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Jurnal Kesehatan Islam : Islamic Health Journal
Published by Universitas Islam Malang
ISSN : 2303022X     EISSN : 26158345     DOI : -
Core Subject : Health, Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health
Jurnal Riset Kedokteran Islam berisi informasi tentang hasil kegiatan penelitian, pemikiran konseptual dan kajian bidang ilmu kedokteran dan kedokteran. Jurnal ilmiah ini diterbitkan oleh Fakultas Kedokteran Universitas Islam Malang. Jurnal ini diterbitkan dengan frekuensi 2 kali setahun, yaitu pada bulan Maret dan bulan September.
Arjuna Subject : -
Articles 113 Documents
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Skrining Fitokimia dan Penetapan Kadar Flavonoid Total Ekstrak Etanol 96% Daun Bangkal (Nauclea subdita (Korth.) Steud) M. Hidayatullah; M. Andi Chandra; Sofi Azzahro
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.21140

Abstract

Abstract. The Bangkal plant (Nauclea subdita (Korth.) Steud.) has benefits as a natural ingredient that can treat wounds, and is applied to boils, tumors, boiled water from Bangkal leaves for diarrhea, and cures toothache. Compounds that have the potential to produce these effects are flavonoids. Flavonoids are important substances in plants, these substances help maintain plant health and are able to protect humans from disease. This study aims to determine the content of secondary metabolites and total flavonoids content of 96% ethanol extract of Bangkal leaves originating from the Astambul region, South Kalimantan using UV-Vis spectrophotometry. Extraction of Bangkal leaves was carried out by maceration method using 96% ethanol solvent, then phytochemical screening was carried out with 5 secondary metabolites and testing for total flavonoid content with AlCl3 reagent. The results showed that the 96% ethanol extract of Bangkal leaves had a yield of 14.70%, secondary metabolites which contained flavonoids, triterpenoids and tannins. The total flavonoid content was 21.508 mgQE/g. In conclusion, the 96% ethanol extract of Bangkal leaves contains high levels of flavonoids
OPTIMASI MORINGA GUM DAN POLIVINIL ALKOHOL DALAM SEDIAAN MUCOADHESIVE BUCCAL FILM DILTIAZEM HIDROKLORIDA Nani Sukmawati; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21718

Abstract

Abstract. Diltiazem Hydrochloride (HCl) is commonly used in hypertension therapy for its beneficial effects, such as reducing blood vessel pressure resistance and relaxing the heart muscles. In an in-vivo study, Diltiazem HCl is known to be decrease by 60% of its bioavailability due to first-pass metabolism. Thus, it is necessary to develop a new administration route, some of which is buccal drug delivery route in mucoadhesive buccal film. Moringa gum is a polyuronide polymer with a hydroxyl group in its side chains, giving the potential use as a mucoadhesive polymer. However, it has poor folding endurance and its release kinetics study has not been investigated. Polyvinyl alcohol (PVA) is a water-soluble polymer with hydroxyl side chain. PVA is known for its high tensile strength and flexibility, though it can be affected by humidity. The aim of this research is to determine the right amount of moringa gum and PVA to obtain a film with good physical characteristics and mucoadhesive residence time. In this study, the optimization of moringa gum and PVA was carried out using factorial design. Mucoadhesive buccal film was prepared by solvent casting method, the films were later evaluated and the obtained responses were analyzed by Software Design Expert 11.0.0. The optimization result shows the film containing the amount of moringa gum 2% and PVA 5% can produce the optimum formula. The mucoadhesive buccal film formula has surface pH of 6.083, mucoadhesive residence time of 445.055 min, swelling index of 4.067, and 87.9913% drug release in in-vitro drug release study after 420 min following the Higuchi model release kinetics. Therefore, it can be concluded that the obtained optimum formula of mucoadhesive buccal film can be used in the preparation of mucoadhesive buccal film Diltiazem HCl.. Kata Kunci: Hypertension; Diltiazem HCl; Mucoadhesive buccal film; Moringa gum; PVA.
AKTIVITAS ANTIOKSIDAN DAN SITOTOKSIK BERBAGAI FASE BUNGA MELASTOMA MALABATHRICUM LINN Isnaini; Denny Anata Kusuma; Anthony Hermawan; Fujiati; Alfi Yasmina
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21719

Abstract

Abstract. Melastoma malabathricum Linn is one of the medicinal plants, and is used by the community. M. malabathricum L. flowers contain quercetin and kaempferol which have antioxidant and anticancer properties. Each phase of flower M. malabathricum L. has different quercetin and kaempferol contents. This study aims to analyze the differences in antioxidant and toxicity activities of various phases of karamunting flowers by DPPH and brine shrimp lethality (BSLT) methods. Antioxidant activity is expressed by IC50 while toxicity activity is expressed by LC50. IC50 and LC50 are calculated using probit analysis. The blooming phase has the greatest antioxidant and toxicity activity (IC50 6,989 ppm (95% CI 6,358 ± 9,276) and LC50 146,325 ppm (95% CI 101,257 ± 215,766) while bud flower phase 2 has the smallest antioxidant and toxicity activity (IC50 8,866 ppm (95% CI 8.075 ± 9,874) and LC50 233,222 ppm (95% CI 151,662 ± 408,101). Conclusion The flower phase of Melastoma malabatricum Linn has low antioxidant activity, causing its toxic properties to be lower Kata Kunci: flower phases, Melastoma malabathricum Linn; antioxidant; toxicity
PENGARUH VARIASI PRIMOGEL SEBAGAI DISINTEGRAN TERHADAP MUTU FISIK TABLET KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DARI CO-PROCESSED EXCIPIENT Hilya Nur Imtihani; Jade Rhea Almira Arif; Galuh Tarita Kasih Putri
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21721

Abstract

Abstract. Mud crab shells contain chitin which can be converted into chitosan. Co-processed excipient or combining two or more excipient ingredients can increase the compressibility, compactibility of tablets. This research aims to formulate the active ingredient chitosan which is synthesized from mangrove crab (Scylla serrata) shells and then make chitosan tablets with a co-processed excipient consisting of two variations of primogel. The difference in formula, namely F1 (primogel 4%) and F2 (primogel 8%) was then seen as to its effect on the physical quality of the tablet. The tablet printing method is direct compression. The physical quality of the tablets was evaluated and the results showed that the formula met the test requirements for tablet weight uniformity, friability, hardness, disintegration time but did not meet the requirements for tablet size uniformity. Then the evaluation results of the co-processed excipient met the specifications for the flow speed test, angle of repose, compressibility index, Hausner ratio, water content test and particle size distribution. Thus, it can be concluded that chitosan from mangrove crab shells (Scylla serrata) can be formulated into tablet preparations from co-processed excipients using the direct compression method but there is no significant difference between Primogel 4% and 8% as a crushing agent on the characteristics of chitosan tablets. mud crab (Scylla serrata) shell. Kata Kunci: Chitosan; Co-processed Excipients; Primogel; Scylla serrata ;Tablets
HUBUNGAN PERILAKU SLEEP HYGIENE DENGAN KUALITAS TIDUR PADA MAHASISWA KEDOKTERAN Syahira Fitri Avesiena; Putri ME
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21722

Abstract

Abstract. Medical students are a group that is vulnerable to sleep deprivation. Entering medical school exposes students to academic pressure and stress. These demands can eventually lead to changes in sleep patterns and daily habits. Apart from academic demands, another factor that can be associated with poor sleep quality among medical students is poor knowledge and practice of sleep hygiene. Therefore, it is important to know whether medical students have sleep problems and whether their sleep disturbances have an effect on academic performance or quality of life, as medical students will undergo a long and intensive academic year before becoming doctors. Objective: To determine the relationship between sleep hygiene behavior (sleep hygiene) and sleep quality in medical study program students of the faculty of medicine and health, Jakarta Muhammadiyah University, class of 2021. Methods: This study used a type of observational analytic method with a cross-sectional research design. Respondents in this study totaled 149 people. The research was conducted from October to December 2023. Results: It was found that 91.9% of students had poor sleep hygiene behavior, 8.1% had good sleep hygiene. As many as 93.3% of students have poor sleep quality, 6.7% have good sleep quality. fisher exact test results state that there is a significant relationship between the variables of sleep hygiene behavior and sleep quality in medical study program students of the faculty of medicine and health, Muhammadiyah university of jakarta class of 2021. Conclusion: Students can improve better sleep hygiene behavior so that they can achieve a more optimal sleep quality Kata Kunci: Sleep Hygiene; Sleep Quality; Students
HUBUNGAN DUKUNGAN KELUARGA TERHADAP KEPATUHAN DIET HIPERTENSI: LITERATUR REVIEW Muhamad Khafid; Dyah Ika Krisnawati; Nety Mawarda Hatmanti; Priyo Mukti Pribadi Winoto
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21778

Abstract

Hypertension is one of the deadliest diseases worldwide and can affect anyone, especially older adults, whose circulatory system functions decline with age. This literature review aims to examine the relationship between family support and adherence to a hypertension diet. The study design is a literature review using the PECOS format with inclusion-exclusion criteria. The research involved analyzing 6 relevant studies from the last 12 years, using Google Scholar and PubMed databases. The findings show that family support can help people stick to a hypertension diet. In conclusion, a hypertension diet can help reduce iodine consumption, potentially lowering the number of people with hypertension.
Simulasi Molecular Docking Aktivitas Antiinflamasi Rimpang Zingiber Officinale var. amarum pada Mediator Inflamasi Prostaglandin D2 (PGD2) dan Tromboksan A2 (TXA2) pada Osteoarthritis Denis Mery Mirza; Erna Sulistyowati; Anta Maulana Fardhani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21779

Abstract

Abstract. Osteoarthritis (OA) is a degenerative joint disease characterized by damage to joint cartilage, subchondral bone, and osteophyte formation. The prevalence of OA is still large with major therapy is non steroid anti inflammatori (NSAID) drug. However, prolonged use of NSAIDs leads to side effects on gastrointestinal tract. Zingiber officinale var. amarum is beneficial herbal for anti-inflammatory therapy in OA. The damage of chondrocytes in OA triggers the activation of inflammatory process through the COX-2 pathway, resulting in the production of chemical mediators prostaglandin D2 (PGD2) and thromboxane A2 (TXA2), causing pain and functional decline. Thus, this research aimed to predict active compounds of Z. officinale var. amarum rhizomes that potential to inhibit PGD2 and TXA2 as anti-inflammatory agents for OA through molecular docking. Method This research use 20 active compounds of Z. officinale var. amarum using molecular docking method with proteins target including of PGD2 (ID:1S2A) and TXA2 (ID:6IIV). The docking process was conducted using the PyRX 0.8 application, and the results were visualized in the BIOVIA Discovery Studio 2020 application. Result the research on the 20 active compounds in the rhizome of Z. officinale var. amarum indicates that compounds such as [6]-Gingerdiol 3,5-diacetate, 10-gingerol, gingerdione, and gingerdiol can interact with the active site of the protein 1S2A through hydrogen bonding with Gln-222. Furthermore, compounds like [6]- dehydrogingerdione, paradol, gingerdiol, geraniol, 10-gingerol, gingerdione, [6]- Gingerdiol 3,5-diacetate, isoborneol, zingerone have been identified to interact with 6IIV through hydrogen bonding with Gln-301 and Thr-81. This indicates that these compounds exhibit activity as inhibitors of PGD2 and TXA2. The interactions occurring between the complex compounds of Z. officinale var. amarum and 1S2A and 6IIV can lead to inhibitory effects on PGD2 and TXA2. Kata Kunci: molecular docking; osteoarthritis; PGD2; TXA2; Z. officinale var. amarum
Profil Deskriptif Pasien dengan Apendisitis Akut di Rumah Sakit Islam Jemursari Dayu Satriya Wibawa; Aditya Bhayusakti; Dwimantoro; Hotimah Masdan Salim; David Sajid Muhammad
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21816

Abstract

Latar Belakang: Apendisitis merupakan penyebab nyeri perut bawah dan sering menyebabkan kunjungan ke Unit Gawat Darurat. Apendisitis disebabkan oleh obstruksi luminal akibat berbagai etiologi sehingga meningkatkan produksi mukus dan pertumbuhan bakteri berlebih. Penelitian ini bertujuan untuk mengetahui profil penderita apendisitis akut di RSIS Jemursari Surabaya. Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan crossectional dengan menggunakan data sekunder dari rekammedis periode 2022. Data didapatkan dari rekam medis pasien yang didiagnosis dengan apendisitis akut. Hasil: Rerata usia pada penelitian ini yaitu 19% adalah usia remaja akhir, dengan jenis kelamin terbanyak yaitu terjadi pada perempuan 73,7%. Adapaun pemeriksaan hematologi didapatkan leukositosis sebanyak 57,9% dengan kadar hemoglobin normal sebesar 47,4%. Kesimpulan pada penelitian ini yaitu Apendisitis akut dialami sebagian besar oleh perempuan. Dilihat dari jumlah leukosit, rata-rata pasien mengalami leukositosis. Kata Kunci :Apendisitis akut, Profil, RSI Jemursari
POTENSI ANTIOKSIDAN FRAKSI n-HEKSANA DAUN UBI JALAR UNGU (Ipomoea batatas L.) Fina Dwi Saadah; Denis Mery Mirza; Dian Novita Wulandari
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 2 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i2.22844

Abstract

ABSTRAK Antioxidants are compounds that have the advantage of neutralizing free radicals and are found in many plants. Purple sweet potato leaves (Ipomoea batatas L.) belong to the Convolvulaceae family and have potential as antioxidants due to their compound content. The n-Hexane fraction of I. batatas leaves have non-polar active compounds that have the potential to act as antioxidants such as terpenoids and steroids. This study aims to determine the active substance content and antioxidant activity in the n-Hexane fraction of I. batatas leaves. I. batatas leaves were extracted using the ultrasonic-assisted extraction method with ethanol p.a. followed by liquid-liquid fractionation using n-Hexane solvent. Identification of active compounds used phytochemical screening methods and continued testing antioxidant activity using the 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) method with ascorbic acid as standard. The data is expressed as percent inhibition and IC50 values calculated from the linear equation. The n-Hexane fraction of I. batatas was positive for containing terpenoid compounds and has antioxidant activity of the DPPH method is in the very weak category with an IC50 value of 278,27 µg/ml compared to ascorbic acid (IC50 8,90 µg/ml) in the very strong category. The n-Hexane fraction of I. batatas leaves contains terpenoid compounds and has antioxidant activity very weak antioxidant activity with an IC50 value of 278,27 µg/mL. Keywords: Antioxidant, DPPH, Faction, Leaf I. batatas.
Penguatan Layanan Primer untuk Ketahanan Jaminan Kesehatan Nasional dalam Perspektif Islam: Studi Kasus di PKU Kotagede Yogyakarta Mohammad Jailani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 2 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i2.22846

Abstract

Abstract This study analyzes the strengthening of primary healthcare services to support the resilience of the National Health Insurance (JKN) from an Islamic perspective through a case study at PKU Muhammadiyah Kotagede Hospital, Yogyakarta. This research's primary focus is applying Islamic principles such as justice, compassion, and social responsibility in managing primary healthcare services. The methodology is qualitative, utilizing in-depth interviews, field observations, and document analysis for data collection. The findings reveal that integrating Islamic values in healthcare services at PKU Kotagede enhances accessibility and service quality while supporting JKN resilience by reducing the burden on secondary services and improving cost efficiency. This research contributes to the health literature by demonstrating how a religion-based approach can strengthen national health systems and offers practical recommendations for developing other healthcare services grounded in religious values in Indonesia. Keywords: Strengthening primary healthcare, healthcare services, national health, Islamic studies

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