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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 20 Documents
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Search results for , issue "Vol 22 No 1 (2024): JIFI" : 20 Documents clear
Post-Market in vitro bioequivalence study of innovator and generic Gefitinib tablets: evaluation of JKN medicine quality Nurhayati, Fitri; Anggriani, Yusi; Syahruddin, Elisna; Andalucia, Rizka; Ath-Thobari, Jarir; Mulatsari, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1593

Abstract

Gefitinib is one of Tyrosine Kinase Inhibitors (TKIs), as first line therapy for Non-Small Cell Lung Cancer (NSCLC) with positive EGFR mutation. Gefitinib started to be accommodated in Jaminan Kesehatan Nasional (JKN) insurance in 2015 with the innovator gefitinib and was replaced by a generic product in middle of 2021. This research was conducted to see whether the quality of generic gefitinib equivalent to the innovator through post-market in vitro bioequivalence test. Assay method refers to previous research by Sandhya et al 2013 wih High Performance Liquid Chromatography (HPLC), while the dissolution test method is in accordance with the Food and Drug Association (FDA) 2010. We collected innovator from the official distributor and 3 batches (all batches that have been used in JKN program) of generic product from hospitals where lung cancer therapy services were provided. We evaluated the dissolution profile with similarity and unsimilarity factors and assess based on standard specification of dissolution profile that informed in innovator’s BPOM-approved brochure (avarage of 6 samples > 85% and no individual result < 75% at 45 minutes). The assay results met the requirements of ± 5% of what is stated on the label. Although dissolution profile of generic and innovator were not equal through difference and similarity factors calculation, but one batch of generics met dissolution profile standard of innovator. So, both generic and innovator drug met the standards of assay and dissolution, even though the dissolution profile were not equivalent.
Optimization of sodium starch glycolate and maltodextrin in chlorpheniramine maleate Fast Disintegrating Tablet (FDT) by factorial design Sutristio, Kezia Livianthi Kirana Budhi; Lestari, Agatha Budi Susiana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1493

Abstract

Chlorpheniramine maleate (CTM) is an antihistamine that is widely available on the market in tablet form. It needs to be formulated in the form of Fast Disintegrating Tablets (FDT) to produce a faster therapeutic effect to treat allergy symptoms, which are often irritating. The FDT contains a super disintegrant to regulate the disintegration speed of tablet and a binder to provide the ability to bind between powders. This research was conducted to obtain the effect of Sodium Starch Glycolate (SSG) as a super disintegrant and maltodextrin as a binder, and their interaction in the chlorpheniramine maleate tablet formulation. This research was categorized as true experimental designs with FDT quality parameters such as organoleptic, hardness, friability, disintegration time, wetting time, water absorption ratio, and content uniformity. The optimization method used is factorial design. Data analysis was performed using Analysis of Variance (ANOVA). Based on the data, it conclude that Sodium Starch glycolate (SSG) affects increasing hardness, increasing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. Maltodextrin, has the effect of increasing hardness, reducing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. The interaction of SSG and maltodextrin has the effect of reducing hardness, increasing friability, shortening disintegration time, shortening wetting time, and increasing the water absorption ratio.
Toxicity of Sida rhombifolia L. 96% ethanol extract based on LD50 and macropathological examination of mice's organs Aulena, Desi Nadya; Kumala, Shirly; Abdillah, Syamsudin; Rahmat, Deni; Zaidan, Sarah; Fitriyani, Dwi; Raihan, Dany
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1463

Abstract

The Indonesian people empirically use Sidaguri (Sida rhombifolia L.) in medicine, such as anti-hyperuricemia. Herbal-based treatment is currently much preferred. Drug metabolism, in general, mainly occurs in the liver, so the possibility of damage to this organ is high. This study aims to determine the acute toxicity category of 96% ethanol extract of sidaguri based on the LD50 value, changes in body weight, changes in organ weight, and macro pathology in the organs of male DDY mice in vivo. The method used in this research was experimental with a fixed dose design following the Indonesian Food and Drug Authority regulations regarding guidelines for in vivo non-clinical toxicity tests. The test group was divided into six dose groups (standard, 50, 300, 2000, 5000, and 15000 mg/kg Body of weight). Observations were made for 24 hours. Observations were continued for 14 days on death parameters, toxicity symptoms, body weight, and relative organ weights using five main organs (heart, lungs, liver, spleen, and kidneys, and pathological examination). The acute toxicity test results showed no death in all dose treatment groups. Macropathological analysis did not show abnormalities in organs in all groups of mice. LD50 value is more than 15000 mg/kg. Sidaguri 96% ethanol extract is safe and Practically non-toxic.
Public perception of COVID-19 vaccination in Banjar District, Indonesia: the role of sociodemographic factors Mardiati, Nurul; Mersa, Lina; Torizellia, Cast
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1565

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2) virus. Vaccination is one way to prevent the spread of the COVID-19 virus. One of the factors causing the low acceptance of COVID-19 vaccination in the community is the perception of COVID-19 vaccination. Socio-demographic factors such as age, gender, occupation, last degree of education, and monthly income have a substantial relationship with public perceptions of COVID-19 vaccination. The purpose of this study was to analyze public perceptions of COVID-19 vaccination. This study used an analytical observational method with a cross-sectional study design. The sample in this study used a consecutive sampling technique, totaling 400 people. The majority of respondents had a enough good perception of COVID-19 vaccination. There is a relationship between socio-demographic factors of age, occupation, last degree of education, and monthly income with people's perceptions of COVID-19.
Ionic liquid-based ultrasound-assisted extraction: a novel insights of green extraction techniques for bioactive compounds from herbal plants Aziz, Fiq'rah Lestari; Lukmanto, Donny; Iswandana, Raditya; Mu'nim, Abdul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1531

Abstract

The ionic liquid-based ultrasound-assisted extraction (ILUAE) is a non-conventional environmentally friendly extraction method. ILUAE is considered as green chemistry since ILUAE utilize ionic liquids as solvents and ultrasound-assisted extraction to extract bioactive chemicals from herbal plants. The growing popularity of ILUAE as preferred extraction method in herbal medicine is not only due to its sustainable, eco-friendly characteristics but also its improvement in extraction efficiency while maintaining the quality of extracted products. Here, we discussed and reviewed ILUAE as preferred extraction method for herbal medicines. Through discussing ILUAE’s potential, advantage against traditional extraction technique, and summarized the successful extraction of bioactive components from various herbal plants using ILUAE, we hope to showcase the technology's efficiency, selectivity, and sustainability. Finally, we discussed current limitations and future challenge for ILUAE and potential ways to address these challenges.
Evaluation of anti-acne gel of Piper crocatum leaves ethanolic extract against Propionibacterium acnes Mendra, Ni Nyoman Yudianti; Givanda, Jesi Dyah Ayu; Putra, Made Agus Sunadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1564

Abstract

The red betel leaf (Piper crocatum) exhibited antibacterial properties by inhibiting Propionibacterium acnes, known for causing acne. The study aimed to develop an anti-acne gel formulation using Piper crocatum leaves ethanolic extract and to evaluate its antibacterial efficacy against Propionibacterium acnes. The extract was formulated into three gel formulas, with concentrations of 15%, 20%, and 25%, respectively. Antibacterial activity was evaluated using the agar well diffusion method, with Clindamycin gel as the positive control. The inhibition diameter were analyzed statistically using One Way ANOVA and Post Hoc LSD tests at a 95% confidence level. The result showed that the gel met the physical test requirements. The inhibition zone of the samples was observed with an inhibition diameter of 7.98 mm, 8.06 mm, and 8.16 mm for 15%, 20%, and 30% extract of gel, respectively, compared to the positive control 27.60 mm (p < 0,05). The research findings indicate that anti-acne gel of Piper crocatum leaves ethanolic extract exhibit moderate antibacterial activity in an in vitro setting. Statistically significant differences in inhibition diameters were observed between each gel sample and positive control.
Antimicrobial activity and phytochemicals compound profile of ethanol extract Moringa leaf (Moringa oleifera) compounds by FTIR Ningsih, Arista Wahyu; Safıra, Aulia Dinda; Giovano, Andre; S.Klau, Ivan Charles
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1231

Abstract

Moringa plants are known in various parts of the world as a type of vegetable plant that is rich in nutrients and has multiple properties, one of which is as an antimicrobial. This research was conducted to test the antimicrobial inhibition of Moringa leaf decoction and ethanol extract against the growth of Escherichia coli and Aspergillus niger. The antimicrobial test in this study used the Disc diffusion method using various concentrations, including 25%, 50%, 75%, and 100%. There were two test samples, Moringa leaf decoction and ethanol extract using the maceration method with 96% ethanol solvent. In addition to the test group, there was also a control group, namely a positive control using chloramphenicol and ketoconazole antibiotics, negative control using aquadest as a decoction solvent, and DMSO as an extraction solvent. The ethanol extract was identified by the FTIR method. The results showed that Moringa leaf decoction and Moringa leaf ethanol extract could be used as antibacterial. Inhibition zones on Escherichia coli bacteria produced at concentrations of 25%, 50%, and 75% had a weak zone of inhibition category for both decoction and ethanol extract of Moringa leaves. Meanwhile, at a concentration of 100%, the decoction has a weak zone of inhibition and 100% ethanol extract of Moringa leaves can inhibit 8.25 mm which is included in the medium category. The inhibition zones of the fungus Aspergillus niger produced at concentrations of 25%, 50%, 75%, and 100% had no inhibition on both the decoction and ethanol extract of Moringa leaves. From the analysis of functional groups using the FTIR method, it can be predicted that in the Moringa leaf extract with methanol as solvent there are groups of phenolic compounds or flavonoids.
Spray-gel formulations of Cantigi extract and Cantigi extract-loaded gelatin nanoparticles as antioxidant Kosasih, Kosasih; Alifiya, Nesshi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1586

Abstract

Spray-gel formulations may contain natural antioxidants like plant extracts. They can reduce free radicals and prevent premature aging. This research aims to study spray-gel formulations using Cantigi extracts and Cantigi extract-loaded gelatin nanoparticles as antioxidants. Extract preparation used the maceration method concentrated by a rotavapor and characterized for specific and nonspecific parameters. Antioxidant activity analysis of extract, nanoparticles, and formulations used the DPPH method. Gelatin nanoparticle synthesis was done using the nanoprecipitation method and then characterized for particle size, polydispersity index, zeta potential, entrapment efficiency, aldimine linkage formation, and morphology. Two spray-gel formulations were manufactured (F1 contained the extract, and F2 contained the nanoparticles) and evaluated for one month for organoleptics, homogeneity, viscosity, flow properties, spray pattern, pH, and antioxidant activity tests. The extract and nanoparticles meet all parameters. The antioxidant activities (IC50) are Cantigi extract of 17.4 ppm, gelatin nanoparticles of 33.6 ppm, F1 of 60.6 ppm, and F2 of 99.5 ppm. After the stability study, the spray-gel formulation characteristics were: Organoleptics, homogeneity, homogeneity, and viscosity complied (F1 and F2); flow property showed plastic thixotrophy properties (F1 and F2); spray pattern showed best at 20 cm distance (F1 and F2); pH complied (F1 and F2); and IC50 of F1 was 63.0 ppm while F2 was 103.3 ppm. Conclusions were that the spray-gel formulations (F1 and F2) complied with the standards and were stable during the storage time. However, F1 has more potent antioxidant activity than the F2.
Association of side effects to medication adherence of antiepileptic drug use in epileptic patients Ernawati, Iin; Wyono, Oktaviani Putri; Yunitasari, Fitria Dewi; Pradani, Erwindy Yastika; Islamiyah, Wardah Rahmatul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1269

Abstract

Epilepsy is a chronic neurological disorder with symptoms characterized by seizures, arising spontaneously with brief episodes with the main symptom of decreased or loss of consciousness. This study aims to examine the effect of side effects of medication adherence to antiepileptic drug use in epilepsy patients. This research is an observational study that was analyzed using quantitative descriptive methods in Neurology patients at the Airlangga University Hospital from March until May 2022. Side effects were measured using the LAEP (Liverpool Adverse Effects Profile) questionnaire and adherence was measured using a pill count. Results showed that the influence of side effects on medication adherence (pill count method) to antiepileptic drugs using linear regression, it is known that the P-value is 0.501. There is no significant relationship between the category of side effects and medication adherence to antiepileptic drugs. Another factor that influences compliance with medication use is the appearance of seizures. Based on the results of this study, it is known that the greater the frequency of seizures, the more likely patients are to be non-compliant (P-value 0.006). To increase adherence, it is necessary to pay attention to other factors such as knowledge, economy, and type of therapy in epilepsy patients so that therapeutic outcomes can be achieved.
Powder drink of Permesia americana Mill. Seed with adding Zingiber officinale Rosc. Var Rubrum and Stevia rebaudiana L. to enhance Cardiovascular health Agustin, Arum Dwi; Purwasih, Ratih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1438

Abstract

In today’s modern era many people consume unhealthy foods, which can lead to decreased immunity. One way to increase immunity is by consuming functional drinks from Avocado seeds and red ginger, which is contain flavonoid compounds. This study aims to determine antioxidant activity in functional drinks of avocado seeds by adding red ginger and stevia. The method used in this research is a quantitative analysis using the UV-Vis Spectrophotometer instrument at a wavelength of 418 nm for F1, F2 and F3 were brown, had a characteristic smell of spices, and had a distinctive taste. The pH test results were 6.243 ± 0.025, 6.167 ± 0.045, and 6.089 ± 0.005 respectively. The raw material and functional drinks positively contain flavonoids. Flavonoid content in F1, F2, and F3 were 12.214 ± 0.009428%, 12.419 ± 0.009428%, and 12.624 ± 0.009428% respectively. Antioxidant test results for functional drinks showed an IC50 value of F1 and F2 were 118.30 ± 1.57 ppm and 105.88 ± 1.11 ppm, which is categorized as moderate levels of antioxidants, and F3 was 88.09 ± 1.62 ppm, which is categorized as strong levels of antioxidants.

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