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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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Effects of Aerobic Exercise on The Six Minutes Walking Test and Quality of Life in EGFR Mutation Non-Small Cell Lung Cancer Patients Sibarani, Lia Priscilia; Setijadi, Ana Rima; Apriningsih, Hendrastutik; Harsini , Harsini; Raharjo, A. Farih; Sutanto, Yusup Subagio
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.613

Abstract

Background: Lung cancer reduces lung function, muscle mass, and psychological well-being, which lowers exercise capacity and quality of life. Pulmonary rehabilitation, such as aerobic exercise, can improve exercise capacity and the quality of life (QoL) in lung cancer patients. This study aimed to investigate the influence of aerobic exercise on the six-minute walking test (6MWT) and the quality of life of lung cancer patients. Methods: A clinical trial with a quasi-experimental, pretest, and post-test design was conducted on stage ≥IVa adenocarcinoma lung cancer patients who were receiving outpatient targeted therapy at the pulmonary clinic of Dr. Moewardi General Hospital for ≥1 month starting from May 2023, until the required sample size was met. The 6MWT and Functional Assessment of Cancer Therapy-Lung (FACT-L) were measured at the baseline and eight weeks ±2 weeks after aerobic exercise by walking about 15-20 minutes and breathing exercises. Results: The study included fourteen patients in the control group and fifteen patients in the aerobic group. The mean difference of 6MWT between the control and the aerobic group was 38.33 m. Functional, lung cancer subscale (LCS), total, and TOI in FACT-L showed significant differences in the increment pre-test and post-test between the control and aerobic group (P<0.05), with significant differences in pre-test and post-test of most categories in both groups, except for social. Conclusion: Aerobic exercise, psychological support, and nutrition have significantly improved the 6MWT and quality of life in lung cancer patients.
The Diagnostic Role of Narrow-Band Imaging Bronchoscopy For Early Detection of Lung Adenocarcinoma in a Young Adult Bu'ulolo, Christina Siuwandy; Semaraputra, Wayan Wahyu; Novitasari, Novitasari
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.649

Abstract

Background: Lung adenocarcinoma is a common type of cancer that is typically associated with older individuals who have a history of smoking. However, in some rare cases, this occurs in young adults. Case: This case report discusses the diagnostic challenges and the important role of bronchoscopy in confirming lung adenocarcinoma in a 35-year-old male patient with a history of smoking. The patient had a persistent cough and unexplained weight loss. This raised concerns about various differential diagnoses, such as infectious diseases, abnormalities in the bronchial tree, and rare lung neoplasms. In this case report, we used a combination of White Light Bronchoscopy (WLB) and the Narrow Band Imaging (NBI) technique to identify pre-cancerous lesions and early-stage cancers within the airways. Discussion: This case report highlights the significance of bronchoscopy as a diagnostic tool for lung cancer in unexpected populations like young adults. The successful diagnosis through bronchoscopy led to prompt treatment initiation. Conclusion: This case underscores the importance of a multidisciplinary approach to lung cancer diagnosis and management, adapting to the unique situations of individual patients.
Increase in Neopterin Serum Levels Based On Exposure Duration of Silica Dust in Marble Industry Workers Suryaman, Rachmat; Astuti, Tri Wahju; Rakhma, Sastia; Sari, Fitri Indah
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.684

Abstract

Background: Workers in the marble industry face the risk of exposure to dust containing silica crystals in their workplace, a substantial contributor to most occupational lung diseases. Neopterin, an early biomarker of the cellular immune response, is recognized for its association with silica dust exposure. According to a previous study, neopterin levels significantly increased in workers with silicosis compared to controls with no exposure to marble dust. This study aims to analyze changes in neopterin levels based on the duration of silica dust exposure among marble workers. Methods: The study design is an analytical cross-sectional study with a subject pool comprising 32 marble industry workers, categorized into 4 groups based on the duration of exposure: 1-5 years, 5-10 years, >10 years, and control. A comparative analysis was conducted with a control group. Neopterin levels were assessed through the utilization of the Human Neopterin ELISA kit. Analysis using T-tests, ANOVA, and Pearson correlation tests, providing a comprehensive evaluation of the impact of exposure duration. Results: Chest X-ray shows normal results in a routine procedure for most workers. When compared to the control groups, there was a significant increase in serum neopterin levels in all workers. A significant increase was also obtained in neopterin levels among workers with over 5 and over 10 years of exposure. Also, a significant positive correlation between neopterin levels and the duration of exposure. But, among smoker workers, neopterin levels and the Brinkman index level do not show a significant increase. Notably, workers who use nonstandard face masks demonstrate no significant difference in neopterin levels. Conclusion: As marble industry workers are exposed to silica dust for an extended period, there is a corresponding increase in their serum neopterin levels. The duration of silica dust exposure, specifically exceeding five years, significantly influences the elevation of serum neopterin levels.
Pulmonary Hypertension: Understanding the Underlying Anatomy and Physiology of Pulmonary Circulation Amien, Bagus Radityo; Putra, Andika Chandra
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.779

Abstract

The circulatory system has a vital role in fulfilling oxygen demand in tissues and maintaining homeostasis. There are two types of circulatory systems in our body, the systemic and pulmonary circulation. Pulmonary circulation, the critical pathway of blood oxygenation through heart-lung-pulmonary vascular interaction, remains poorly understood despite its central role in the various pulmonary vascular diseases. One of the most prevalent pulmonary vascular diseases is pulmonary hypertension (PH), which is characterized by high mortality and disease progression. A thorough understanding of the physiologic structure and function of pulmonary circulation is essential for diagnosing and treating patients with PH.  Pulmonary blood flow is determined by pulmonary vascular pressure (PVP) and pulmonary vascular resistance (PVR). Lung volume, neural factors (sympathetic and parasympathetic nervous systems), humoral factors (vasoconstrictor and vasodilator), and alveolar hypoxia play an important role in regulating PVR. Alveolar hypoxia triggers hypoxic pulmonary vasoconstriction to maintain the ventilation-perfusion ratio balance. High PVR increases pulmonary arterial pressure (Pa), which is the main pathophysiology of PH. In addition, endothelial dysfunction and vasoactive imbalance also contribute significantly to the pathogenesis of the disease.
Analysis of Pulmonary Function between E-Cigarette Users and Non-Smokers Aged 20–30 Years in Jakarta Digambiro, Reza Aditya; Parwanto, Edy; Tjahjadi, David; Ditriana, Ditriana
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.791

Abstract

Background: This study aimed to compare pulmonary function between e-cigarette users and non-smokers aged 20–30 years in Jakarta. Methods: A cross-sectional study was carried out between May 2023 and May 2024 at SMC Clinic Jakarta, Ibnusina Hospital Jakarta, and Naura Medika Clinic Depok. The sample consisted of 65 individuals who used e-cigarettes and 63 individuals who did not smoke. Spirometry was employed to evaluate pulmonary function by measuring forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. The data were analyzed using independent t-tests using IBM SPSS software version 25.0. Results: The study revealed substantial disparities in pulmonary function between individuals who use e-cigarettes and those who do not smoke. Individuals who use e-cigarettes had significantly reduced FEV1 at 3.02±0.50 L and FVC at 4.00±0.47 L, in comparison to non-smokers (FEV1=3.51±0.57 L; FVC=4.57±0.50 L). E-cigarette users exhibited a considerably lower FEV1/FVC ratio (74.86±5.55) compared to non-smokers (79.29±5.11), suggesting a higher occurrence of obstructive airway diseases. Conclusion: Young adults aged 20-30 years in Jakarta who use e-cigarettes experience a decrease in pulmonary function. The results emphasize the possible respiratory hazards associated with the use of e-cigarettes and emphasize the necessity for greater awareness and regulatory actions to tackle these hazards.
The Predictive Factors of Mortality In COVID-19 In The Intensive Care Unit: A Retrospective Study From Universitas Airlangga Hospital Surabaya Wennas, Vindy Vanessa; Bakhtiar, Arief; Yusuf, Mochamad; Effendi, Wiwin Is
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.830

Abstract

Background: Coronavirus disease 2019 (COVID-19) poses a significant global challenge due to its highly transmissible nature and many positive cases and deaths. Myriad factors are known to affect the outcome of COVID-19 patients. Therefore, identifying predictive factors is essential for developing strategies to reduce mortality. Methods: An analytical observational retrospective study was conducted at Universitas Airlangga Hospital Surabaya from January to June 2021. A total of consecutive sampling was performed on all patients in the intensive care unit. Thirty-one variables were included and analysed using a two-step statistical analysis: univariate and multivariate logistic regression. Results: The mortality rate among 116 patients was 61.2%. The univariate analysis showed that dyspnoea, hypoxia, hyperglycaemia, and fever at admission were positively correlated with mortality. The multivariate analysis showed that fever (adjusted odds ratio [OR]=5) and hyperglycaemia (adjusted OR=8) at admission were independent predictors of mortality. Conclusion: Patients with hyperglycaemia or fever at admission face an increased likelihood of dying from COVID-19, with risks elevated by eight times and five times, respectively.
Association Between the Severity of Chronic Obstructive Pulmonary Disease and the Probability of Pulmonary Hypertension In a Tertiary Hospital Handayani, Friska; Herman, Deddy; Fitrina, Dewi Wahyu
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.873

Abstract

Background: Chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH) have a poor prognosis, which worries doctors. The prevalence of COPD-related PH is unclear. The lack of anatomical criteria for right ventricular hypertrophy may explain research variance. Only type 1 PH patients undergo direct right cardiac catheterization of pulmonary artery pressure. Methods: A cross-sectional analytical descriptive study examined stable COPD patients visiting the pulmonary department at M. Djamil Hospital, Padang, from November 2023 to February 2024 for PH probability. Results: This study included 64 participants, with a majority aged between 40 and 65 years (59.4%), a significant proportion male (82.8%), and a junior high school (29.7%) level of education. Most of the subjects smoked (81.2%), had severe Brinkman Index (75.0%), had severe GOLD criteria (50.0%), and had no comorbidities (53.1%). No correlation was found between the severity of COPD and the likelihood of PH (P=0.591). The Brinkman Index of smokers was a significant risk factor for PH (P=0.010; OR=1.282; 95% CI=0.260-6.315).  Conclusion: There is no significant association between the severity of COPD according to GOLD criteria and the likelihood of PH.
Diagnostic Accuracy and Clinical Utility of InaTB-Rif, Locally Developed Molecular Test for Tuberculosis, in Comparison with Xpert MTB/RIF in Indonesia Handayani, Diah; Haryanto, Budi; Adyasiwi, Galoeh; Dahlan, Muhammad Sopiyudin; Agustin, Heidi; Wardoyo, Muhammad Prasetio; Ilham, Ahmad Fadhil; Burhan, Erlina
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.907

Abstract

Background: Tuberculosis (TB) remains a significant public health issue in Indonesia. Early and accurate diagnosis and drug susceptibility testing are essential for TB management. This study compared the diagnostic accuracy of the locally developed InaTB-Rif molecular test and Xpert MTB/RIF, using Mycobacterium Growth Indicator Tube (MGIT) culture as the reference standard. Methods: A cross-sectional study was conducted at Persahabatan Hospital, Jakarta, from February to August 2023. Presumptive pulmonary TB patients were recruited and tested using Xpert MTB/RIF, InaTB-Rif, and MGIT culture. The study assessed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and agreement between InaTB-Rif and Xpert MTB/RIF for Mycobacterium tuberculosis (MTB) detection and rifampicin resistance. Diagnostic accuracy was compared using receiver operating characteristic (ROC) curves. Results: MGIT culture identified 29 TB-positive and 26 TB-negative cases. InaTB-RIF showed a sensitivity of 93.1% (95% CI=0.77-0.99), specificity of 76.9% (95% CI=0.56-0.91), PPV of 81.8% (95% CI=0.64-0.93), and NPV of 90.9% (95% CI=0.70-0.98). Xpert MTB/RIF had a sensitivity of 89.7% (95% CI=0.726-0.978), specificity of 80.8% (95% CI=0.606-0.93), PPV of 83.9% (95% CI=0.66-0.94), and NPV of 87.5% (95% CI=0.67-0.97). The area under the curve (AUC) was 0.8501 for InaTB-RIF and 0.8521 for Xpert MTB/RIF, with no significant difference in accuracy (P=0.965). The kappa value for MTB detection was 0.776, indicating substantial agreement, while the kappa value for rifampicin resistance detection was 0.517, indicating moderate agreement. Conclusions: InaTB-RIF demonstrates comparable diagnostic accuracy to Xpert MTB/RIF with good diagnostic performance and agreement for detecting MTB and moderate agreement for rifampicin resistance detection.
The Effect of Magnesium Citrate on %FEV1, %PEFR, and Asthma Control Test Score in Patients with Controlled Asthma and Uncontrolled Asthma Atmojo, Anang Purwoko; Sutanto, Yusup Subagio; Adhiputri, Artrien; Reviono, Reviono; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.503

Abstract

Background: Asthma is one of the most common non-communicable diseases in the world and affected an estimated 262 million people in 2019. Magnesium is one of the nutrients known to improve lung function in asthma by inhibiting the production of proinflammatory cytokines, exhibiting anti-inflammatory benefits, and having beneficial muscle-relaxing and bronchodilatation effects. Measurement of percent predicted forced expiratory volume in 1 second (%FEV1), percent predicted peak expiratory flow rate (%PEFR), and asthma control test (ACT) score is are indicator of lung function. Magnesium citrate may be used as an adjunct therapy in patients with controlled and uncontrolled asthma. Methods: Clinical trial research with quasi quasi-experimental method using a pre-test and post-test design. The study subjects were 34 controlled and uncontrolled asthma patients at the outpatient clinic of Universitas Sebelas Maret Hospital and dr. Soehadi Prijonegoro Hospital in February - March 2023, using consecutive sampling. The control group (n=17) received standard therapy, while the treatment group (n=17) received standard therapy plus 300 mg magnesium citrate for 42 days. Serum magnesium level, %FEV1, %PEFR, and ACT score were measured at enrollment and on the forty-third day of treatment. Results: There were significant differences between the treatment group compared to the control group in increasing %PEFR (P=0.001), increasing ACT score (P=0.011), and increasing %FEV1 (P=0.071). Conclusion: Administration of magnesium citrate to patients with controlled and uncontrolled asthma can increase levels of %PEFR, ACT score, and %FEV1.
Effects of Hypnotherapy on Pain Scale, Interleukin-6 Levels, and Quality of Life in Lung Cancer Patients Who Experience Cancer Pain Widyasanti, Diana; Sutanto, Yusup Subagio; Septiawan, Debree; Aphridasari, Jatu; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.624

Abstract

Background: Pain is a common symptom in lung cancer patients and can affect their quality of life. Interleukin 6 (IL-6) plays a role in malignant cell proliferation and differentiation as well as the initiation and persistence of cancer pain. Hypnosis can reduce pain by reducing anxiety through relaxation and/or directly affecting neurophysiological activity that underlies the subjective experience of pain. This study aimed to evaluate hypnotherapy as a non-pharmacological method for managing cancer pain. Methods: Clinical trial of 30 subjects with quasi-experimental pre-test and post-test in treatment and control groups of lung cancer patients of NSCLC and SCLC stage III and IV who experienced cancer pain with pain scale ≥3 at RSUD Dr. Moewardi Surakarta in June to August 2023 with a consecutive sampling method. The treatment group received hypnotherapy intervention for 4 weeks. Subjects were assessed for pain scale, interleukin-6 levels, and FACT-L quality of life questionnaire. Results: A 4-week hypnotherapy intervention can significantly reduce the pain scale (P=0.0001) and improve the quality-of-life FACT-L (P=0.002) in lung cancer patients experiencing cancer pain. Hypnotherapy also significantly reduced IL-6 in the treatment group (P=0.008), but when compared with the control, the results were not significant (P=0.345). Conclusion: Hypnotherapy may reduce the pain scale and improve the quality of life of lung cancer patients who experience cancer pain, but does not significantly lower IL-6 levels.

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