cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota surakarta,
Jawa tengah
INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
 20   21   22   23   24 
The Kandungan Fitokimia dan Aktivitas Antioksidan Krim Fraksi Etanol Kulit Buah Jeruk Manis (Citrus sinensis (L.) Osbeck) WAHYUNITA YULIA SARI; Definingsih Yuliastuti; Maria Ulfa
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1196

Abstract

Sweet citrus fruit is generally used on the pulp, while the peel only becomes waste. Waste of sweet orange fruit peel is often found in the community which contains antioxidant compounds. Waste of sweet orange fruit peel can be processed into cream preparations that can be used by the community. Cream from waste of sweet orange fruit peel is made using maceration extraction and liquid-liquid fractionation methods. The maceration extraction method used 70% ethanol as solvent, while the fractionation method used n-hexane, ethyl acetate and 70% ethanol as solvents. Cream of 70% ethanol fraction of sweet orange fruit peel is made in several formulas of FI (3%), FII (6%) and FIII (9%). Screening for the phytochemical content of sweet orange fruit peels was carried out using chemical reagents. Sweet orange fruit peel contains vitamin C compounds, flavonoids and essential oils. Cream preparations with 70% ethanol fraction of orange fruit peels (FI, FII, FIII) indicate that the cream has good color, texture and physical properties.
Uji Formulasi Spray Scant Diffuse Untuk Memanipulasi Bau Tubuh setia budi; Melviani Melviani
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1238

Abstract

A person's activities are often disturbed by the presence of body odor which can affect self-confidence and social interaction. The use of body fragrances cannot reduce or overcome body odor, so that there is a need for new preparations that can neutralize body odor and bind and break down odors. The type of food consumed can affects body odor and can also be influenced by hormones. The body odor presence as the result of sweat processed by the normal flora on the skin. Bacteria such as the Corynebacterium group, Propionibacterium group, and Staphylococcus epidermidis play a role in the occurrence of body odor. Other bacteria that cause body odor are Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes. Combination of Scant Diffuse Formulation (antibacterial) with hydrogen peroxide (antimicrobial), activated carbon (odor binding), and sodium bicarbonate (bacterial metabolism inhibitor), is expected to be solution to get rid of body odor. The research focus is to determined the stability of the preparation, with use and storage evaluation criteria. Methods the research itself uses the evaluation test stage of laboratory pre-experimental spray preparations, namely the one-shoot case study by looking at the organoleptic test, viscosity, storage stability, degree of inertia, and homogeneity, and stability. Results In organoleptics, there was sedimentation in formulations 2 and 3, which made it difficult to disperse and could be re-dispersed when shaken strongly. Stable spray preparation is in formula 1 with a concentration of active substances, namely 20 mg sodium bicarbonate and 2 mg active carbon.
Potensi Interaksi Antar Obat dalam Peresepan Rawat Jalan Pasien Penyakit Jantung Akibat Hipertensi Ilil Maidatuz Zulfa; Yessy Asli Rahmawati; Putri Febri Anggraini
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1253

Abstract

Hypertension or high blood pressure have contributed to the occurrence of cardiovascular disease. One of its complication is the development of Hypertensive Heart Disease (HHD). HHD pharmacological treatments usually combine antihypertensive and other agents that lead to polypharmacy. The use of multiple medications or polypharmacy will increase the potential of drug-drug interactions (PDDIs) that affect the therapeutic effect and increase adverse events. This study was aimed to analyze the prevalence and predictor of the PDDIs among HHD patients prescriptions in order to prevent the adverse effects and optimalize the therapy management. A retrospective observational study was conducted on HHD outpatients prescriptions. Medscape Drug Interaction Checker application was used to identify PDDIs. The mechanism, severity, number of interaction per prescription and most common interaction pairs of PDDIs were documented. In addition, age, gender, and the number of drug prescribed were analyzed as predictors of PDDIs using logistic regression binomial test. A total of 100 HHD outpatients prescriptions was analyzed and 94 of them had PDDIs. Majority of prescriptions had 3-4 and >4 PDDIs (33.00% each). Total of PDDIs observed were 397 cases. Most of PDDIs happened in the pharmacodynamic phase (86.40%) and need to monitored closely (93.20%). The concomitant use of Candesartan and Bisoprolol was found to be the most commpon interaction pair (11,08%) that can lead to the raise of potassium serum levels. The result of predictors analysis showed that the higher number of drug prescribed the higher the risk of the occurrence of PDDIs respectively (p-value 0,005) which addition 1 drug item will increase the PDDIs 7,232 time higher. In conclusion, the higher number of drug prescribed the closer monitoring need for PDDIs. In addition, closely monitoring in the elevating of potassium serum levels and the symptoms of hyperkalemia are needed in the treatment of HHD outpatients
Perbandingan Flavonoid Total dan Aktivitas Antioksidan Fraksi Etil Asetat Biji Kelor (Moringa oleifera L.) dan Biji Kecipir (Psophocarpus tetragonolobus L.) Annisa Krisridwany; Miftah Rizkia Tatra; Dyani Primasari Sukamdi
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1264

Abstract

Moringa seeds (Moringa oleifera L.) and winged bean seeds (Psophocarpus tetragonolobus L.) are medicinal plants used by the community as food and as traditional medicine preparations. They also contain compounds that have potential as antioxidants. It is necessary to compare the levels of one of the compounds and test the antioxidant activity. This study aims to determine the comparison of total flavonoid levels and antioxidant activity in the ethyl acetate fraction of Moringa oleifera L. and winged bean seeds (Psophocarpus tetragonolobus L). The ethanol extracts were partitioned by using n-hexane, ethanol, and ethyl acetate. This research focused on the ethyl acetate fraction. The total flavonoid determination was based on measuring each fraction's absorbance value at a wavelength of 446 nm and using a quercetin comparator. The antioxidant activity test of ethyl acetate fraction of Moringa oleifera L. and winged bean seeds (Psophocarpus tetragonolobus L.) was carried out by measuring the reduction of each fraction against DPPH radicals (1,1- diphenyl 2-picrilhidrazil) using UV-Vis spectrophotometry method at a wavelength of 517 nm. The antioxidant activity test was carried out by using a comparison of vitamin C. The results showed the total flavonoid level of ethyl acetate fraction of Moringa oleifera L seeds and winged bean seeds (Psophocarpus tetragonolobus L.) were 42.80 ± 1.61 mg QE/g and 71.56 ± 5.50 mg QE/g, respectively while the antioxidant activities of ethyl acetate fraction of Moringa oleifera L seeds and winged bean seeds (Psophocarpus tetragonolobus L.) were 134.34 ppm and 179.57 ppm, respectively. The result showed that the ethyl acetate fraction of Moringa seeds (Moringa oleifera L.) had moderate antioxidant activity and more potent compare to Winged bean seeds; however, Winged bean seeds's flavonoid total was higher than Moringa seeds’s. Keyword : Antioxidant; DPPH; Flavonoid; Moringa oleifera L., Psophocarpus tetragonolobus L., seed
Aktivitas Ekstrak Kasar Enzim Fibrinolitik Bakteri Bacillus cereus yang Diisolasi dari Air Hutan Mangrove Maroon Edupark Semarang secara In Vitro Rizky Bimantara HA; Ana Indrayati; Desi Purwaningsih
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1322

Abstract

Fibrinolytic enzymes are enzymes that work by degrading fibrin in blood clots. Fibrinolytic enzymes are produced by many organisms, one of which is the bacterium Bacillus cereus from the water of the Maroon Edupark mangrove forest, Semarang. Isolation of fibrinolytic enzymes from bacteria is very important because bacteria are easy to grow, have a fast generation time, do not require a large area for cultivation, and are easily genetically modified so that it will be more economically profitable. In addition, fibrinolytic enzymes from natural ingredients have fewer side effects than synthetic fibrinolytic drugs. This study aims to determine the activity of the crude extract of the fibrinolytic enzyme B. cereus in lysis blood clots in vitro. The study began with confirmation of the presence of genes encoding fibrinolytic enzymes from bacteria B. cereus uses NCBI's popular resources 'nucleotide', identification of bacterial morphology in blood agar media, Gram staining, endospore staining, catalase and coagulase testing. Isolation of crude extract of fibrinolytic enzyme B. cereus is carried out by enzyme extraction. Protein concentration were determined using Bradford method and fibrinolytic activity test in vitro using fibrin plate media with nattokinase as positive control. The resulting clear zone shows the ability of the enzyme extract in degrading fibrin The results of the identification of the B. cereus bacterial gene uses the NCBI data base registered as the AprE gene. The results of the identification of gram and endospore staining, B. cereus is a Gram-positive bacterium and has endospores. Identification of bacteria on blood agar media indicates that B. cereus represents the group of the β-hemolysis. Catalase and coagulase test results show that the bacteria produce catalase and coagulase enzymes. Total protein concentration from crude extract of B. cereus obtained at 19.63 mg/mL. Fibrinolytic activity at concentrations of 20, 40, 80% was 2.54; 6.11; and 7.94 mm respectively. Based on the above results it can be concluded that the crude extract of fibrinolytic enzyme B. cereus has the potential to be developed as a natural fibrinolytic agent.
PENETAPAN KADAR FENOLIK DAN FLAVONOID SERTA AKTIVITAS INHIBISI ENZIM TIROSINASE FREEZE DRY JUS BUAH JAMBLANG (Syzygium cumini (L.) Skeels) Nani Suryani; Dimas Danang Indriatmoko; Alfi Mahmudah; Dodik Efendi
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1331

Abstract

The skin is the largest organ that protects the body from various traumas such as thermal, chemical, and ultraviolet radiation. Melanin biosynthesis is the conversion of L-Tyrosine (4-hydroxyphenylalanine) to L-DOPA (L-3,4-dihydroxyphenylalanine) with the help of the tyrosinase enzyme. Phenolics and flavonoids significantly affect the inhibition of tyrosinase activity. Phenolics and flavonoids are thought to be contained in the fruit of Syzygium cumini. This study aimed to determine the levels of phenolics and flavonoids and to determine the tyrosinase enzyme inhibitory activity of freeze-dried S. cumini fruit juice. The method used to determine the levels of phenolics and flavonoids using UV-Vis spectrophotometry and tyrosinase inhibition test using in vitro ELISA (Enzyme Linked Immunosorbent assay). S. cumini contains total phenolic is 0.13155 mg GAE/g and total flavonoid is 37,333 mgQE/g. Freeze dry fruit juice of S. cumini has potential as a tyrosinase enzyme inhibitor at 31.25 ppm (14.846%), 62.5 ppm (16.246%), 125 ppm (19.238%), 250 ppm (22.059%), 500 ppm (25.665). %), 1000 ppm (32.283%) and 2000 ppm (44.188%).
Pengaruh Konsentrasi dan Waktu Perendaman Ampas Tebu terhadap Kadar Akrilamida pada Minyak Goreng Bekas Gatut Ari Wardani; Widdy Erlinasari; Lilis Tuslinah
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1335

Abstract

Hydrolyzed cooking oil will form glycerol and free fatty acids, so that when heated glycerol will form acrolein, one of the compounds forming acrylamide. Bagasse contains cellulose which can bind acrylamide. The purpose of this study was to determine the effect of adding pulp and the effect of soaking time on acrylamide levels. Analysis was performed using High-Performance Liquid Chromatography, column Agilent TC-C18 mobile phase 0.1% phosphoric acid and methanol in a ratio of 95:5; flow rate 1 mL/min; the sample volume injected was 20µL. Acrylamide in oil was identified at a retention time of 4,939 minutes, theoretical plate 39,029, HETP 0.00064, and capacity factor 2.265 This study meets the method validation parameters such as linearity with the results of y = 259.37x + 103.39 and a correlation coefficient of 0.9993, precision with % RSD < 2%, detection limit 0.46 ppm, quantification limit 1.396 ppm, accuracy with % recovery 94 .55 - 100.04. The results of FTIR, bagasse can bind the C=O and C-H groups of one of the acrylamide groups. The adsorption kinetics model used was the Ho model with linearity of 0.9752. Sugarcane bagasse concentration of 5% and soaking time of 24 hours affected the decrease in acrylamide levels in used cooking oil. Soaking used cooking oil samples with 5% bagasse for 24 hours can reduce acrylamide levels by 65%.
Evaluasi Rasionalitas Penggunaan Antidiabetes Oral pada Pasien Diabetes Melitus Tipe 2 Rawat Inap di Rumah Sakit Nasional di Dili Putu Dian Marani Kurnianta; Gracia Isabel Baptista Soares; Anak Agung Ngurah Putra Riana Prasetya; Agustina Nila Yuliawati
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1338

Abstract

Among several types of diabetes mellitus (DM), type-2 DM seemed to demonstrate the highest prevalence. Appropriate management in type-2 DM should follow rational use of antidiabetic agents to prevent any unfavorable impacts. In fact, due to the limited guidelines and medication resources, medication process for patients with type-2 DM has not been evaluated in Timor-Leste, especially at a national hospital in Dili. This was the first study which aimed to evaluate the use of oral antidiabetic agents (OAD) in hospitalized patients with type-2 DM at a national hospital, Dili Timor-Leste.This study was conducted retrospectively under cross-sectional design to describe the rational drug use evaluation based on indicators: right patient, right dose, right indication, right drug, and cautious to adverse events according to guideline from American Diabetes Association (2020). The included patients were diagnosed as type-2 DM, hospitalized during year 2020, and received OAD. Data were calculated (%) for each indicator of rational drug use.A total number of 83 hospitalized patients with type-2 DM at a national hospital in Dili had taken metformin (62.65%), gliclazide (12.15%), and combination of both metformin and gliclazide (22.89%), respectively. The evaluation results of OAD use according to ADA guideline comprised of right indication 100%, right patient 100%, right drug 72.28%, right dose 100%, and cautious to adverse events 93.7%. Despite favorable results in rational medication, enhancement for limitation of OAD use at a national hospital in Dili, Timor-Leste is compulsory.
Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Cengkeh (Syzygium aromaticum) Terhadap Tikus Putih Jantan dan Gambaran Histologi Pankreas Chemayanti Surbakti; Pricella Aqwilla Br Ginting; Hafizhatul Abadi; Yoksan Duha
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1375

Abstract

Diabetes is a chronic disease caused by impaired insulin secretion. WHO has emphasized the use of ethnomedicine for diabetes control. More than 1200 plants have been traditionally used for hypoglycemic effects, of which 800 plants have been scientifically reported to have antidiabetic potential, one of which is clove. Previous research stated that the total flavonoid content in clove leaves was 73.08 mgRE/g extract with a percentage of 7.308%. These flavonoids are thought to be antidiabetic agents. The purpose of this study was to determine the antidiabetic activity of clove leaf ethanol extract and histology of the pancreas of the test rats. Clove leaf simplicia powder was extracted by maceration method using 70% ethanol as solvent. Antidiabetic testing of clove leaf ethanol extract using alloxan at a dose of 150 mg/kgBW. The results showed that clove leaf extract had antidiabetic activity. The percentage decrease in blood sugar levels extract dose 100; 200 and 300 mg/kgBW were 55.61%, 64.06%, and 73.06% and the positive control was 65.83%. The results of histology observations of the pancreas of mice in the negative control group showed that the structure of the islets of Langerhans changed, shrank, irregular, and degenerated cells and pyknosis were found. While the treatment group that was induced by alloxan and given clove leaf extract doses of 100, 200, and 300 mg/kgBW and the positive control showed a clear structure of the islets of Langerhans, more cell mass, cells regenerated and no cells that experienced degeneration and pyknosis were found. The conclusion of this study is that clove leaf extract can reduce blood sugar levels with an effective dose of 300 mg/kgBB and clove leaf extract can improve pancreatic islets of Langerhans cells.
Sintesis dan Uji Aktivitas Senyawa Dibutil Timah (IV) Bis-Metil Ditiokarbamat Pada Bakteri Salmonella Typhi dan Escherichia Coli Mukhlis Sanuddin; lia purnamasari; Amelia Soyata
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1408

Abstract

The majority of bacterial infection therapy uses antibiotics which result in resistance and dangerous side effects. If the wrong method is used, it is necessary to develop antibiotics from new compounds that are effective against bacteria and are able to avoid the occurrence of antibiotic resistance by using organotin and dithiocarbamate compounds. The purpose of this study was to determine the antibacterial activity of dibutyl tin (IV) bis-methyl dithiocarbamate on Salmonella typhi and Escherichia coli bacteria. This compound was synthesized by an in situ technique by adding methanol to methyl amine + carbon disulfide + metal dibutyl tin (IV) dichloride which was identified using 13C NMR, FTIR and 1H NMR. Then, the antibacterial activity was tested using the paper disc diffusion technique with concentrations of 50 ppm, 70 ppm and 90 ppm using NA (Nutrient Agar) media. The results of this study obtained results in the form of a synthetic powder of 1.28 g with a compound percentage of 25%. The results of the antibacterial activity test with a concentration of 90 ppm resulted in the largest inhibition zone with a very strong category at 27.33 mm Salmonella typhi and 26.48 mm Escherichia coli. The compounds in this research have been successfully synthesized and form an overview of the structure of complex compounds and have very strong antibacterial agent activity.

Page 22 of 28 | Total Record : 271

 20   21   22   23   24 

Filter by Year

2009 2024


Reset
Filter By Issues
All Issue Vol 21 No 2 (2024): Jurnal Farmasi Indonesia Vol 21 No 1 (2024): Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia Vol 17 No 1 (2020): Jurnal Farmasi Indonesia Vol 16 No 2 (2019): Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia Vol 14 No 1 (2017): Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia Vol 10 No 2 (2013): Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia Vol 8 No 2 (2011): Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia More Issue