli; Marwoto, Marwoto; Suryawati, Betty; Redhono, Dhani; Sebayang, Pribadi M
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: WHO identifies diabetes mellitus (DM) as a neglected risk factor for tuberculosis (TB). Currently, there is no gold standard test for latent TB infection (LTBI). Centers for Disease Control and Prevention (CDC) recommends using Tuberculin Skin Test (TST) and Immunoglobulin Gamma Release Assay (IGRA) to diagnose LTBI. TST is an LTBI classic diagnostic tool that has low sensitivity and specificity. But it is still preferred in diagnosing LTBI due to its lower price, and more health facilities can perform the examination compared to IGRA (T-SPOT.TB). The study aimed to measure the agreement of TST and T-SPOT.TB testing in detecting LBTI in DM and the correlation of HbA1c with TST and T-SPOT.TB.Subjects and Method: Subjects were DM patients who underwent TST and T-SPOT.TB testing. If the results of TST and T-SPOT.TB was positive, the test would be continued with Xpert MTB/RIF microbiological testing. TST used PPD RT23 2TU. T-SPOT.TB was performed toward peripheral blood mononuclear cells. The degree of agreement between TST and T-SPOT.TB testing was calculated using the Test of Agreement (Kappa Cohen). The degree of correlation between the two variables was calculated by using Pearson correlation.Results: The selected 30 study subjects with DM undergoing antidiabetic therapy showed 6 (20%) detected LTBI and 24 (80%) without LTBI using TST and T-SPOT.TB test. There was a substantial agreement level between TST and T-SPOT.TB testing in detecting LTBI among diabetes mellitus patients undergoing anti-diabetic therapy with kappa value= 0.62 (p<0.001). HbA1c increased T-SPOT (r= 0.07; p= 0.716) and TST (r= 0.11; p= 0.956).Conclusion: TST testing may substitute T-SPOT.TB to detect LTBI among diabetes patients undergoing antidiabetic therapy.Keywords: latent tuberculosis infection, diabetes mellitus, TST, Immunoglobulin Gamma Release Assay (IGRA), T-SPOT.TBCorrespondence: Reviono. Department of Pulmonology and Medical Respiratory, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Email: reviono@staff.uns.ac.id.Indonesian Journal of Medicine (2021), 06(03): 298-306https://doi.org/10.26911/theijmed.2021.06.03.07

Meta-Analysis Effectiveness of Massage on Spasticity in Children with Cerebral Palsy Muazarroh, Salma; Kristiyanto, Agus; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Children with spastic cerebral palsy generally experience spasticity in the upper and lower extremities. Spasticity is stiffness that occurs due to damage to the central nervous system caused during the child's growth and development from prenatal to postnatal. Spasticity can be controlled with intervention. The purpose of this study is to analyze, and estimate the effectiveness of massage for spasticity in children with cerebral palsy.Subjects and Method: This study uses a meta-analysis study design with PICO as follows: P= children with cerebral palsy, I= massage, C= non massage, O= Modified Ashworth Scale (MAS). The article search process was carried out between 2000-2020 using databases from PubMed, Google Scholar, PEDro, NCBI. Based on the database, there were 9 articles that met the inclusion criteria. This study involved 817 articles. The analysis was performed using Review Manager software (RevMan 5.3).Results A total of 9 Randomized Control Trial (RCT) studies from Europe, America, Asia and Africa were selected for systematic review and meta-analysis. COVID-19 patients receiving Ivermectin therapy decreased the duration of hospital stay by 1.52 units compared to standard therapy and this result was statistically significant (SMD= -1.52; 95% CI= -2.34 to -0.70; p= 0.003).Conclusion: Ivermectin can reduce the duration of hospital stay for COVID-19 patients.Keywords: Massage, cerebral palsy, Modified Ashworth Scale, meta analisisCorrespondence: Salma Muazarroh. Masters Program in Public Health. Universitas Sebelas Maret, Jl.Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: salma.azza@gmail.com. Mobile: 085642431178.Indonesian Journal of Medicine (2022), 07(02): 209-218https://doi.org/10.26911/theijmed.2022.07.02.09

The Efficacy of Aquatic Therapy for Pain in Knee Osteoarthritis: A Systematic Review and Meta-Analysis Rachmat, Ahdiyat Ananta; Wahyuni, Wahyuni
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Osteoarthritis (OA) is a joint disease that affects adults to the elderly in which the incidence and prevalence of OA will increase with age. One of the interventions to reduce pain for improving the quality of life in patients with knee osteoarthritis is by providing aquatic therapy. This study aims to determine the effectiveness of aquatic therapy for pain in patients with knee osteoarthritis.Subjects and Method: It was a metaanalysis study using PICO. P: patients with knee osteoarthritis. I: aquatic therapy. C: nonaquatic therapy. O: reduced pain. The articles used in this study were obtained from several databases namely Google Scholar, PubMed, NCBI, Science Direct, and Springer Link. The keywords used were "osteoarthritis knee" OR "OA knee" AND "aquatic" OR "aquatic physiotherapy" OR "aquatic therapy" OR "aquatic exercise" OR "hydrotherapy" AND "quality of life" OR "QOL" AND "pain" and "RCT" or "randomized control trial". The article included in this study was a fulltext article with a Randomized Controlled Trial study design. The Review Manager 5.3 application was used to analyze articles. Results from the metaanalysis were reported using the PRISMA flow diagram.Results: A total of 9 articles that had been analyzed were from Spain, Thailand, Brazil, Australia, New Zealand, Korea, and Italy. Studies show that elderly with knee osteoarthritis who obtained aquatic therapy experienced lower pain by 0.62 units than those who did not obtain aquatic therapy thus improving the quality of life, and this effect was claimed to be statistically significant (SMD = 0.62; CI 95% 1.13 to 0.11; p <0.001).Conclusion: Aquatic therapy reduces pain and has an impact on improving quality of life.Keywords: aquatic therapy, knee osteoarthritis, pain, quality of life.Correspondence: Ahdiyat Ananta Rachmat, Study Program of Physiotherapy, Faculty of Health Science, Universitas Muhammadiyah Surakarta. Jl. A. Yani, Mendungan, Pabelan, Kartasura, Sukoharjo Regency, Central Java 57169, Indonesia. Email: ahdytannta@gmail.com. Phone: 082255733709.Indonesian Journal of Medicine (2022), 07(04): 428-438https://doi.org/10.26911/theijmed.2022.07.04.08

The Difference of Neiguan Acupressure Points (Pc6), Hypnotherapy, and Hypnopressure in Reducing Anxiety of Hemodialysis Patients Prasetya, Hanung; Yatmihatun, Sri
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.608

Background: The anxiety felt by patients undergoing hemodialysis can decrease the quality of life, cause a sleep disorder, and even aggravate the disease. Acupressure, hypnotherapy, or hypnopressure have minimal side effects and are easy to do in reducing anxiety. The study aims to analyze the different effects of acupressure, hypnotherapy, and hypnopressure in reducing anxiety in patients undergoing hemodialysis programs.Subjects and Method: It was an experimental study using a randomized controlled trial. It was conducted at Dr. Moewardi Hospital Surakarta, Central Java. The number of study subjects from March 2021 - July 2022 was 300 patients undergoing the hemodialysis program, with 75 subjects obtaining acupressure intervention, 75 subjects obtaining hypnotherapy intervention, 75 subjects obtaining hypnopressure intervention, and 75 subjects obtaining standard/control treatment. The sampling technique used was purposive sampling. The dependent variables in this study were acupressure, hypnotherapy, and hypnopressure, while the independent variable was the anxiety of patients who underwent a hemodialysis program for less than a year or less than 10 times. Anxiety was tested using the Hamilton Rating Scale for Anxiety questionnaire. Data analysis was conducted using an independent t-test, with the SPSS statistics program.Results: Post-acupressure anxiety score (Mean= 17.31; SD= 3.22) was lower than pre-acupressure (Mean= 23.17; SD= 2.68) and the result was statistically significant (p<0.001). Post-hypnotherapy anxiety score (Mean= 15.13; SD= 2.83) was lower than pre-hypnotherapy (Mean= 23.09; SD= 2.38), and the result was statistically significant (p<0.001). anxiety score after hypnopressure (Mean= 12.64; SD= 2.23) was lower than before hypnopressure (Mean= 23.13; SD= 2.53) and the result was statistically significant (p<0.001).Conclusion: Hypnopressure is more effective in lowering anxiety in patients undergoing a hemodialysis program.Keywords: anxiety, acupressure, hypnotherapy, hypnopressure, hemodialysisCorrespondence: Hanung Prasetya. Health Polytechnique of Health Ministry Surakarta. Jl. Letjend Sutoyo, Mojosongo, Surakarta 57127. Email: hanungprasetya168@gmail.com. Mobile: 08122638908Indonesian Journal of Medicine (2023), 08(01): 59-67https://doi.org/10.26911/theijmed.2023.08.01.06

Effect of Combinations of Quadriceps Exercise and Hip Abductor Exercise on Pain in Knee Osteoarthritis Patients in Orthopedic and Traumatology Outpatient Care Metasari, Dia; Sukartini, Tintin; Qona’ah, Arina
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.634

Background: Osteoarthritis is a disorder of the moving joints. Pain functioning are the main complaints of the disease osteoarthritis of the knee. The purpose of the study was to analyze the effect of a combination of quadricep exercise and hip abductor exercise on pain in knee among osteoarthritis patients.Subjects and Method: The study was carried out at the East Java Regional Hospital for the period of December 2022 to March 2023. The study population was knee joint osteoarthritis patients of degree 1 to degree 2. The sampling technique used in this study was purposive sampling, with inclusion and exclusion criteria. The number of samples in quantitative research was 60 respondents. The dependent variable is pain, while the independent variable is quadriceps exercise and hip abductor exercise. The instrument used is the WOMAC questionnaire. Analysis of the study was using the Wilcoxon test and the Mann Whitney test.Results: There was a significant difference in pain between the control and intervention groups after conducting a combination of quadriceps exercises and hip abductor exercises (p=0.043)Conclusion: The combination of quadriceps exercise and hip abductor exercise is effective on pain reduction in knee osteoarthritis patients.Keywords: quadriceps, hip abductor, osteoarthritis.Correspondence: Dia Metasari. Master of Nursing, Universitas Airlangga, Indonesia. Jl. Dr. Ir. H. Soekarno, Mulyorejo, Surabaya, East Java 60115. Email: dia.metasari-2021@fkp.unair.ac.id. Mobile: +628563040303.Indonesian Journal of Medicine (2023), 08(02): 186-193https://doi.org/10.26911/theijmed.2023.08.02.08

Toxicity Test of Sentul Fruit (Sandoricum koetjape) Peel Extract on Mice Wirata, I Nyoman; Agung, Anak Agung Gede; Arini, Ni Wayan; Raiyanti, I Gusti Ayu; Novya Dewi, I Gusti Agung Ayu
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.619

Background: Sentul fruit peel extract has an antibacterial activity since it contains saponin, flavonoid, phenol, and tannin. Hence, it can be utilized in oral infection treatment. The safety level of herbal medicines needs to be studied by using a toxicity test. The study aims to discover the toxicity of Sentul fruit peel extract.Subjects and Method: The study was conducted in the laboratory of the Faculty of Food Technology of Warmadewa University and the laboratory of the Faculty of Medicine and Health Sciences of Warmadewa University. The independent variables of the study were the various doses of Sentul peel extract administered orally. The dependent variable was an acute toxicity test. The toxicity test in mice used an experimental study design in the laboratory that was observed qualitatively and quantitatively. The animals used were 25 male white mice (Mus musculus) and were divided into 5 groups. Data were collected based on the results of examinations from the laboratory and subsequently analyzed qualitatively and descriptively.Results: Based on the results of the LD50 Toxicity Test on Mice, Sentul peel extract samples did not cause toxic symptoms in the form of decreased heart activity, convulsions, decreased movement activity, and slow breathing. The administration of Sentul peel extract was categorized as non-toxic because mice do not experience abnormal symptoms and there was no death after the administration of the extract using the oral gavage method at all doses for 14 days, thus Sentul peel extract was safe to use as a medicinal ingredient.Conclusion: Sentul peel extract is categorized as non-toxic because mice do not experience abnormal symptoms and no death occurs.Keywords: Sentul peel, extraction, oral infection, mice, toxicityCorrespondence: I Nyoman Wirata, Health Polytechnic of the Ministry of Health Denpasar. Jl. Sanitasi No.1, Sidakarya, South Denpasar, Denpasar City, Bali 80224. Email: wiratainyoman@gmail.com. Mobile: 08123649998.Indonesian Journal of Medicine (2023), 08(01): 114-120https://doi.org/10.26911/theijmed.2023.08.01.11

Effect of Ethanolic Extract of Moringa oleifera, Lam. Roots on Expression of Cyclin D1 in Testicular Tissue of Metabolic Syndrome Induced Wistar Rats Lutfi, Sephendra; Budiani, Dyah Ratna; Setyawan, Novan Adi
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.562

Background: Metabolic syndrome (MS) impacts on inhibition process of spermatogenesis by damaging various components of cell cycle proteins. Cyclin D1 protein which plays role in regulating the cell cycle of spermatogenic cells is depleted due to the metabolic syndrome. Variation results of M. oleifera studies on fertility are interesting for further research. This study aimed to determine the effect of ethanolic extract of M. oleifera roots towards expression of testicular cyclin D1 of metabolic syndrome induced Wistar rats.Subjects and Method: This study was an experimental laboratory. Thirty subjects of male Wistar rats were randomly divided into 5 groups consisted of 6 rats, control group (K1), MS group (K2), and treatment groups (K3, K4, and K5) which were given doses of 150, 250, and 350 mg/kgBW, respectively for 28 days. Induction of MS was achieved by high-fat diet for 28 days and injection of streptozotocin-nicotinamide (STZ-NA) on day 25. Cyclin D1 data was calculated using Intensity Distribution Score (IDS) and analyzed using one-way ANOVA test followed by post hoc multiple comparisons with Tukey HSD. Simple liniar regression test conducted on cyclin D1 data of K2, K3, K4, and K5.Results: One-way ANOVA test showed that the administration of ethanolic extract M. oleifera Lam. roots with doses of 150, 250, and 350 mg/kgBW in 28 days increased cyclin D1 significantly (p= 0.000). There were significant differences between K1 and K2 (p= 0.000), K2 and K3 (p= 0.000), K2 and K4 (p= 0.000), K2 and K5 (P= 0.000). Liniar regression test showed significant (p= 0.000) and moderate effect (R2= 0.65) of doses of ethanolic extract of M. oleifera roots on the expression of cyclin D1.Conclusion: The administration of ethanolic extract Moringa oleifera Lam. roots with doses of 150, 250, and 350 mg/kgBW for 28 days increased cyclin D1 in testicular rats.

Women Empowerment in Health: Systematic Review Rumpiati, Rumpiati; Murti, Bhisma; Peristiowati, Yuly; Katmini, Katmini
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.630

Background: Women's Empowerment is an integral part of human rights and development because the value system leads to the development of a good family, community, and country. Empowerment of women can have important implications for health in the form of education, access, and change in terms of services and family welfare. This systematic review aims to determine the influence and model of empowerment of women in the health sector.Subjects and Method: This systematic review begins with searching data using 5 databases with keywords women’s empowerment, women’s health, and empowerment model. Researchers used five databases, PubMed, Scopus, Science Direct, Springer Link, and BMC with a range of 2017-2022. Articles were searched using keywords that had been determined by the researcher then the articles were extracted based on criteria inclusion and exclusion using the PRISMA protocol. Thus, 11 articles were found that matched the criteria of JBI's critical assessment tool for analysis.Results: A total of 11 studies were included in the analysis originating from several countries such as Iran, Australia, and the Netherlands. Empowerment of women is a multilevel construction that refers to individuals, organizations, and society. Women's empowerment needs to involve mutual respect, critical reflection, caring and group participation, where people gain greater access to and control over their resources.Conclusion: Factors that influence women's empowerment are age, education, occupation, religion, marital status, socio-economic, demographics, different behavior, special characteristics of society, household harmony, place of residence, mobility, decision-making, social life, media exposure, information technology, socio-culture and access to health services. The women's empowerment model that has been developed refers to 3 domains: micro, meso, and social capital levels; as well as macro level.Keywords: empowerment, women, model, healthCorrespondence: Rumpiati. Institute of Health Science STRADA Indonesia Jl. Sumberece 37 Tosaren Pesantren Kota Kediri. Email: rumpiati75@gmail.com. Mobile: +62812-3007-1403.Indonesian Journal of Medicine (2023), 08(02): 194-203https://doi.org/10.26911/theijmed.2023.08.02.09

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