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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 230 Documents
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Penyakit Ginjal Kronis : apakah pola makan berbasis nabati efektif? Wawan Kurniawan; Nany Hairunisa; Gerie Amarendra
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.373-382

Abstract

Chronic kidney disease (CKD) is a global problem whose number of sufferers is increasing. Various methods have been widely used to prevent worsening of kidney function. In addition to controlling causative factors, diet planning also plays a role in improving kidney function. Confining protein utilization has long been a foundation of wholesome treatment for patients with CKD. In any case, the suggested sum of dietary protein admissions may change between consensus. A vegan who eats less that's exceptionally low in protein has appeared to diminish the chance of kidney failure in patients with progressed CKD. These findings indicate that protein sources can also influence the improvement of kidney function. Dietary medications play a good part in the management of CKD and avoiding or postponing kidney replacement therapy. The study proposes that a plant-dominant low-protein diet (PLADO) of 0.6–0.8 g/kg/day composed of >50% plant-based sources, managed by nutritionists prepared in non-dialysis CKD care, is promising and reliable with the exactness diet. Plant-based Very low-protein diets may inhibit decreased eGFR (estimated glomerular filtration rate) and the need for renal replacement therapy. This literature review aims to find evidence about the effectiveness of plant-based diets in treating cases of chronic kidney failure.
Emerging Threats in the Age of Pandemics: A Focus on COVID-19 and the Novel Sub-Variant EG 5 ("Eris"): Review Article Raghda Alsayed; Hamsa Thamer; Seenar Hameed; Mohammed Kadhom; Nany Hairunisa; Husnun Amalia; Yasmine Mashabi; Dina Ahmed; Sarah Mahdi; Amani Husain; Israa Salman; Emad Yousif
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.262-267

Abstract

This paper draws attention to a recently identified sub-variant of SARS-CoV-2 known as EG 5, colloquially named "Eris," designated by the World Health Organization (WHO) as a variant of interest. The organization has urged nations to monitor and respond to the spread of this sub-variant since its identification on February 17, 2023. The discovery of the EG 5 variant, a sublineage of the Omicron variant, has introduced new challenges. Designated a "variant of interest" by the WHO, EG 5 carries distinctive genetic mutations, including an additional F456L amino acid mutation in the spike protein. Global prevalence has doubled, raising concerns about increased transmissibility. Although specific symptoms of EG 5 are not yet fully characterized, the variant has spread to 51 countries, with over 7,000 reported cases by August 15, 2023. The manuscript also explores the unique situation in Iraq, where, as of August 17, 2023, no EG 5 cases have been officially recorded. However, challenges such as self-treatment at. As the world grapples with the ongoing challenges of the COVID-19 pandemic, understanding the dynamics of emerging variants is crucial for effective public health responses and the development of targeted interventions.
Hubungan Flat Foot terhadap Kelincahan pada Anak Usia 7–10 Tahun Nuryani Sidarta; Ririn Afyora
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.52-60

Abstract

Background Lower extremity deformity could cause changes in the anatomical structure of the body, one of which was a flat foot. It was stated that 90%  of the clinic visits for foot problems were related to flat foot.  Studies still showed controversy regarding the relationship between flat foot and agility especially in children. This study aims to see the relationship between the incidence of flat foot and the level of agility in children aged 7 to 10 years. Methods A cross-sectional study was conducted on children aged 7-10 years who attend primary school in  Jakarta. Sampling used simple random sampling with inclusion criteria for research subjects who had a normal BMI, were cooperative, and were willing to take part in the study. Exclusion criteria included children with special needs, children with pain or a history of lower extremity injuries, those having a cavus foot, and children in unhealthy conditions. The research was carried out from February to April 2023. Assessment of flat feet used the wet footprint test and shuttle run test was being used to measure the children’s agility. Bivariate data analysis used the Chi-square test with a significance level of p <0.05. Results As 168 respondents were studied, it was found that 58.3% had flat feet. Measurement of agility with the shuttle run test results in 51.8% of respondents who have below-average agility. The results of the Chi-Square test showed that there was a significant relationship between flat feet and agility (p<0.05). Conclusions There is a relationship between flat foot and agility in children aged 7-10 years.
ST-Depresi pada Infark Miokard Akut dengan Elevasi Segmen ST–Pentingnya Perubahan Resiprokal pada Elevasi Segmen ST yang Minimal Risalina Myrtha; Matthew Aldo Wijayanto; Desy Puspa Putri; Berty Denny Hermawati
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.339-344

Abstract

Coronary artery disease remains the leading cause of mortality globally. Management of ST-elevation myocardial infarction (STEMI) starts from the point of first medical contact. Time delay to treatment influences the mortality in STEMI patients. The aim of this study is to underline the importance of reciprocal ECG changes in helping diagnosis STEMI with subtle ST elevation. We present an obese and hypertensive male patient with atypical symptoms of MI and was diagnosed as peptic ulcer. The ECG showed subtle ST elevation in inferior ECG leads and reciprocal changes in I and aVL. Highly sensitive troponin was elevated. Serial ECG showed evolution, thus revealed acute inferior MI. Successful percutaneous coronary intervention was performed. ECG is one of the most important diagnosis tools in STEMI and a cornerstone to direct the decision to immediate reperfusion therapy. Minimal ST-elevation often leads to inappropriate diagnosis, thus delayed the time to reperfusion. A study shows that 11-23% of STEMI do not reach the cutoff for accepted ECG criteria. In a study of infarctions with minimal ST-elevation, reciprocal changes are reported in 58% of all cases. Reciprocal ECG changes is extremely useful to help identifying STEMI in the absence of obvious ST-elevation on ECG
Efektifitas Ekstrak Daun Sirsak (Annona muricata L) Dalam Terapi Kanker Payudara Pada Jalur Apoptosis Ramadhani, Nadhira Tsurayya; Maharani, Putri; Wahono, Shafira; Maharani, Tasya Aulia; Adenina, Masayu Syarinta
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.79-86

Abstract

Breast cancer is one of the leading causes of cancer-related mortality in Indonesia. The number of new breast cancer cases has reached 68,858 cases (16.6%) out of a total of 396,914 new cancer cases. Conventional approaches to cancer therapy include surgery, radiation, and chemotherapy. However, these treatments are often expensive and associated with significant side effects. As a result, various preventive and therapeutic efforts have been developed, including the use of herbal plants with potential anticancer properties such as Annona muricata L. Therefore, a more in-depth review of this compound is needed. This article is based on data retrieved from databases such as PubMed, ScienceDirect, ClinicalKey, and Google Scholar using the keywords: “Annona muricata L.”, “breast cancer”, “acetogenin”, “apoptosis”, and “oxidative stress”. Articles in English or Indonesian within the last 10 years were included. The literature review revealed that Annona muricata L. contains active compounds, primarily acetogenins, which exhibit cytotoxic activity through the induction of apoptosis. Acetogenins act by inhibiting mitochondrial complex I (NADH dehydrogenase), resulting in decreased adenosine triphosphate (ATP) production, energy stress, and subsequently, apoptosis induction. In addition, acetogenins affect the intrinsic apoptotic pathway by downregulating anti-apoptotic proteins such as Bcl-2 and Bcl-xL, while upregulating p53 gene expression, which plays a key role in activating the extrinsic apoptosis pathway. Another mechanism is its ability to reduce oxidative stress by enhancing the activity of antioxidant enzymes, thereby protecting normal cells from free radical-induced damage. However, to date, studies of Annona muricata L. as an adjuvant therapy for breast cancer remain limited—especially regarding its long-term use and effects on normal cells. Therefore, Annona muricata L. holds potential as an adjunct therapy in the treatment of breast cancer. Further research is needed to determine the appropriate dosage, long-term effectiveness, and potential side effects, particularly in breast cancer patients.
Indek Matos-Carvalho sebagai Perbandingan dengan Indeks Diskriminan Lain pada Talasemia Beta Awal Mulyadi Mulyadi; Mulyati Mulyati; Tri Ratnaningsih; Nur Imma Harahap; Indra Lesmana; Niken Satuti Nur Handayani
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.208-217

Abstract

Background Microcytic hypochromic anemia is the most common type of anemia found in Beta Thalassemia Trait and Iron Deficiency Anemia, posing a diagnostic challenge due to their similar presentations. Diagnostic errors among them can lead to incorrect treatment, potentially resulting in fatal outcomes. In Indonesia HPLC (High Performance Liquid Chromatography) usage as gold standard for discrimination between these diseases are expensive. Discrimination indices offer an alternative for cheaper and effective initial screening. However, a comprehensive performance evaluation of those indices, such as Matos and Carvalho indices, alongside Mentzer index, Green and King index, England and Fraser index, RBC index, Shine and Lal index, and Srivastava index, has not been conducted in Indonesia. This study aims to determine the best discriminative performance index based on the highest Youden’s indes value between those seven indices. Methods Study consisted of 30 subjects of beta thalassemia trait and 35 subjects of iron deficiency anemia. Index calculations were performed using blood profile formulas and compared with gold standard test results to find each index sensitivity, specificity, and Youden’s index value. Results Matos and Carvalho indices exhibited superior discriminatory performance, achieving 80% sensitivity, 77.1% specificity, and a Youden's index of 57.14%. Among other indices, the RBC index demonstrated the highest sensitivity (90%), while the Green and King index excelled in specificity (97.14%). MCV and MCH values did not significantly differ between BTT and IDA groups. Conclusions The study's findings underscore the efficacy of Matos and Carvalho indices in discriminating BTT and IDA in this study population, highlighting their potential as valuable tools in initial screening efforts.
JN.1 COVID-19: Variant of interest Husnun Amalia; Yasmine Mashabi
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.261-263

Abstract

Corona Virus Disease-19 (COVID-19) is an acute respiratory syndrome caused by the Coronavirus 2 (SARS-CoV-2) virus. WHO groups the SARS-CoV-2 virus into two categories, namely a variant of interest (VOI) and a variant of concern (VOC). The VOI category is given if there is a new mutation with predictable phenotypic implications and must be fulfilled by one mutation that causes local transmission or causes multiple clusters or is detected in several countries. In September 2023, a new variant of COVID-19 was detected in the United States, namely JN.1 as VOI. This variant is a variation of the BA.2.86 variant with the only difference being the mutation of 1 spike protein, namely the addition of the L455S protein in the JN.1 variant. This variant has the potential to evade the immune system. Globally, there has been a rapid increase in the number of sufferers, especially in 3 WHO regions, namely America (AMR), West Pacific (WPR) and Europe (EUR). However, the effectiveness of the monovalent vaccine against this variant can still protect sufferers. Several studies show that the risk of hospitalization is low in the case of elderly and young patients.
Perbedaan Fungsi Sistolik Ventrikel Kanan antara Hipertensi Arteri Pulmonal dan Hipertensi Vena Pulmonal Rayhansyah, Vito; Yanni, Mefri; Irramah, Miftah; Hamdani, Rita; Revilla, Gusti; Linosefa, Linosefa
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.14-25

Abstract

Background Pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) are both associated with increased right ventricular (RV) afterload, potentially leading to RV systolic dysfunction. Despite its prognostic value in predicting right heart failure (RHF), echocardiographic evaluation of RV function remains underutilized in the routine assessment of patients with PAH and PVH. Methods This study aims to evaluate differences in RV systolic function between PAH and PVH patients. A total of 116 patients (58 PAH and 58 PVH) were selected through consecutive sampling from medical records at RSUP Dr. M. Djamil Padang. Echocardiographic parameters were analyzed using appropriate statistical tests based on data distribution and type, including Chi-square, Fisher’s exact, and Mann-Whitney U tests. Results Significant differences were observed between PAH and PVH groups in terms of tricuspid regurgitation (TR) severity (p = 0.003), tricuspid annular plane systolic excursion (TAPSE) (p = 0.013), and tissue Doppler-derived systolic velocity of the tricuspid annulus (S′) (p = 0.001). No significant differences were found in ejection fraction (EF), systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP), or TR velocity (TR Vmax). Overall, RV systolic function differed significantly between the PAH and PVH groups (p = 0.006). Conclusions The findings demonstrate a statistically significant difference in RV systolic function between patients with PAH and PVH. These results underscore the need for more comprehensive and routine echocardiographic evaluation of RV function in these populations to enhance risk stratification and management.
Perbandingan Hasil Biometri dan Tajam Penglihatan pada Katarak Anak, Sebelum dan Sesudah Operasi Katarak Uirianto, Meiliana Angeline; Umboh, Anne; Rares, Laya; Witjaksana, Riani
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.45-54

Abstract

Background Lens disorders in pediatrics include cataracts and abnormalities in the shape, size, and location of the lens. These abnormalities are a significant source of visual impairment in children. Cataracts are responsible for nearly 10% of all childhood vision loss worldwide. Cataracts in children cause over one million cases of Blindness among Asian children. The purpose of this study is to analyze the differences in axial length (AL)—corneal curvature, and best-corrected visual acuity (BCVA) before and after surgery in pediatric cataract eyes. Methods This study used a comparative experimental analytical research design with a Pretest-Posttest on a single group without control, utilizing ocular biometry instruments and BCVA examination in pediatric cataract eyes before and after surgery. Results The BCVA and AL in 8 children showed significant differences. The average BCVA with logMAR decreased from 1.98 to 1.36 one month after surgery, with a paired t-test yielding a t-value of 2.595 and p-value of 0.018 < 0.05. Moreover, the initial BCVA average of 1.98 improved to 0.79 three months after surgery, with a t-value of 5.574 and a p-value of 0.001 (< 0.05). As for the AL, it increased from 22.21 mm to 22.57 mm one month after surgery, with a t-value of -2.475 and p-value of 0.021 < 0.05. Furthermore, the initial AL average of 22.21 mm increased to 22.75 mm three months after surgery, with a t-value of -4.375 and p-value of 0.003 < 0.05. Conclusions There were significant differences in BCVA and AL in the sample before pediatric cataract surgery, as well as one and three months after the surgery.
Pengaruh Latihan Keseimbangan Terhadap Keseimbangan Postural pada Lansia Widiyanta, Fauzyah Azzahra; Sidarta, Nuryani
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.6-13

Abstract

Background The elderly have a higher potential for injury due to reduced body stability. In Indonesia, the incidence of elderly falls is 12.9%. Factors contributing to the increased risk of falls include biological changes such as aging and sedentary lifestyle habits. Balance training is one form of exercise that is considered effective in improving postural stability in the elderly. However, the success of this exercise is highly dependent on the duration of its application. Therefore, in this study, we aimed to evaluate the effect of balance training on postural stability with a two-week training program. Methods This study used a quasi-experimental design involving 25 elderly individuals aged more than 60 years. Consecutive non-random sampling technique was applied in the selection of participants. The balance training program was implemented three times per week for a period of two weeks. The exercise protocol was based on the guidelines released by the American College of Sports Medicine (ACSM). To assess postural stability, the Timed Up and Go Test instrument was used, which was administered before and after the exercise program. Data analysis was performed using the Wilcoxon test method with a significance limit of p<0.05. Results The findings of this study indicated that the elderly group over 70 years old dominated the study participants, with the proportion of women at 56% and men at 44%. The results of the postural balance evaluation revealed that 64% of the subjects showed a low level of balance, especially in the elderly over 70 years old with female gender. Bivariate analysis gave a p value = 0.00, indicating a significant effect of a balance training program performed three times a week with an interval of days for two consecutive weeks on improving postural stability in the elderly. Conclusions Balance training 3 times a week with alternate days for 2 consecutive weeks has an effect on improving postural balance in the elderly.

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