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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 270 Documents
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Hubungan Antropometri dengan Sindrom Metabolik pada Pekerja Kantor di Universitas Trisakti: Studi Potong Lintang Trilaksmi, Antin; Nazma, Diani; Soesilo, Christian; Sari, Meiriani; Mahardieni, Karlina; Panduwati, Lira
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.26-34

Abstract

Background Metabolic syndrome is a disease with an increasing prevalence and a high health burden. Most individuals with metabolic syndrome have a sedentary lifestyle, such as office workers who rarely undergo health check-ups. Therefore, this study aims to investigate the profile and correlation of anthropometric indices and metabolic syndrome parameters among office workers at Trisakti University. Methods Office workers from the Faculty of Medicine, Trisakti University, were recruited for this study, and informed consent was obtained. Subsequently, data on blood pressure, laboratory tests including glucose levels and lipid profiles, as well as anthropometric measurements such as weight, height, body mass index (BMI), waist circumference, and hip circumference were collected. The data were statistically analyzed using univariate analysis and bivariate correlation analysis with Spearman's test, as well as intergroup difference tests using the Kruskal-Wallis test and ANOVA. Results The average age of the subjects was 41.46±9.87 years. The data showed that approximately 43.33% had hypertension, with a concentration of data in the profiles of grade I obesity, normotension, normal triglyceride levels, normal blood glucose levels, and normal high-density lipoprotein (HDL) levels. The analysis revealed a significant difference in HDL levels between the normal BMI group and the overweight BMI group (MD: 9.534; 95% CI: 1.68-17.39; p = 0.018). A very weak and non-significant correlation was found between BMI and metabolic syndrome parameters. Conclusions Anthropometric indices reflect central obesity as well as the characteristics of metabolic syndrome among employees at the Faculty of Medicine, Trisakti University.
Keefektifan Injeksi Toksin Botulinum Tipe A (BTX-A) untuk Terapi Neuralgia Pasca Herpes: Sebuah Tinjauan Pustaka Wijaya, Edward; Winaya, Ketut Kwartantaya; Utami, Desak Nyoman Trisepti
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.87-97

Abstract

Postherpetic neuralgia (PHN) is a common and debilitating complication of shingles, characterized by persistent pain that lasts for months to years after the resolution of the herpes zoster rash. While various treatments, such as anticonvulsants and opioids, are commonly used, they often fail to provide adequate pain relief and are associated with significant side effects. Botulinum toxin type A (BTX-A), traditionally used for muscle spasticity, has emerged as a promising treatment for PHN due to its ability to reduce pain through its neurotoxic effects. This literature review evaluates the safety and efficacy of BTX-A in treating PHN by reviewing 30 studies sourced from databases such as PubMed, Medline, and PubMed Central. The results indicate that BTX-A injections significantly alleviate PHN-associated pain, with many patients experiencing a reduction of up to 70% in pain severity. Additionally, BTX-A has been shown to improve patients' quality of life by enhancing sleep quality and reducing the need for oral medications. Although the results are promising, the review calls for further research to determine optimal dosing protocols and the long-term effects of BTX-A. Despite its limitations, BTX-A presents a potential therapeutic option for managing PHN, particularly for patients who do not respond well to traditional treatments.
Definisi Ketidakstabilan Mikrosatelit pada Kanker: apa yang harus diketahui Abdallah, Mays Talib; Al-Shakarchi, Ola E; Hussein, Asmaa A; Abdulmuttaleb, Mohammed Essam; Alsammarraie, Ahmed Zuhair; Aziz, Ismail H; Dawood, Noor Jabbar; Kadhom, Mohammed
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.98-110

Abstract

Microsatellite instability (MSI) is the result of flaws in the DNA mismatch repair (MMR) system that cause insertions or deletions in repetitive DNA sequences known as microsatellites. A hallmark of Lynch syndrome, MSI affects 8–22% of sporadic cancers, including colorectal, gastric, and endometrial carcinomas. Clinically, MSI predicts immune checkpoint inhibitor (ICI) treatment; MSI-high (MSI-H) tumors show better response rates than others. Treatment results, prognosis, and chemotherapy sensitivity among MSI-H patients show notable variation, though.  Next-generation sequencing (NGS), which concurrently evaluates tumor mutational burden (TMB) and actionable mutations, immunohistochemistry (IHC) for MMR protein loss, and PCR-based fragment analysis, defines MSI detection. Although IHC is affordable for Lynch screening, NGS provides more extensive genomic profiling. Though they need verification, new technologies such as artificial intelligence-based histomorphological analysis and single-molecule molecular inversion probes (smMIPs) are encouraging. The prognostic effect of MSI differs by cancer kind and stage. MSI-H in early-stage colorectal cancer (CRC) is linked to better survival, but less advantage from 5-fluorouracil chemotherapy. Confounding variables like BRAF mutations cloud the prognostic function in metastatic CRC. Apart from CRC, MSI-H forecasts good results in prostate, gastric, and ovarian cancers but a bad prognosis in breast cancer. Emphasizing its dual function as a diagnostic, prognostic, and therapeutic biomarker, this paper combines MSI's molecular mechanisms, detection techniques, and clinical relevance. Among the difficulties are test standardization and immunotherapy response heterogeneity resolution. Future studies should look at liquid biopsies and combination treatments to maximize precision cancer driven by MSI.
Studi Banding in-vitro terakit Efikasi Antelmintik Ekstrak Daun Pegagan (Centella asiatica) dan Daun Putri Malu (Mimosa pudica) terhadap Cacing Ascaris suum Cliffton, Cliffton; Situmorang, Evi Ulina Margareta; Dewi, Rita; Joprang, Freggy Spicano
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.35-44

Abstract

Background Nematode infections result in 60.000 deaths each year. The majority of these infections are dominated by Ascaris Lumbricoides, which is asymptomatic and is currently treated with albendazole. However, prolonged use increases the risk of drug resistance. Research on herbal anthelmintics is very much needed. Herbs like C. asiatica and M. pudica (a wild tropical plant), have proven to possess antiparasitic properties due to their anthelmintic content. Methods This research used in-vitro experiments to compare the effectiveness of M. pudica and C. asiatica herbal extracts and their concentrations on the death time of A. suum worms. Herbal extracts were obtained through remaceration techniques, and each herb was made in concentrations of 10%, 20%, and 50%. Each experimental group was given 5 A. suum worms, which were observed every hour for 24 hours. Results A total of 53.3%, 86.6%, and 93.3% of the worms died in the C. asiatica group using 10%, 20%, and 50% concentration. Meanwhile,  60%, 73.3%, and 100% of the worms died in the M. pudica group using the same concentrations. By using two-way anova to compare the effectiveness of each concentration and also to compare the two plants, it could be concluded that there was no significant difference between C. asiatica and M. pudica either in their respective concentrations (p=0.0588) or between herbs (p=0.1670). The post-hoc test carried out also showed that there was no difference in the lethal effect of the two extracts. Conclusions Both extracts exhibited similar anthelmintic effects (p > 0.05), with LC50 of 8.91% for C. asiatica and 9.33% for M. pudica.
Efektivitas Pemberian Probiotik Bifidobacterium longum Terhadap Pertumbuhan Pseudomonas aeruginosa Pada Mencit (Mus musculus) Adrian, Adrian; Wiriansya, Edward Pandu; Ikram, Dzul; Muchtar, Amrizal; Anshary, Suci Noviyanah; Karim, Marzelina; Fazdlurrahman, Fazdlurrahman; Ahmad, Izhar Fitrah; Faisal, M. Fathir; Usman, Muh. Muflih; Ilham, Muhammad
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.64-72

Abstract

Background Pseudomonas aeruginosa is an opportunistic, Gram-negative bacterium that can cause infections both acutely and chronically. Antibiotics are essential for treating acute bacterial infections. The use of probiotics is one effort to reduce the number of resistant antibiotics. One of the probiotics derived from microorganisms is Bifidobacterium longum. This study was conducted to determine the effectiveness of Bifidobacterium longum on the growth of Pseudomonas aeruginosa in mice (Mus musculus). Methods This study was conducted using the True Experimental Post-test method. The population used was 3- to 4-month-old mice, with a body weight of 20 to 40 grams, as determined by the Federer formula. The mice were fed standard food and given sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The test carried out is a test of the distribution of the number of colonies. Results Of the five groups studied, the administration of Bifidobacterium longum combined with the antibiotic ceftriaxone in the probiotic intervention group yielded an effective result (p < 0.05), as did the group that received only Bifidobacterium longum probiotics (p < 0.05). at the same time, the other group did not show an effective result (p >0.05). Conclusions Based on the study, it was explained that the administration of Bifidobacterium longum was effective as a supportive and curative group, but not as a preventive measure against the growth of Pseudomonas aeruginosa in mice.
Gambaran Schizencephaly dengan Polymicrogyria pada Berbagai Magnetic Resonance Imaging (MRI) Sekuens Tanaji, Tandy; Hendara, Farah; Marliana, Caecilia; Astien, Astien; Nareswari, Gupita; Napitupulu, Partogi; Rahmansyah, Mulia; Wahab, Revalita
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.73-78

Abstract

Schizencephaly is a rare congenital cerebral malformation within the category of neurological migration defects. Hemiparesis, developmental delays, and seizures are clinical signs that are influenced by both the size and the location of the lesion. This condition is characterized by a cleft that traverses the brain's parenchyma lined by grey-mater (transmantle cleft). In less severe cases, the cleft does not extend into the lateral ventricle. Identification of the cleft's path, accurate assessment of the cortex, and recognition of polymicrogyria are crucial for the radiological evaluation of schizencephaly. We report a case of 18-year-old male diagnosed with closed-lip schizencephaly, which supported by MRI findings. The transmantle cleft and polymicrogyria are most effectively visualized in T2-weighted and FLAIR images. The utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) sequences as well as susceptibility-weighted imaging (SWI) sequence in the context of schizencephaly currently remains uncertain, however it may be useful for ruling out other abnormalities such infarct, hemorrhagic, tumors or other vascular abnormalities. In this context, we emphasize the significance of MRI examination for diagnosing this condition and for recognizing the related abnormalities.
Human Metapneumovirus (hMPV): Tantangan Baru dalam Kesehatan Global Khairani, Rita
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.1-5

Abstract

Human metapneumovirus (hMPV) is a respiratory virus belonging to the Pneumoviridae family, first identified in 2001. hMPV is closely related to respiratory syncytial virus (RSV), causing upper and lower respiratory tract infections that primarily affect vulnerable populations, such as children, the elderly, and individuals with weakened immune systems. It often circulates seasonally during winter and early spring. The incidence of hMPV is highest in young children. It is responsible for 5-10% of acute respiratory infections in hospitalized children and causes a crude mortality rate of 9%, similar to influenza A. Symptoms of hMPV infection vary from mild upper respiratory tract infections to bronchiolitis, bronchitis, and pneumonia. Nasal congestion and runny nose, cough, sore throat, and fever are common symptoms of this infection. Wheezing is common in children and requires the use of bronchodilators. Most hMPV patients recover within 7-10 days without complications. Some groups are at high risk for severe complications such as pneumonia and multi-organ failure requiring intensive care. Currently, laboratory diagnosis of hMPV infection is done by detecting viral nucleic acid in respiratory tract specimens. Serological tests using Immunofluorescence or ELISA (Enzyme-Linked Immunosorbent Assay) can be used to detect hMPV-specific antibodies, which are helpful in retrospective diagnosis and epidemiological studies. Rapid antigen tests, although practical, can vary in sensitivity and specificity. There is currently no specific treatment, and vaccination is still in the development stage, although significant progress has been made. Prevention remains the most important aspect in reducing the impact of hMPV, focusing on infection control to limit the spread of the virus, especially in vulnerable populations.
Biomarker pada Kanker Payudara Indriastuti, Endah; Nur Fitriani, Fatimah; Djunaidi, Anwar
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.218-231

Abstract

Breast cancer is the leading cause of cancer-related death among women worldwide. A biomarker is a molecule in the body that signals an abnormal process or condition, such as cancer. Numerous studies have focused on biomarkers in breast cancer. Widely used biomarkers in clinical settings include estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), Ki67, carcinoembryonic antigen (CEA), and cancer antigen (Ca) 15-3. Currently, circulating tumor cells (CTCs) and genome sequencing are being researched and are expected to play significant roles in managing breast cancer patients. These biomarkers can be detected in various sample types, enabling detection tailored to different purposes. They are vital for diagnosis, classification, and selecting effective treatment strategies, including personalized and targeted therapies, as well as predicting treatment response and monitoring for disease recurrence. Understanding of breast cancer biomarkers has improved considerably over time. This knowledge should be applied effectively to enhance diagnosis accuracy and personalize treatment. This narrative review aims to summarize previously used breast cancer biomarkers and provide updates on those currently being developed to improve patient care and outcomes.
Trematoda Darah: Schistosomiasis pada Sistem Saraf Pusat Yuliana, Yuliana; Machrumnizar, Machrumnizar
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Schistosomiasis (bilharzia) is a disease caused by blood trematode worms of the genus Schistosoma, which can be acute or chronic. There are five species of Schistosoma (S. japonicum, S. mansoni, S. intercalatum, S. Mekongi, and S. haematobium) known to infect humans, which are distributed across a wide geographic range. Severe clinical symptoms of schistosomiasis infection on the central nervous system (CNS) are caused by the deposition of eggs when adult worms migrate abnormally to the brain or spinal cord. As a result, radiculopathy, myelopathy, increased intracranial pressure, and clinical sequelae occur. Each species shows different tendencies for atopic infections and clinical symptoms. The most common neurological symptom associated with Schistosoma mansoni or S. haematobium infections is myelopathy, while severe encephalitis is more likely to be caused by S. japonicum infections. The symptoms of encephalopathy can manifest as headache, vision disturbances, delirium, convulsions, motor limitations, and ataxia. Spinal abnormalities may lead to backache, lower limb radiating discomfort, muscular weakness, loss of sensation, and urinary impairment. Histopathological analysis, which shows granulomas and Schistosoma eggs, is necessary for a definitive diagnosis. Current management involves surgical procedures, steroids, and schistosomicide drugs. Corticosteroids are administered in the acute stage, and praziquantel is given after the female worm begins to lay eggs. If medical intervention fails to relieve compression or medullary degeneration, surgery should be postponed in some instances. The earlier a diagnosis is identified and proper therapy begins, the better the patient's outcome.
Efek Anti-Inflamasi Tanaman Avicennia : Kajian Sistematik Dinanti, Fathia Kesuma; Madusari, Benny Diah; Hernanda, Ary Setya
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Avicennia, commonly known as mangrove plants, has been traditionally used to treat various diseases, including cancer, malaria, asthma, rheumatism, and ulcers. This genus possesses a range of unique secondary metabolites, belonging to various classes, which play a crucial role in numerous pharmacological activities, including the regulation of inflammation. Although many research articles have been published on the pharmacological properties of different species within this genus, no systematic review is yet available regarding their ethnomedicinal uses in the inflammatory process. This systematic review critically discusses studies on Avicennia species that exhibit anti-inflammatory effects, providing insights and guidance for future research on the plants as potential sources of new dietary supplements or medicinal agents. A literature search was conducted using internet databases such as PubMed, Scopus, Science Direct, and PubPharm, combining keywords like “Avicennia,” “inflammation,” and other related terms, following the PRISMA 2020 guidelines. Research articles were included if they were experimental (in vitro and in vivo) studies on the anti-inflammatory effects of Avicennia species and published in either Bahasa or English between 2012 and 2024. Ten studies on the anti-inflammatory effects of Avicennia species were selected. The five species of the genus Avicennia examined in these studies are A. alba, A. marina, A. schaueriana, A. officinalis, and A. rumphiana. The anti-inflammatory effects of Avicennia were demonstrated by the inhibition of inflammatory cytokine production, nitric oxide production, and inflammation in animal models. Additionally, the secondary metabolites and antioxidant effects of Avicennia species are reported in the selected articles. The phytochemicals of several Avicennia species have been shown to exhibit strong anti-inflammatory effects. Further preclinical studies, including toxicity and pharmacokinetic assessments, are necessary before they can be considered for clinical trials. The genus Avicennia has great potential to be developed into medicinal agents for diseases related to inflammation.

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