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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 115 Documents
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Quality and Release Profile of Captopril from Mucoadhesive Gastroretentive Tablet by Using Matrix Sodium Carboxymethyl Cellulose and Carbopol 934P Isriany Ismail; M. Asrah Hidayah Usman; Nur Ida
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14028

Abstract

Captopril have good absorption in gastric pH and ionized on intestinal pH. It is necessary to keep the drug in the form of molecules in the area of the absoption. The mucoadhesive gastroretensive drug delivery system provides the possibility of controlled release in stomach in a certain amount of time. Research has been conducted to assess the quality and profile of captopril release in of a mucoadhesive gastroretensive tablet. Mucoadhesive tablets (MK) were made in 5 formulas by wet granulation method using carbopol 934P and sodium carboxymethyl cellulose as matrix with ratio 10: 0 (MK1), 0: 10 (MK2), 5: 5 (MK3), 7: 3 (MK4), and 3: 7 (MK5). The parameters which was evaluate were characteristics of granules and tablets and kinetics model of captopril release from tablets in 0,01 N HCl medium. Mucoadhesive tablets had different characteristics for each formula. Mucoadhesive tablets that had good quality and release profile were shown by MK4 and MK5 formula. They had controlled drug release profiles accorded to the Korsmeyer-Peppas and Higuchi kinetics models, respectively.
The Effect of Papaya (Carica Papaya L.) Leaves on Adolescents with Dysmenorrhea Desy Aulia Rahmah; Mukti Priastomo; Laode Rijai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.16478

Abstract

Papaya leaves (Carica papaya L.) contain active compounds of flavonoids and alkaloids which have the function of reducing dysmenorrhea. Dysmenorrhea is a condition that occurs at any time during menstruation that experiences pain or pain in the abdominal and pelvic area so it can interfere with activities and require treatment. This study aims to determine the effect of the effectiveness of offering papaya leaf herbal drink in reducing dysmenorrhea. The research design used in this study was a pre-experimental research design with a pre-experimental test design with accidental sampling technique. Measurement of pain intensity using pain scale measurements (Pre-Test) and final pain (Post-test using a numerical rating scale, time of incidence on the first and second day of menstruation (77%), location of lower abdominal dysmenorrhea (92%), symptoms of dysmenorrhea, namely abdominal pain (75%), moderate pain scale (48%)], and treatment was resting (63%). Based on the results of the study, subjects who were given a papaya leaf herbal drink were able to reduce the pain scale of dysmenorrhea with a large difference in pain scale reduction in the treatment group of chopped papaya leaf stew by 3,2.
Activity of Bidens Pilosa Herb Infussion as Antiinflammatory Munifah Wahyuddin; Nurdaonah Nurdaonah; Ferawati Ferawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14004

Abstract

Ajeran (Bidens pilosa), traditionally, was widely used to reduce pain and inflammation. This study aims to determine the activity of Ajeran herb infusion as an anti-inflammatory. Determination of activity using 18 mice which were divided into 6 groups. Blank group (I) was given aquadest, groups II, III, IV and V were given Ajeran dry herb infusion with concentrations 10, 20, 30 and 40% w/v, respectively, and group VI was given sodium diclofenac suspension 0,195 mg/ml, each 1 ml. Inflammation induction was performed by administering eggwhite suspension 1% v/v on the sole of the left foot. Foot volume before and after induction were measured as normal and initial edema volume. After that, the mice were given treatment and measurements of foot volume again at 15, 30, 45 and 60 minutes. The test results showed that the infusion of Ajeran and diclofenac sodium could reduce edema starting at 15 minutes, which were 17.8% (II); 20.6% (III); 22.2% (IV); 25% (V); and 15% (VI). It was different with blank group, the volume of edema did not decrease (0%). At 60 minutes, the volume of edema in all groups higher decreased that at 15 minutes, namely 23.4% (I); 28.9 (II); 35.6 (III); 37% (IV); 41.7% (V); and 30% (VI). The conclusion is that the administration of Ajeran infusion can reduce the volume of edema of feet with inflammation of mice.
Bioavailability Study of Propranolol Patch Muh Ikhlas Arsul; Latifah Rahman; Agnes Lidjajah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.19498

Abstract

Bioavailability is a measure of the rate and amount of drug or active ingredient that is absorbed by a drug product and available at the site of action. By definition, the bioavailability of a drug when administered intravenously is 100%. However, when a drug is given by a different route of administration, its overall bioavailability will decrease (since the drug is not completely absorbed and metabolized first pass effect) or may vary from patient to patient. Bioavailability is very important in pharmacokinetics. One of them is that bioavailability needs to be taken when calculating the doses for administering a drug other than by intravenous route. The aim of this study was to describe the bioavailability of propranolol in patch preparations. Propranolol is made in patch formulations using menthol, PEG, and various combinations of PVP and Eudragit. PVP and Eudragit each dissolved in alcohol and then mixed until homogeneous. Propranolol was dissolved with a menthol solution and then mixed into a solution of PVP and Eudragit. Finally, PEG is added to the solution and stirred until homogeneous and then poured into the patch mold. The patches produced were then measured for each patch and bioavailability assay. The patch formula produced can be used transdermally, but of the three formulas, the F3 formula with a ratio of PVP K30 and Eudragit RS-100 3: 7 gives the best results with a tmax of 2 hours, Cmax 79.33 µg / ml and AUC 49.07 µg hours / ml.
Administered of Lavender (Lavandula Angustifolia) Aromatherapy To Improve Sleep Quality for the Elderly Ni Made Maharianingsih; A.A Sagung Istri Iryaningrat; Dhiancinantyan Windidaca Brata Putri
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.17926

Abstract

Elderly people are age group with a higher incidence of disease or disorders than adults because of physical or psychological changes such as insomnia or decreased quality of sleep. Around 35 % of the total population decreased in sleep quality in the world and in Indonesia around 50%. Aromatherapy that using essential oils can be used as an alternative therapy besides drugs to treat sleep difficulties such as lavender Lavender contains linalool and linalyl acetate which can improve sleep quality and has a calming effect. The purpose of this study was to see the effect of lavender aromatherapy to improve sleep quality elderly. This research design used a pre-experimental design with one group pretest-posttest design method. Respondents were 42 elderly which taking with purposive sampling who resides in panti werda. Data analysis used a non-parametric test, namely the Wilcoxon test. The results obtained were that before using lavender aromatherapy there were 42 respondents (100%) who experienced a decrease in sleep quality. After giving lavender aromateraphy, 38 respondents (90.47%) experienced an increase in sleep quality and 4 respondents (9.53%) did not experience any changes, with p = 0.000. Improved sleep quality can be seen from the difference in the value of subjective sleep quality parameters, sleep latency, sleep duration, sleep efficiency, sleep disturbances, and daytime dysfunction based on the difference between the pretest and posttest scores. It can be concluded that giving lavender aromatherapy can improve the quality of sleep in the elderly.
The Effect of NaOH Concentration on Cellulose Levels of Kepok Banana Hump (Musa paradisiaca L.) Surya Ningsi; Nurshalati Tahar; Nur Azizah Syahrana; Yuri Erika Arifin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.20146

Abstract

The high cellulose content of Kepok banana hump has great potential to be used as a pharmaceutical excipient. This research aims to determine the effect of NaOH concentration on cellulose levels from kepok banana hump. NaOH solution was made in five concentrations, namely 5%; 7.5%; 10%; 12.5% and 15%. Cellulose levels were analyzed using the Chesson method. The research results showed that the NaOH solution with a concentration of 5%; 7.5%; 10%; 12.5% and 15% yielded cellulose content of 12.5%, 15.9%, 64.9%, 60.7% and 41.9%. The highest cellulose content is produced at a concentration of 10% NaOH solution.
Comparison of Thiamine Contain in Mung Beans (Vigna radiata L.) and Soybean (Glycine max (L.) Mer.) with Fresh and Boiled Treatment Agus Suprijono; Yuni Utami
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13896

Abstract

Mung beans (Vigna radiata L.) and soybeans (Glycine max (L.) Mer.) are species of nuts that contain good nutrients for health, such as thiamine or vitamin B1. Thiamine can increase appetite and important in nervous system. Both species of beans can be processed into consumable sprouts, both fresh and boiled. The research aims to compare the concentrations of thiamine in mung beans sprouts and soybeans sprouts in fresh and boiled conditions. The research procedure began with prepared fresh and boiled samples. Boiled samples were prepared by boiled sprouts for 3 minutes at 100°C. Thiamine was extracted from samples used 0,1 N HCl by heated on a water bath at 100°C for 30 minutes. The extracts of fresh and boiled sprouts were analyzed qualitatively used chemical reagents and quantitatively used spectrophotometer UV-Vis. Qualitative analysis showed that both fresh and boiled mung beans sprouts and soybeans sprouts contain thiamine. Quantitative test results for boiled and fresh mung beans sprouts were 0,26% and 0,15%, while soybeans were 0,64% and 0,44%, respectively. The thiamine content in soybeans sprouts is higher than in mung beans sprouts. Decrease of thiamine concentration in mung beans sprouts was higher at 42,31%, for boiled sample than soybeansbenas sprouts at 31,25%. The results of statistical tests used the t test showed a significant difference in thiamine concentration between fresh and boiled beans, both mung beans and soybeans.
Antiproliferation potential of Botto-botto (Chromolaena odorata L.) leaves methanol extract fraction against HeLa Cell Line Muhammad Rusdi; Haeria Haeria; Nursalam Hamzah; Afrisusnawati Rauf; Faradibha Amriani
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.14051

Abstract

Botto-botto (Chromolaena odorata L.) was one of plants that its leaves used empirically in South Sulawesi society as wound and anti-inflammatory drugs. This study aimed to determine the potential of Botto-botto toward cancer cells (HeLa Cells) and normal cells (Vero cells) using the MTT assay method (Microculture Tetrazolium Salt Method). Ethyl acetate extract from methanol extract being fractionated by vacuum liquid chromatography method by a different polarity level of solvent. Cytotoxic effect test was using MTT method to cancer cells (HeLa), and normal cells (Vero) with the percent parameter of cell growth inhibition. Selectivity index was determined from percentage of cancer cell growth inhibition ratio of cancer cells to normal cells. The results showed that A, B, C, D, E, F, and G fractions had a selectivity index on HeLa cells at 0.845, 3.387, 2.004, 1.508, 1.625, 1.284, 1.299. This result proved that B fraction of methanol extract of Botto-botto leaves had a potential to be developed as chemotherapy agents in increasing the effectiveness treatment of cervix cancer.
Efficacy of Sangkareho Leaves Ethanol Extract (Callicarpa longifolia l.) As Anti-Diarrhea Munifah Wahyuddin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.20413

Abstract

Diarrhea is a public health problem in developing countries such as Indonesia, because it still often occurs in the form of Extraordinary Events (KLB), and is accompanied by high mortality, especially in Eastern Indonesia. Based on the results of Riskesdas in 2007, it was shown that diarrheal disease was the main cause of death in infants. This study aims to determine the concentration of how much extract from DaunSangkareho can provide antidiarrheal effects on male mice test animals by looking at the frequency and consistency of stool. 15 mice were used which were divided into 5 groups and each group consisted of 3 mice, the negative control group was given a 1% Na.CMC suspension, groups II, III, and IV were given extracts of 2%, 4%, and 6 respectively. % b / v, as a treatment group. And for group V was given positive control of the loperamid-HCl suspension as a comparison. All groups were injected with English saline solution orally as diarrhea inducers. Evaluation of antidiarrheal effects was carried out by observing the consistency of mouse stools every 1 hour for 10 hours. The results showed that Sangkareho Leaf Extract with a concentration of 2%, 4%, and 6% b / v, had an antidiarrheal effect on the gastric or intestinal mucosa caused by an English saline solution. Sangkareho Leaf Extract at a concentration of 6% b / v has an optimal antidiarrheal effect and is the same as giving Loperamid-HCl suspension as a comparison.
Efficacy of Petai (Parkia speciosa, HASSK) leaf extract as an antidyslipidemic herb in Rattus norvegicus induced by high-fat feed Jatmiko Susilo; Anita Widya Astuti; Dewi Larasati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13761

Abstract

This study aims to analyze the effect of Petai (Parkia speciosa, HASSK) leaf extract on total cholesterol, triglycerides, LDL and HDL levels in dyslipidemic rat models induced high-fat feed. The pre and post-test with control group design using 30 rats were divided into 5 groups, namely positive, normal, and Petai leaf extract at doses of 100, 200 and 400 mg/kg BW. All rats were fed high fat diet for 14 days. The extract group was given Petai leaf extract orally from day 14 to day 28. Lipid profiles were tested using enzymatic spectrophotometry method. Petai leaf extract was identified to contain flavonoid compounds. The research showed that the Petai leaf extract at a dose of 100, 200 and 400 mg / kg BW  were able to decrease total cholesterol: (-32.06 ± 3.63), (-47.23 ± 2.98), and (-49,18 ± 2.66), mg / dL; triglyceride: (-11.12 ± 3.99), (-37.31 ± 0.65), and (-43.01 ± 1.17) mg / dL; LDL: (-17.14 ± 9.30), (-46.51 ± 1.99), and (-46.51 ± 1.99) mg / dL; and increasing HDL levels: (6.44 ± 0.21), (8.42 ± 0.73), and (12.1 ± 0.43) mg / dL respectively. This study proves that Petai leaf extract has anti-dyslipidemic activity in rat models by reducing total cholesterol, triglycerides, and LDL and increasing HDL levels.

Page 4 of 12 | Total Record : 115

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