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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Efek Protektif Nigella sativa Terhadap Karsinogenesis Sel Ginjal Tikus yang Diinduksi 7,12-dimetilbenz(a)antrasena (DMBA) DIAH AYU ANDINI; HANIF NASIATUL BAROROH; HENY EKOWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Black cumin (Nigella sativa) is known to have anticancer activity. Previous study showed that chloroform extract of N. sativa, have cytotoxic activity on T47D cell line. The purpose of this study was to determine the antiproliferation activity of chloroform extract N. sativa in female rats induced-DMBA based on histopathologic changes on renal cell of cell proliferation and to observe the optimal concentration of N. sativa as antiproliferative agent. Sprague Dawley strain female rats were divided into live groups. Group 1 was given DMBA 20 mg/kg BW. Group 2, 3, 4, were given DMBA and chloroform extracts of N. sativa with 250; 500; 750 mg kg BW rank dose. Group 5 was given corn oil. Renal cell histopathology was observed by H&E and AgNOR staining. The inhibition of renal cell proliferation was observed with mAgNOR value. mAgNOR data were analyzed using Kolmogorov-Smirnov test, ANOVA and Tukey HSD. The results of H&E and AgNOR staining showed that at a dose of 7 SOmg/kg BW chloroform extract of N. sativa reduced cell damage and inhibit renal cells proliferation with mAgNOR value of 1.069. This result suggest that the chloroform extract of N. sativa had the potential effect as chemopreventive agent.
Sintesis dan Uji Antioksidan Senyawa 1,5-bis(3’-etoksi-4’-hidroksifenil)-1,4-pentadien-3-on (EHP) ESTI MUMPUNI; ENJANG RUSNAWAN; EVI SULASTRI; INDRIANA PERMATASARI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 2 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Synthesis of 1,5-bis(3’-etoxy-4’-hydroxyphenyI)-1,4-pentadiene-3-on (EHP) by aldol condensation method from ethyl Vanilin and acetone, using hydrochloride acid as a catalyst, has been conducted. Identification of the EHP compound was done through interpretation of UV-Vis, FT-IR, GC-MS and NMR data, The antioxidant activity of EHP (IC50 8.66 µg/mL) is higher than curcumin (IC50 11.44 µg/mL) as demonstrated by the DPPH method.
Formulasi dan Uji Anti Inflamasi Masker Peel Off Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.) Miratun Syarifah; Nining Sugihartini; Laela Hayu Nurani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (521.123 KB) | DOI: 10.35814/jifi.v17i2.564

Abstract

Infl ammation of the skin often occurs in acne-prone skin. Acne can be prevented in variousways, one of them by maintaining clean skin. Noni fruit (Morinda citrifolia L.) with the active ingredientof scopoletin has been proven to be eff ective as an anti-infl ammatory. Noni is dried into simplicia,extracted was ethanol 96% solvent until it becomes concentrated extract. The extract is formulated intoa peel off mask with a concentration variation of 5%, 10 and 15%. The masks produced is evaluated forphysical characteristic of pH, viscosity, spreadability, and adhesivity test), as well as anti-infl ammatoryproperties using mice with the parameters of COX-2 expression and irritation test using rabbit. Theevaluation results of the physical characteristic of the peel off mask fulfi lled the physical characteristicrequirements of the peel off mask preparation. Whereas in the viscosity test there were groups thatmet the viscosity requirements, namely the formula I and II groups and the group that did not meet theviscosity requirements, namely the formula III group. Anti-infl ammatory test in mice showed that themask lead to reduction in the amount of COX-2 expression. The best formula in 3 preparations wasindicated in formula I with COX-2 expression value of 22.635%. The results of irritation test on rabbitsdid not cause irritation. According to the test results it can be concluded that the optimum value of theethanol extract concentration is shown in formula I with a concentration of 5%.
Efek Pemberian Dosis Berulang dan Dosis Tunggal Ekstrak Kulit Batang Cempedak (Artocarpus Champeden Spreng.) Pada Mencit Terinfeksi Plasmodium Berghei SOFIANA SARI; ACHMAD FUAD HAFID; ATY WIDYAWARUYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Artocarpus champeden Spreng. (Moraceae) known as “cempedak”, was traditionally used for antimalarial remedies in Indonesia. Study to determine antimalarial activity of ethanol extract of cempedak stembark was carried out. Artocarpus champeden Ethanol Extract (ACEE) was administered twice per day (multiple dose) and once per day (single dose) orally. The study was carried out by modification method of the “4 Days Suppressive Test” originally described by Peter. The result showed that ACEE administered twice per day inhibited parasites growth (ED 0.19 mg/kg BW) higher than once per day (ED 6.0 mg/kg BW) and 10 mg/kg body weight of dose administrated twice per day was more effective than 100 mg/kg body weight once per day.
Uji In Vitro dan Studi In Silico Senyawa Turunan n’-benzoylisonicotinohydr Ruswanto Ruswanto; Nur Rahayuningsih; Nur Laeli Dwi Hidayati; Ginna Sri Nuryani; Richa Mardianingrum
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.686 KB) | DOI: 10.35814/jifi.v17i2.703

Abstract

There have been in silico and in vitro studies of N-Benzoylisonicotinohydrazide derivatives as antituberculosis candidates. The aims of this research were determined that the N'-benzoylisonicotinohydrazide derivatives could inhibit the activity of gram-positive, gram-negative and Mycobacterium tuberculosis, as well as having good interactions with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis. From the in vitro test it was found that the N'-benzoylisonicotinohydrazide compound had a Minimum Inhibitor Concentration (MIC) of 0.33 µg / ml against the Basillus subtilis, while the Minimum Inhibitor Concentration (MIC) of N '- (2-chlorobenzoyl) isonicotinohydrazide against Mycobacterium tuberculosis (H37Rv) was 3.125 µg / ml. From the in silico study, it was found that the binding affinity value between N '- (2-chlorobenzoyl) isonicotinohydrazide enzyme Enoyl-Acyl Carrier Protein Reductase (2X23) had the smallest binding affinity so that it could be predicted that it had a stable interaction than other compounds so that the N '- (2-chlorobenzoyl) isonicotinohydrazide could be used as a more potent antituberculosis candidate.
Analisis In-silico Senyawa Kimia dalam Teh Hijau yang Bekerja pada Aktivator (PPAR-γ) sebagai Antiobesitas Faridah Faridah; Esti Mumpuni; Yudha Iswara Yunanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.061 KB) | DOI: 10.35814/jifi.v17i2.763

Abstract

Teh hijau dikenal banyak memiliki manfaat dan umum digunakan masyarakat sebagai antiobesitas, tetapi senyawa aktif yang berpotensi sebagai antiobesitas. Tujuan penelitian untuk mencari bahwa senyawa kimia yang terdapat dalam tanaman teh hijau mempunyai aktivitas sebagai antiobesitas pada reseptor PPAR-γ. Metode penelitian dilakukan dengan cara analisis in silico melalui molecular docking terhadap senyawa yang terdapat dalam tanaman teh hijau untuk mencari senyawa aktif dan memodelkan interaksi senyawa aktif pada reseptor yang berperan sebagai antiobesitas. Software yang digunakan adalah PLANTS, YASARA, ChemSketch, dan Pymol. Mula-mula dilakukan validasi internal pada reseptor PPAR-γ dengan kode 2ATH. Proses docking dilakukan terhadap native ligand, senyawa pembanding dan masing-masing senyawa uji dengan reseptor PPAR-γ yang sama, dan senyawa pembanding yang digunakan sebagai kontrol positif ialah Pioglitazone. Hasil penelitian menunjukan sisi aktif terdapat 3 senyawa aktif dengan sisi aktif ikatan ligan pada reseptor PPAR-γ yaitu ARG288, LYS367, PHE363, HIS323, HIS449, ILE326, MET364, LEU340, CYS285, SER342. Terdapat 3 senyawa aktif yaitu epigalokatekin-3-galat, epikatekin-3-galat dan teaflavin sebagai antiobesitas dengan mekanisme kerja mengaktivasi PPAR-γ.
Produksi Kit Immunoradiometricassay (IRMA) CA-125 untuk Deteksi Dini Kanker Ovarium PUJI WIDAYATI; AGUS ARIYANTO; WENING LESTARI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 2 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ovarian cancer is the second highest incidence after cervix cancer, but has higher fatality level than cervix cancer. Generally, patient is known suffering ovarian cancer in very late stadium, III or IV, which is almost incurable. Cancer Would be easier to cure if detected early. In blood of ovarian cancer patient, Carbohydrate Antigen-125 (CA-125), an antigenic glycoprotein, is presence in a very low concentration initially and will increase proportionally with the level of malignancy. Therefore, early detection of ovarian cancer can be carried out by measurement of low level CA-125 in the blood. The most suitable method for the measurement is immunoradiometricassay (IRMA). Our laboratoryhas developed CA-125 IRMA kit since 2003, at first in form of CA-125 IRMA kit components that consisted of 125I-CA-125 tracer, CA-125 standard, and monoclonal antibody-coated tubes. We then made assay optimization of the IRMA CA-125 kit which gave B/T value of 19.05%, NSB value of 0.53% and Working area of 0 to 200 mIU/mL. Our further Works on validation of IRMA CA-125 kit using high and low concentration quality control (QCH and QCL) showed an intra assay (n=15) CV value of 9.9% for QCL and 2.97% for QCH, While inter assay (n=7) CV value of 13.1% and 4.9% for QCL and QCH respectively. The results comply with the IAEA protocol requirement.
Percepatan Penyembuhan Luka oleh Krim Ikan Gabus (Ophiocephalus striatus) terhadap Luka Kulit Kelinci secara Histopatologi ROBERT TUNGADI; FAISAL ATTAMIMI; EVA FIRMINA SABU; EKO NUGRAHA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The aims of the study were to investigate the effect of cream containing various concentrations of snakehead fish on the duration of wound recovery and skin histology as compared to control. Samples of the study were nine rabbits divided into three groups for treatment, i.e. group I (0.5%), group II (1%), and group III (2%). Each rabbit in each group was wounded with scalpel as wide as 4 cm2 on the left and right dorsal thigh. Wound on the left dorsal was applied with snakehead fish cream (accordingly to each concentration) and the right dorsal with basic cream as control. The observations were carried out on day 3, day 6 and day 12 by measuring the wound size and taking picture of the wounded area. On the day 12, skin incision were performed on each group to observe histopathology. The data were analyzed statistically by the SPSS 15 program of repeated measures test. The results indicated that group III (2%) had significant effect on wound recovery by decreasing the wound size every day (p < 0.05). The results were confirmed by observing the skin histopathology, indicating that cream containing 2% snakehead fish could faster improve the tissue granulation as compared to the 0,5% and 1% concentration. It can be concluded that the application of 2% snakehead fish cream for 12 days can accelerate the wound recovery.
Analisis Pendahuluan Metabolit Sekunder dari Kalus Mahkota Dewa (Phaleria macrocarpa [Scheff.] Boerl.) Erlindha Gangga; Henita Asriani; Linda Novita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Callus is a cell mass which is formed by cell tissues and formed in explants surface or explants slice which divide them continuously in a controlled condition. With tissue culture method, the aim in using callus is for reproduce new plants to get the secondary metabolite which match with the secondary metabolite from the origin plants. Mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.), from Thymelaceae family is a very useful plant which can be used for medicine. Its leaves and seed's skin are the most important parts that usually used. In this experiment, Mahkota’s seed is planted in germination media to get a sterile plant, and then from the plant, we take the leaves for callus initiation. We do a phytochemical filtering, TLC, and HPLC tests with this callus that we produced then we compared the result with Mahkota Dewa's leaves. From the phytochemical filtering result we found that both of them have alkaloid secondary metabolite, flavonoid saponin, tannin, steroid/triterpenoid. We also found some chromatograms which are similar in TLC and HPLC.
Natrium Alginat sebagai Polimer Mukoadhesif terhadap Daya Lekat serta Pelepasan Granul Mukoadhesif Amoksisilin Yudi Srifiana; Ari Widayanti; Nopriadi Nopriadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (462.346 KB) | DOI: 10.35814/jifi.v17i1.683

Abstract

Mucoadhesive is a bioadhesive dosage form which forms a bond with mucous membranes. Mucoadhesive dosage forms stayed on mucous membranes in prolonged time so can increase bioavailability. This study intended to determine the effect of sodium alginate as bioadhesive polymer to mucoadhesive strength of granules. The granules prepared using amoxicillin as active agent and sodium alginate as bioadhesive polymer by wet granulation method. Granule evaluation are moisture content, particle size, wash off test using rat stomach and dissolution test. Test results of total recovery F1, F2, F3, F4, F5, 540 mg, 560 mg, 580 mg, 600 mg, 620 mg. Test results of flow rate 10,78-11,75 g/second, and angle of repose 33,50-35,15°, test of particle size distribution in the range of 1410-1680 µm, moisture content from 11.07 to 13.57%, wash off test of F1, F2, F3, F4 and F5 as consecutively 12.67, 14.00, 18.67, 26.00 and 33.33%. 2-way ANOVA test to % dissolution and wash-off test results sig. <0.05, so there is a significant difference between formulas. Based on the results showed that increasing concentration of sodium alginate increase mucoadhesive strength of granules but less able to resist of drug release, and the best formula is F3 that containing sodium alginate 580 mg.

Page 40 of 73 | Total Record : 721

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