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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 237 Documents
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Antihyperuricemia Activity Test of Tempuyung Leaf Infusion (Sonchus arvensis L.) on Male Swiss Webster Mice (Mus musculus) Estevany Priliansi; Sarah Puspita Atmaja; Ari Widhiarso
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2588

Abstract

Background: Treatment of hyperuricemia with allopurinol has a risk of hypersensitivity reactions that can be fatal with mortality rates reaching 20%-25%. As an alternative, tempuyung leaves (Sonchus arvensis L.) are known to contain flavonoids that have the potential to reduce uric acid levels. Objectives: To identify chemical compounds and evaluate their effects as antihyperuricemia. Methodology: A laboratory experimental study conducted for 14 days using male mice. The mice were divided into several groups, namely the negative control (Na-CMC 0.5%), positive control (allopurinol), and groups treated with Sonchus arvensis leaf infusion at doses of 50 mg/kg BW, 100 mg/kg BW, and 150 mg/kg BW. Hyperuricemia induction was performed for 7 days using potassium oxonate and chicken liver juice. Uric acid levels were measured using an enzymatic method with a UV-Vis spectrophotometer. Data analysis was performed using Paired T-Test and One-Way ANOVA statistical tests. Result: The infusion of Sonchus arvensis L. leaves indicates the presence of flavonoids, alkaloids, saponins, and tannins. The highest uric acid-lowering effect appears at a dose of 150 mg/kg BW, with a reduction of 26.517%. All doses of the infusion show a significant decrease in uric acid levels, both after hyperuricemia induction and on days 7 and 14 of treatment. A significant difference in uric acid reduction between groups appears at doses of 50 mg/kg BW and 100 mg/kg BW, while the dose of 150 mg/kg BW does not show a significant difference.
Comparison of Different Extraction Methods on Sorghum Seeds (Shorgum bicolor (L). Moench) on Extract Yield and Secondary Metabolite Compound Levels Maramis, Rilyn Novita; Nahor, Evelina Maria; Rindengan, Elvie Rifke
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2592

Abstract

Sorghum, as a potential crop, has been promoted by the government as a national food source. Sorghum contains primary metabolites such as carbohydrates, proteins, and high fiber, as well as secondary metabolites including alkaloids, tannins and phenols, steroids, and terpenoids. The secondary metabolites produced and the yield obtained depend on the extraction method used. This study aimed to determine the yield and concentration of sorghum seed extract obtained through cold extraction (Percolation) and hot extraction (Reflux). Sorghum seed extract was obtained using cold (Percolation) and hot (Reflux) extraction methods with 96% ethanol as the solvent. The resulting yield was then calculated, followed by identification and quantification using UV-Vis spectrophotometry. The results show that the cold extraction (Percolation) method produced a yield of 3,733%, while the hot extraction (Reflux) method produced a yield of 10,133%. The identification of secondary metabolites in sorghum seed extracts from both cold (Percolation) and hot (Reflux) extraction methods reveals the presence of saponins, flavonoids, tannins, and terpenoids, but no alkaloids or steroids. The percolation method yields a total saponin content from Quillaja bark of 0,94% w/w, a total flavonoid content equivalent to quercetin of 0,84% w/w, and a total tannin content equivalent to tannic acid of 0,45% w/w. Meanwhile, the reflux extraction method yields a total saponin content from Quillaja bark of 1,07% w/w, a total flavonoid content equivalent to quercetin of 0,0615 %b/b, and a total tannin content equivalent to tannic acid of 19,44% w/w.
Profile of Suaitabilit of BPJS Patient Drug Prescription With The National Formularium at Juata Community Health Center During The Periode of May-July 2024 Arny_, arnny pertiwi sari; Sari Wijayanti; Jufri Ubrusun
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2605

Abstract

Background: Compliance with the National Formulary not only improves the quality of health services in primary health facilities but also ensures the efficiency of treatment costs and the fulfillment of the right and safe drug needs for the community. This study supports efforts to strengthen the implementation of the National Formulary as a strategic guideline to increase access to quality health services, improve pharmaceutical governance, and encourage efficiency of the health budget. Objective: This study aims to assess the suitability of drug prescriptions for patients registered in the BPJS Kesehatan program in accordance with the National Formulary (Fornas) at the Juata Health Center during the period May to July 2024. Research Methods: The research design applied was non-experimental with a retrospective descriptive approach. A total of 300 BPJS patient prescriptions were selected as samples from a total population of 8704 prescriptions using the Slovin method with a precision level of 90%. Data were analyzed descriptively to calculate the percentage of prescription suitability based on prescription sheets and drug items. Results: The results showed that the suitability of prescriptions based on prescription forms and drug items reached 100% during the study period. Of the total 101 prescribed drug items (28 items in May, 41 items in June, and 32 items in July), all were based on the National Formulary. Conclusion: These results provide the conclusion that the Juata Health Center has met the standards of pharmaceutical services, with drug prescriptions that fully support rational, efficient, and effective drug use. The results of this study have significant relevance to national health policies, especially in the implementation of the National Health Insurance (JKN) program.
Evaluation of Skin Irritation Level and Effectiveness of Foot Sleeping Mask Containing Tengkawang Fat in Nanostructured Lipid Carriers System Fidayanti, Ayu; Mayangsari, Fransisca Dita; Pratiwi, Elasari Dwi
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2608

Abstract

One of the export commodities from the Non-Timber Forest Products (NTFP) group is tengkawang fruit. This fruit can be processed into fat which has properties similar to cocoa butter. The advantage of this fat compared to cocoa butter is that the price is relatively cheaper. However, the use of tengkawang fat in cosmetics is not widely known. Therefore, researchers are interested in developing cosmetic products based on tengkawang fat to treat xerosis of the feet. To increase occlusivity, tengkawang fat is formulated into an NLC (Nanostructured Lipid Carriers) system. In this research, a foot sleeping mask product was made containing NLC tengkawang fat with the addition of gel (to improve viscosity) and sweet orange oil (to improve aroma). The aim of this research was to determine the irritation skin level and effectiveness of moisturizing the skin of the soles of the feet from a foot sleeping mask containing NLC tengkawang fat. The results of the physical characteristics test show that the foot sleeping mask made meets the desired specifications. The results of skin irritation tests with 35 panelists showed that there was no redness or edema on the panelists' skin during 24, 48 and 72 hours of observation. The results of the moisture effectiveness test showed that the average moisture content of the soles of the panelists' feet on day 0 was 34.531%, while on day 28 (4 weeks) it was 42.815%. There was an increase in humidity of 8.284% during 4 weeks of use. The conclusion of this research is that a foot sleeping mask containing Tengkawang fat NLC can increase the moisture of the skin of the soles of the feet by 8.284% during 4 weeks of use.
A Review: Propolis As An Antiinflammatory Adjunct Therapy in Chronic Kidney Disease Depari, Elpiani; Malisie, Ririe Fachrina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2613

Abstract

Chronic Kidney Disease (CKD) is a disease with abnormalities of the structure and function of kidney that last for at least 3 months and has an impact on health. Inflammation is a progression factor and outcome of CKD. Diabetes, hypertension, cardiovascular disease, exposure to environmental pollution and use of nephrotoxic drugs develop into CKD through inflammation. Inflammation in CKD caused complications in cardiovascular disease, bone mineral disorders, anemia and immune disorders, as well as reducing the patient's quality of life. Cardiovascular complications are the main cause of CKD patients’ death. Renal replacement therapy such as hemodialysis is not effective enough to overcome the inflammation, because unable to remove intermediate molecules and protein-bound molecules, the majority of which are inflammatory markers such as cytokines, namely TNF-?, IL-1, IL-6 and others. Propolis, a natural bee resin product, has anti-inflammatory effects, because it contains many bioactive phytochemicals such as flavonoids, phenolic acids, esters, diterpenes, aromatic aldehydes, amino acids, fatty acids, vitamins and minerals. It inhibits the production and release of cytokines through inhibiting NF-kB (nuclear factor kappa Beta) activity, reducing COX-2 expression and inhibiting nitric oxide (NO). Many clinical trials of propolis in CKD have been carried out and reported safe and beneficial, including in patients undergoing dialysis. Propolis has been proven able to reduce several inflammatory markers, such as TNF-?, interleukin and others. It has great potential as a safe additional therapy in CKD patients, both dialysis and non-dialysis.
Analysis of Strategic Business Planning for a New Pharmacy in the Depok Area Putra, Gunawan Satria; Saragih, Sahat; Hatta , Iha Haryani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2618

Abstract

This study evaluates the business strategies of new pharmacies in Depok post the Covid-19 pandemic, which experienced significant growth. Despite the emergence of numerous new pharmacies in 2024, their management is deemed to fall short of pharmaceutical standards. This research aims to analyze the implemented business strategies, their alignment with vision and mission, and relevant strategies for performance improvement. The research method employed is descriptive qualitative, utilizing SWOT analysis as a data analysis tool. Data collection was conducted through in-depth interviews with 9 informants from 6 pharmacies and a concise survey. The respondents were pharmacy owners and managers. The findings indicate that these six pharmacies lack a structured business strategy plan. The primary performance metric used is sales turnover. Business vision and mission have not been established, hindering the alignment of business strategies. Implemented business strategies remain normative, such as promotions via brochures, pamphlets, and discounts. The resulting business strategy recommendations encompass two key aspects: fulfilling pharmaceutical service standards and enhancing financial performance. Pharmaceutical service standards include drug consultation, medical records, drug availability, patient education, and legal compliance. Financial performance improvement can be achieved through price adjustments, operational cost efficiency, sales growth, inventory management, service diversification, and customer satisfaction. It is recommended that pharmacies engage with local communities to socialize programs and services. Informal approaches are considered more effective.
Effort to Reduce The Incidence of Anemia in Grade XII Students of SMAN 1 Sei Rampah Using The Action Research Approach M Taufik Alfyan; Felix Kasim; Fadlilah Widyaningsih; anggraeni, Ratih
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2637

Abstract

Anemia is a condition of low hemoglobin levels in the blood. This condition often occurs in adolescent girls due to menstrual cycles and a tendency to diet. Adolescent girls who suffer from anemia are at risk of giving birth to babies with low birth weight and stunting. The incidence of anemia is very high in North Sumatra, one of which is in Sei Rampah District. Because of this condition, researchers feel the need to make efforts to reduce the incidence of anemia by providing iron tablets. The action research method was carried out to determine whether there were changes in hemoglobin levels in the anemia group of grade XII SMAN 1 Sei Rampah students who were given intervention. The students' hemoglobin levels were measured to group which ones had the potential for anemia, then given iron tablets once a week for 4 weeks and then their hemoglobin levels were measured again. Action research plays a role in achieving a decrease in the incidence of anemia. Researchers concluded that there was an increase hemoglobin levels by 96.7% in the group of female students categorized as anemic after the intervention of anemia concept education and the provision of iron tablets with assistance.
Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

Abstract

Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.
Formulation of Body Scrub Containing Ethanol Extract of Temulawak Rhizome (Curcuma xanthorrhiza Roxb) as a Skin Moisturizer H, Herlina; Melda Astrika Sianipar; Yaturramadhan Harahap, Hasni; Aritonang, Barita; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2650

Abstract

A body scrub is a cosmetic formulation intended to exfoliate dead skin cells and enhance skin hydration. One promising natural ingredient for body scrub formulations is the rhizome of Java turmeric (Curcuma xanthorrhiza Roxb.), which contains curcumin, a potent antioxidant known to support skin moisture retention. This study aims to evaluate the moisturizing efficacy of a body scrub formulated with Java turmeric rhizome extract. Methods: The rhizome was extracted through maceration using 96% ethanol and incorporated into body scrub formulations at concentrations of 10%, 15%, and 20%. The formulations were assessed for organoleptic characteristics, homogeneity, pH, spreadability, adhesion, oisturizing effect, and potential skin irritation on human volunteers. A commercial body scrub served as the comparator in a study involving 12 volunteers over four weeks, with applications performed once per week. Results: All Java turmeric body scrub formulations remained physically stable at room temperature and did not induce skin irritation. The physical characteristics of the formulations met standard cosmetic criteria, including consistent appearance, pH range of 6–7, spreadability between 5–7 cm, adhesion time above 4 seconds, and absence of irritation. Moisturizing effectiveness was evaluated using a skin analyzer, and data were statistically analyzed using SPSS. The p-value of 0.046 indicates that there is a significant difference between F1 and the commercial product, while for F2 and F3, there is no significant difference in moisturizing effectiveness between the temulawak formulations and the commercial product.. Among the tested formulations, the body scrub containing 20% Java turmeric extract exhibited the highest moisturizing effect. Conclusion: The body scrub formulated with Java turmeric rhizome extract, particularly at a concentration of 20%, is safe for use and shows potential as a natural moisturizing product comparable to commercial products on the market.
Formulation of Nanoemulgel Preparation from Jernang Resin Extract (Daemonorops draco (Wild.)) for Healing Burn Wounds in Male White Rats (Rattus norvegicus) Yulia Sari, Ersa; Cut Mutia; Fitri, Zahwa Syuhada; R.A. Talitha Nabila Sakhi; Indri Maharini; Elisma
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2651

Abstract

Background: Jernang resin (Daemonorops draco) contains secondary metabolite compounds, namely flavonoids, alkaloids, triterpenoids and steroids that play a role in the healing process of burns. Objective: The development of jernang resin into a pharmaceutical dosage form can be done in the form of nanoemulgel. Nanoemulgel is easy to apply to the skin, and can be specifically targeted to the site of treatment, avoiding first metabolism, and reducing gastric or systemic side effects. Method: the method used is experimental using a Completely Randomized Design (CRD) with a Post Test Only Control Group Design approach using 25 male white rats consisting of 5 treatment groups: positive control (bioplacenton), negative control (vaseline flavum) F1 1%, F2 3%, F3 5%. The parameters observed were the physical properties of nanoemulgel and the effectiveness of burns on male white rats, namely burn diameter, wound healing percentage, collagen density and fibroblast cells through histological observations. Results: each treatment has effectiveness, The best burn healing effectiveness is in F3 5% with a healing percentage of 93.32% and very dense collagen and fibroblast cells among other treatment groups, followed by F1 1% with a healing percentage of 90.65% and dense collagen density, the effectiveness produced is the same as the positive control (bioplacenton) which is with a burn healing percentage of 90.77%, and the concentration with the lowest effect is in F2 3% with a burn healing percentage of 84.14%. Conclusion: Nanoemulgel with different concentrations does not affect the physical properties of nanoemulgel but has different burn healing effects, with the best concentration being 5% jernang resin extract.

Page 17 of 24 | Total Record : 237

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