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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
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Potensi Krim Ekstrak Etanol Daun Stroberi (Fragaria x ananassa var Duchesne) sebagai Tabir Surya Petrick Gilang Pambudi; Suhartinah Suhartinah; Hery Muhamad Ansory; Nurrohmah Dwi Mahesti
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1133

Abstract

Ekstrak daun stroberi dilaporkan memiliki aktivitas tabir surya yang baik. Formulasi sediaan yang baik menjadi hal yang diperlukan untuk tahapan berikutnya. Penelitian ini bertujuan untuk mengetahui mutu fisik dari sediaan krim dan menentukan nilai SPF krim ekstrak etanol daun stroberi (Fragaria x ananassa var duchesne) sebagai tabir surya. Metode ekstraksi yang digunakan adalah refluks dengan pelarut etanol 96%. Analisis kandungan ekstrak dilakukan dengan kromatografi lapis tipis (KLT). Konsentrasi ekstrak yang digunakan untuk membuat krim tabir surya adalah 0,250% ; 0,500% dan 1,000%. Evaluasi yang dilakukan pada sediaan adalah uji mutu fisik, uji stabilitas sediaan dan aktivitas tabir surya baik in vivo dengan uji iritasi pada kulit manusia dan in vitro dengan spektrofotometri UV-Vis. Hasil penelitian ekstrak etanol daun stroberi didapatkan rendemen sebanyak 20,5% dan uji KLT menunjukan bahwa ekstrak daun stroberi positif mengandung flavonoid dan tanin. Krim ekstrak etanol daun stroberi yang paling baik pada konsentrasi 1,000% dengan nilai SPF sebesar 52,90.
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Johar (Cassia siamea Lamk.) dan Daun Alpukat (Persea americana Mill.) terhadap Salmonella Typhi Hanugrah Ardya Crisdian; Kusumaningtyas Siwi A
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1172

Abstract

Typhoid fever is an acute febrile disease caused by Salmonella typhi bacteria, WHO 2018 data states that in the world it reaches 11-20 million cases per year, in Indonesia it reaches a prevalence rate of 358-810/100,000 population. The purpose of this study was to determine the antibacterial activity of the combination of johar leaves (Cassia siamea Lamk) and avocado leaves (Persea americana Mill) against the growth of salmonella typhi bacteria. Testing the antibacterial activity of a combination of 1:1 70% ethanol extract of johar leaves and avocado leaves by diffusion and dilution methods, treatment using control (+) ciprofloxacin and control (-) DMSO 2% with series concentrations of 25, 50, 75 and 100%. Each treatment was repeated 3 times. The results of the antibacterial activity test of the combination of ethanol extract of johar leaves and avocado leaves had the greatest activity against Salmonella typhi bacteria at a concentration of 100% with a clear zone diameter of 9.9 mm while the smallest average was at a concentration of 25% with a diameter of 6 mm, and ciprofloxacin with a diameter of 29.3 mm. The minimum inhibition level was at a concentration of 12.5%.
Pengaruh Purifikasi Terhadap Kandungan Zat Aktif dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.) Diyan Sakti Purwanto; Hari Susanti; Nining Sugihartini
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1232

Abstract

Purification extract ethanol 50% of Moringa dry leaves was carried out to increase the active substance content of flavonoids, β-carotene, saponins and tannins which have antioxidant activity. The purpose of this study was to determine the optimal solvent between ethyl acetate and n-hexane in the ethanol extract fractionation of 50% Moringa leaves. The viscous extract obtained was then purified by fractionation. Fractionation was carried out by dissolving the viscous ethanol extract of 50% Moringa leaves (E1) in aquadest of 70ºC and then adding ethyl acetate to a separating funnel to obtain ethyl acetate (E2) fraction. In addition, the viscous ethanol extract of 50 % Moringa leaves (E1) was fractured with n-hexane (E3). The extract and fraction were evaluated for the parameters including the water level of the extract with gravimetry, levels the β-carotene by HPLC and the antioxidant activity with DPPH . Data were analyzed statistically with a confidence level of 95%. The results the water level of the ethanol extract of 50% Moringa leaves is 4.16 with a CV of 4.62%. The β-carotene level on fractured with n-hexane (E3) then ethyl acetate fraction (E2) and ethanol extract 50 % (E1) that is 1.48 ± 0.01%, 1.19 ± 005% and 0.73 ± 0.01%. While antioxidant activity (IC50) were the most optimal in the n-hexane fraction(E3) then ethanol extract 50 % (E1) and ethyl acetate fraction (E2) that is 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml and 58.79 ± 0.10ug/ml. The ethanol extract of 50% Moringa leaves and n-hexane fraction were included in the very strong category while the ethyl acetate fraction was included in the strong category so that it has the potential to be an antioxidant.
Pengaruh Edukasi Terhadap Pengetahuan Swamedikasi Batuk pada Anak di Kecamatan Wonosari Kabupaten Klaten Jawa Tengah Inaratul Rizkhy Hanifah; Annisa Nur Safitri; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1268

Abstract

Self-medication is one way people treat a symptom of a disease without using a doctor's prescription. Knowledge of correct self-medication is needed to cure coughs without other adverse effects on the sufferer. This study aimed to determine the effect of education through online media on the level of knowledge about cough self-medication for children in Wonosari District, Klaten Regency, Central Java in 2020. This research is a quantitative study with a Quasi-Experimental research method with the technique of Two Group Pre-Test-Post-Test Control Group Design. The population in this study were parents who had children in Wonosari District, Klaten Regency. The sample in this study amounted to 268 people. The data collection tool uses a questionnaire that has been tested for validity and reliability. The results showed that the level of public knowledge when the pre-test was carried out was classified as good (41.04%), moderate (54.48%), poor (4.48%), not good (0%). The provision of education was able to increase the respondent's knowledge as indicated by the results of post-test knowledge, which were classified as good (89.55%), moderate (10.45%), not good (0%), poor (0%). The Wilcoxon test analysis obtained a p-value of 0.000 000 <α value of 0.05, which means that education through online media affects public knowledge about cough self-medication in children.
Desain Vaksin Berbasis Epitop dengan Pendekatan Bioinformatika untuk Menekan Glikoprotein Spike SARS-CoV-2 M Afrizal Firmansyah; Aris Susilo; Septina D Haryanti; Rina Herowati
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1351

Abstract

Vaccination is one of the main prevention of the spread of Covid-19. Technological engineering based on virus attenuation has been applied in vaccine development. This study aims to obtain an epitope-based vaccine design with low risk of allergic reactions, safe, and inexpensive. The design of the vaccine was conducted by the collection of SARS-CoV-2 sequence data, phylogenetic analysis, prediction of protein antigenicity, and identification of CD 8+ T cell epitopes. Furthermore, epitope conservation and immunogenicity prediction, as well as molecular docking analysis were carried out to see the interaction between epitopes and alleles. The next step was B cell epitope prediction, population coverage prediction, construction and visualization of vaccine design, structural analysis and validation, interaction analysis between vaccines with TLR 3 and TLR 4, and evaluation of vaccine design immunogenicity. All stages were carried out using the appropriate webserver. The designed vaccine had an antigenicity of 0.5134, not toxic, and not allergenic. The physicochemical parameters met the requirements except for the molecular weight which was less than 40 KDa. The designed vaccine was predicted to have a population coverage of 95.14% for the Indonesian population. The results of the immunogenicity prediction of the vaccine design showed an increase of IgM and IgG until day 35.
Studi Potensi Interaksi Antibiotik Dengan Obat Lain Pada Peresepan Pasien Pneumonia Di Intensive Care Unit Yeni Farida
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.816

Abstract

Pneumonia is one of the most common acute lower respiratory tract infection that causes morbidity and mortality. Most of it is caused by bacteria. Antibiotics is the main therapy of bacterial infection cases. Concomitant use of antibiotics and other drugs may risk harmful interaction. This study aimed to determine the potential antibiotic drug interactions and their effects on the patient's condition based on clinical data and laboratory. A retrospective study were conducted in ICU, NICU and PICU. Medical records of pneumonia patients in 2016 who met the inclusion criteria, including patients diagnosed with pneumonia with co-morbidities, received antibiotic therapy at least 3 days, and had bacterial culture data. Drug interactions were analyzed using Stockley's Drug Interaction, Drug Interaction Fact, and Medscape then calculated the percentage potential of interaction, phase, and significance of interactions. The results showed that among 28 patient there were 17 types of drugs which potentially cause drug interactions in patients with pneumonia based on literature. Percentage of pharmacokinetics drug interaction was 80%; pharmacodynamics was 20%. Potential drug interactions on metabolism phase were 44%; excretion phase was 36%. The potential effect of drug interactions was major (10%), moderate (80%) and minor (10%). Potentially, most of drugs interact in the metabolic phase with moderate significance. The high drug interaction potential was gentamycin and furosemide with moderate significance about 16%.
Aktivitas Analgetik dan Antiinflamasi Fraksi Daun Ashitaba (Angelica keiskei (Miq.) Koidz.) Pada Tikus Jantan Galur Wistar dan Keamanannya Terhadap Lambung EKA NDHARI ROCHMA
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.827

Abstract

Ashitaba (Angelica keiskei (Miq.) Koidz.) is a plant that has analgesic and anti-inflammatory activity. The content of compounds which are thought to be efficacious are flavonoids, saponins, alkaloids, and tannins. The purpose of this study was to determine the extracts and fractions having analgesic activity with the hot plate and tail flick method, anti-inflammatory activity with the randall-selitto method and the formation of udema, safety of the stomach and to find out which fraction provided the strongest and safest activity against the rat's stomach. Ethanol extract of Ashitaba leaf was fractionated with n-hexane, ethyl acetate, and water. The analgesic test was carried out by the hot plate and tail flick method, the anti-inflammatory test was carried out by the randall-selitto method and the formation of edema was then examined by the rat's gastric safety using macroscopic and microscopic.The dosage of Ashitaba leaf extract and fractions were extract 300 mg/kgBB, n-hexane fraction 120.7 mg/kgBB, ethyl acetate fraction 20.6 mg/kgBB, water fraction 158.65 mg/kgBB, negative control of Na CMC 1%, and negative control of Na CMC 1% mefenamic acid 500 mg/kgBB. The results showed ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction Ashitaba leaf had analgesic and anti-inflammatory activity. Extract 300 mg / kg body weight and n-hexane fraction 120.7 mg / kg body weight showed analgesic and anti-inflammatory activity equivalent to mefenamic acid and showed safety in the stomach equivalent to negative control.
Optimasi Formula Lotion Ekstrak Etanol Bunga Krisan (Crhysanthemum cinerariaefolium (Trevir.)Vis.) menggunakan Kombinasi Asam Stearat dan Setil Alkohol sebagai Repelan dengan Metode Simplex Lattice Design Rifkarosita Putri Ginaris; Rina Herowati; TN Saifullah Sulaiman
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.857

Abstract

Chrysanthemum flower (Crhysanthemum cinerariaefolium (Trevir.) Vis.) contains flavonoids, saponins and polyphenols which are efficacious as repellents against Aedes aegypti mosquitoes. Lotions with a combination of stearic acid and cetyl alcohol are used to improve adhesion and thickening. The purpose of this study was to make a lotion preparation using a combination of stearic acid and cetyl alcohol to obtain optimum physical quality and obtain an effective concentration of chrysanthemum flower extract as a repellant lotion against A. aegypti mosquitoes and a safe effect on the skin. Chrysanthemum extraction was carried out using 70% ethanol. Chrysanthemum ethanol extract was then dose oriented with a concentration of 1.2%. Chrysanthemum flower ethanol extract lotion formulations were made into 7 formulations using stearic acid and stearic acid bases, Formula I 9.00: 8.00%, Formula II 15.00: 2.00%, Formula III 11.00: 6.00 %, Formula IV 15.00: 2.00%, Formula V 13.00: 4.00%, Formula VI 7.00: 10.00%, Formula VII 11.00: 6.00%. Determination of the optimum formula using the Simplex Lattice Design method using the Design Expert program. The optimum formula is obtained, then tested for physical stability including viscosity, adhesion, dispersion and pH. Physical stability was tested using the One Way Anova method followed by Tuckey HSD. Irritation test with the method of Human 4-hour patch test and hedonic test by giving questions to probandus. Chrysanthemum extract concentration of 1.2% has pharmacological activity that functions as a repellent power of mosquitoes. The optimum combination of stearic acid and cetyl alcohol, 7% stearic acid and 10% cetyl alcohol, get optimum physical quality with the Simplex Lattice Design method. The optimum formula of chrysanthemum flower ethanol extract lotion does not have good physical quality stability based on the parameters of adhesion, dispersion, pH and viscosity during 30-day storage. The lotion irritation test results obtained an irritation index of 0, so it can be concluded that the optimum formula of chrysanthemum extract lotion extract does not cause skin irritation and is quite acceptable to probandus.
Evaluasi Penggunaan Analgesik pada Pasien Sectio caesarea di Rumah Sakit St. Elisabeth Semarang Paulina Maya Octasari
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.877

Abstract

Section caesarea (SC) is a one birth methods by surgery if the mother has a difficult way to take the baby out by vagina. At 2010 year, Indonesia have prevalence of section caesarea as 15.3% from 20.591 mother over five last year in 33 province. One of the most mother birth have symptoms, is pain. Ketorolac is the one of analgesic as a first choice for cesarean section patients. This research aims to evaluate the analgesic usage in cesarean section patients at St. Elisabeth Hospital, Semarang. This research is an observasional descriptive research with retrospektive data. Data was collected from sc patient who was given ketorolac after SC on July – December 2017 at St. Elisabeth Hospital, Semarang. The inclusion criteria were patient with JKN assurance and patients who had SC for the first time. The data were analyzed qualitatively and quantitavely The result shows that the most patients were 26 – 30 years old. The amount of the patients after was given ketorolac who had mild pain scale were 95.1% and moderate pain scale were 4.9%. The average pain scale was slightly decrease over 3 – 4 hours after injection, as 1,46 scale. The most kind of analgesic who used as an extra were tramadol (32.93%). Mefenamic acid and diclofenac natrium was the biggest amount to use at home.
Analisis Efektivitas Biaya Antinyeri Pasien Diabetik Neuropati Di Puskesmas Kaliwungu Kudus Dan RSI Sultan Agung Semarang Isna Rahmawati
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1186

Abstract

Diabetic neuropathy that affects peripheral nervous system as a complication of Diabetes Mellitus (DM). A total of 1785 DM patients in Indonesia, 63.5% experienced neuropathy. Choosing the right analgetics for diabetic neuropathy patients will improve therapy, so the costs of using the drugs will also be affordable. This study aims to cost effectiveness analysis of analgetics in diabetic neuropathy patients at Kaliwungu Kudus Health Center and Sultan Agung Islamic Hospital in Semarang. This study was hold in September - November 2020. The research method was cohort retrospective and collected data with purposive sampling involving all populations who had complete medical record and include inclusion criteria. The instruments used were data report, medical record and details of the patient's payment. The cost data used was based on a payer perspective from direct medical costs related to drug prices based on perspective of the hospital and e-catalogue or BPJS. Then CEA to determine which therapy was more cost-effective therapy from the use of analgeticss by calculating the ACER (Average Cost Effectiveness Ratio) and ICER (Incremental Cost Effectiveness Ratio). The results show that the cost effectiveness of analgetics at the Kaliwungu Kudus Health Center is diclofenac sodium 50 mg and a combination of 500 mg paracetamol and 200 mg ibuprofen with ICER values of Rp. 2765.02 and Rp.-8,837.94. Meanwhile, at the Sultan Agung Islamic Hospital in Semarang, are single amitriptyline and a combination of amitriptyline and tramadol, with the ICER value on single amitriptyline which is Rp. -7,690.08.

Page 21 of 28 | Total Record : 271

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