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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 270 Documents
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Hubungan Antara Kelelahan dan Sindrom Burnout Pada Residen di Departemen Anestesiologi dan Terapi Intensif Venawati, Feni; Lubis, Andriamuri Prima; Bangun, Chrismas Gideon; Yunanda, Yuki
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.330-339

Abstract

Background Anesthesiologists in Indonesia are still in high demand. The large number of patients and the heavy workload faced by residents are accompanied by quite high pressure from various aspects, this can cause anesthesia resident participants to experience fatigue so they are prone to a syndrome called burnout syndrome. This study aims to determine the relationship between fatigue and burnout syndrome among residents in the Anesthesiology and Intensive Therapy Department, Faculty of Medicine, Universitas Sumatera Utara. Methods This study was a cross-sectional study on 106 residents that was performed using a questionnaire consisting of characteristics of study samples, translated Fatigue Assessment Scale (FAS), and Maslach Burnout Inventory-Human Service Survey (MBI-HSS). Results From the analysis, it was discovered that 50% of the residents didn’t experience fatigue with a median score of FAS 21.5, and 84.9% of the residents didn’t experience burnout syndrome with a median score of MBI-HSS was 51,84 ± 19,59. There was a significant relationship between FAS and total score of MBI-HSS, emotional exhaustion, depersonalization, and personal achievement with p-value <0.001. Conclusions There was a significant relationship between FAS and total score of MBI-HSS, emotional exhaustion, depersonalization, and personal achievement.
Pengaruh Pemberian Glukosa Oral Pra Operasi Terhadap Kadar Glukosa Darah pada Pasien Diabetes Melitus yang dilakukan operasi dengan anestesi Umum Harahap, Dhiny Yolanda; Hanafie, Achsanuddin; Lubis, Andriamuri Primaputra; Amelia, Rina
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.199-207

Abstract

Background The administration of general anesthesia during surgery can trigger the body’s stress response causing changes in regular metabolic patterns that result in hyperglycemia and ketosis. The goal of this study is to investigate how preoperative oral glucose and non-glucose administration affect patients with diabetes mellitus with blood glucose levels during surgery under general anesthesia. Methods This is a single-blind, randomized controlled trial (RCT) being carried out by the Central Surgical Installation and postoperative recovery area at Haji Adam Malik General Hospital Medan. The study sample consists of 38 patients with diabetes mellitus who underwent electively scheduled laparotomies under general anesthesia and met inclusion/exclusion criteria. For treatment group participants, mineral water containing 50 grams of glucose was administered with 400 cc. Research hypotheses were assessed using the t-test, and significant findings had p-values equal to or less than 0.05 within a confidence interval of 95%. Results The study sample had a mean age of 50.1 ± 12.73 and showed a significant effect between glucose levels before (178.47) and after (163.78) administration of maltodextrin, with a P value (0.001). No side effects were observed during or after the post-operative evaluation process conducted in this study's participants. Conclusions Patients with diabetes mellitus experience a preoperative oral glucose-induced impact on blood glucose levels.
Hubungan Kualitas Tidur dan Waktu Layar dengan Konsentrasi Belajar Siswa SMA Desnissa, Ratu Aurany; Sidarta, Nuryani
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.300-309

Abstract

Background Learning concentration is the main capital for students to receive teaching materials and indicators of the success of the learning process. One factor that contributes to study concentration is good sleep quality. The learning process in the technological time involves the use of many devices which will indirectly increase screen time and ultimately be considered to affect learning concentration. This study aimed to assess the relationship between sleep quality and screen time with the learning concentration of high school students. Methods This cross-sectional study was conducted in Serang involving 185 high school students aged 16-18 years who had good verbal and non-verbal communication skills  Sample selection is done by Consecutive Non-Random Sampling. Students who were under several conditions such as unpleasant psychological conditions (loss of family members, and loved ones), mental disorders, and psychotropic medication would not participate in this study. Data were taken directly with a PSQI questionnaire to assess sleep quality, The Army Alpha Test was used to measure study concentration, and a screen time questionnaire to calculate screen time. Data was processed and analyzed with SPSS version 22 with the Chi-Square test used to see the meaning of variable relationships. Results Out of the 185 students studied, 153 (82.7%) students had poor sleep quality and 103 students (55.7%) had high screen time exposure (56 hours/week). However, it was found that 83.2% of the students had good learning concentration. Chi-square test results ≥ showed no relationship between sleep quality and screen time with learning concentration (p>0.05). Conclusions There was no relationship between sleep quality and screen time and high school students learning concentration.
Kadar Vitamin D dengan Sindrom Mata Kering pada Karyawan Margo, Eveline; Meiyanti, Meiyanti; Kartadinata, Erlani; Kartadinata, Noviani
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.264-274

Abstract

Background Dry eye syndrome (DES) is the most common eye disease with a prevalence of around 5 – 50% of the worldwide population. In Indonesia alone, the prevalence of DES is around 27.5%. DES is a multifactorial disorder indicating that inflammation plays an important role in the pathophysiology of DES. The inflammation causes increased oxidative stress which can cause decreased tear production and inflammation on the ocular surface can cause an increase in excessive tear evaporation, causing instability of the tear film. Vitamin D has an anti-inflammation effect. The role of vitamin D in the eye through receptor vitamin D (VDR), which is expressed in the retinal pigment epithelium, retinal photoreceptors, ganglion cells layer, ciliary body, lens, cornea epithelium, and endothelium, as well as in aqueous humor, vitreous humor, and tears film. Vitamin D deficiency is said to have a contribution to DES. For that reason, this study aims to examine the relationship between vitamin D levels with DES. Methods The research design in this study was an observational analytic with a cross-sectional approach, which was followed by FK USAKTI employees in February – March 2021. Fifty-seven employees aged 25 – 60 were according to criteria and willing to take part in this study. OSDI questionnaire, Schimer’s test and tear break-up time (TBUT) were used to examine DES. Examination of vitamin D by measuring 25(OH)D levels. The data were analyzed using a chi-square test with significance level p<0.05. Results The vitamin D levels examination with DES using Schimer’s test was found to be unrelated (p=0.948), comparing vitamin D levels with the TBUT test, it was found significantly related to DES (p=0.030), meanwhile using the OSDI questionnaire was found to be unrelated (p=0.285). Conclusions There is a significant relationship between vitamin D levels and DES through TBUT examination.
Hubungan antara Asupan Magnesium dan Kekuatan Genggam pada Lansia Putra, Muhammad Iqbal Arigi; Herwana, Elly
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.275-282

Abstract

Background Elders experience an aging process that is marked by a decrease in muscle mass that can result in a decrease in overall muscle strength.  Handgrip strength is a parameter used to assess maximum handgrip which can represent an overall muscle strength. Magnesium has a role for skeletal muscles and also affects muscle performance. This study aims to measure the relationship between magnesium intake and handgrip strength in the elderly. Methods This study is an observational analytical study with a cross-sectional design, involving elders aged  60 years in elderly nursing homes as the study subjects. Elders who were able to communicate actively were included and elders who had physical disability were excluded. The Semi Quantitative Food Frequency Questionnaire (FFQ) was used for assessing magnesium intake and handgrip strength was measured using a handgrip dynamometer. Data were analyzed with Chi-Square statistical test and Fisher’s Exact Test with a significance of < 0.05. Results A group of 71 elders participated in this study. The result of this study shows that subjects with sufficient magnesium intake amounted to 18 subjects (25.4%) and 53 (74.6%) with low magnesium intake.  The distribution of subjects with sufficient handgrip strength amounted to 36 subjects (50.7%) and 35 (49.3%) with low handgrip strength.  Statistical analysis shows that there is no significant relationship between magnesium intake and handgrip strength in elders (p=0.539; p>0.05), while sociodemographic factors of age and gender showed a significant relationship towards handgrip strength (p=0.012 and p=0.028; p<0.05). Conclusions There is no significant relationship between magnesium intake and handgrip strength in elders.  Sociodemographic factors of age and gender showed significant relationships towards handgrip strength.
Pencegahan Disabilitas pada Kusta Thiodorus, Robert; Rusyati, Luh Made Mas; Sadeli, Marrietta Sugiarti
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.216-223

Abstract

Leprosy, a chronic granulomatous infectious disease caused by Mycobacterium Leprae, presents a complex challenge with profound social, physical, and economic implications. The burden of leprosy is a persistent concern in many developing countries, despite substantial control efforts. The World Health Organization (WHO) initiated the "Global Leprosy Strategy 2016-2020" to combat this issue, focusing on reducing children diagnosed with leprosy, eliminating visible deformities, and enacting anti-discrimination laws. Disability in leprosy is multifaceted and preventing disability in leprosy is a critical endeavor, such as prophylaxis, early diagnosis, and comprehensive care strategies. Vaccination with the BCG vaccine provides moderate protection, and combining it with single-dose rifampicin (SDR) can enhance its effectiveness, particularly for lepromatous cases with delayed diagnoses. Improved training for healthcare providers can facilitate early detection, reducing the risk of disability. After effective leprosy treatment, longterm morbidity remains a concern. Continued education of healthcare workers and communities is pivotal in preventing damage to hands, feet, and eyes, especially in cases of peripheral neuropathy. Disability progression is a substantial risk, highlighting the need for ongoing medical assessments, even post-MDT treatment. Restructuring primary care services to ensure quality post-treatment care is essential. Stigma remains a significant obstacle in leprosy prevention. Community awareness and stigma reduction can motivate individuals to seek treatment. Epidemiological patterns transmission within households, play a crucial role in identifying new cases. Routine examinations of household contacts of leprosy patients can expedite early diagnosis. Nutrition also plays a role in leprosy prevention. Ensuring access to nutritious food is critical to reducing the risk of developing the disease. In conclusion, the prevention of disability in leprosy is a multifaceted endeavor that demands comprehensive strategies, early intervention, awareness, and community engagement. Addressing this issue is vital for improving the quality of life for individuals affected by leprosy and for achieving a leprosy-free world.
Kadar Transforming Growth Factor- Serum Berkorelasi Positif dengan Kadar Immunoglobulin M Anti-Phenolic Glycolipid-1 pada Narakontak Serumah Pasien Kusta Multibasiler Primasari, Putu Yunita; Rusyati, Luh Made Mas; Karmila, I Gusti Ayu Agung Dwi; Winaya, Ketut Kwartantaya; Suryawati, Nyoman; Karna, Ni Luh Putu Ratih Vibriyanti
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.146-157

Abstract

Background Leprosy is a chronic progressive infectious disease. Phenolic glycolipid-1 (PGL-1) is an antigen of Mycobacterium leprae, which can trigger the host’s antibody response. Transforming growth factorβ (TGF-β) plays an immunosuppressive role when the host is exposed to PGL-1 antigen or other M. leprae antigens. This study aims to determine the correlation of TGF-β levels with IgM anti-PGL-1 levels in patients with multibacillary leprosy household contacts. Methods Observational analytical study with a cross-sectional approach. The study subjects consisted of 48 household contact subjects and 24 non-household contact subjects aged 15-65 years old who were selected by consecutive sampling based on inclusion and exclusion criteria. 3 mL of venous blood samples were taken and then examined for IgM anti-PGL-1 and TGF-β with the ELISA kit. Data analysis was carried out using SPSS version 23, and a p-value <0.05 was significant. Results The mean level of IgM anti-PGL-1 in the household contact group was 685.46 ± 290.79 u/mL, while in the non-household contact group was 345.50 ± 206.58 u/mL. The mean TGF-β level in household contact groups was 256.69 ± 127.41 pg/mL, while in the non-household contact group was 144.85 ± 36.73 pg/mL (p<0.001). This study found a moderate positive relationship (r=0.450, p<0.001) between levels of TGF-β and IgM anti-PGL-1 household contacts and non-household contacts group. Conclusions The mean level of IgM anti-PGL-1 and TGF-β in household contacts is higher than in non-household contacts, with a significant difference. There is a moderate positive significant relationship between levels of TGF-β and IgM anti-PGL-1 household contacts and non-household contacts group.
Meningkatkan Preservasi DNA asal Saliva melalui Inaktivasi DNase I: Peran Suhu dan EDTA Yamamoto, Zulham; Sulviani, Nurul; Widjaja, Sry Suryani
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.152-162

Abstract

Background Deoxyribonuclease I (DNase I) catalyzes the cleavage of double-stranded DNA into its end products. This enzyme requires cations for its activity. In addition, DNase activity is influenced by indirect DNase inhibitors (i.e. EDTA) and temperature. EDTA is an indirect DNase I inhibitor. Therefore, DNase inactivation is crucial for DNA preservation, especially for salivary samples, and the downstream application of genetic techniques using non-blood samples. Saliva is a complex mixture contaminated with oral microbes and contains DNase which is harmful for DNA preservation. This study aims to preserve salivary DNA through temperature and EDTA treatment. Methods This is an experimental study. Salivary DNA was extracted using the spin-column method. DNA degradation assays were carried out using either 5 µL of salivary supernatant or 2.5 mg/mL of DNase I which were incubated at -20°C, 2-8°C, room temperature, 40°C, and 50°C; and added with 0.125 mM, 0.25 mM, 0.5 mM, 1 mM, and 2 mM EDTA for 60 minutes. After incubation, the results were visualized using agarose gel electrophoresis. Results The average concentration of salivary DNA was 61.70 µg/mL (30.50-109.05) and the purity was 1.893 µg/mL (1.800-2.005). Incubation at -20°C, 2-8°C, and room temperature degraded salivary DNA but incubation at 40 and 50°C did not completely degrade DNA. Addition 0.125 mM, 0.25 mM, 0.5 mM, 1 mM, and 2 mM EDTA to 5 µL of salivary supernatant or 2.5 mg/mL DNase I preserved salivary DNA. Conclusions Temperature of 40 and 50°C, and 0.125 mM EDTA can inactivate DNase and preserve salivary DNA.
Pengaruh Pola Tidur terhadap Kejadian Hipertensi: Studi Kasus-Kontrol pada Nelayan di Pesisir Puger Kabupaten Jember Astuti, Nur Fitri Widya; Munawaroh, Nazilatul Wahyuni
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.34-43

Abstract

Background Hypertension prevalence in coastal areas is higher (53.3%) than in mountainous areas (6.8%). The high prevalence of hypertension in coastal areas is caused by lifestyle, one of which is poor sleep patterns. The research purpose was to determine the effect of sleep patterns on hypertension incidence in Puger fishermen. Methods This research used a Case-Control design. This research was conducted in February-March 2023. The research sample was calculated using a formula Lemeshow and there were 31 respondents in each group for a total of 62 respondents. The sampling technique used simple random sampling and the data taken included the variables hypertension and sleep patterns which consist of quality, duration, latency, efficiency, sleep disturbances, use of sleeping pills, and concentration problems during the day. Analysis data used frequency distribution for univariate analysis and tests Chi-Square and Fisher for bivariate analysis. Results The results showed that both groups had short sleep duration, it’s <7 or 8 hours. The results showed that 93.5% of fishermen in the case group experienced poor sleep patterns (score>5), while as many as 45.2% of fishermen in the control group experienced poor sleep patterns. Obtained (p-value <0.001; OR 17.6; CI 95%: 3.6-87.0), which means that the influence between sleep patterns and hypertension is the incidence in Puger fishermen and the OR value is 17.6 indicates that fishermen who have a poor sleep pattern have a 17.6 times risk attacked of hypertension than fishermen who have a good sleep pattern. Conclusions Sleep pattern is a risk factor for hypertension in Puger fishermen, so it’s recommended that respondents implement sleep patterns by optimizing sleeping hours as well and for The Puger Community Health Center to encourage respondents to utilize the facilities so they can monitor symptoms of hypertension.
Pterigium berhubungan dengan Sindroma Mata Kering pada Pengemudi Ojek Online Kartadinata, Erlani; Amalia, Husnun; Adiwardhani, Anggraeni; Witjaksana, Riani; Prasetyaningsih, Noviani; Margo, Eveline; Yohana, Yohana
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.71-81

Abstract

Background Dry eye syndrome (DES) is an eye disease caused by many factors involving the ocular surface, with characteristic damage to tear layer homeostasis accompanied by ocular symptoms due to tear layer instability, hyperosmolarity, damage and inflammation of the ocular surface, and neurosensory abnormalities. Delivery motorbike drivers are often on the streets where the role of environmental factors will be able to pose a risk of experiencing DES. This study aims to assess risk factors associated with the incidence of dry eye syndrome in delivery motorbike drivers.  The benefit of this research is to improve public health, especially in preventive behavior against factors associated with dry eye syndrome. Methods This study used observational analytical methods with a cross-sectional research design.  The selection of samples by consequential non-random sampling amounted to 124 with the criteria of inclusion of delivery motorbike drivers, exclusion of not using artificial tears eye drops, and not use of contact lenses.  Data were collected by filling out a DES risk factor questionnaire and a Tear Break Up Time (TBUT) examination to assess DES. The research data were analyzed using the Chi-Square test. Results This study's results show that subjects with dry eye syndrome are dominated by adults aged 19–44 and male sex. Subjects who experienced DES 76.6%, adult age 78.2%, male 80.6%, no pterygium 66.1%, working period 2-5 years 62.9%, length of work ≥8 hours 94.4%, always using a closed helmet 83.9%, not using protective glasses 39.5%, coffee consumption 71.8%, active smokers 66.1%, using gadgets >6 hours 91.9%.  There is no significant relationship between subjects' characteristics and DES (p>0.05). The incidence of DES in pterygium showed significant results (p= 0.001). Conclusions There is a significant relationship between the incidence of pterygium and DES.

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