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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 237 Documents
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The Influence of Abdominal Circumference and Body Mass Index On Hypertension anggraeni, Ratih; Marbun, Romauli Anna Teresia; Siagian, Hartika Samgryce; Lubis, Amelia Hasana
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2358

Abstract

The Body Mass Index (BMI) value is used to determine the body composition value, calculated using a formula involving height and weight. Increasing body weight will affect the size of the stomach circumference. One indicator of BMI that can identify the risk of morbidity due to increased body weight is the measurement of the size of the abdominal circumference. If there is an increase in BMI, the risk of developing hypertension and other heart diseases also increases. Hypertension is when a person's blood pressure exceeds normal (120/80mmHg). This research was conducted to analyze the influence of BMI and abdominal circumference on hypertension symptoms using analytical observation. Random sampling was taken from the USU Faculty of Medicine student population with the criteria of having a history of heart disease, a history of metabolic disease, taking heart medication, and being an athlete. Respondents had their height and weight measured, their BMI values were calculated, then their abdominal circumference, and their blood pressure. The results showed that there was an influence between BMI and abdominal circumference on symptoms of hypertension. There was a significant correlation between BMI and systole (p=0.000) and diastole (p=0.014) as well as a moderate correlation coefficient for systole (r=0.466) and diastole (r=0.340). There is a correlation between abdominal circumference and systole (p=0.000) and diastole (p=0.038) and a moderate level correlation coefficient with systole (r=0.480) and diastole (r=0.289). It can be concluded that there was an influence of BMI and LP on hypertension.
Implementation Of Early Warning Score By Healthcare Workers In Primary Care To Prevent The Deterioration Of Catastrophic Diseases Sigalingging, Yulia Emma Wahyu Kristi Astuti
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2503

Abstract

Title: Implementation of Early Warning Score by Healthcare Workers in Primary Care to Prevent the Deterioration of Catastrophic Diseases Background: Catastrophic diseases, such as cardiovascular disease, stroke, and kidney failure, contribute significantly to morbidity and mortality rates worldwide. The implementation of the Early Warning Score (EWS) in primary healthcare settings plays a crucial role in the early detection of patient deterioration, allowing for timely interventions and reducing emergency referrals. Objective: This study aims to analyze the implementation of EWS by healthcare workers in primary care, assess its effectiveness in preventing disease deterioration, identify challenges faced during implementation, and provide recommendations for optimizing EWS utilization. Methodology: This research employs a mixed-method approach (quantitative and qualitative) with a descriptive-analytical design. Data collection methods include questionnaires, direct observations, in-depth interviews, and medical record analysis. The study involves healthcare workers (doctors, nurses, and midwives) in primary healthcare facilities that have adopted EWS. Quantitative data were analyzed using statistical methods, while qualitative data were processed using thematic analysis. Results: The findings indicate that EWS is effective in early detection of patient deterioration, reducing emergency referrals by approximately 30%. Most healthcare workers demonstrated a good understanding of EWS, but challenges remain, including lack of training, limited resources, and inconsistent adherence to EWS protocols. Healthcare workers reported that EWS improved patient monitoring and decision-making processes, contributing to better patient outcomes. Conclusion: The implementation of EWS in primary healthcare significantly enhances patient safety, early detection, and timely intervention, ultimately preventing the worsening of catastrophic diseases. However, successful implementation requires adequate training, sufficient medical equipment, and strong institutional support. Strengthening EWS utilization in primary care can improve health service quality and reduce complications associated with catastrophic diseases
The Effect of Emergency Education for Health Cadres in Improving Early Detection of Catastrophic Diseases Kasim, Felix
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Catastrophic diseases, such as stroke, heart disease, and kidney failure, are the leading causes of morbidity and mortality in Indonesia. Early detection is crucial to prevent further complications. Health cadres play a strategic role in the early detection of these diseases; however, their understanding of emergency conditions remains limited. Therefore, emergency education is necessary to enhance the ability of health cadres in the early detection of catastrophic diseases.Objective: To analyze the impact of emergency education on improving the ability of health cadres in the early detection of catastrophic diseasesThis study employed a quasi-experimental design with a pre-test and post-test approach involving 50 health cadres in the working area of Puskesmas X. Data were collected through questionnaires before and after the emergency education intervention. Data analysis was conducted using univariate and bivariate statistical tests, with a paired t-test to examine differences before and after the intervention Univariate Analysis: Before the education was provided, 60% of health cadres had low knowledge levels, 30% were at a moderate level, and only 10% had a high level of knowledge. After the intervention, there was a significant increase, with 70% of cadres having a high level of knowledge and 30% in the moderate category.Bivariate Analysis: The paired t-test results showed a significant difference (p < 0.05) in the knowledge level of health cadres before and after receiving emergency education. Emergency education significantly improves the ability of health cadres in the early detection of catastrophic diseases. Therefore, this educational program should be continuously implemented to enhance the capacity of health cadres in efforts to prevent and detect catastrophic diseases in the community
Study on the Effectiveness of Thrombolytic Drugs in Emergency Treatment of Ischemic Stroke: Time and Outcome Analysis Tarigan, Indra
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2506

Abstract

Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Thrombolytic therapy, such as the use of alteplase (tPA), is an effective standard of care when given in a timely manner. However, its effectiveness in clinical practice still varies, especially related to factors such as the time of drug administration and patient clinical outcomes. This study aims to analyze the effectiveness of thrombolytic drugs in ischemic stroke emergencies based on the relationship between the time of drug administration and patient clinical outcomes, using univariate and bivariate analysis. This study used an observational analytical design with a retrospective approach. Data on ischemic stroke patients who received thrombolytic therapy were collected from medical records at the hospital during a certain period. The independent variables included onset-to-needle (OTN) time and door-to-needle (DTN) time, while the dependent variable was clinical outcome based on the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Univariate analysis was used to describe the distribution of patient characteristics and main variables, while bivariate analysis was performed with correlation and logistic regression tests to see the relationship between the time of drug administration and patient outcomes. The results of univariate analysis showed that the majority of patients (70%) received thrombolysis within the OTN time range <3 hours, with an average initial NIHSS value of 12.5 ± 4.3. From the bivariate analysis, a significant relationship was found between DTN time <60 minutes and improvement in NIHSS score after 24 hours (p <0.05). In addition, patients with mRS <2 at 90 days after therapy were more common in the group receiving thrombolytics faster (OTN <3 hours) than those who received slower (p <0.01).
Management of Hypertensive Crisis Emergencies in Primary Healthcare Facilities: Challenges and Solutions Syah, Rahmad
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension crisis is a medical emergency that requires immediate treatment to prevent serious complications, such as stroke and heart failure. Primary healthcare facilities have an important role in early detection and early treatment of crisis hypertension, but still face various challenges in its implementation. Objectives: This study aims to analyze the challenges in the management of hypertensive crisis emergencies in primary healthcare facilities and identify solutions that can be implemented to improve the effectiveness of services. Methods: This study used a descriptive qualitative approach with in-depth interviews with medical personnel in primary healthcare facilities. In addition, an analysis of current policies and direct observation of the availability of drugs and medical devices that support the management of hypertension crisis were conducted. Results: The results showed that the main challenges in the management of hypertension crisis include the lack of training of medical personnel, limited availability of emergency antihypertensive drugs, and an unoptimal referral system. Lack of patient awareness of the symptoms of hypertensive crisis is also a contributing factor to the delay in treatment. Conclusion: To overcome these challenges, strategies are needed that include periodic training for medical personnel, improving the distribution and availability of drugs in primary health facilities, and optimizing the referral system.
Test to Determine The Quercetin Content of Tenggiang (Polystichum setiferum) Using the High Performance Liquid Chromatography (HPLC) Method and Its Antifungal Activity Against Pityrosporum ovale Turnip, Nur Ulina M. Br.; Ratih Anggraeni; Sihombing, Yanna Rotua; Suci Wulandari
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2361

Abstract

Background: Indonesia is a country with high temperature and humidity, which are supporting factors for the development of microbes. One of the microbes that causes infection is the fungus Pityrosporum ovale which can cause dandruff, especially on the scalp. Treatment is usually done using shampoo containing an antidandruff formula. Synthetic chemicals used in hair care have been widely known and used to treat various infections caused by fungi. Tenggiang, a shrub originating from the Toba Samosir area, is used empirically as a wound medicine. In previous studies, Tenggiang has been shown to have antimicrobial, antioxidant, and anti-inflammatory effects. This is related to the content of secondary metabolites found in tenggiang, such as flavonoids, terpenoids/steroids, saponins, and phenolics. Flavonoids, which are secondary metabolites of the polyphenol group. Objective: to measure the levels of quercetin in tenggiang using the HPLC method and to evaluate its antifungal activity against Pityrosporum ovale. Method: measurement of quercetin using the HPLC method and measurement of antifungal activity using the Kirby-bauer method. Results: The measurement results were then calculated as quercetin equivalents, the extract contained a total of 1.33% flavonoids. The retention time data of the standard quercetin was 5.405 minutes and the retention time of the ethanol extract of mackerel was 5.332. The ethanol extract of mackerel was  said to contain quercetin because it had a retention time that was relatively the same as the retention time of the standard quercetin. The extract also showed potential as an antimicrobial agent, where an increase in extract concentration was directly proportional to an increase in the diameter of the inhibition zone. In addition, when compared to the blank, the resulting difference was statistically significant (p <0.05). Conclusion: Tenggiang, extract has antifungal activity and antioxidant potential.
Formulation and Evaluation of Maggot Extract Nanocream (Hermatia illucens) as a Future Anti-Aging Candidate Situmorang, Novidawati Boru; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2399

Abstract

Background: Premature aging is a serious problem, especially for women. Skin aging is mainly caused by solar radiation. Ultraviolet (UV) A and B rays from sunlight induce the formation of reactive oxygen species in the skin and cause oxidation. Antioxidants are compounds that can neutralize free radicals by slowing down oxidation reactions. Maggots are widely consumed by the public and used as topical medicines because they have high levels of lauric acid, which acts as an anti-inflammatory, antibacterial, and antiprotozoal. Purpose: to analyze the formulation of nanocream preparations, antioxidant activity and evaluate the physical stability of maggot extract nanocream. Research method: The method used was the maceration method with n-hexane, antioxidant testing using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method, and testing the physical stability of the preparation. The results of the antioxidant activity test showed an IC50 value of maggot extract of 40.36 ± 1.21 µg / mL. Results: It shows that the sample has very strong antioxidant activity. Based on the organoleptic test, the nanoceram preparation in Formula 1, 2, 3 and 4 has a milky white color which is influenced by the difference in the amount of extract, a distinctive aroma and semi-solid consistency. The pH examination of nanocream preparation must be adjusted to the skin pH, which is 5-7. The results of the viscosity test on the maggot extract have met the requirements, which are 2,000-5,000 cps. Conclusion: formulation and evaluation of the nanocream extract meet the requirements as a good nanocream and have the ability as an anti-aging.
Test Of Antibacterial Activity and GC-MS analysis of ethyl acetate and N-hexane fractions of Kenitu leaves (Chrysophyllum cainito L.) Megawati, Sefi; Meta Safitri; Rangkuti, Saru Noliqo; Luthfiyyatul Makiyyah; Arum Mawarni, Nur Indah
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2421

Abstract

Background: As a result of the large number of infectious diseases, every year 3.5 million people die. The more microorganisms that are resistant to antibiotics, the search for and research into new antibacterials must be carried out from medicinal plant extracts such as the kenitu leaf plant, whose antibacterial activity is still rarely researched. Objectives: to analyze the factors that influence the management of solid media waste of hazardous and toxic materials at RSUD.Kumpulan Pane, Tebing Tinggi City. Research method: This research is a type of laboratory experiment using the semi-polar solvent ethyl acetate and the non-polar solvent n hexane from kenitu (Chrysophyllum cainito L.) leaves to test their antibacterial activity using the disk diffusion method. In this study there were six treatment groups: positive control (+) ciprofloxacin, negative control (-) DMSO 10%, as well as four concentration variations, namely K1: 25 mg/ml, K2: 50 mg/ml, K3: 100 mg/ml, and K4: 500 mg/ml. Results: The results of the ANOVA test of the antibacterial activity test of the Bacillus subtilis fraction against the ethyl acetate fraction obtained a p value <0.001. From the results of the homogeneity test, a significant value of p = 0.023 was obtained. These values ??are in accordance with the criteria (p <0.05), meaning that the concentration treatment has a significant impact on the diameter of the inhibition zone. Based on the results of the two tests, the data obtained in this study were analyzed using the non-parametric Kruskal-Wallis statistical test showing that there was a difference in the average Asymp value in each treatment. Sig. = 0.005 (p <0.05). The results of the Mann-Whitney test of the ethyl acetate fraction on Bacillus subtilis bacteria stated that it had a significant difference in providing an inhibition zone. Conclusion: the analysis stated that there were 27 compounds that were identified in the ethyl acetate fraction and 19 compounds that were identified in the n-hexane fraction of kenitu leaves. The results of testing regarding antibacterial activity stated that the kenitu leaf fraction from ethyl acetate solvent was only able to inhibit the growth of Bacillus subtilis and Staphylococcus aureus bacteria at a concentration of 500 mg/ml, for the kenitu leaf fraction from n-hexane solvent stated that all concentrations were not possible. able to inhibit the growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis.
The Effect of Giving Green Apple (Malus Domestica) Juice on the Histopathology of White Rat Pulmonary Organs Induced by Cigarette Smoke Pranata, Chandra; Asti Pratiwi
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2437

Abstract

Background: Cigarette smoke contains oxidants or free radicals and around 4700 dangerous chemicals. The high level of free radicals in the body triggers the emergence of Reactive Oxygen Species (ROS) which results in oxidative stress, this can occur if there is an imbalance between the amount of oxidants and antioxidants. In this process, there is a leak of O2 which will turn into superoxide radicals (*O2) which can form pro-inflammatory cytokines such as IL-6. Objective: to identify the effect of exposure to cigarette smoke on the histopathological appearance of rat lungs. Method: This research uses Post Test Only Control Group Design. Samples were taken from 20 male rats that met the inclusion criteria and were randomly divided into 4 groups, namely K1, K2, K3, and K4. K3 was given standard feed plus green apple juice at a dose of 13.5 grams/day. Meanwhile, the K4 group was given standard feed plus green apple juice at a dose of 27 grams/day. However, both were given exposure to cigarette smoke for 14 days. On the 15th day, blood was taken from male Wistar rats to carry out a histopathological examination of the rats' lungs using Hematoxillin-Eosin staining. Results: The results showed that there was damage in the negative group when compared with the normal group and the highest improvement in lung tissue was found at a dose of 27 grams/day when compared with the negative and normal groups. Conclusion: There is an effect of giving green apple juice on IL-6 and SOD levels in mice exposed to cigarette smoke.
An Overview of The Implementation of Pharmaceutical Service Standards at Puskesmas in Tarakan City in 2024 Syam, Siti Muti'ah; Irma Novrianti; Jufri Ubrusun
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2439

Abstract

Pharmaceutical services that are guided by Permenkes No. 74 of 2016 in the form of presentation and accountability for patients who are directly related to pharmaceutical products at public health centers throughout Tarakan City to become a starting point for optimizing service quality and supporting the progress of the health sector that contributes comprehensively. The purpose of the study was to describe the implementation of pharmaceutical service standards in all community health centers in Tarakan City. Descriptive strategy observation research method through survey media. The results of research on 6 Puskesmas that have a pharmacist in charge can be described that the implementation of pharmaceutical service standards has been successfully implemented in all Puskesmas of Tarakan City by 83.5%, covering the first aspect of clinical pharmacy (69.1%) and the second aspect of the management of pharmaceutical preparations and consumable medical materials (97.9%). The study concluded that most of the implementation was dominated by the Pharmacist in Charge (53.6%), followed by Pharmacy Vocational Workers (24.2%) and Pharmacist Assistants (5.6%).

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