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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 237 Documents
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Development Of Body Lotion From Ethanol Extract Of Temulawak (Curcuma Xanthoriza Roxb) As Antioxidant H, Herlina; Desi Paramita; Pitriani; Lasmaryna Sirumapea
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2093

Abstract

Kulit, sebagai bagian terluar dari tubuh dan penjaga utama dari radikal bebas, dapat dilindungi oleh senyawa antioksidan. Lotion tubuh adalah produk kosmetik yang dioleskan pada kulit luar untuk meningkatkan daya tarik. Temulawak (Curcuma xanthoriza Roxb) mengandung senyawa flavonoid yang dapat berfungsi sebagai antioksidan, mencegah kerusakan kulit akibat radikal bebas. Penelitian ini bertujuan untuk menentukan bahwa lotion tubuh yang mengandung temulawak dapat memiliki sifat antioksidan. Penelitian ini meliputi persiapan bahan simplisia, ekstraksi etanol temulawak, pembuatan lotion tubuh dengan ekstrak etanol temulawak, pengujian stabilitas lotion tubuh, dan pengujian aktivitas antioksidan menggunakan metode DPPH. Lotion tubuh dengan ekstrak etanol temulawak pada konsentrasi 0,25%, 0,5%, dan 1% menunjukkan stabilitas pada sifat organoleptik, homogenitas, dan pH. Namun, pengamatan tentang kemampuan penyebaran dan daya lekat menunjukkan bahwa konsentrasi 0,25% lebih baik. Pengujian aktivitas antioksidan lotion tubuh dengan ekstrak etanol temulawak menggunakan konsentrasi 1% untuk mewakili formulasi pada konsentrasi 0,25% dan 0,5% dan memberikan hasil nilai IC50 sebesar 77,6435 ppm. Berdasarkan hasil ini, dapat disimpulkan bahwa ekstrak etanol temulawak (Curcuma xanthoriza roxb) dapat diformulasikan menjadi lotion dan menunjukkan aktivitas antioksidan yang kuat.
Testing The Activity Of Antimicrobial Cream Formulation Of Ethanol Extract Of Kedondong Leaves (Spondias Dulcis) Against Bacteria Propionibacterium Acnes And Staphylococcus Aureus Octora, Debi Dinha; Agnestine Jeliana Nababan; Pratiwi Christa Simarmata
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2118

Abstract

One of the causes of infection in acne is bacteria, such as Propionibacterium acnes and Staphylococcus aureus. Kedondong leaves have been used to treat diseases caused by bacteria. The purpose of this research is to: formulate a cream preparation containing ethanol extract of kedondong leaves and assess whether the cream preparation has antibacterial activity against P. acnes and S. aureus bacteria. The research method employed in this study is experimental, involving the following steps: preparation of ethanol extract of kedondong leaves using the maceration method with 96% ethanol solvent, formulation of the cream with a base consisting of cetyl alcohol, liquid paraffin, albumen vaseline, and distilled water. It is made in three concentrations of extract: F I with 10%, F II with 15%, and F III with 20%. Subsequently, the evaluation of the preparation was conducted, including physical stability evaluation, homogeneity, and antibacterial activity test against P. acnes and S. aureus bacteria using agar diffusion method with disc paper. The research results indicate that the cream has good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial cream preparation containing ethanol extract of kedondong leaves showed antibacterial activity against P. acnes and S. aureus bacteria. The average inhibition zones against P. acnes for formulations I, II, and III were 12.25 mm, 16.15 mm, and 24.15 mm respectively, while for S. aureus, the average inhibition zones were 10.75 mm, 15.45 mm, and 17.55 mm respectively, and the Positive Control (Clindamycin Antibiotic) had an inhibition zone of 30.35 mm. Based on the obtained results, it can be concluded that the cream preparation containing ethanol extract of kedondong leaves has inhibitory activity against P. acnes and S. aureus bacteria.
Study Of the Adverse Drug Reaction (ADR) On Geriatric Patients in Internal Medicine Inpatient at A Private Hospital in Bukittinggi City, West Sumatera Jannah, Miftahul; Sari, Yelly; Almasdy, Dedy
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2142

Abstract

Geriatri merupakan populasi yang beresiko tinggi mengalami efek samping obat merugikan (ESO). Hal ini disebabkan karena perubahan farmakokinetik dan farmakodinamik obat akibat penurunan fungsi organ. Penelitian ini bertujuan untuk mengetahui pengetahuan, pengalaman, penanganan dan pelaporan ESO yang terjadi pada pasien geriatrik oleh tenaga kesehatan di suatu rumah sakit swasta di Kota Bukittinggi, Sumatera Barat secara kualitatif. Pengumpulan data dilakukan melalui wawancara semi terstruktur terhadap 12 orang informan yang terdiri dari Dokter, Perawat, dan Apoteker. Topik wawancara meliputi pengetahuan informan tentang farmakovigilans dan ESO, pengalaman tentang kejadian, penanganan dan pelaporan ESO, pendapat tentang upaya yang harus dilakukan untuk menurunkan ESO. Wawancara direkam dan ditranskipsi, kemudian dilakukan analisis dengan pendekatan content analysis menggunakan software NVivo versi 12. Hasil penelitian menunjukkan sebagian besar informan belum memiliki pengetahuan yang cukup mengenai farmakovigilans dan ESO. Informan umumnya pernah menemukan ESO pada pasien geriatri selama dirawat di rumah sakit. Sebagian informan mengetahui alur penanganan dan pelaporan kejadian ESO, namun belum terlaksana dengan baik. Pendapat tentang upaya yang harus dilakukan untuk menurunkan ESO adalah dengan mengadakan pelatihan, adanya monitoring dan evaluasi, adanya diskusi dan diseminasi ilmu, mengurangi polifarmasi serta adanya SOP yang jelas.
Formulation and Antibacterial Activity Test of Ethanol Extract Gel of Laruna Root (Chromolaena odorata L.) Against Staphylococcus aureus and Propionibacterium acnes St. Rahmadani; Awaluddin, Nurhikma; Awaluddin, Akbar
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2231

Abstract

Background: The formulation of gel preparations from laruna root extract (Chromolaena odorata L.) has been carried out using Na-CMC base accompanied by physical stability tests of the gel preparations. Objectives: to determine the physical stability of the laruna root extract gel preparation and its good concentration against Staphylococcus aureus and Propionibacterium acnes bacteria. Research method: The physical stability of the gel preparation was determined based on observations of changes in color, odor, shape, pH, uniformity, spreadability, and viscosity before and after storage for 6 cycles at temperatures of 4o C and 40oC. The pH test was carried out using a pH meter and viscosity measurements were carried out using a Brokfield viscometer. Results: The results of the study showed that the laruna root extract gel preparation was declared stable in the homogeneity indicator Results: The results showed that the gel preparation of laruna root extract could be said to be stable on homogeneity parameters where there were no solid particles in the preparation. Stable in good spreading power diameter, i.e. formulas 0, I, II, and III have a diameter of no more than 5-7 cm. For the results of measuring the viscosity of the gel preparation of laruna root extract, it is said to be stable because it is not more than 2000-4000 mPaS. For pH measurement, it is said to be stable because it has a pH in accordance with the quality requirements of skin preparations, which is 4.5-8.0. Conclusion: In the antibacterial activity test, a good clear zone result was obtained at a concentration of 0.3%.
Relationship Between Working Length of Pharmacy Personnel, Working Length of Doctors and Treatment Length of Patients with the Availability of Medicine in the Era of National Health Insurance (JKN) in the Hospital Grandmed Lubuk Pakam in 2024 Pasaribu, Anita; Br Bangun, Sri Melda; Kusuma, Teja
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2252

Abstract

Background: Quality public health services must have sufficient quantities and varieties of medicines when needed. The availability of these medicines can be ensured through good pharmaceutical standards and regulations. Optimal availability of medicines is the availability of medicines that can meet patient needs. One important step in medication management is the purchase of medicines. If the purchase of medicines is not managed carefully and responsibly, for example buying more medicines than needed, it will result in wasteful budget, increased purchasing and storage costs, and medicines or goods cannot be distributed. or expired.Objectives: To find out what factors influence the availability of drugs in the health insurance era (JKN) at the Grandmed Lubuk Pakam Hospital in 2024.Research method: This type of research is quantitative and is descriptive quantitative with a cross-sectional time approach. Results: There is a relationship between the length of service of pharmacists. The length of service of doctors and the length of treatment of patients with the availability of drugs in the era of JKN at the Grandmed Hospital in Lubuk Pakam in 2024. Conclusion: The availability of medicine for the community is one of the government's commitments in implementing public health services. The efforts made by the government are certainly aimed at maintaining public health.
Implementation of Drug Logistics Management in The Pharmacy Installation of Surya Insani Hospital Pasir Pangaraian Rokan Hulu Regency Lumbangaol, Sik Fikal; Samran
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2256

Abstract

Background: The availability of drugs currently creates demand for medical services. Drug logistics management in hospitals includes stages such as planning, procurement, storage, distribution, processing, evaluation and monitoring, and are interdependent on each other so that they must be well coordinated so that each stage can run optimally. Objectives: Knowing the Implementation of Drug Logistics Management in Hospital Pharmacy Installations Surya Insani Research method: Qualitative descriptive research with a cross-sectional approach. Results: In the input  component, There is a positive and significant relationship between training and employee performance. To ensure the quality of supplies and extend the life of equipment, there must be a sufficient budget for purchasing drugs and maintaining drug storage facilities and other related equipment. Guaranteed to be sensitive to measurements and meet requirements, lighting, and calibrate certain equipment annually. In the Process component, planning, procurement, storage, distribution, processing, control. The composition of output, the availability of drugs at the Surya Insani is in accordance with demand, but there are still some drugs that are sometimes not available because the distributor or PBF warehouse runs out of stock. The results of the study also showed that the adequacy of planned drugs and the number of drugs available during the inventory period are important and appropriate when needed. In addition, at the Surya Insani Pasir Pangaraian Hospital. There are still many damaged or expired drugs. This shows that drug management, both input and drug administration processes, still need to be evaluated so that drug management at the Surya Insani Pasir Pangaraian Hospital  can be effective and efficient. Conclusion: The availability of drugs at the Pharmacy Installation of Surya Insani Hospital is in accordance with needs.
Antimicrobial Activity of Ethanol Extract of Sea Pandan Leaves (Pandanus odorifer) Against Staphylococcus aureus and Escherichia coli Rizki, Muhammad Ikhwan; Sari, Anna Khumaira; Rahma, Salsabila Fadiya; Rahmatullah, Satrio Wibowo; Izma, Hayatun
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2280

Abstract

Sea pandan (Pandanus odorifer) is used in traditional medicine in India. Sea pandan is efficacious in treating pain, parasites, digestive, liver, and cognitive disorders. Sea pandan is found in coastal areas in South Kalimantan. Sea pandan contains flavonoid compounds that have the potential to be antimicrobials. This study aimed to determine the antimicrobial activity of sea pandan leaf extract. The study began with sample preparation, which included washing the leaves, drying them using an oven, refining the particle size, extracting 70% ethanol, and evaporating the solvent until a thick extract was obtained. Total flavonoid levels in sea pandan leaf extract were determined using the colourimetric method using quercetin standards. Antimicrobial testing was conducted using the diffusion method at concentrations of 30%, 40%, and 50% against Staphylococcus aureus and Escherichia coli. The positive control used was chloramphenicol. The determination of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values ??was carried out using the dilution method. The results showed that sea pandan leaf extract contains phenolics, flavonoids, saponins, steroids, and tannins. The total flavonoid content in sea pandan leaf extract is 10.01% w/w equivalent of quercetin. The antimicrobial activity of sea pandan leaf extract against Staphylococcus aureus bacteria is 10.15 - 25.36 mm, while against Escherichia coli in the range of 8.15 - 23.16 mm. Ethanol extract of sea pandan leaves at a concentration of 50% is included in the very strong category in inhibiting Staphylococcus aureus and Escherichia coli. Ethanol extract of sea pandan leaves has an MIC value of 7.5% on Staphylococcus aureus and 15% on Escherichia coli. MBC of sea pandan extract is 15% on Escherichia coli bacteria. This study concludes that the ethanol extract of sea pandan leaves has antimicrobial activity against Staphylococcus aureus (bacteriostatic) and Escherichia coli (bactericidal).
Utilization of Cinnamon Leaves (Cinnamomum burmannii, Blume) and Effectiveness Test as Mouthwash against Oral Microbes Octora, Debi Dinha; Irwanto, Reno; Simarmata, Pratiwi Christa
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2287

Abstract

Oral health is an important aspect to pay attention to because it is part of the digestive system. Disorders in oral health function can impact other bodily health. The use of mouthwash is necessary to improve the cleanliness and health of the mouth, especially when brushing alone is not optimal. The active compounds in mouthwash enhance cleanliness and effectively inhibit the growth of pathogenic oral microflora. Cinnamon leaves have not been widely utilized and are often left unused or discarded. Previous research has been conducted on the potential of the compounds in cinnamon leaves. This research was carried out by determining the best essential oil content of cinnamon leaves through several preliminary treatments and varying distillation times. Active compounds such as cinnamaldehyde, L-linalool, and cinnamyl acetate were found in the cinnamon leaves, making them a potential ingredient for mouthwash formulation. The aim of this study is to produce an effective mouthwash that reduces the growth of pathogenic oral microflora using underutilized local materials. The mouthwash preparation method was modified from several active ingredient mouthwash preparation methods by varying the concentration of cinnamon leaf essential oil at 5%, 10%, and 15%. The formulations were then evaluated for organoleptic properties, stability, homogeneity, and antibacterial activity against S. mutans using the disc diffusion method. The results showed that the preparations remained physically stable and homogeneous during 30 days of storage at room temperature. The cinnamon leaf mouthwash exhibited antibacterial activity against S. mutans, with average inhibition zones of 15.25 mm, 19.06 mm, and 24.34 mm for formulations I, II, and III, respectively. Based on these results, it can be concluded that the cinnamon leaf mouthwash has the potential to inhibit the growth of S. mutans bacteria."
Test of the Anti-Inflammatory Effectiveness of Ethanol Extract of Cat's Whiskers Leaves (Orthisiphon Aristatus) on Paw Edema in Male Mice (Mus Musculus) Pranata, Chandra; Darmirani, Yosi; Limbing, Reida
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2289

Abstract

Cat's whisker leaves contain secondary metabolite compounds, flavonoids and essential oils. The chemical compounds contained in cat's whisker leaves have antioxidant, antibacterial, anti-inflammatory and antifungal properties. Flavonoids are known to function as anti-inflammatories by inhibiting pro-inflammatory enzymes, namely by blocking cyclooxygenase or lipoxygenase, can influence cellular signaling pathways such as NF-kB which can inhibit the migration of inflammatory cells to areas of inflammation. Objective: to test the anti-inflammatory effectiveness of ethanol extract of cat's whisker leaves in-vivo. Method: Anti-inflammatory effectiveness testing was carried out on male mice (Mus musculus) by inducing edema on the soles of their feet using 0.1 ml of 1% carrageenan. This research was an experimental study with 5 treatments and 5 replications. The parameters observed were edema volume, edema percentage, and edema inhibition percentage. Edema volume measurements were taken every 60 minutes for 6 hours. The results of measuring the volume of edema were used to calculate the percentage of edema, which was then used to calculate the percentage of edema inhibition. Data on the percentage of edema inhibition were statistically analyzed using the One Way ANOVA test. Result: the results of statistical tests showed significant differences in data on the percentage of edema inhibition and the percentage of edema between treatment groups showing p<0.05. From the results of the percentage of edema inhibition, it shows that cat's whisker leaf extract with a concentration of 15% has the best anti-inflammatory effect, namely inhibition of 88.42% is the concentration with the optimum dose.
Antioxidant and Antibactery Activity of Ethanol Extract of Selutui Puka Leaves (Tabernaemontana macrocarpa Jack.) Against Propionibacterium acnes Handayani, Fitri; Fatimah, Nurul; Ansyori, Achmad Kadri; Sari, Putri Eka; Agustina, Ika
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2290

Abstract

The selutui puka plant (Tabernaemontana macrocarpa Jack.) is a plant that has many benefits for the Dayak community in the West Kutai area, Karangan Village, Mook Manaar Bulatn District, East Kalimantan. Empirically, the Dayak tribe uses selutui puka to treat cancer, herpes, scabies, itchy skin, acne and blisters. Metabolites contained in selutui puka leaves such as alkaloids, flavonoids, tannins, saponins, and steroids have potential as antioxidants and antibacterials. Selutui puka leaf can be used as an alternative to natural acne treatment, because it is known that the use of natural ingredients has lower side effects. The purpose of this study was to determine the antioxidant and antibacterial activity of the ethanol extract of selutui puka leaves against Propionibacterium acnes. This research was conducted by experimental method. The research sample was selutui puka leaf. The research phase includes sample preparation, plant determination, simplicia manufacture, extraction, testing of antioxidant activity using UV/VIS Spectrophotometer at extract concentrations of 300 ppm, 325 ppm, 350 ppm, 375 ppm and 400 ppm. Quercetin as a positive control and comparison. The antibacterial activity test consisted of making media, culturing Propionibacterium acnes, and testing antibacterial activity using the disc diffusion method at extract concentrations of 5%, 10%, and 15%. Data were analyzed descriptively. The data from the results of this study are presented in the form of tables and figures. IC50 of ethanol extract of selutui puka leaves was 333.60 ppm with very weak category. The diameter of the inhibition zone of the ethanolic extract of selutui puka leaves against Propionibacterium acnes was 7.81 mm (5%), 7.44 mm (10%) and 8.63 mm (15%) in the medium category.

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