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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Evaluasi Penggunaan Antibiotika Profilaksis Operasi Digestif Laparatomi Selly Septi Fandinata; Eziah Ika Lubada; Ilil Maidatuz Zulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13496

Abstract

Laparotomy is a major operation and causes a lot of injuries, so the risk of infection of the laparotomy surgery wound is quite high. Surgical Site Infection (ILO) or Surgical Site Infection (ITP). Prevention of postoperative infection in patients with clean-contaminated surgery, and some clean operations with the use of prophylactic antibiotics. The purpose of this study was to evaluate the use of prophylactic antibiotics in patients with laparotomy surgery in a hospital in Surabaya. The research method is descriptive operational with retrospective data. The results of this study obtained as many as 160 patients aged 46-55 years at 20.6%, the sex of the respondents were dominated by male sex 66.3%, and the diagnosis of generalized peritonitis was 46.9%. The use of prophylactic antibiotics is class I cephalosporin antibiotics (cefazolin) with a dose of 1000-2000 mg, which is by the 2011 Ministry of Health guidelines.
Pengaruh Pemberian Ekstrak Kulit Pisang dan Kulit Nanas terhadap Kadar Kalium Tikus Putih Wistar Hiqbar Hiqbar; Hadi Kurniawan; Pratiwi Apridamayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13633

Abstract

The waste of banana peels and pineapple peels in its utilization is still very lacking, even though it has the potential to be developed because they have high potassium as potassium intake in the body. The combination of banana peel extract and pineapple peel extract is expected to have a synergistic effect as a potassium supplement. The purpose of this study was to determine serum potassium levels of rats (Rattus norvegicus L.) Wistar with banana peel and pineapple peel extracts. Banana peel and pineapple peel were extracted using the infusion method. The test animals used male and female Wistar rats. The control group was given glucose and sucrose bases, the test group was given doses of 100, 400, and 1000 mg/KgBW of banana peel and pineapple peel extract with glucose and sucrose bases, and the control satellite group and satellite dose of 1000 mg/KgBW. The results of all groups showed normal levels of potassium in blood serum. Potassium levels between each group did not show a significant difference (p≥0.05) in male and female rats. Conclusion: administration of banana peel and pineapple peel extract did not affect the serum potassium level of Wistar rats.
Histopatologi Organ Pankreas Tikus DM tipe 2 yang diberi Ekstrak Etanol Daun Gedi Merah (Abelmoscus manihot L. Medik) Nuralifah Nuralifah; La Ode Muhammad Fitrawan; Parawansah Parawansah; Mesrawati Trisetya
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13566

Abstract

Gedi Merah leaf (Abelmoschus manihot L.Medik) is a tropical plant used by the community as a traditional medicine to reduce cholesterol, hypertension, and antidiabetic levels. Diabetes mellitus is a disorder of carbohydrate, protein, and fat metabolism due to a lack of the hormone insulin so that glucose in the blood increases which is characterized by changes in the histopathological structure of the pancreatic islets of Langerhans. The purpose of this study was to see the histopathological description of the pancreas in male white rats (Rattus norvegicus) Wistar strain model of type II diabetes mellitus by administering ethanol extract of red gedi leaves (Abelmoschus manihot L.Medik). Modeling of diabetes mellitus in experimental animals was carried out by administering a high-fat diet and intraperitoneal induction of streptozotocin 30 mg/kg. After modeling, male rats were grouped into 6 treatment groups, namely a normal control group, a positive control group, a negative control group, and a group that was given the ethanol extract of red gedi leaves at a dose of 75 mg/kg BW, 150 mg/kg BW 300 mg/kg BW. The results of the histopathological examination of the pancreas and the number of endocrine cells showed that the ethanolic extract of red gedi leaves (Abelmoschus manihot L.Medik) was effective in repairing pancreatic cells and regenerating endocrine cells in the islets of langerhans.
Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac Gabena Indrayani Dalimunthe; Ricky Andi Syahputra
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.11914

Abstract

Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.
Identifikasi Kandungan Senyawa Antioksidan Ekstrak Daun Bidara (Ziziphus mauritiana Lamk.) Dengan Menggunakan Metode DPPH La Sakka; Rahmatullah Muin
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13518

Abstract

Bidara is a plant that is known to be rich in antioxidants and is a plant that can withstand extreme temperatures and is able to survive in a rather dry environment. Bidara leaves are included in the type of compound leaves where these compound leaves have branching stalks and on the stem branches there are leaf blades, on one stalk there are more than one leaf blade, a compound leaf is considered to come from a single leaf whose incision is so deep that the the leaves between the nicks are separate from each other and each is a separate little strand. The purpose of this study was to determine the level of antioxidants contained in bidara leaf extract (Ziziphus mauritiana Lamk) using the DPPH method. The method used is the DPPH method (2,2-diphenyl-1-picrylhydrazyl). This test consisted of 4 concentration treatments, namely, 50 ppm, 100 ppm, 150 ppm, and 200 ppm with each comparison of vitamin C with a concentration of 2 ppm, 4 ppm, 6 ppm and 8 ppm. By testing using Uv-Vis Spectrophotometry. The results of this study obtained a linear equation Y = 0.0005x + 0.4172, so the IC50 value is 119.84 (μg/ml), this means that the level of antioxidant activity of bidara leaf extract is moderate.
Efektivitas ekstrak etanol bayam merah (amaranthus tricolor l.) Terhadap glukosa darah Tikus putih ( rattus novergicus) jantan Yang dipapar dengan asap rokok suryanita suryanita; Ferna Indrayani; Muhammad Asri
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13507

Abstract

Research has been carried out on the effect of giving ethanol extract of red spinach (Amaranthus tricolor L.) on blood glucose of male white rats (Rattus novergicus) exposed to cigarette smoke for an interval of 15 days with the administration of ethanolic extract of red spinach. This study aims to determine the effect of ethanol extract on blood glucose levels of male white rats which were divided into 4 groups. Group I as a positive control that was not given any treatment, group II was given ethanolic extract of red spinach 200 mg/kg BW, group III was given ethanolic extract of red spinach 400 mg/kg BW, and group IV as a negative control was only given cigarette smoke exposure without any treatment. extract administration. From the research that has been done, the results of the decrease in blood glucose in group I is 63,3 mg/dl, group II is 98 mg/dl, group III is 116 mg/dl, and group IV is 155 mg/dl. Based on the results obtained, it can be concluded that the decrease in blood glucose caused The most effective is red spinach ethanol extract with a concentration of 200 mg/kg BW, which is 98 mg/dl.
Penggolongan Obat Berdasarkan Peresepan Obat Asma Di Instalasi Rawat Jalan RSUD Dr Agoesdjam Ketapang Defiga Kasrin; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13648

Abstract

Asthma was included in the top ten causes of morbidity and mortality in Indonesia. The priority of asthma treatment so far is to control symptoms. Therefore, the classification of drugs based on asthma drug prescribing is very necessary. This study aims to determine the characteristics and classes of drug prescribing in outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. This research method was carried out in December 2021-January 2022 with a retrospective descriptive method, data obtained from medical record cards of outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. The data obtained are presented in the form of percentages, average values and tables. The results showed that of the 61 outpatient asthma patient medical records analyzed by the percentage data, the majority of patients were women (59%) and at the age of 42-49 years (31%). The most widely prescribed drug group was beta-2 agonist (48%) with the most common dosage form being inhalers (51%) and the route of drug use was inhalation (51%). The conclusion is that the use of drugs in asthma patients in the outpatient installation of RSUD Dr. The majority of Agoesdjam Ketapang are women. The majority occurred at the age of 42-49 years, the most widely used drug class was the beta-2 agonist group with the inhaler dosage form and the inhalation route was the most widely used.
Evaluasi Mutu Pelayanan Kefarmasian Berdasarkan Standar Pelayanan Minimal (Spm) Di Instalasi Farmasi Teti Sutriyati Tuloli; Widy Susanti Abdulkadir; Nur Rasdianah
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.9668

Abstract

Quality refers to compliance with predetermined standards or by requirements. The minimum service standard (MSS) in the health sector at the hospital is crucial because it is a measure of the hospital's performance of health services. This study was intended to describe the service quality in the pharmacy installation of Toto Hospital in Kabila based on four indicators of minimum pharmacy service standards, viz. drug waiting time for treatment completion, the absence of drug administration errors, customer satisfaction, and prescription writing according to the formulary. This descriptive cross-sectional research involved 154 outpatients and inpatients for the category of prescription writing according to the formulary and 154 outpatients for other categories as respondents as samples. Besides, the instruments were a customer satisfaction questionnaire and observation sheet. The results showed that the indicators of waiting time were nine minutes seven seconds and 18 minutes six seconds for concocted drug treatment; there was no error in administering drugs by 100%; customer satisfaction was 86.9%, and; prescription writing according to the formulary was 92.7%. . It was concluded that the Pharmacy Installation of Toto Hospital had not met the specified Minimum Service Standards (MSS).
Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes Fahmi Sadik; A. Rifqah Amalia Anwar
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13310

Abstract

Gotu kola (Centella asiatica L.) is empirically used as a medicinal plant and scientifically it can be used to treat various diseases based on the results of the Scientification of Herbal Medicine. Gotu kola leaf (Centella asiatica L.) is one of the potential medicinal plants that can be used as herbal medicine because it contains various kinds of nutritious compounds. Because of the many benefits of gotu kola leaves, it is necessary to standardize the extract to ensure the quality associated with the identity substance, and the composition of the chemical content whose specifications are stated in the monograph as a quality requirement listed in Materia Medika Indonesia. Standardization includes organoleptic test, identification of chemical content, determination of water soluble extract content, ethanol soluble extract content and other tests, namely seeing the activity of gotu kola as an antidiabetic. The results and data on the characteristics of the specific parameters indicated that the extracts made had met the requirements of the herbal pharmacopoeia, which means that the ethanolic extract of gotu kola had met the standards, and based on activity testing it was known that the leaf of gotu kola (Centella asiatica L.) was efficacious as antidiabetic.
Perbandingan Aktivitas Ekstrak Etanol Kulit Pisang Kepok Kuning Dengan Ekstrak Etanol Kulit Pisang Kepok Mentah Terhadap Bakteri Salmonella typhi Penyebab Tifus Andi Nurpati Panaungi; La Sakka
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13528

Abstract

Research has been carried out by testing the antibacterial activity against Salmonella typhi using the diffusion method on NA medium with 3 times replication. Each concentration used was 1.25%, 2.5% and 5.0%. The results obtained show the zone of inhibition around the paper disk with different diameters for each concentration. For raw kapok banana peel with a concentration of 1.25% is 9.82 mm, 2.5% concentration is 10.54 mm and 5.0% concentration is 11.39 mm, while the positive control chloramphenicol is 14.14 mm and the control negative, no inhibition was found and for yellow kapok banana peel with a concentration of 1.25% was 6.67 mm, 2.5% concentration was 7.47 mm, 5.0% concentration was 8.58 and positive control chloramphenicol was 14, 5mm. So it can be concluded that the ethanol extract of raw kepok banana peel (Musa paradisiaca L) has a greater inhibitory power than yellow kapok banana peel (Musa paradisiaca L) against the growth of Salmonella typhi bacteria. It is hoped that further researchers will be able to conduct research on other microbes

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