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INDONESIA
JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 237 Documents
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EVALUATION OF THE USE OF THE DRUG IN PATIENTS ACUTE RESPIRATORY TRACT INFECTION (ARI) NON PNEUMONIA AT PUSKESMAS SIGUMPAR Sihombing, Yanna Rotua; Romauli Anna teresia Marbun; Friska Novita Pasaribu; Novidawati Br Situmorang
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1630

Abstract

Acute Respiratory Infection (ARI) is one of the main causes of patient visits to health centers (40%-60%) and hospitals (15%-30%). In Indonesia the level of use of antibiotics is still quite high. The unwise use of antibiotics and the incorrect application of standard precautions in health care facilities an lead to the occurrence of resistane. This study aims to determine the evaluation of drug use in non-pneumonia Aucute Respiratory Infection (ARI) patients at the Sigumpar Health Center. This Type of research is an observational study with a descriptive design and data taken retrospectively. The total sample of 101 medical records was taken by purposive sampling technique. The patients who often suffer from non-pneumonia acute respiratory infections at the Sigumpar Health Center occur in the age group of 6-11 years, namely children by 20,79%. Based on the results of this study, the most widely used drugs were analgesic-antipyretic (69.30%), antihistamine (65.34%), vitamins (62.37%), mucolytics (48.51%), expectorants (32.67%), antibiotics (27.72%) and corticosteroids (23.76%). The use antibiotics for non-pneumonia ARI patients at the Sigumpar Health Center was 27,72% so that it was categorized as not in accordance with the provisions of the Inonesian Ministry of Health in 2017 that the use of antibiotics in non-pneumonia ARI patients was ? 20%.
THE IMPLEMENTATION OF PHARMACEUTICAL SERVICE STANDARDS IN PHARMACIES OF ROKAN HULU DISTRICT Situmorang, Manotar; Saman; Basyariah Lubis
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1820

Abstract

Currently, pharmaceutical services have experienced a lot of development, which initially used to focus on drug management, but have now turned into drug and clinical pharmacy services aimed at raising the standard of living of patients. Pharmaceutical applications are carried out according to pharmaceutical service standards in pharmacies which serve as the basis for providing services. Minister of Health Number. 73 of 2016 is a benchmark that is always guided by pharmaceutical staff in providing services. In this research, qualitative research was chosen which is descriptive quantitative through a cross sectional approach. The sample is determined using the Non-Probability Sampling technique, namely the Total Sampling type where the total population is determined as a sample. Where the number of samples selected amounted to 25 people. Research data must be in-depth, clear, and specific through in-depth interviews and observations. Data analysis was performed on variables through univariate analysis and bivariate analysis using the Chi Square test with a 95% confidence level. Aspects of infrastructure, Management of Pharmaceutical Supplies and Health Supplies, and administration have a significant relationship to pharmaceutical services at pharmacies in Rokan Hulu district with each sequential p-value being 0.002; 0.003; and 0.003. In improving services in accordance with Permenkes Number. 73 of 2016, it requires qualified facilities and infrastructure, good health management and provision, as well as complete administration.
ANTIBACTERIAL ACTIVITY TEST OF CELERY LEAF ETHANOL EXTRACT (APIUM GRAVEOLENS L.) AGAINST BACTERIA STREPTOCOCCUS SANGUINIS Pranata, Chandra; Renty Monica; Asti Pratiwi; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Health is a very important part of human life, especially oral health. Diseases that occur due to lack of oral hygiene include gingivitis caused by Streptococcus sanguinis bacteria. Chlorhexidine is a solution that is used to clean the oral cavity and prevent plaque formation on the teeth. An alternative mouthwash that comes from nature is celery leaves (Apium graveolens L.) with secondary metabolites, namely alkaloids, flavonoids, saponins and tannins. This study was conducted to determine the antibacterial activity of celery leaf ethanol extract against Streptococcus sanguinis bacteria at concentrations of 12.5%, 25%, 50% and 100% using the disc diffusion method with chlorhexidine as a positive control and Aquadest as a negative control. The celery leaf extraction method was carried out by maceration method using 96% ethanol solvent. The results of the inhibition test with a concentration of 12.5%, 25%, 50% and 100% celery leaf ethanol extract can inhibit the growth of Streptococcus sanguinis bacteria with an average diameter of the inhibition zone in the negative control group (aquadest) is 0 mm, 12.5% concentration is 8.15 mm, at 25% concentration is 7.95 mm, 50% concentration is 9.05 mm, 100% concentration is 9.9 mm, while in chlorhexidine (positive control) an average of 17.83 mm is obtained. From these results, it can be concluded that there is activity of celery leaf ethanol extract against the growth of Streptococcus sanguinis bacteria with a concentration that effectively inhibits the growth of Streptococcus sanguinis bacteria is 100% concentration. Keywords: Celery Leaf, Gingivitis, Streptococcus sanguinis
ANDALIMAN QUERCETIN (ZANTHOXYLUM ACANTHOPODIUM DC.) USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD AND ITS ANTIFUNGAL ACTIVITY AGAINST PITYROSPORUM OVALE siska, Fitri; Anisa Maharani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1857

Abstract

People today complain with dandruff accompanied by itching will cause a lack of confidence because of the unpleasant smell and reduce the beauty of the hair. Andaliman is a plant that grows a lot in the Toba Samosir area which is usually used as a spice for cooking. Examination of secondary metabolite compounds contained in these natural materials is the main thing that is important to do. In other studies, andaliman has been studied to provide antimicrobial, antioxidant, and anti-inflammatory effects. The test method is carried out using the High Performance Liquid Chromatography (HPLC) Method and the minimum inhibitory concentration test using the diffusion method in order to use paper backups with several variations in test concentration. This is related to the content of secondary metabolites such as flavonoids, terpene alkaloids, benzophenthridine alkaloids, pyranoquinoline alkaloids, quaternary isoquinoline alkaloids, aporphyrine alkaloids, essential oils and several types of lignin. Flavonoids are secondary metabolites of polyphenols found in many plants and have a variety of biological effects including antiviral, anti-inflammatory, and antioxidant. Quercetin to derivative active compounds The test results of the minimum inhibitory concentration of the extract showed an average inhibitory power of 17.26 mm at a concentration of 80% and EEAD quercetin levels with a concentration of 6.25; 12,5; 25; 50; and 100 ?g/ml contains quercetin percentages of 143.5, 242.15, 395.12, 865.2, and 1134.12 ?g/ml.
TEST OF THE INHIBITOR EFFECTIVENESS OF THE COMBINATION OF ETHANOL EXTRACT OF LEMON LEAVES (Cymbopogon citratus) AND GREEN BETEL LEAF (Piper betle L.) AGAINST Staphylococcus aureus BACTERIA Octora, Debi Dinha; Samuel Marpaung; Jhoti Sumitra
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1860

Abstract

The discovery of natural substances has the potential for applications in the development of pharmaceuticals or natural alternatives to combat bacterial infections. Green betel leaves (Piper betle L.) and lemongrass stems (Cymbopogon citratus) may aid in treating infections due to their specific strength in bacteria eradication. Staphylococcus aureus is one of the pathogenic bacteria types that can cause serious infections and skin disorders under conducive conditions, such as acne and boils. The aim of this study is to determine the antibacterial activity using the maceration and disk diffusion methods on lemongrass stem and green betel leaf extracts against Staphylococcus aureus bacteria. The research conducted is qualitative in nature and aims to assess the inhibitory effect of the combination of ethanol extracts from lemongrass and green betel leaves at various concentrations on the growth of Staphylococcus aureus bacteria. Different concentrations of green betel leaf and lemongrass stem extracts were also tested to determine the most effective concentration in inhibiting bacterial growth. The results demonstrate that specific concentrations of green betel leaf and lemongrass stem extracts have a stronger antibacterial effect compared to other concentrations. The combination of ethanol extracts from lemongrass stems and green betel leaves can inhibit the growth of Staphylococcus aureus bacteria using the paper disk method, with inhibition zone diameters observed for each extract concentration and the positive control Ciprofloxacin, which had a diameter of 25.92 mm. The best concentration formula for the combination of lemongrass stem (Cymbopogon citratus) and green betel leaf (Piper betle L.) ethanol extracts is at 15% concentration, resulting in an average diameter of 18.90 mm. Keywords: Antibacterial, Piper betle L., Cymbopogon citratus, Staphylococcus aureus
FORMULATION AND TEST INHIBITORY EFFECT OF MUSHROOMS CREAM PREPARATION ETHANOL EXTRACT AVOCADO SEEDS (PERSEA AMERICANA MILL) AGAINST MALASSEZIA FURFUR IN VITRO Turnip, Nur Ulina M. Br.; Novandi Purba; Novidawati Boru Situmorang; Sarah Gabetta br Napitupulu
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1872

Abstract

Avocado seeds (Persea americana Mill) are household waste that contains secondary metabolites that can be used as antifungal agents. The antifungal activity of pure ethanol extract from avocado seeds (Persea americana Mill) has been tested and shown to have inhibitory effects on the fungus Malassezia furfur. Pityriasis versicolor is one of the diseases that can be treated due to the infection of Malassezia furfur, and skin diseases are generally treated using semi-solid formulations like creams. The objective of this study is to determine the antifungal activity of a cream formulation of ethanol extract from avocado seeds against Malassezia furfur. The method used to test the inhibitory activity of the cream containing ethanol extract from avocado seeds (Persea americana Mill) against Malassezia furfur is the disc diffusion method. Phytochemical screening results indicated that the ethanol extract from avocado seeds contains alkaloids, flavonoids, tannins, and saponins. The cream containing ethanol extract from avocado seeds (Persea americana Mill) was tested at concentrations of 20% (10 grams), 40% (20 grams), and 60% (30 grams), along with a positive control of Ketoconazole 2%. The research results showed that the cream containing ethanol extract from avocado seeds (Persea americana Mill) at concentrations of 20%, 40%, and 60% exhibited inhibitory zones with diameters of 5.85 mm, 6.73 mm, and 7.66 mm, categorizing them as having a moderate inhibitory effect. Therefore, it can be concluded that the greater the concentration of the extract, the larger the diameter of the inhibitory zone." Keywords: Panu, Malassezia furfur, Antifungal, Cream, Avocado seed (Persea americana Mill).
KINETICS OF PIROXICAM RELEASE THROUGH IONTOPHORESIS AT VARIOUS PHS FROM POLYELECTROLYTE HYDROGELS WITH SODIUM ALGINATE-TRAGACANTH GUM POLYMER Nining, Nining; Fith Khaira Nursal; Abu Rijal Algifari
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1904

Abstract

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used to treat symptoms of osteoarthritis and rheumatoid arthritis. This drug can irritate the stomach as a side effect of oral administration. One strategy to overcome these side effects is transdermal delivery in polyelectrolyte hydrogel with iontophoresis. This research aims to study the pH-varying effect of polyelectrolyte hydrogel on piroxicam release from hydrogel via iontophoresis using a Franz diffusion cell. The formulation was made with pH variations, namely 4.2 (F1), 5.5 (F2), 6.4 (F3), and 7.4 (F4). Evaluations include organoleptics, pH, homogeneity, spreadability, viscosity, flow properties, conductivity, and diffusion tests. The polyelectrolyte hydrogel obtained was yellow and homogeneous with a pH variation of 4.2 ± 0.02 to 7.42±0.02, spreadability of 4.22±0.21 cm to 4.35±0.28 cm, viscosity 47,378 cps to 59,297 cps; flow properties include thixotropic plasticity; and conductivity 8.01±0.78 ms/cm to 9.58±1.00 ms/cm. Moreover, piroxicam was released from the hydrogel assisted by DC-type iontophoresis with flux values of 634.52 ?g/cm2 (F1), 427.91 ?g/cm2 (F2), 205.76 ?g/cm2 (F3), and 253.56 ?g/cm2 (F4). Statistical analysis showed that decreasing pH had a significant effect (sig<0.05) on increasing piroxicam release from hydrogel based on flux value. The release kinetic behavior of all formulas (F1-F4) does not show the same type of kinetic model based on the correlation coefficient value approach, which is closest to 1. Keywords: Diffusion, flux, drug release, release kinetics.
ANALYSIS OF DATA ON PROCUREMENT AND USE OF INSULIN IN DIABETES MELLITUS PATIENTS AT THE GENERAL HOSPITAL Dr. FL TOBING SIBOLGA Hasni, Hasni Yaturramadhan Harahap; Sofyan Syarifuddin; Debi Meilani; Deliwarni Rajagukguk; Fatimah Sari Simatupang; Reni Aprinawaty Sirait
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1907

Abstract

Abstract Drug management is a series of drug control starting from the process of selection, procurement, distribution, to use. Drug management is closely related to the budget and expenditure of health installations such as hospitals, health centers, and pharmacies. The aim of this study is to determine the suitability of insulin procurement in public hospitals. Dr. FL. Tobing Sibolga with the needs of diabetes mellitus patients in 2022. This research method includes descriptive research, namely by looking at usage reports and insulin request sheets at RSU Dr. FL. Tobing Sibolga. The results of the study showed that insulin was procured at the FL Hospital. Tobing is in accordance with the need/use of insulin throughout 2022 because the amount of procurement is greater than the need. And there is no significant difference in the planned amount of insulin and insulin needs throughout 2022. Keywords: Management, Use, Appropriateness  
LIP BALM PREPARATION FORMULATION CORIANDRUM LEAF EXTRACT (CORIANDRUM SATIVUM L.) AS A MOUSTURIZING LIPS* Wulandari, Suci; Hasanah Fitria; Siti Wahyuni
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1921

Abstract

Leaf coriander (Coriandrum sativum L.) known own activity high antioxidants Lip balms is Wrong One preparations pharmaceutical form product functional beauty For help increase humidity on lips. Leaf coriander can made as substance active addition on lip balm formulas. it become reason use lip balms in study this. Study This aim For know is extract leaf coriander (Coriandrum sativum L.) can formulated become preparations lip balms And For know difference variation concentration extract leaf coriander (Coriandrum sativum L.) can influential as moisturizer on preparations lip balms Manufacturing process extract ethanol leaf coriander with method maceration use solvent 96% ethanol. preparation lip balms made in 4 formulas viz each with concentration extract leaf coriander 0% (F1), 5% (F2), 10% (F3), and 15% (F4). Testing to preparations lip balms covers test homogeneity , pH test , test stability for 4 weeks, test irritation , and test humidity to lips volunteer use tool skin analyzer with the parameters being measured covers moisture (water content). Maintenance done during four Sunday with use lip balms every a week once. Results study show that all preparations lip balms characteristic homogeneous , pH 7, shape , color , and the smell stable during storage And No irritate skin. Results measurement humidity show that lip balms extract ethanol leaf coriander 15% can increase the most moisture (water content). Extract ethanol leaf coriander (Coriandrum sativum L.) 15% in preparations lip balms more Good in increase moisture (water content) compared with extract ethanol leaf coriander 0%, 5% and 10%. Lip balms comparison show activity more moisture (moisture content). Good compared to with lip balms extract ethanol leaf coriander 15%.
ANTIBACTERIAL TESTED STAPHYLOCOCCUS AUREUS FROM ETHANOL EXTRACT OF NONI FRUIT anggraeni, Ratih
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1926

Abstract

The various types of plants that Indonesia has should be protected and maintained in diversity. Many types of plants are used as medicinal plants. Some taste sweet, astringent, sour, and even bitter. One of them is the noni plant. The noni plant has fruit that tastes bitter and gives off an unpleasant odor. However, noni fruit contains antibacterial properties. More than one bacteria is found in the human body. One of them is Staphylococcus aureus which can infect if the immune system is low. The main treatment for bacterial infections uses antibiotics. Frequent use of antibiotics can cause resistance. To overcome this resistance, research was carried out on ethanol extract of noni fruit which is expected to inhibit the growth of these bacteria. This research is experimental using Staphylococcus aureus bacteria as a bacterial test using the disc diffusion method. The antibiotic amoxicillin was used as a positive control. The diameter of the inhibition zone will determine the antibacterial activity of the bacterial medium. The ethanol extract of noni fruit that was tested provided evidence that it could prolong the growth of Staphylococcus aureus bacteria. The concentration of the test solution is divided into 3, namely 25%, 50% and 75%. The diameters of the inhibition zones are 15.67 mm, 19.7 mm, and 23.97 mm, respectively. Differences in the concentration of the test solution can affect the diameter of the inhibition zone in the bacterial medium. The test solution with a concentration of 75% had the best antibacterial inhibition power, namely 23.97 mm. Keywords: noni fruit, Staphyococcus aureus, antibacterial

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