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<![CDATA[Pemberian Jus Mentimun (Cucumis Sativus Linn) Pada Penderita Hipertensi Wanita Usia Produktif ]]>
<![CDATA[Zul Fikar Ahmad]]>;
<![CDATA[Siti Surya Indah Nurdin]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v1i2.2663
<![CDATA[Hypertension is one of the public health problems that cause mortality and inability to reach life expectancy. The aim of the research is to assess the effect of juice cucumber (Cucumis sativus Linn) on blood pressure of hypertension patients. The research used a quasi experiment design with Non-Randomized Control Group Pre-test Post-test Design. The populations include pre-hypertension and hypertension grade I patients of women childbearing age in the working area of Telaga Biru Health Centre of Gorontalo Regency. The samples were 42 pre-hypertension and hypertension grade I patients. They were divided into two groups, a group given cucumber juice without seeds and another group given cucumber juice with seeds. The data were analyzed using Paired-samples t Test and Independent-samples t Test. The result of the study indicate that giving cucumber juice without seeds decrease of systolic blood pressure by 18,524 mmHg (p = 0,000) and decrease diastolic blood pressure by 8,905 mmHg (p = 0,000). Giving cucumber juice with seeds could decrease systolic blood pressure by 15,952 mmHg (p = 0,000) and diastolic blood pressure by 7,571 mmHg (p = 0,000). There was no difference between giving cucumber juice without seeds and giving cucumber juice with seeds in the decrease of systolic blood pressure (p = 0,257) and the decrease of diastolic blood pressure (p = 0,414). This shows that giving cucumber juice can decrease blood pressure.]]>
<![CDATA[Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar ]]>
<![CDATA[Nuralifah Nuralifah]]>;
<![CDATA[Wahyuni Wahyuni]]>;
<![CDATA[Parawansah Parawansah]]>;
<![CDATA[Ulan Dwi Shintia]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Volume 2 Edisi 1 2020 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v2i1.2704
<![CDATA[Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.]]>
<![CDATA[Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span ]]>
<![CDATA[Muhamad Handoyo Sahumena]]>;
<![CDATA[Suryani Suryani]]>;
<![CDATA[Neni Rahmadani]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v1i2.2660
<![CDATA[Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.]]>
<![CDATA[Hubungan Dukungan Keluarga dengan Kepatuhan Pengobatan Pasien Rawat Jalan Skizofrenia di RSUD Banyumas ]]>
<![CDATA[Alfu Wa Ichda]]>;
<![CDATA[Laksmi Maharani]]>;
<![CDATA[Masita Wulandari Suryoputri]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v1i2.2661
<![CDATA[Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga dengan kepatuhan pengobatan pasien rawat jalan skizofrenia di RSUD Banyumas. Teknik pengambilan sampel secara total sampling selama 1 bulan dengan jumlah 35 pasien dan caregiver. Dukungan keluarga diukur menggunakan Kuesioner Dukungan Keluarga dan kepatuhan pengobatan diukur menggunakan kuesioner MARS. Hasil penelitian dukungan keluarga diperoleh 94,3% caregiver memberikan dukungan tinggi dan 5,7% memberikan dukungan rendah, sedangkan kepatuhan pengobatan diperoleh 68,6% pasien memiliki kepatuhan tinggi, 25,7% kepatuhan sedang, dan 5,7% kepatuhan rendah. Hasil uji korelasi Spearman menunjukkan adanya hubungan yang bermakna antara kepatuhan pengobatan pasien rawat jalan skizofrenia (p]]>
<![CDATA[Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [l.] Pers) Pada Tikus Putih Jantan ]]>
<![CDATA[Yane Dila Keswara]]>;
<![CDATA[Sri Rejeki Handayani]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v1i2.2662
<![CDATA[Pain is an uncomfortable feeling caused by strong or destructive stimulation, if unchecked can affect daily routine. This study aims to determine the analgesic effect and dosage of the leaf extract ethanol, as well as to determine the effectiveness of the leaf extract ethanol as a narcotic analgesic by the Tail Flick method or as a non-narcotic analgesic by the Paw Pressure Test Randall Selitto method. Extraction was done by maceration of leaf powder with a solvent 96% ethanol. 25 male Wistar white rats were divided into 5 groups, positive group mefenamic acid 9 mg /200 g BW for the Paw Pressure Test Randall Selitto Method and tramadol 0.9 mg /200 g BW for the Tail Flick Method, negative control CMC Na 0,5%, ethanol extract leaves inggu leaves a dose of 10 mg /200 g BW, 20 mg /200 g BW and 40 mg /200 g BW. The data obtained were analyzed by ANOVA test, then LSD test was used to determine differences between groups. The results showed extract dosage of 10 mg /200 g BW, 20 mg /200 g BW, 40 mg /200 g BW had analgesic effect. Extract dosage of 20 mg /200 g BW and 40 mg /200 g BW in the Randall selitto Paw Pressure Test method is equivalent to mefenamic acid, extract dose 10 mg /200 g BW, 20 mg /200 g BW, and 40 mg /200 g BW the Tail Flick method is equivalent to Tramadol. Ethanol leaf extract is more effective as a narcotic analgesic by the Tail Flick method.]]>
<![CDATA[Hubungan Antara Peran Pengawas Menelan Obat (PMO) dengan Keberhasilan Pengobatan Tuberkulosis Paru Kategori I ]]>
<![CDATA[Selly Septi Fandinata]]>;
<![CDATA[Rizky Darmawan]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v1i2.2664
<![CDATA[TB is an infectious disease caused by Gercobacterium tuberculosis that attacks the lungs and can cause disturbances in the respiratory tract. The DOTS Program can help the achievement of successful treatment targets. The role and motivation of PMO and family are essential for the successful treatment of lung TB patients. This type of study is an analytical observational research with prospective data collection in March – May 2019, which is recorded as medical data of patients diagnosed with lung TB category I in September – November 2018 at Rubaru Puskesmas Sumenep Regency. The purpose of this research is to know the role of PMO relationship with the successful treatment of lung TB category I. With the number of samples of this research 40 patients. The results of this study using Pearson correlation statistics indicate that the value significance 0.013 < 0.05, this means a significant link between the PMO role with the success of patient treatment. The value of the correlation coefficient R obtained from 0388, the relationship between PMO role and the success of patient treatment in direct, this means that the greater the role of PMO then the higher the success of treatment, the smaller the PMO role then the lower the Successful treatment. In addition, the table also gained that the relationship between the PMO role and the successful treatment of the patient is weak due to the correlation coefficient of R < 0.4.]]>
<![CDATA[Aktivitas Antidiare Daun Harendong (Malestoma malabathricum L) ]]>
<![CDATA[ika kurnia Sukmawati]]>;
<![CDATA[Elin Yulinah Sukandar]]>;
<![CDATA[Neng Fisheri Kurniati]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Volume 2 Edisi 1 2020 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v2i1.2674
<![CDATA[Diarrhea still become main health problem especially in several developing countries including Indonesia. Hharendong leaf have been used by people traditionally as the treatment of various Gastrointestinal tract disorders including diarrhea. The purpose of this study was tested antidiarrhea and antibacterial activity of extracts and fractions of the three selected plants. The extraction was conducted using reflux method with ethanol 96% as solvent. Extract was fractinated by liquid-liquid extraction methods using n-hexane and ethylacetate solvents gradually. Antimicrobial activity assays was performed by using broth microdiluiton methods toward extract and fractions of plants selected. Escherichia coli, Shigella dysenteriae, Shigella flexneri, and Salmonella typhi. were used as microbes test. Antidiarhhea activity was tested to diarrhea animal induced by castor oil. Dosage test was given one hour before induction then carried out observations of feces (frequency, consistency and weight). Transit intestinal method was also performed in this experiment with comparing the length of the intestinal through by marker with the total length of the intestine. Antidiarrhea activity result have shown that Harendong leaf extract at the doses 50 and 100 mg/kg BW showed decreased of frequency ,consistency and weight of feces better than another extract. Ethylacetate fraction of the leaf harendong showed antibacterial activity to Shigella dysenteriae ( MIC of 128 µg/ml), dan Salmonella typhi (MIC 512 µg/ml), and fraction n-heksan of the leaf harendong showed antibacterial activity to Shigella dysenteriae and Salmonella typhi the MIC 512 µg/ml.]]>
<![CDATA[STANDARISASI PARAMETER SPESIFIK EKSTRAK METANOL BIJI KEBIUL (CAESALPINIA BONDUC L.) SEBAGAI BAHAN BAKU OBAT HERBAL TERSTANDAR ]]>
<![CDATA[Mustapa, Mohammad Adam]]>;
<![CDATA[Abdulkadir, Widy Susanti]]>;
<![CDATA[Halid, Indriany Femina]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Maret 2020 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.3731/jsscr.v2i1.4209
<![CDATA[The determination of specific parameters standardization of knicker nut (Caesalpinia BonducL.) methanol extract as the standardized herbal medicine raw materials has been carried out to ensure the quality improvement of traditional medicines and the efficacy of the plant. The purpose of this research is to determine the specific parameters of knicker nut extract so that it can be consumed as herbal medicines that have been scientifically tested. The knicker nut extract was obtained from the extraction employing the maceration method with methanol as the solvent. Specific parameters testing included extract identity, extract organoleptic, dissolved compound in certain solvents, along with extract chemical test. The results of extract identity testing show that the Latin name is CaesalpiniaBonducL. with the nut as the used part of the plant. The organoleptic test reveals that the plant is in the form of thick extract, blackish-brown in color, bitter, has pungent smell/typical smell of knicker nut, contains water-soluble compound of 10.33% with the standard deviation ±1.154707755, N-hexane-soluble compound of 3.33% with the standard deviation ±1.154707755, and methanol-soluble compound of 17.33% with the standard deviation ±3.511886957. Moreover, the flavonoids wavelengths are 382 nm (band I) and 262 nm (band II).]]>
<![CDATA[Aktivitas Antihiperkolesterolemia Ekstrak Etanol Daun Stevia Rebaudiana Bertoni Pada Tikus Putih Jantan ]]>
<![CDATA[meta kartika untari]]>;
<![CDATA[Ganet Elo Pramukantoro]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Volume 2 Edisi 1 2020 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v2i1.2700
<![CDATA[Hypercholesterolemia is a state of increased levels of LDL (Low Density Lipoprotein) and total cholesterol in the plasma. Stevia leaves have benefits to overcome hypercholesterolemia. The aimed of this study was to obtain ethanol extracts of Stevia rebaudiana Bertoni leaves which have activity to reduce total cholesterol levels in patients with hypercholesterolemia with effective doses. The method that will be carried out to achieve this goal was to make extracts by maceration of Stevia rebaudiana Bertoni leaf powder using a water solvent for 5 days. Testing antihypercholesterolemia activity by giving treatment to 20 male white rats. Rats were divided into 5 treatment groups. Group I was negative control, II was simvastatin control, III extract was 30 mg / 200 g BW, IV extract was 60 mg / 200 g BW, V extract was 120 mg / 200 g BW. The mice were induced by propylthiouracil 12.5 mg / day and high-fat feed for 21 days, after which the rats were given the test for 14 days. Cholesterol levels were measured on days 0, 21st and 28th. The method of determining cholesterol levels uses the Easy Touch tool. On the 35th day, a total cholesterol level was examined and data analysis was performed. The results showed that the ethanol extract of stevia leaves had antihypercholesterolemia activity, extract dose of 30 mg / 200 g BW had antihypercholesterolemia activity which was equivalent to simvastatin.]]>
<![CDATA[Evaluasi Pelaksanaan Standar Pelayanan Farmasi Rumah Sakit Umum Daerah Kelas C di Propinsi Nusa Tenggara Barat ]]>
<![CDATA[M Sidrotullah Sidrotullah]]>;
<![CDATA[Khairil Pahmi]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Volume 2 Edisi 1 2020 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v2i1.4514
<![CDATA[Pharmacy as a place for a main and professional service in hospital has the important role for supporting quality health services. One attempt to improve the quality of pharmaceutical care was by implementing the standards of hospital pharmaceutical care. The research aimed at finding out illustration of the implementation of pharmaceutical care standard at Local Public Hospitals Class C in Nusa Tenggara Barat province, as well as supporting or obstacle factors in the implementation.This research was a descriptive study. The study was conducted in three local public hospitals class C in Nusa Tenggara Barat province. Data was collected by using interview method of pharmacy hospital service standard. This interview comprises seven standards that are divided in twenty three parameters. The Pharmacy Department is agree with standard if the percentage of mean score was more than 75%, the other way it is not agree with standard if the percentage of mean score was less than 75%.The research result showed that the implementation of pharmaceutical care standard at Local Public Hospitals Class C in Nusa Tenggara Barat province had not implemented well yet, which could be seen from the result showing the percentage of standard achievement of three hospitals were less than 75 %. The percentage of standard achievement of hospital A was 52, 12 %, hospital B was 54, 78 %, and hospital C was 44, 35 %.]]>
