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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 315 Documents
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CRISPR-CAS System: Current Applications and Future Prospect Adinda Adinda; Irene Ruth Saputra; Rachel Maya
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.219

Abstract

The CRISPR-Cas system is a revolutionary technology that has transformed gene editing and has the potential to revolutionize many fields. It is a bacterial immune system that can be programmed to recognize and cleave specific DNA sequences using Cas proteins and guide RNAs. This technology has numerous biotechnological and bioengineering applications and is simpler to design with high targeting efficiency and multiplex editing capability compared to older gene editing technologies. This review aims to explore the general application, impact on molecular biology and medicine, limitations, and future potential of the CRISPR-Cas system. With its potential to revolutionize medicine, agriculture, and environmental science, the CRISPR-Cas system is a powerful gene editing tool that offers hope for a wide range of applications.
Genetic Conditions Associated with Intellectual Disability in Indonesian Population: A Review Ziske Maritska; Atikah M. Ihsan; Ina Rahmawati; Perawati Perawati; Mohammad Hilal Atthariq Ramadhan; Bintang Arroyantri Prananjaya; Nita Parisa
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.220

Abstract

Intellectual disability (ID) brings challenges to the affected individuals, their families, and the community at large. It is a multifactorial condition with many contributing factors, namely genetics. This review aims to briefly provide several related genetic conditions for ID in the Indonesian population. Literature studies search relevant articles using PubMed and Google Scholar using the terms ‘intellectual disability’, ‘genetics', ‘Indonesian population’. In Indonesia, the prevalence of children with ID is 1–3%, with 62,011 school-aged children affected with Intellectual Disability. Genetics plays a role in around 25–50% of cases. ID in the Indonesian population is associated with several genetic disorders, namely Duchenne muscular dystrophy (DMD), autism spectrum disorder (ASD), fragile X syndrome (FXS), Down syndrome (DS), Apert syndrome, and subtelomeric chromosomal rearrangements. There is limited research on genetics related to intellectual disability in Indonesia, implying further research is needed.
Characteristic Analysis of Serum Vitamin D Levels with Hba1c in Type 2-Diabetes Mellitus Patients Emma Novita; Mariana Mariana; Hana U; Alya Tsabita; Irma Yolanda; Syafira Yulia Sari
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.221

Abstract

Diabetes is one of the most rapidly growing global health emergencies of the 21st century, it is estimated that 537 million (10.3%) people have diabetes, and this number is expected to reach 643 million (11.3%) in 2030, and 783 million (12.2%) %) in 2045. Vitamin D plays a role in insulin secretion by stimulating beta-cell secretion or facilitating the conversion of pro-insulin to insulin. Therefore, vitamin D deficiency may be involved in the pathogenesis of DM type 2. This study aims to analyze the characteristics, HbA1c level status, and vitamin D level status in DM type 2 patients in primary care. The research was conducted in September 2022 with DM type 2 patients who came to the Plaju Palembang Health Center as research subjects. The results showed that there was a significant relationship between age and HbA1c levels in DM type 2 patients (p=0.020) and there was no relationship between gender, occupation, education level, BMI, abdominal circumference, family history, duration of diabetes, and vitamin D levels with HbA1c levels in DM type 2 patients (p>0.05)
The Relationship Between The Menstrual Cycle and The Incidence of Acne Vulgaris in Female Students at The Faculty of Medicine, Baiturrahmah University Padang Class of 2022 Sri Handayani; Irma Primawati; Roland Helmizar; Letvi Mona
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.222

Abstract

Acne vulgaris is a disease that attacks the pilosebaceous unit and can cause non-inflammatory and inflammatory lesions, as well as varying degrees of scarring. In Southeast Asia, the prevalence of acne vulgaris reaches 40-80% of cases. The exact etiology and risk factors for the development of acne vulgaris remain uncertain. However, one factor that is thought to play a role is the fluctuation in estrogen and progesterone that occur during the menstrual cycle in women. This study aimed to determine the relationship between the menstrual cycle and the incidence of acne vulgaris in student at the faculty of medicine, Baiturrahmah University, Padang, class of 2022. The type of research is observational analytics, consist of 48 samples using a consecutive sampling technique. Univariate data analysis is presented and bivariate analysis using the chi-square test. Data processing using the computerized SPSS version 25.0. The highest incidence of acne vulgaris was 75.0% and the highest menstrual cycle was normal was 64.6%. There is relationship between menstrual cycle disorders and the incidence of acne vulgaris (p=0.015) and none the relationship between abnormal menstrual cycles and the incidence of acne vulgaris (p=1.000). There is relationship between menstrual cycle disorders and the incidence of acne vulgaris and there is no relationship between abnormal menstrual cycles and the incidence of acne vulgaris instudent at the Faculty of Medicine, Baiturrahmah University, Padang, Class of 2022.
The Relationship Between The Level of Knowledge and The Way of Handling Burns In Employees of The Fire Department of Palembang City Qonitah Muhsinah; Tri Suciati; Iqmal Perlianta
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.223

Abstract

Burns are injuries characterized by damage to skin tissue due to direct contact with a source that conducts heat. Some action activities that have a high risk of burns are firefighters. This reflects that the level of knowledge and handling of burns is very important and becomes the main focus as a firefighter. This study aims to determine the relationship between the level of knowledge and how to handle burns on fire department employees in Palembang. This study was an observational analytic study with a case series approach. with a sample of Fire Department Employees in Palembang. The data used is primary data derived from questionnaires. Researchers recorded data such as age, gender, education, level of knowledge of burns, and knowledge of how to treat burns. 180 people met the research criteria. The dominating characteristics were age 26-35 years (58.3%), male (81.7%), female (18.3%), the level of knowledge about burns was in the good category (40.5%). And knowledge of how to handle burns is in the good category (61.7%). Analysis using bivariate analysis found that there was a significant correlation between the level of knowledge and how to handle burns (p=0.000; r=0.452). Most respondents in this study were aged 26-35 years, male and had a Diploma / Bachelor's degree. The level of knowledge about burns and how to handle them was mostly in the good category. In the correlation test, there was a significant correlation between the level of knowledge and how to handle burns.
Relationship of Hemoglobin and Muscle Strength with Quality of Life in Patients with Chronic Renal Failure Safitri Nur Rahayu; Patwa Amani
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.224

Abstract

The elderly population is vulnerable to degenerative diseases, one of which is Chronic Kidney Disease (CKD). The age of most hemodialysis patients is between 45 and 54 years. Hemoglobin levels and muscle strength in CKD tend to be low which is associated with a decrease in quality of life in CKD. This research is an observational analytical study with a cross-sectional approach. A total of 24 data points from chronic kidney failure patients at Budhi Asih Regional Hospital, Jakarta, were used in this study. Both primary and secondary data were collected. Hemoglobin levels were obtained from medical records, muscle strength was measured using a Camry handgrip dynamometer, and quality of life was assessed through interviews using the Kidney Disease Quality of Life Short Form questionnaire. Statistical analysis was performed using Fisher's exact test with SPSS 29 for Windows, with a p-value of <0.05. Of the 24 study subjects, 20 (83.3%) had anemia, 17 (70.8%) had low muscle strength, and 9 (37.5%) had a poor quality of life. The study's results showed a significant relationship between hemoglobin levels and both muscle strength and the quality of life of chronic kidney failure sufferers, with p-values of 0.012 and 0.022, respectively. There is a relationship between hemoglobin levels and muscle strength and the quality of life of chronic kidney disease sufferers at Budhi Asih Regional Hospital.
The Relationship of Knowledge and Attitude to The Behavior of Using Celery as An Antihypercholesterolemia at The Gandus Health Center in Palembang Nia Savitri Tamzil; Debby Handayati Harahap; Evi Lusiana; Nita Parisa; Ayeshah Augusta Rosdah; Syarinta Adenina; Desi Oktariana
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.230

Abstract

Efforts to lower cholesterol levels can be made using traditional medicine. The better a person's knowledge and attitude towards traditional medicine will influence his actions in choosing medicine. This study aims to determine the relationship between knowledge and attitudes regarding traditional medicine on the behavior/actions of choosing celery to treat hypercholesterolemia in the community around the Gandus Health Center, Palembang. Analytical observational research with a cross-sectional design has been carried out at the Gandus Palembang Health Center from 13 to 20 September 2023. 30 respondents met the inclusion criteria. There are still many (43.3%) respondents who have poor knowledge about the use of herbs as anti-hypercholesterolemia, especially celery, while 30% of respondents with a negative attitude towards choosing traditional medicine were found. Based on statistical analysis, the results showed that there was an insignificant relationship between knowledge and behavior (PR = 1.500 (IK95% 0.325 – 6.918); p = 0.896). However, there is a significant relationship between attitudes and behavior (PR = 21.00 (95% CI 2.868 – 153.754); p = 0.002). A person's attitude towards traditional medicine is related to their behavior/actions in choosing celery for the treatment of hypercholesterolemia.
The Relationship between Knowledge and Self-Medication Practices for Dysmenorrhea among Female Students of SMK Negeri 2 Palembang Kamalia Layal; Syarinta Adenina; Septi Purnamasari; Ayeshah Augusta Rosdah; Msy Rulan Adnindya
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.236

Abstract

Dysmenorrhea is a common occurrence in most women. The pain arising from dysmenorrhea ranges from mild to moderate and can disrupt daily activities and performance. Many women practice self-medication to alleviate this pain. This self-medication practice is influenced by several factors, one of which is the level of knowledge. This study aims to explore the relationship between the level of knowledge among female students and self-medication behavior in dysmenorrhea. This study used a cross-sectional design with a random sampling of female students from SMK Negeri 2 Palembang. The total sample involved 41 students. Data were collected and analyzed using chi-square and Mann-Whitney U tests. The majority of students experienced dysmenorrhea (87.8%) with an average Visual Analog Scale (VAS) score of 4.6. The duration of pain varied, with most experiencing pain for 2-3 days after menstruation. Almost all students (97.6%) had good or sufficient knowledge about dysmenorrhea. However, only a few students practiced self-medication (11.1%), with paracetamol being the most commonly used medication. The analysis showed a significant relationship between knowledge level and self-medication behavior (p=0.002, OR: 12.681). The level of knowledge among female students is significantly associated with self-medication behavior in dysmenorrhea. Better health education on dysmenorrhea management and the use of safe medication needs to be strengthened to reduce the risk of side effects and improve the well-being of students.
The Role of Multimodalities Approach in Diagnosing Disorders of Sex Development (DSD): Brief Review Ziske Maritska; Masagus Irsan Saleh Hasani; Fachmi Idris; Zen Hafy; Didit Pramudhito; Kemas Yusuf Effendi
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.238

Abstract

Disorders of Sex Development (DSD) encompass rare congenital conditions involving atypical development of chromosomes, gonads, or sex anatomy. The 2006 global consensus led to a shift in the approach to handling DSD cases, emphasizing integrated treatment involving various scientific disciplines. DSD diagnosis involves a structured and multimodality approach, including history, pedigree analysis, physical examination, imaging, hormone and chromosome analysis, and genetic testing. An in-depth anamnesis and detailed pedigree analysis help trace family history and inheritance patterns of Mendelian traits in DSD cases. Thorough physical examination, including general and specific assessments, helps screen for abnormalities in sexual development. Karyotyping, hormone level investigation, and imaging examinations are crucial for supporting the diagnosis of DSD. However, genetic or molecular examination remains the modality for definitively confirming the genetic disorder underlying DSD, subsequently leading to a better understanding and management of the condition. Considering the limited resources available in the field in efforts to establish a molecular diagnosis of DSD, it is recommended to explore the role of anamnesis, pedigree analysis, physical examination, imaging examination, hormonal laboratory examination, and chromosome analysis in efforts to approach the diagnosis of DSD.
Correlation of Face Washing, Mask Use, and Acne Incidence During COVID-19 Among Gunadarma University Students Warni Zulhija Putri; Fifinela Raissa; Wahyunia Septiana; Endang Rahmawati
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.239

Abstract

Prevention of COVID-19, in addition to washing hands and keeping distance, can be achieved by using masks regularly. The use of masks in the long term can cause acne vulgaris. Acne vulgaris is a chronic inflammatory condition in the pilosebaceous follicle. Acne vulgaris often occurs in adolescents and young adults. Housekeeping face aims to reduce bacteria, dirt, or microorganisms from the skin's surface by reducing sebum and impurities without removing the lipid barrier in the face. This study aims to understand the relationship between the habit of washing the face and using masks during the COVID-19 pandemic and the incidence of acne vulgaris in students at Gunadarma University, Depok. This type of research is an analytic observational cross-sectional design; the primary data is collected through questionnaires. The sample of this research is the students of the faculty of medicine at Gunadarma University. The sample size is as many as 64, and the sampling technique is simple random sampling. The data were analyzed using the SPSS program and tested using a multivariate logistic regression test. Statistical tests between the facial washing habits and acne vulgaris show a p-value = 0.948. This study shows no relationship between facial washing habits and acne vulgaris. The statistical test results between mask use and acne vulgaris show a p-value = 0.017. This study shows the presence of meaningful relationships between the use of the mask and acne vulgaris (OR = 3.992). The statistical test results of the type of mask with acne vulgaris p value> 0.05. This study shows no relationship between the kind of mask and the incidence of acne vulgaris. This study shows no relationship between facial washing habits and acne vulgaris. Still, there is a relationship between the use of masks and acne vulgaris, and there is no relationship between the type of mask and the incidence of acne vulgaris.

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