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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol Untia Kartika Sari Ramadhani; Joshita Djajadisastra; Iskandarsyah Iskandarsyah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (673.545 KB) | DOI: 10.35814/jifi.v15i2.501

Abstract

Carvedilol is β-blocker antihypertensive drug with low oral bioavaibility and short half time which causes the frequency of oral drug used more often or the oral dose might be increased. Transdermal patch with the matrix system can deliver drug through skin in controlled within specifi c time period and hopefully it can improve carvedilol bioavaibility and convenience for patients.The aim of research was to fi nd out the effect of polymer and penetration enhancer toward penetration characteristic of carvedilol transdermal patch matrix seen from kinetics release data and penetration data of carvedilol. The polymer ratio of Polyvinyl Alcohol (PVA) : Ethyl cellulose (ES) polymers and Sorbitan Monolaurate (SM) as penetration enhancer concentrations used were F1 (1:1) / 8%, F2 (1: 1) /10%, F3 (2:1) /8%, F4 (2:1)/10%. Formula F1 did not pass in the organoleptictes so next test only carried out for formula F2, F3 and F4. The in vitro release of carvedilol showed formula F2, F3 and F4 lasted for 24 hours and the released kinetics of carvedilol followed the order of 0 and Higuchi. Carvedilol % cumulative from penetration test in vitro showed for F2, F3 and F4 formulas respectively were 15,384%, 16,495% and 18,287%.
Isolasi dan Identifikasi Senyawa (-)-Asam Usnat dari Lichen Usnea sp. serta Aktivitas Sitotoksiknya terhadap Sel Murine Leukemia P388 MAULIDIYAH MAULIDIYAH; THAMRIN AZIS; SITTI HADIJAH SABARWATI; MUHAMMAD NURDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Lichen is a symbiotic organism composed by algae and fungi that already known produces spesific secondary metabolites having bioactivities. The aim of this study were to isolate and determine the structure of secondary metabolites of Lichen Usnea sp. and to examine the cytotoxic activity against murine leukemia P388 cells. Isolation was carried out by utilizing colom chromatography using silica gel 60 stationary phase with eluent mixtures of n-hexane and ethyl acetate in a gradient elution. Isolates compounds were identified using UV-Vis spectroscopy, IR, 1H-NMR and 13C-NMR. The identification result obtained was (-)-usnic acid compound with molecular weight (MW) of 344 g/mol, needle-shaped yellow crystals. Test results cytotoxic compound of (-)-usnic acid against murine leukemia P388 cells were derived IC50 5.738 ± 0.61 µg/mL.
Aktivitas Antikarsinogenesis Ekstrak Etanol Daging Buah Mahkota Dewa pada Mencit yang Diinduksi 7,12-Dimetilbenz(a)antrasena YANDI SYUKRI; SAEPUDIN SAEPUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Mahkota dewa (Phaleria macrocarpa Boerl.) was used empirically for treatment of any kind of diseases, including cancer. The aim of this research is to explore the carcinogenesis inhibition effect of mahkota dewa epicarp extract. The effect was examined using 7,12-dimethylbenz(a)anthracene (DMBA) induced new born mice which Were divided into five groups. All groups received 0.25 mg single intraperitoneal injection of DMBA, except group of normal control. The extract was tested onto three different groups of the mice at the age of 28 days which Was separated from their parental with the doses of 6.25 mg, 12.5 mg, and 25 mg for 16 Weeks and one group Was used as negative control. Anticarcinogenic effect of the extract was evaluated after 16 Weeks by observing the histopathology and total number of all types of neoplasm in hepar, kidney, lung, gastric, intestine, and lymphatic tissue. The result showed that the extract at 6.25 mg, 12.5 mg, and 25 mg decreases carcinogenesis event by 50%, 83%, and 100% , respectively, compared with negative control. In conclusion, the dose of 25 mg extract improved several organs carcinogenesis than other dose, and thereby can be developed as a potential anticancer agent.
3,3’-Di(5,7-dibromoindol-3-il)-indolin-2-on: Sintesis dan Uji Sitotoksik terhadap Sel Kanker Kolon WiDr KAMILIA MUSTIKASARI; MARDI SANTOSO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Colon cancer is one of the causes of death in the world of concern, because until now there has not been found specific drug for its treatment. Therefore, the study aimed to synthesize compounds that have the potential as a novel anticancer compound derivative such as 3,3’-di (indol-3-yl) indolin-2-one is required. Synthesis was done by reacting 5,7-dibromoindole and isatin in methanol with an acid catalyst to produce 3,3’-di (5,7-dibromoindol-3-yl)-indolin-2-one compound with a yield of 48%. 3,3 ‘-di (5,7-dibromoindol-3-yl)-indolin-2-one is cytotoxic against colon cancer cell line WiDr with IC50 of 6.64 μM.
Pemanfaatan Nanoteknologi dalam Sistem Penghantaran Obat Baru untuk Produk Bahan Alam DELLY RAMADON; ABDUL MUN’IM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sejak dahulu banyak ekstrak dari bahan alam yang secara empiris dimanfaatkan untuk pengobatan. Ekstrak-ekstrak tersebut digunakan karena mengandung senyawa bioaktif yang dapat memberikan efek farmakologis. Isolat dari ekstrak tersebut diuji baik secara in vitro maupun in vivo untuk mengetahui efek dan bioavailabilitas dalam tubuh secara ilmiah. Namun demikian diperkirakan lebih dari 40% senyawa bahan alam memiliki kelarutan yang rendah di dalam air atau bahkan memberikan toksisitas yang tinggi. Kelarutan yang rendah di dalam air serta kurangnya kemampuan permeabilitas menembus barrier absorpsi dapat mempengaruhi bioavailabilitas senyawa bahan alam di dalam tubuh. Tidak hanya itu, bioavailabilitas suatu senyawa juga sangat dipengaruhi oleh stabilitas terhadap pH lambung dan kolon, metabolisme oleh mikroflora normal dalam saluran pencernaan, absorpsi melalui dinding usus, mekanisme aktif pompa efflux dan metabolisme lintas pertama. Solusi dari permasalahan tersebut adalah dengan mengembangkan sistem penghantaran obat yang dikenal dengan sistem penghataran obat baru (novel drug delivery system). Sistem penghantaran obat baru merupakan suatu sistem penghantaran obat yang lebih modern dengan cara mengontrol pelepasan obat sehingga aktivitas farmakologis menjadi lebih baik. Pembuatan sediaan berbasis teknologi baru ini dapat menjadi alternatif dalam pembuatan produk herbal dan diharapkan bioavailabilitas produk herbal dalam tubuh menjadi lebih baik sehingga dapat memberikan efek terapi yang lebih baik
Formulasi Gel Pengelupas Sel Kulit Mati yang Mengandung Sari Buah Nanas (Ananas comosus L) antara 17 sampai 78% TETI INDRAWATI; FINA ZISSAKINA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The juice of Ananas comosus L. contains bromelain which has been known to defoliate dead skin cells. Investigation on five gel formulations containing 17%, 33%, 50%, 67% and 78% of the juice of Ananas comosus L with 4% of HPMC as gelling agent, have been carried out. The stability of all formula were examined by the accelerated test method at room temperature and 40 oC for 6 weeks. Parameters observed were organoleptic, homogeneity, syneresis, viscosity, flow behavior, spreading ability, and pH. Results indicated that the higher the juice concentration in the gel would reduce the gel stability progressively. Gel formula using 4% of HPMC containing 17% or 33% of Ananas comosus juice can be produced while maintaining good physical stability for 6 weeks. The products were pale yellow to yellow in color, homogeneous, and have viscosity of 13000-45800 cps, pH 4.0-4.9, pseudo plastic flow, and spreading ability of 2732.58 to 4534.16 mm².
Pengeringan Sari Buah Mengkudu (Morinda citrifolia L.) secara Spray Drying Sri Ningsih; Siti Kadarsih; Wahono Sumaryono
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 1 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Drying process of Mengkudu (Morinda citrifolia L.) juice by spray drying method had been carried out. Two kinds of fillers were used in this process, i.e. 5%, 15%, 20%, and 25% of lactose monohydrate or 15% and 20% of maltodextrin, both in w/w %. The result obtained showed, that the dried powder containing 15 % of maltodextrin was better (dry fine and brown) than those with other concentration of fillers.
Effect of Pleurotus Ostreatus on Pancreatic Beta Cells of Diabetes Mellitus Mice Model Ningrum Wahyuni; Syafrudin Ilyas; Alya Amila Fitrie
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (652.724 KB) | DOI: 10.35814/jifi.v15i2.507

Abstract

Over the last 30 years, the number of people suffering from diabetes mellitus has doubled globally. Adipose tissue dysfunction plays an important role in insulin resistance. Mushroom has been traditionally used to prevent diabetes. This research aims to study the anti-oxidative effect of Pleurotus ostreatus on pancreatic beta cells. This study is an experimental posttest only control group design. The subjects were 24 male wistar mice, divided into six groups. Group P0 was given distilled water and citrate buffer. Group P1 was given high fat diet (HFD) and low dose streptozotocin (STZ). Group P2 and 3 were given HFD and low dose STZ along with Pleurotus ostreatus ethanol extract. Group P4 and P5 were given HFD and low dose STZ, and then given Pleurotus ostreatus ethanol extract. Blood glucose levels and pancreatic beta cells area count were done after treatment. Data obtained was analyzed using one-way ANOVA test. One-way ANOVA test showed signifi cant difference in all the groups (p<0.05). Post Hoc test results showed difference in blood glucose levels and pancreatic beta cells area count. Pleurotus ostreatus ethanol extract can prevent cellular damage to murine pancreatic beta cells but unable to reverse the damage to the beta cells.
Isolasi dan Karakterisasi Agarosa dari Rumput Laut Gracilaria verrucosa ZAINAL ABIDIN; MARCELLINO RUDYANTO; SUDJARWO SUDJARWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

: Agar is complex polysaccharide which could be isolated from group Rhodophyta of seaweeds, sucs as Gracilaria verrucosa. Agar consists of two components, namely agarose and agaropectin. Agarose is neutral polysaccharide, while agaropectin is polysaccharide that contain sulphate, so agarose could be used for gel electrophoresis. The use of NaOH solution was aimed to hydrolyzes the agar to form 3,6-anhydro-L-galactose, whereas the use of propylene glycol was to separates agarose from agaropectin. This research was aimed to isolate agarosa from Gracilaria verrucosa using NaOH solution with the concentrations of 4%, 6%, 8%, 10% and propylene glycol of 30, 50 and 70 mL. The agarose obtained was giving specivic absorbtion band in IR spectrum with wave number in the region of 930 and 890 cm-1, and there were absorbtion band in the region of 860 and 830 cm-1, indicated that the agarose still contained sulphate. The increase of NaOH concentration and propylene glycol volume caused drawback sulphate and ash content, constant melted temperature and gel temperature but increase gel strength. The best amount of agarose was obtained with the use of NaOH 10% and 70 mL of propylene glycol, with the characteristics were: ash content of 2.0035±0.0429% (w/w), sulphate content of 0.3236±0.0131% (w/w), melted temperature of 34 oC, gel temperature of 90 oC, gel strength of 432.195±26.172 g/cm2 and degree of electroendosmosis of 0.20±0.005.
Penapisan Senyawa Antimalaria yang Berasal dari Tumbuhan SYAMSUDIN SYAMSUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Efforts to discover and develop new antimalarial drugs have increased dramatically in recent years mainly because of the parasites’ resistance to existing antimalarial drugs. Selection of drug candidates for clinical trials in man and the design of clinical protocols are based upon consideration of data from a battery of preclinical test systems. All compounds are assessed initially in one or more primary models. A compound which is considered active by well established criteria in primary screening test is considered for further evaluation in successively more rigorous clinical test. At the end of each stage of testing, a decision is taken to advance the compound to the next stage or to discontinue it. Primary screening tests should have optimal sensitivity, a high degree of reproducibility, high throughput, should require a minimum quantity of test compound and bear low cost. As there is growing need for newer and more efficacious antimalarial drugs escpecially in tropical countries, more sensitive and economical screening models are needed. This review is an update of various conventional and latest in vitro and in vivo screening methods being used for evaluation of antimalarial compounds.

Page 30 of 73 | Total Record : 721

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