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Jurnal Kesehatan Islam : Islamic Health Journal
Published by Universitas Islam Malang
ISSN : 2303022X     EISSN : 26158345     DOI : -
Core Subject : Health, Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health
Jurnal Riset Kedokteran Islam berisi informasi tentang hasil kegiatan penelitian, pemikiran konseptual dan kajian bidang ilmu kedokteran dan kedokteran. Jurnal ilmiah ini diterbitkan oleh Fakultas Kedokteran Universitas Islam Malang. Jurnal ini diterbitkan dengan frekuensi 2 kali setahun, yaitu pada bulan Maret dan bulan September.
Arjuna Subject : -
Articles 113 Documents
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OPTIMASI MORINGA GUM DAN GLISERIN DALAM SEDIAAN MUCOADHESIVE BUCCAL FILM DILTIAZEM HIDROKLORIDA Lusia Oktora Ruma Kumala Sari; Lidya Ameliana; Putri Mustika Nandani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20866

Abstract

Moringa Gum is a gum derived from the Moringa oleifera tree which can be used as a stabilizer, binder, mucoadhesive, disintegrant, sustained release and controlled release matrix. Diltiazem Hydrochloride is a drug with low bioavailability and has a low plasma half-life (3-4 h). The bioavailability and half-life of Diltiazem Hydrochloride can be improved by buccal film mucoadhesive formulation. In this study, a combination of natural polymers, namely Moringa Gum and glycerin plasticizer, was used to produce a film with swelling, mucoadhesive properties and also good folding resistance. This studi was conducted to optimize Moringa Gum and glycerin to see the release profile of Diltiazem Hydrochloride in the muchoadhesive buccal film. The formulation was carried out using the solvent casting method with optimization using a design expert while verification of the optimum formula was carried out using a one sample t test with a confidence level of 95% with the condition that the significance was p>0,05. The optimum formula obtained from the amount of polymer Moringa Gum is 75 mg and the plasticizer glycerin is 5 mg. The results of the FTIR test showed that there was no interaction between Diltiazem Hydrochloride and the moringa gum polymer. As for the release test results, the release percentage was 99.69% by following the Higuchi release model. This study concludes is that buccal film was successfully prepared using a combination of moringa gum and glycerin with its potential to increase the bioavailability and half-life of Diltiazem Hydrochloride by prolonging the contact time and controlling the release. Kata Kunci Diltiazem Hidroklorida; Mucoadhesive Buccal Film; Moringa Gum; Gliserin
Formulasi-evaluasi mie gluten-free dengan kombinasi Tepung sagu, tepung porang, tepung garut dengan menggunakan metode ekstrusi Santoso, Rahmat; Mohammad Isronijaya; Sonia Bella Cantika
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.20608

Abstract

Indonesia menempati peringkatkedua sebagai negara yang menggemari mieinstant dengan 14,260 juta porsi, yangmengakibatkan menurunnya devisa negarakarena bahan baku yang berupa tepung impordan juga meningkatnya penderita penyakitmetabolisme. Sehingga penelitian ini bertujuanmembuat mie gluten-free yang lebihmenguntungkan dari bahan baku indigenousIndonesia : tepung sagu, tepung porang, dantepung garut, dengan metode ekstrusi yangbekerja dengan memberikan tekanan dandorongan sehingga akan menghasilkan bentukyang diinginkan, serta dikemas dalamkemasan ramah lingkungan, yang sesuaiStandar Nasional Indonesia (SNI). Dalampenelitian ini dibuat lima formula mie kering (F1-F5) dengaN substitusi tepung sagu, tepung garutdan tepung porang dengan mie yang dihasilkanberwarna putih sampai kecoklatan, rasa khastelur dengan tekstur yang kenyal. Dari hasiltersebu kemudian dilakukan uji evaluasi berupacooking time, elongasi, susut pengeringan danuji kesukaan panelis dengan pengolahan datahasil pengujian dengan analisis statistiSPSS.Berdasarkan hasil uji, dapat disimpulkanbahwa metode ekstrusi (teknologi ekstruder)dapat digunakan untuk membuat mie glutenfree yang dikemas dengan kemasanbiodegradable dengan formula F4 merupakanformula terbaik. Kata kunci : biodegradable, ekstrusi, Mie, glutenfree,
Kajian Sistematis: Moringa oleifera L. untuk Meningkatkan Status Gizi Balita Nikmatul Ikhrom Eka Jayani; Ayu , Ida Ayu Putu Diah Asthagina; Fauna, Fauna Herawati; Krisyanti , Krisyanti Budipramana; Karina , Karina Citra Rani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20809

Abstract

ABSTRAK Moringa oleifera L. atau yang sering dikenal dengan tanaman kelor merupakan bahan pangan lokal yang diketahui dapat digunakan sebagai alternatif untuk meningkatkan status gizi pada balita. Kelor mengandung protein, karbohidrat, lemak, vitamin dan mineral yang dapat memenuhi kebutuhan gizi pada balita. Penelitian ini bertujuan untuk mengetahui potensi Moringa oleifera L. untuk meningkatkan status gizi balita. Data base yang digunakan pada pencarian artikel terkait potensi Moringa oleifera L. untuk meningkatkan status gizi balita seperti Google Scholar, Science Direct, dan PubMed, dengan menggunakan kata kunci yang sesuai topik penelitian. Penilaian artikel diperoleh dengan menggunakan critical appraisal dari Joana Briggs Institute (JBI) dan penilaian reputasi jurnal. Hasil analisis diperoleh 12 artikel yang memenuhi kriteria inklusi dan berkualitas baik. Dari 12 artikel yang diulas, 8 artikel merupakan penelitian dengan design quasi experimental dan 4 penelitian dengan design Randomized Controlled Trial (RCT). Dua penelitian dengan design RCT dan tujuh artikel dengan design Quasi Experimental menunjukkan peningkatan berat badan balita secara bermakna pada pemberian daun kelor. Empat penelitian yang terdiri dari 2 penelitian RCT dan 2 penelitian Quasi Experimental menujukkan hasil positif pada parameter nilai Z-score setelah pemberian daun kelor. Satu penelitian dengan design Quasi Experimental menunjukkan adanya peningkatan Indeks Massa Tubuh (IMT) balita setelah pemberian daun kelor. Dari 12 penelitian, hanya satu penelitian yang menunjukkan tidak adanya perubahan parameter Berat Badan (BB) yang bermakna setelah pemberian daun kelor. Pemberian daun kelor dalam bentuk ekstrak daun kelor, serbuk daun kelor, bentuk olahan kelor lainnya seperti moringa nugget, Pemberian Makanan Tambahan Bahan Makanan Campuran (PMT BMC) kelor, cookies, biskuit, bubur balita dan fortified food dapat meningkatkan berat badan, nilai Z-score dan IMT pada balita dengan gizi buruk. Keywords: Moringa oleifera; status nutrisi; anak; berat badan.
Non-Pharmacological Therapy For Adolescent Depression: Literature Review Indra Maulana; Hesti , Hesti Platini
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20811

Abstract

ABSTRACT Introduction: Adolescence is a period of transition between childhood and adulthood, characterized by biological, cognitive, and socio-emotional changes. Most adolescents have behaved more maturely as they have become aware of a new formal status, either at home or at school. Adolescents are at risk for depressive disorders due to their inability to deal with stress or pressure. To alleviate depression symptoms, pharmacological and non-pharmacological therapies can be used. The goal of this study was to conduct a literature review on non-pharmacological therapies for treating depression in adolescents. Methods: A literature review with the keywords "Teenagers," "Depression," and "Therapy" was used as the research method. Several search engines were used to find articles, including Google Scholar, PubMed, and Science Direct. which were published between 2016 and 2020. Article searches turned up 29,982 results. Following the evaluation, the remaining six articles were chosen for a literature review. Results and Discussion : Six non-pharmacological therapies were discovered to treat depression in adolescents based on a literature review. Music therapy, life writing therapy, bright light therapy, exercise, and behavioral health interventions, such as cognitive behavioral therapy and assertive training, can all be used. Conclusion: Music therapy, life writing therapy, bright light therapy, exercise, and behavioral health interventions, such as cognitive behavioral therapy and assertive training, are all effective treatments for depression. Keyword:Depression, Teenagers, Therapy
Perbandingan Rendemen, Skrining Fitokimia Dan Profil Kromatografi Lapis Tipis Ekstrak Etanol 96% dan Metanol Daun Sungkai (Peronema canescens Jack) M. Andi Chandra; Hidayatullah, M. Hidayatullah; Putri, Putri Ermina Sari
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20818

Abstract

Abstract. Kalimantan is rich in plants that are used as medicinal plants, one of which is the sungkai plant (Peronema canescens Jack). The aim of this research was to determine the comparison of yields of different solvent extracts and the comparison of phytochemical screening results and TLC profiles of 96% ethanol and methanol extracts. Extraction was carried out by maceration, then phytochemical screening and stain profiles were carried out using the thin layer chromatography (TLC) method using the mobile phase N-Hexane and Ethyl Acetate (8:2). The results of the research showed that the ratio of % yield of 96% ethanol extract was 8.87% and methanol was 8.85%. The results of phytochemical screening with 96% ethanol identified more secondary metabolites than maceration using methanol. The conclusion in this study is that the % yield ratio of ethanol extract is 96% greater than methanol extract. Phytochemical screening had more secondary metabolites in the 96% ethanol extract compared to methanol and TLC analysis of the 96% ethanol extract of sungkai leaves produced 5 stains with Rf values ​​of 0.06, 0.2, 0.25, 0.31 and 0.41, extract methanol produced 6 stains with Rf values ​​of 0.05, 0.13, 0.21, 0.25, 0.45 and 0.58. Kata Kunci: Sungkai (Peronemacanescens Jack,) TLC, 96% Ethanol Extract: Methanol
THE POTENTIAL OF BUTTERFLY PEA FLOWER (Clitoria ternatea) AS AN ANTIBACTERIAL AGAINST Escherichia coli BY IN VITRO Andyanita Hanif Hermawati; Aesthetica , Aesthetica Islamy
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20819

Abstract

Abstract. The prevalence of Escherichia coli resistance in Indonesia to antibiotics is 43%. This is a serious problem because it can reduce the efficiency and effectiveness of treatment. Therefore, new products with high antibiotic potential are needed, one of which is telang flower. Telang flowers have active substances with the ability to inhibit bacterial activity. This study aims to test the antibacterial potential of telang flower (Clitoria ternatea) by maceration using 96% ethanol solvent. The research design was an experiment with a control group. The antibacterial testing method used was the agar diffusion method with three repetitions. The telang flower (Clitoria ternatea) extracts used were 50% and 100%. Data were obtained in the form of inhibition zone diameter data. The data were analyzed univariately and bivariate, namely comparing the diameter of the inhibition zone produced from each concentration with the diameter of the inhibition zone of positive and negative controls and bivariate using ANOVA. The results of this study showed that the average diameter of the inhibition zone produced was 15.28 mm (50% concentration) and 19.68 mm (100% concentration). The results of the bivariate analysis showed a p-value = 0.000. This indicates that there is a difference in the diameter of the inhibition zone in all treatment groups. The recommendation from the results of this study is that telang flower extract (Clitoria ternatea) can be continued in vivo research to identify its potential as an alternative antibacterial drug. Keywords: antibacterial; antibiotic; butterfly pea flower; herbal
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETIL ASETAT BUAH OKRA HIJAU (Abelmoschus esculentus L.) Rahmi , Rahmi Muthia; Fatmawati, Fatmawati; Hidayatullah, M. Hidayatullah; Putri, Putri Indah Sayakti; Aditya, Aditya Noviadi Rakhmatullah
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20820

Abstract

Abstract. Okra fruit (Abelmoschus esculentus L.) is a potential medicinal plant because it contains several compounds such as alkaloids, phenols, flavonoids, steroids and tannins which have anti-diabetic, antioxidant, antimicrobial, antiallergic, antiviral and anti-inflammatory properties. The purpose of this study was to identify the content of flavonoid compounds qualitatively and quantitatively. The extraction method was maceration, used ethyl acetate solvent. Qualitative testing of flavonoid compounds used TLC, 5% AlCl₃ spotting appearance. Quantitative test used UV-Vis Spectrophotometry method, quercetin as comparison, λmaks 415 nm. The TLC results show three stains with each Rf value of 0.76; 0.53; 0.23. The results of determined the total flavonoid content of okra fruit were 4.069 ± 0.211 mg QE/g extract. From the research results obtained, it can be concluded that the ethyl acetate extract of green okra contains flavonoids. Kata Kunci: Abelmoschus esculentus L; total flavonoid content; ethyl acetate extract; TLC
Formulasi Lotion dari Ekstrak Buah Bit (Beta vulgaris) dengan Perbedaan Komposisi Asam Stearat Fendi Yoga Wardana; Riska , Riska Milani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20826

Abstract

Abstract. Lotion is a skin moisturizing cosmetic preparation that has non-greasy properties and is easily applied to the skin. This study aims to make a lotion formulation from beetroot (Beta vulgaris) extract according to the physical stability properties. In this study, three lotion preparation formulas were made with differences in stearic acid with a composition of 5%, 10% and 15%. Determination of the physical stability of the product is determined according to organoleptic, homogeneity, spreadability, pH and preference tests. The results showed that beetroot extract produced a yield percentage of 8.34%. Phytochemical screening showed that beetroot extract contains flavonoids, tannins, saponins and steroids or triterpenoids. Beetroot extract lotion was evaluated for 16 days. The results of the organoleptic evaluation on lotions F1, F2 and F3 showed no change. In the lotion homogeneity test F1, F2 and F3 produced a homogeneous lotion. Spreadability tests on F1, F2 and F3 had a spreading diameter of 4.5 – 5.5 g.cm/s. The pH test of lotions F1, F2 and F3 produced the same as a pH value of 7. F1 was the most preferred formula because all parameters give good results. Based on this study, it can be concluded that differences in stearic acid concentrations have no effect on the physical quality test of beetroot extract lotion preparations. Kata Kunci Buah bit, Lotion, Uji mutu fisik
PENGARUH PEMBERIAN SUSU KEDELAI KUNING (Glycine max (L.) Merr.) TERHADAP KADAR KOLESTEROL TOTAL PADA PRIA HIPERKOLESTEROLEMIA Santi Widiasari; Mutiara , Mutiara Muslimah; Eliya Mursyida
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20831

Abstract

Abstract.Hypercholesterolemia is an increase in blood cholesterol levels, which is more than 200 mg / dl. In Indonesia, 9.3% of the incidence of hypercholesterolemia is in productive age, namely the age range of 25-40 years. One of the drugs for hypercholesterolemic sufferers is a statin which is believed to reduce LDL levels and inhibit the formation of cholesterol by indirectly affecting cholesterol levels in the blood. Soybeans are known to reduce cholesterol levels because they contain isoflavones that bind to the endoplasmic reticulum, then increase the Low-density lipoprotein (LDL) receptors in the liver. So that LDL levels in plasma are measured to be low. Objective: To analyze the effect of giving soy milk on cholesterol levels in hypercholesterolemic men. Method: Experimental using the design "One-Group Pretest-Postest Design". The sample consisted of 10 men with hypercholesterolemia given 250 ml / day for 2 weeks. Results: The results showed a significant value of p <0.05. The average total cholesterol level in the provision of soy milk decreased by 6.2 mg / dl. Conclusion: The provision of soy milk has an effect on total cholesterol levels in hypercholesterolemic men. Kata Kunci antibakteri; Hiperkolesterolemia, kolesterol, susu kedelai
OPTIMASI SODIUM STARCH GLYCOLATE DAN POLYVINYLPYRROLIDONE K-30 DALAM SEDIAAN ORALLY DISINTEGRATING TABLET SALBUTAMOL SULFAT Budipratiwi Wisudyaningsih; Lusia Oktora Kumala Sari; Tiara Puspita Arisanti
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20838

Abstract

ABSTRACT Difficulty in swallowing drug and slow onset of action of drug are common problems of conventional tablet. Orally disintegrating tablet (ODT) is an innovative dosage form to overcome the problem of swallowing drug and provide quick onset of action of drug because it can disintegrates quickly when contact with saliva in less than 3 minutes. This study formulate and evaluate ODT containing salbutamol sulphate to relieve the respiratory disorders immediately. Materials that affect the disintegration time of ODT are superdisintegrants and binders. Sodium Starch Glycolate (SSG) is a superdisintegrant that has high swelling capacity and its efficiency is not affected by compression and hydrophobic materials. PVP K-30 is a water soluble binder that effective to increase hardness and decrease friability of ODT without prolonging the disintegration time. The aim of this study is to optimize SSG and PVP K-30 to get the optimum formula of ODT salbutamol sulphate. ODT salbutamol sulphate was made by direct compression method. The optimization was carried out using two-level and two-factor of factorial design. Disintegration time, hardness, and friability of ODT were responses that evaluated to get the optimum formula of ODT salbutamol sulphate. The result showed that SSG affected in increasing of disintegration time of ODT. PVP K-30 affected in increasing of disintegration time, decreasing friability, and increasing hardness of ODT. The optimum formula contained 4% of SSG and 1,5% of PVP K-30 resulted in 37,58 seconds of disintegration time, 4,713 kg/cm2 of hardness, and 0,6298% of friability. The optimum formula dissolved 92.296 % after 30 minute. Keywords : Orally disintegrating tablet; salbutamol sulphate; SSG; PVP K-30

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