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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
Arjuna Subject : -
Articles 270 Documents
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Korelasi Karbon Monoksida dan Derajat Rokok dengan Fungsi Paru pada Pengemudi Ojek Online Khairani, Rita; Putri, Mustika Anggiane; Setyaningrum, Dyah Ayu Woro
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.283-290

Abstract

Background Cigarette smoke is the main source of exposure to carbon monoxide (CO) besides air pollution. When cigarette smoke is inhaled, carbon monoxide is absorbed through the lungs, enters the bloodstream, and then binds to hemoglobin to form carboxyhemoglobin (COHb), whose levels in the blood can be measured as a marker of cigarette smoke absorption. Both smoking habits and CO levels can affect lung function, after smoking, blood CO levels will increase and lung function will decrease significantly. Methods This study used an analytic observational method with a cross-sectional design with a total sample of 99 respondents. Data collection in September-December 2022 using the Brinkman Index questionnaire, Fagerstrom Test for Nicotine Dependence (FTND) questionnaire, exhaled CO levels, and spirometry examination. Results 47.5% exhaled CO levels on 0-6 ppm or in a green zone, 77.8% of subjects smoked, 57.6% FTND score was 0-2, 51.5% of subjects had restricted lung function, and 79.5% subjects with obstruction. Exhaled CO levels were strongly correlated with the Brinkman index (r=0.654, p=0.000), and moderately significant correlation with the FTND score (r=0.544, p=0.000). There is no correlation between exhaled CO levels and degree of smoking with lung function. Conclusions Exhaled CO levels have a significant correlation with smoking and nicotine dependence but do not correlate with pulmonary function test.
Pengetahuan Pengemudi Ojek tentang Bantuan Hidup Dasar di Kehidupan Sehari-Hari Setelah iberikan Pelatihan Nazma, Diani; Trilaksmi, Antin; Panduwati, Lira; Devantoro, M Ridho
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.320-329

Abstract

Background Basic Life Support (BLS) is the first aid required for patient cardiac arrest and respiratory arrest, especially those occurring outside the hospital. In Indonesia, approximately 300,000–350,000 people experience cardiac arrest each year, mainly on the roads due to trauma/accidents. This research aims to determine the influence of BLS training on the knowledge and skills of the general public, especially online motorcycle taxi drivers, in providing first aid for cardiac arrest. Methods This research employs a one-group pre-post test design to compare knowledge of basic life support before and after training. The sample consists of 193 individuals, with sample selection using consecutive non-random sampling, and data collection conducted through interviews using a questionnaire. Results The research findings using the Wilcoxon Signed Ranks Test yielded a P-value of 0.001, indicating the acceptance of the alternative hypothesis (Ha). This result indicates that there is a statistically significant effect of basic life support training on the knowledge of online motorcycle taxi drivers around Jakarta. Conclusions There is a significant effect of basic life support training on the knowledge of online motorcycle taxi drivers as well as increasing the ability to act on BHD  in areas around Jakarta.
Penyakit Asbes Akibat Kerja di Indonesia: Himbauan untuk Segera Melakukan Tindakan dan Kesadaran Dwi Lestari, Ade; Hairunisa, Nany; Mohamad Ridwan, Alvin
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.224-234

Abstract

Despite many countries have either reduced or banned asbestos use, Indonesia has yet to ban the use of asbestos. Asbestos exposure poses significant health risks, particularly respiratory diseases such asbestos-related lung cancer, mesothelioma, and asbestosis known as an asbestos-related disease. According to the World Health Organization (WHO), asbestos is a major global health concern with millions of people exposed to its hazards and resulting in a significant number of deaths each year. We conducted a literature review study on the topic of asbestos-related diseases in Indonesia. Based on our findings, due to the large amount of asbestos being handled, it is expected that there should be hundreds to a thousand cases of asbestos-related disorders in Indonesia each year. Unfortunetely it is uncommon to find and diagnose cases of asbestos-related diseases in Indonesia. The lack of awareness, inadequate diagnosis, and underreporting of asbestos-related diseases contribute to the challenges faced in Indonesia. The study emphasizes the need for a comprehensive ban on asbestos, safer alternative materials, standardized medical surveillance for exposed workers, increased awareness and cooperation among stakeholders to eliminate asbestos-related diseases in Indonesia.
Hubungan Kadar Timbal (Pb) Darah Dengan Hipertensi Pada Pengemudi Ojek Chendrasari, Julian; Lestari, Indah Widya; Ilona, Florinda; Digambiro, Reza
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.17-23

Abstract

Background Hypertension is a disease that is a major health problem in developed and developing countries and is the number one cause of death in the world every year. The causes of hypertension can be divided into genetic and environmental factors. One of the causes of hypertension from environmental causes is exposure to lead. This study aims to determine the relationship between blood lead levels and hypertension. Methods The design of this research is descriptive research with laboratory analysis using a cross-sectional approach. Sample selection using a purposive sampling method. The research sample was online motorcycle taxi drivers aged >35 years, with a minimum of 1 year as an online motorcycle taxi driver. Research samples were taken at the Faculty of Medicine, Trisakti University in September 2022. Laboratory examinations were carried out at the Prodia clinical laboratory, in Jakarta. Results Of the 133 samples examined, high lead levels were found in 20 respondents (15%) and low lead levels in 113 respondents (85%). High lead levels were found in 7 respondents who had hypertension and 13 respondents with normal blood pressure. The chi-square statistical test value shows a p-value = 0.260. Conclusions Blood lead levels do not have a significant relationship with blood pressure in motorbike taxi drivers.
Gambaran Penyakit Neurodegeneratif: Huntington, Alzheimer, dan Parkinson: Sebuah Tinjauan Karlina, Ina; Andriyani, Eka Fitri Siti; Pratiwi, Arini Dian; Prasasti, Filosofia Florista Tesla Aulia; Tunjung, Woro Anindito Sri; Rohmah, Zuliyati; Nuriliani, Ardaning
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.113-123

Abstract

Neurodegenerative diseases occur due to dysfunction of the nervous system, which is accompanied by memory and movement disorders. Neurodegenerative diseases can be viewed from an etiological and pathological perspective (pathophysiological and histopathological). The most common neurodegenerative diseases are Huntington's, Alzheimer's, and Parkinson's. This review article will review the etiology and pathology of Huntington's, Alzheimer's, and Parkinson's diseases. The method used in this writing uses journals and books from Google Scholar, PubMed, ResearchGate, and the Web. The keywords used are etiology, pathology, pathophysiology, histopathology, neurodegenerative disease, Huntington's, Alzheimer's, and Parkinson's. The author limited the last 10 years of literature used. Based on a literature review, it is known that the etiology of Huntington's disease is caused by mutations in the huntingtin gene on chromosome four. The pathology of Huntington's disease is caused by unstable expansion of trinucleotide-encoded polyglutamine (CAG) repeats. One of the histopathological features of Huntington's disease can be identified from increased iron levels in the striata of the brain. The etiology of Alzheimer's disease involves interactions between genetic factors, lifestyle, environment, and the aging process. The pathology of Alzheimer's disease occurs due to the presence of apolipoprotein and its relationship to 3 mutated genes. The histopathology of Alzheimer's disease is identified by the presence of neuronal cell death, which is characterized by the shrinking of the nuclei of brain neuronal cells and the cytoplasm has a more eosinophilic color. The etiology of Parkinson's disease is progressive nerve damage to certain areas of the brain. The pathophysiology of Parkinson's disease is thought to involve a reduction in striatal dopamine, which causes an increase in inhibitory output from the globus pallidus pars interna/substantia nigra pars reticulata (Gpi/SNr), resulting in movement suppression. Histopathologically, Parkinson's disease is characterized by degeneration of neurons and neurophagia. This review concludes that Huntington's, Alzheimer's, and Parkinson's diseases can be caused by aging and genetic factors. The pathology of the disease is due to mutations, increased levels of iron, apolipoprotein, neuronal cell death, increased inhibitory output, and neuronal degeneration. The symptoms caused can be motoric, cognitive, and psychiatric.
Korelasi Karakteristik Pasien dengan Biaya Perawatan Pasien Stroke Iskemik Geriatri Nugraha, Dhanang Prawira; Aditya, Martanty
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.44-51

Abstract

Background Ischemic stroke is a degenerative condition that primarily affects the elderly and has high treatment expenses. There is no data on how much it costs to treat stroke patients in Indonesia, and there are many factors that influence the cost of ischemic stroke treatment, particularly in geriatric patients. Methods This study was conducted from October to December 2018 using a cross-sectional technique. In this study, 53 patients who met the exclusion and inclusion criteria were employed as samples. The patient's characteristics, such as age, gender, length of stay, number of comorbidities, and drug quantities, are the independent variables in this study. The cost of treatment is the dependent variable. Data was acquired utilizing data collecting sheets from hospital information systems and medical records. The Spearman test and the eta test were conducted with 95 percent confidence to determine the correlation between patient characteristics and treatment costs, and the value of R was used to determine the strength of the correlation between variables. Results According to the findings, the average cost of treatment for geriatric ischemic stroke patients was Rp 5,144,083 Rp 4,423,794. The length of stay (p-value 0.05; R=0.756), the number of comorbidities (p-value 0.05; R=0.44), and the number of drugs (p-value 0.05; R=0.60) all had a significant correlation with the cost of treatment. Conclusions The factors that significantly affect the cost of hospitalisation for geriatric ischemic stroke patients are the length of stay, number of comorbidities, and number of drugs.
Kekerasan di Tempat Kerja dalam Pelayanan Kesehatan Hairunisa, Nany
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.142-145

Abstract

Violence in the workplace is an act or threat of violence against workers, both inside and outside the workplace, ranging from insults, threats, intimidation, and physical assault to murder. Although violence in the workplace has become a global concern, the true extent of this problem is still underreported due to low awareness and lack of awareness of the issues within the body. Therefore, if violence in the workplace is not addressed, especially in the health sector, it will become a global phenomenon that will disrupt the peace and stability of the working community and pose a risk to the health and welfare of society. Therefore, this review aims to identify the risk factors and impacts of workplace violence in health care and demonstrate the collaborative efforts needed to support managing and preventing violence in the workplace.   Keywords: Violence, workplace, Healthcare worker.
Peran Intensitas Latihan dalam Hipertrofi Otot Skeletal Irawati, Nur Ayu Virginia; Sylviana, Nova; Lubis, Leonardo
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.124-132

Abstract

Endurance training, a form of physical activity that relies on continuous aerobic exercise and repetitive muscle contractions, is widely acknowledged for its positive effects on overall physical fitness. Aerobic exercise, an essential component of endurance training, has numerous benefits including improved cardiovascular and respiratory health, increased muscle endurance, and enhanced resistance against fatigue. It has also been found to contribute to skeletal muscles, potentially by stimulating the synthesis of proteins involved in muscle fiber formation. Although resistance exercise has been favored for promoting muscle growth, some suggests that aerobic exercise can also produce skeletal muscle hypertrophy comparable to that of resistance exercise if performed correctly. The duration, intensity, and specific type of aerobic exercise play important roles in determining skeletal muscle mass. The mammalian target of rapamycin (mTOR) known as a key regulator of muscle protein synthesis that associated with exercise activity. Several signaling pathways, such as Akt/mTOR and MAPK, are involved in controlling muscle protein synthesis during exercise. This review aimed to understand the impact of aerobic exercise intensity and other training parameters on skeletal muscle, to provide valuable insights for optimizing exercise programs and fostering muscle hypertrophy. In this review, we had systematically searched PubMed and Google Scholar from January 2013 to May 2023. Our result indicated that aerobic exercise can be expected to promote skeletal muscle hypertrophy and improve muscle mass and function. The regulation of skeletal muscle mass is complex, involving various signaling pathways such as mTOR, as well as the influence of hormones and growth factors.
Hubungan Parameter Laboratorium dengan Derajat Klinis COVID-19 pada Kehamilan Nirmalasari, Rully Ayu; Surjadi, Lily Marliany; Maharani, Laksmi; Lisnawati, Yuyun; Mangun, Dhea
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.291-299

Abstract

Background Pregnant women were one of the most susceptible groups because they are vulnerable to respiratory infection. They may get more severe symptoms due to their physiological changes during pregnancy including the immunological response. This study was performed to find whether there is an association between laboratory parameters (Hb, leukocytes, platelet, neutrophils, lymphocyte, monocyte, NLR, PLR and CRP) and the severity of Covid-19 infection in pregnant women. Methods This study is a retrospective cohort study using secondary data from patient’s medical records at Persahabatan General Hospital, Jakarta from March to June 2021. Results Pregnancy cases with COVID-19 in this study were in the mean of 29 year age. Most of them are in the third trimester of pregnancy. 80.5% from 67 patients have no- mild symptom while 19.5% have moderate to severe symptom. There are no difference in vital sign nor oxygen saturation at first admission. Lower level was found in the parameter of leukocyte, lymphocyte and monocyte.  Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein increase as the degree of severity increase.  The mean neutrophil in pregnant women with moderate to severe COVID-19 symptom was 80.49±7.47 while median NLR value was of 6.76 (2.73-18.71) . Conclusions Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein has associate significantly to severity symtomps of COVID-19 in pregnancy.
Metachronous Multifocal Osteosarcoma Setelah 5 bulan terapi: Metastasis atau Lesi Primer Lain? Astien, Astien; Hairunisa, Nany; Abikusno, Nugroho; Abikusno, Revalita; Agil, Nadifa; T, Febrina
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.347-353

Abstract

Multifocal osteosarcoma is a rare form osteosarcoma. It is diagnosed by having two or more lesions without any visceral damage. Osteosarcoma is characterized by having concurrent numerous lesions; the synchronous type,  and metachronous type are characterized by non-concurrent multiple lesions form. This case reports a boy 4 years old with a left femur osteosarcoma; histopathologically confirmed as chondroblastic osteosarcoma. After 5 months of chemotherapy, a new lesion was found at the left side of the cruris and pedis bones that were multiple, destructive, permeative, and exhibiting periosteal reaction. No visceral damage was found.  In this case, the patient had a primary lesion and new non-concurrently lesions and no visceral damage, as conclusion was diagnosed as metachronous multifocal osteosarcoma that had never been reported in Indonesia.

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