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INDONESIA
JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 237 Documents
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Formulation of Ethanol Extract Cream of Sikkam Leaves (Bischofia javanica Blume) as an Antifungal Against Candida albicans wulandari, Suci; Br Purba, Sri Ulina; Miranti; Zebua, Kristian Cahayani
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2293

Abstract

Skin health issues in Indonesia, including those caused by fungal infections such as (Candida albicans), can lead to various conditions like candidiasis, scabies, tungiasis, and leprosy. This study aims to evaluate the potential of sikkam leaf extract in developing an antifungal cream to combat (Candida albicans). Fungi are eukaryotic organisms that cannot photosynthesize and reproduce through branching filaments composed of hyphae. Fungi can thrive in diverse environments such as water, soil, and decaying organic matter. A cream is a semi-solid emulsion preparation in which one or more medicinal substances are dissolved or dispersed within a base. This formulation determines the cream’s effectiveness, including the optimal ethanol extract concentration needed for antifungal activity. Extraction of sikkam leaves was conducted using maceration with 70% ethanol, and creams were formulated with extract concentrations of 5%, 10%, and 15%. Data were analyzed using the Kruskal-Wallis test. The study results showed that sikkam leaf-based creams meet quality standards, including organoleptic properties, homogeneity, pH, spreadability, and physical stability. Effectiveness testing indicated that creams with 5%, 10%, and 15% concentrations produced inhibition zones against (Candida albicans) with average diameters of 6.3 mm, 9 mm, and 15.3 mm, respectively. The higher the extract concentration, the stronger the inhibition of fungal growth. The cream with a 15% concentration proved to be the most effective, with inhibition classified as strong. Thus, sikkam leaf extract shows potential as a key ingredient for antifungal cream formulations.
Combination Tea of Vernonia Amygdalina Del. Leaves and Syzygium Polyanthum Leaves as Complementary Therapy for Type 2 Diabetes Mellitus Wahyudi, Wahyudi; Sinaga, Haryanti; Tanjung, Hazira Yulistia
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2303

Abstract

Type 2 diabetes mellitus (T2DM) is a global health problem that increase every year. This study aims to test the effectiveness of a combination of African leaf and bay leaf tea as a complementary therapy for type 2 diabetes mellitus (TEDAS). This experimental research used mice induced with alloxan. Treatment and observation of antidiabetic effects were carried out for 12 days of treatment and KGD was measured every 3 days. There were 6 test groups including positive control using glibenclamide, negative control, no treatment, TEDAS1, TEDAS2 and TEDAS3. Phytochemical screening shows that TEDAS contains secondary metabolite compounds including tannins, alkaloids, flavonoids and saponins. The results showed that all TEDAS groups significantly reduced blood glucose levels. KGD examination on day 12 showed that the KGD in the group without treatment was 87, negative control 126 mg/dL, positive control 90 mg/dL, TEDASI 95 mg/dL, TEDAS2 91 mg/dL, and TEDAS3 96 mg/dL. The most effective group is TEDAS2 with glibenclamide + DA 100mg/Kgbb + DS 50mg/Kgbb treatment. Research indicates that TEDAS is effective as a complementary therapy for T2DM.
Formulation of Cushion Preparations from Duck Egg Shells and SPF Value Testing Using the UV-Vis Spectrophotometry Method Fitriyana, Rahma; Fauzi, Muhammad; Ramadhani, Juwita
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2312

Abstract

The effectiveness of a sunscreen can be indicated by the value of Sun Protection Factor (SPF), which is defined as the amount of UV energy needed. Cream is a semi-solid dosage from containing one or more medicinal ingredients dissolved or dispersed in a suitable base material. One of the compounds contained in eggshells is CaCO3. Calcium carbonate is necessary for cell regeneration and as a barrier to ultaviolet (UV) rays. This study aims to determine the potential SPF in duck eggshell, the SPF value contained in the cushion and the physical properties of the cushion preparation. Here, three variations of duck egg shell flour concentrations (4%, 8% and 16%) were made, tested in vitro using UV-Vis spectrophotometry from a wavelength of 290-320 nm every 5 nm and the absorbance was measured and the properties were tested. and physical stability (organoleptic, pH, spreadability, stickiness, viscosity, centrifugation, and Freeze-Thaw Cycling for 6 days (3 cycles) at temperatures of 40°C and 4°C). Our research results show that the duck egg shell formulation cannot be used as an SPF product. Formula 1 has an SPF value of 2.6, formula 2 has an SPF value of 3.3 and formula 3 has an SPF value of 3. The test results for the properties and stability of formula 2 with a concentration of 8% duck egg shell flour show the most stable results compared to the other 2 formulas
Test of the Anti-Inflammatory Effectiveness of Ethanol Extract Gel Preparation of Sabrang Onion Bulb (Eleutherine bulbosa) on Incisional Wounds in Wistar Rats Harahap, Hasni Yaturramadhan; Syarifuddin, Shofian; Cahya, Cucu Arum Dwi; Br Sinaga, Irma Suryani Kristina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2317

Abstract

Background: The use of medicinal plants is increasingly widespread among the community, especially due to their properties in healing various diseases. One of the developing medicinal plants is bawang sabrang (Eleutherine bulbosa), which has been proven to accelerate the healing process of wounds. Objective: To evaluate the effectiveness of administering gel extract from bawang dayak tubers on the healing process of incised wounds in rats. The test subjects used were 25 male rats. Incisions measuring 2 cm were made on the backs of the rats using a surgical knife. Method: Laboratory experimental study with a Completely Randomized Design (CRD) consisting of five treatments: one positive control (bioplacenton gel), one negative control (gel base), and three graduated concentrations of gel extract, namely 5%, 10%, and 15%. Treatments were administered twice daily for 14 days. Results: Measurement of wound diameter showed that the gel extract of bawang sabrang at a concentration of 15% and the positive control provided a more effective healing effect compared to the gel extract at concentrations of 5%, 10%, and the negative control (gel base). Conclusion: Ethanol extract of bawang sabrang is effective as a gel for healing incised wounds in rats at a concentration of 15%. The physical properties of the gel show a characteristic aroma and a golden red color, homogenous without grains or lumps, a pH of 4.9, and a spreadability of 5 cm.Keywords: Bawang sabrang tuber, Anti-inflammatory, rats, Edema.
Purification of used Cooking Oil using a Combination of Activated Carbon and Bentonite Adsorbents Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; Wiratma, Dicky Yuswardi; Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2331

Abstract

The repeated use of cooking oil at high temperatures can significantly degrade its quality, as indicated by darkened color, unpleasant odor, elevated peroxide value (PV), and free fatty acid (FFA) levels. This deterioration can contribute to health risks such as obesity, high cholesterol, heart disease, and cancer. This study investigated the effectiveness of combined activated carbon and bentonite adsorbent in reducing peroxide value and free fatty acid levels in used cooking oil. The purification method involved an adsorption process using a combination of activated carbon derived from mangosteen peel waste and bentonite. The carbonization process was carried out at 600°C for 3 hours, followed by chemical activation with H?PO? at varying concentrations of 1M, 3M, and 5M. Bentonite was activated using 5M HCl. The results demonstrated that 5 grams of activated carbon from mangosteen peel, treated with 5M H?PO?, and bentonite activated with 5M HCl, were highly effective in lowering the peroxide value and free fatty acid levels in used cooking oil. Initially, the PV of the untreated used cooking oil was 16 meq O?/kg, reduced to 3.6 meq O?/kg after treatment with the combined adsorbents. Similarly, the FFA content decreased from 2.2% to 0.09%. Both peroxide value and free fatty acid levels met the standards set by SNI 3741:2013. In conclusion, using activated carbon and bentonite is an efficient method for purifying used cooking oil, as their strong adsorption capacity effectively reduces peroxide value and free fatty acid levels.
Antibacterial Activity Test of Ethanol Extract of Torch Ginger Flowers (Etlingera elatior) Against Streptococcus Pyogenes Bacteria Causing Pharyngitis Disease in Vitro Turnip, Nur Ulina M. Br.; Sinulingga, Siska Esperanza; Sahada, Putri
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2334

Abstract

Background: In Indonesia, practically everyone has experienced pharyngitis, an illness with a relatively high prevalence. Coughing, sore throat, and trouble swallowing are all symptoms of pharyngitis. According to the WHO, pharyngitis can be caused by a range of species, with viral and bacterial infections being the most prevalent. The goal was to investigate the antibacterial activity of kecombrang flower extract in an ethanol solvent against microorganisms that cause pharyngitis, specifically Streptococcus pyogenes. Methodology: This study was conducted utilizing laboratory experimental procedures. Bacteria were cultivated on nutrient agar media, and 70% ethanol was used to extract kecombrang blossoms. The test was conducted out using the diffusion method, which involved soaking paper discs in a solution of kecombrang flower extract at concentrations of 20%, 40%, and 60% before placing them in NA media. As a positive control, amoxicillin was utilized. The incubation procedure took 24 hours and was carried out at 370 degrees Celsius. Three inhibitory zone measurements were performed on each extract and positive control. Results: This experiment revealed that the inhibition zone generated by kecombrang flower extract as an antibacterial was an average of 9 mm at a concentration of 20%, 11.6 mm at a concentration of 40%, 12.8 mm at a concentration of 60%, and 14.8 mm at the positive control, 100 mg amoxicillin tablets. Conclusion: The results show that kecombrang flower extract has antibacterial activity against Streptococcus pyogenes bacterium and is considered strong. The best ethanol extract of kecombrang flowers is at a concentration of 60%. Statistical analysis using One Way Annova revealed significant differences between treatments (p<0.05). To confirm, a Post Hoc Tukey (HSD) test was used.
Antiinflamation Activity Test of Keji Beling (Strobilanthes crispa (L.) Blume) Leaves Extraction on White Mencites (Mus musculus) Purba, Novandi; Lubis, Kholilah Putri
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2340

Abstract

Background: Inflammation often occurs in According to data from WHO, 2004) the number of people with bone inflammation worldwide reached around 11.9 million people. In high-income countries, around 1.3 million people experience bone pain, while in low to middle-income countries, the prevalence reached 5.9 million. In Southeast Asia, there are 4.4 million people with arthritis. In North Sumatra, the prevalence of arthritis according to the diagnosis of health workers is 8.4%, while based on diagnosis or symptoms it reaches 19.2%. In Medan City, the prevalence based on the diagnosis of health workers is 5.1%, and based on diagnosis and symptoms it is 17.2%. The method used in this study is the formation of artificial edema on the soles of the feet of male white mice with 1% carrageenan induction. Testing the anti-inflammatory activity of keji beling leaf extract was carried out with 25 test animals divided into 5 treatment groups. The groups consisted of positive controls given sodium diclofenac at a dose of 6.5 mg/kgBW, negative controls given Na-CMC 0.5%, and three extract groups at doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW. The results showed that the percentage of inflammation in the five test groups decreased consistently from the 60th minute to the 360th minute after carrageenan induction. The highest percentage of inflammation was recorded at the 120th minute for the Na-CMC group, followed by the 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, and sodium diclofenac groups. The highest percentage of inflammation inhibition was obtained from the sodium diclofenac portion, followed by 300 mg/kgBW, 200 mg/kgBW, and 100 mg/kgBW. This shows that the good inhibition percentage is owned by EDKB 300 mg/kgBW continued sodium diclofenac, and EDKB 200 mg/kgBW and 100 mg/kgBW. This indicates that the sodium diclofenac portion and extract with doses of 100, 200, and 300 mg/kgBW have the power to function as anti-inflammatory agents, compared to the Na-CMC group which showed no effect.
Lotion Formulation with Papaya Seed Extract (Carica Papaya L) as a Skin Moisturizer Syarifuddin, Aminah; Juliana, Iga
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2342

Abstract

Papaya seeds (Carica papaya L) have many vitamin contents that function to help increase immunity, fight free radicals, and also help increase skin moisture. Lotion is one of the pharmaceutical preparations in the form of beauty products that function to brighten and help increase skin moisture. In this research, a formulation of papaya seed extract will be made to become a lotion preparation that can increase skin moisture. This study tested the effectiveness of the preparation on the skin of volunteers. This study was conducted by making papaya seed extract through a maceration process using 96% ethanol, the extract was formulated in a lotion preparation in various concentrations. The resulting lotion was tested for homogeneity, pH, organoleptic, moisture and irritation on volunteers. Treatment was carried out for three days using lotion once a day. Lotion with a concentration of 3%, 5% and 7% which was homogeneous with a blank pH of 5.64, a 3% formulation pH of 5.84, a 5% formulation pH of 5.72, and a 7% formulation pH of 5.95 was found to not irritate the skin of volunteers, stable in room temperature storage. The results of the humidity test on Blanko were 43.3%, 3% formulation 45.2%, 5% formulation 49.95, 7% formulation 52.45%, and comparator 41%. The best result of the humidity test was formulation 3 with a concentration of 7% with an average value of 52.45%. Papaya seed extract can be formulated as a lotion preparation because it meets the physical test requirements of the preparation which shows that the preparation is homogeneous, the pH is stable during storage at room temperature, and does not irritate the skin. The papaya seed extract lotion preparation with a concentration of 7% provides a better humidity level effect compared to Blanko, F1 (3%), F2 (5%), F3 (7%) and also the comparator preparation.
Testing the Antioxidant Activity of Ethanol Extract on Terap Fruit Seeds (Artocarpus odoratissimus) using the DPPH Method: Uji Aktivitas Antioksidan Ekstrak Etanol Pada Biji Buah Terap (Artocarpus odoratissimus) Menggunakan Metode DPPH Aisya Maulidia; Wijayanti, Sari; Mustamin, Faizal; Ubrusun, Jufri
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2350

Abstract

Plants contain compounds that are classified as secondary metabolites. One of them is terap fruit (Artocarpus odoratissimus). Terap (Artocarpus odoratissimus) is a plant that grows a lot in Kalimantan. Most of the Artocarpus genus have pharmacological properties. One of the benefits of these compounds is as an antioxidant. Antioxidants can remove free radical compounds in the body and prevent the onset of disease. Secondary metabolite compounds found in plants have been isolated and used as components in medicine. The study was intended to determine the antioxidant activity of ethanol extract of terap fruit seeds (Artocarpus odoratissimus) using the DPPH method. The method in this study was quantitative experimental, which included collecting and collecting plants, making simplicia, making extracts from terap seeds (Artocarpus odoratissimus) using 96% ethanol solvent, and for antioxidant activity testing using the DPPH method. The presence of antioxidant compounds in plant extracts can cause a change in the color of DPPH from purple to yellow. This color change will indicate antioxidant activity against DPPH free radicals and is measured by UV-Vis Spectrophotometry. Antioxidant activity was measured using the IC50 value (50% Inhibitory Concentration). From the results of the antioxidant activity test using the DPPH method, it can be concluded that the ethanol extract of terap fruit seeds obtained from the Tarakan area showed antioxidant activity. The IC50 value of 197.45 mg/ml indicates that its antioxidant ability is impaired as a weak antioxidant.
Analysis of Rhodamin B Levels in Lipbalms Sold Online Using Uv-Vis Spectrophotometry Cahya, Cucu Arum Dwi; Saragih, Agustinus; Br Sinaga, Hana Lorenta
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2352

Abstract

A frequent cosmetic preparation for moisturizing and shielding dry lips is lip balm. The textile industry uses a synthetic dye called rhodamine B. Because rhodamine B is a synthetic dye having carcinogenic qualities that can encourage the formation of cancer cells if used repeatedly, the Indonesian Food and Drug Administration (BPOM) forbids its usage as a cosmetic colorant. The purpose of the study is to ascertain, both qualitatively and quantitatively, if five distinct lip balm brands sold online contain the dangerous synthetic pigment Rhodamine B. The study was conducted quantitatively using UV Vis spectophotometry and qualitatively using the Thin Layer Chromatography (TLC) test and color response test with the reagents used, 10% NaOH. One of the five samples (sample B) tested positive for Rhodamine B according to the color response and TLC tests. With an Rf value of 0.91, which is near the typical Rhodamine B Rf value of 0.96, this was demonstrated by a color shift to red-orange upon the addition of 10% NaOH. Visual inspection of Sample B revealed a pink area as well. Rhodamine B was not detected in samples A, C, D, or E.Sample B had an average Rhodamine B content of 3,2281 mg/g.

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