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TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia
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INDONESIA
Indonesian Journal of Pharmaceutical and Clinical Research
Published by Universitas Sumatera Utara
ISSN : 26156199     EISSN : 26203731     DOI : https://doi.org/10.32734/idjpcr.v1i1.203
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical technology, pharmacology, clinical pharmacy, medical sciences, biological pharmacy and pharmaceutical chemistry. The journal also receives systematic reviews, meta-analysis and review article on new issues in pharmaceutical and clinical sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal. At the initial stage, this journal will be published online twice a year.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 112 Documents
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Antibacterial Activity of Gel of Ethanol Extract of Papaya Leaves (Carica papaya L.) againts Propionobacterium acnes Pertiwi, Dewi; Ihsanul Hafiz; Rahmalia Salma
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.416 KB) | DOI: 10.32734/idjpcr.v2i1.869

Abstract

Abstract Papaya plants (Carica papaya L) besides being a food ingredient are also believed to have medicinal properties and are used traditionally, one of which is in dealing with acne problems. The purpose of this study was to formulate papaya leaf extract in the form of a gel preparation and test its antibacterial activity against the Propionibacterium acnes bacteria. The preparation of the ethanol extract of papaya leaves was made in three concentrations namely 5, 10 and 15%, then tested for antibacterial activity and compared with negative controls (blank gel) and positive control (erythromycin). The results showed that the papaya extract ethanol extract of 10 and 15% leaves had significantly different activities to the negative controls, but the 5% gel formula did not show any different activity towards negative controls. The conclusion of this study is that active papaya leaf ethanol extract gel inhibits bacterial growth at concentrations of 10 and 15%. Keywords: Carica papaya L., gel formula, antibaterial activity, Propionibacterium acnes
The Effect of Turmeric Extract (Curcuma Domestica Val) Against the Durability of Yellow Rice Storage Maha, Hetty Lendora; Sitompul, Erly; silalahi, Jansen
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (749.872 KB) | DOI: 10.32734/idjpcr.v2i1.950

Abstract

Yellow cooked rice is a traditional food in some regions in Indonesia. Yellow cooked rice with the addition of turmeric and flavoring which can longer shelf life of savings because it has antibacterial activity and flavor. The purpose of this study was to determine the effect of turmeric extract (Curcuma domestica Val) to extend shelf life of yellow cooked rice. The samples used were made of yellow cooked rice with handmade and without any seasoning flavored with turmeric extract concentration of 1.8% and 2.4%. Organoleptic testing were conducted every 3 hours, test of microbial growth daily and inhibition of turmeric extract with a concentration of 1.8% and 2.4% of fungi isolated from yellow cooked rice with a total plate count method. Research showed that turmeric extract concentration and the addition of herbs affect the longer shelf life of yellow cooked rice store. High more and more concentration of the turmeric extract can made longer the shelf life of yellow cooked rice either through organoleptic and also total plate count. Yellow cooked rice without seasoning with turmeric extract concentration of 1.8% and 2.4% were 30 and 33 hours respectively, while the yellow cooked rice was flavored with the same concentration of turmeric extract were 36 and 39 hours respectively.
Antibacterial Activity of Ethyl Acetate Fraction of Passion Fruit Peel (Passiflora Edulis Sims) on Staphylococcus Aureus and Escherichia Coli Nugraha, Sony Eka; Suryadi Achmad; Erly Sitompul
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (737.607 KB) | DOI: 10.32734/idjpcr.v2i1.972

Abstract

North Sumatera is one of the central areas of purple passion fruit production in Indonesia. Processing passion fruit into beverage products (passion fruit juice) produces peel has not been utilized. The use of passion fruit skin needs to be studied so that it can be useful as a raw material for antibacterial drug preparations. The aim of this study was to determine the phytochemical constituent screening and antibacterial activity of ethyl acetate fraction of purple passion fruit peel against Staphylococcus aureus and Escherichia coli. Simplicia and ethyl acetate fraction were determinated its phytochemical properties. The extraction process by percolation method using ethanol 96% and continue to fractionation process by liquid liquid extraction method using n-hexane and ethyl acetate. The antibacterial activity were tested against Staphylococcus aureus and Escherichia coli using agar diffusion method with paper discs. The result showed that the simplicia characteristic of passion fruit peel were water content of 8.64%, water soluble extract of 31.69%, ethanol soluble extract of 13.02%, ash total of 7.89%, and insoluble ash in acid of 0.816%. The phytochemical screening simplicia and ethyl acetate fraction showed the presence of flavonoids, glycosides, saponins and tannins. The antibacterial activity test showed that the ethyl acetate fraction has an effective inhibition at the concentration of 100 mg/ml against Staphylococcus aureus and Escherichia coli, it showed dose dependent manner. The ethyl acetate fraction of passion fruit peel (Passiflora edulis Sims) has an antibacterial activity on Staphylococcus aureus and Escherichia coli
Appropriateness of Antibiotic Utilization in Hospitalized Post-Surgery Patients Nasution, Azizah; Fashilah, Noor; Nugraha, Sony Eka
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (759.492 KB) | DOI: 10.32734/idjpcr.v2i1.1103

Abstract

Abstract. One of the most common health problems related to surgery is infection which needs treatment with antibiotics. Inappropriate use of antibiotics results in many problems including microbial resistance, interference of the required clinical outcomes, increasing side effects of the provided antibiotics and health resources utilization, causing toxic effects to the body organs, and even death. This study aimed to evaluate the appropriateness of antibiotic utilization on post-surgery patients admitted to Haji Adam Malik (HAM) Hospital, Medan, Indonesia. This three-month prospective descriptive study was conducted to evaluate the appropriateness of antibiotic utilization based on Gyssens method categorized into appropriate and inappropriate (in terms of dose, interval, route, too long provision, too short provision, less effective, toxicity, price, and the spectrum), and trustable literatures on post-surgery patients assessed from their medical records (n=31) in HAM Hospital Medan. Most (54.8%) of the patients were females. The study proved that 23 (74.2%) of the patients received appropriate/rational antibiotic therapy and 8 (25.8%) of them received inappropriate antibiotic therapy consisted of problems with: inappropriate dose, 13%; too long duration, 3.2%); too short duration, 29%. More than a quarter of the patients received inappropriate dosages of antibiotics.
Potential Medication Errors in Electronic Prescribing in A Primary Health Care Nurfitria, Rizki Siti; Adillah Effendi , Rima Nur; Iskandar , Deni
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (781.006 KB) | DOI: 10.32734/idjpcr.v2i1.1166

Abstract

An effort to reduce medication errors is to use drugs prescription electronically[1,2,4]. However, there needs to be an evaluation of this system, because this system is not free from errors in medication. This study aimed to find out the description of prescribing flow, to examine electronic prescription completeness, and find out the potential medication errors that occur in the prescribing phase of electronic prescription using prescribing indicators[1,5,9,10]. This study used observational method by taking general practice outpatient prescription data of March 2018 in a company health service located in Bandung and analyzed descriptively[6,7,8]. Electronic prescription of medicines at this health care was made and inputted by doctors. When an error occured on a computer system, the doctor would prescribe it manually so that the patient can still be served. Incompleteness of the most common recipe was on administrative requirements where all prescriptions did not listed the doctor's practice permit, patient's gender, patient's weight, telephone number of the place of practice, and patient's contact number. Medication errors had the most potential for the occurrence of prescription writing with two or more drugs interacting and this error was classified as category D according to The National Coordinating Council for Medication Error Reporting and Prevention (NCC-MERP).
The Antioxidant Activity of Pagoda Flower (Clerodendrum paniculatum L.) Ethanol Extract using Visible Spectrophotometric Method Hafiz, Ihsanul; Ginting, Mandike; Yuermaileni, Yuermaileni
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1026.976 KB) | DOI: 10.32734/idjpcr.v2i2.2060

Abstract

Abstract. Pagoda flower is one of the plant species included in the genus Clerodendrum which has a number of different species of 580 species, and is spread evenly in Asia, Africa, America, and Australia. A number of species of this genus have been used in traditional medicine in Asia and Africa. India, China, Korea, Thailand and Japan. The antioxidant activity of this plant is known to be very strong, so in this article the antioxidant activity of the flower part of the Clerodendrum paniculatum L. species will be described. The ability of antioxidant activity was measured by the DPPH method (1,1-diphenyl-2-picrylhydrazyl) which was measured using a Visible spectrophotometer using Vit C as a comparison. The results showed that the ethanol extract of pagoda flowers has antioxidant activity with an IC50 value of 64.889 ppm (strong). The Vit C comparison has an IC50 value of 8.539 ppm (very strong). Keyword: Antioxidant, Clerodendrum Paniculatum L., Visible Spectrophotometric. Abstrak. Bunga Pagoda merupakan salah satu spesies tanaman yang termasuk dalam genus Clerodendrum yang memiliki jumlah spesies yang berbeda sejumlah 580 spesies, dan tersebar merata di Asia, Afrika, Amerika, dan Australia. Sejumlah spesies dari genus ini telah digunakan dalam pengobatan tradisional di kawasan Asia dan Afrika. India, China, Korea, Thailand, dan Jepang. Aktivitas antioksidan dari tanaman ini diketahui sangat kuat, sehingga dalam artikel ini akan dipaparkan aktivitas antioksidan yang dimiliki oleh ekstrak etanol bagian bunga dari spesies Clerodendrum paniculatum L. Pengujian aktivitas antioksidanya dilakukan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) yang diukur menggunakan spektrofotometer Visibel dengan menggunakan Vit C sebagai pembanding. Hasil penelitian menjukkan bahwa ekstrak etanol bunga pagoda memiliki aktivitas antioksidan dengan nilai IC50 sebesar 64,898 ppm (kuat). Pembanding Vit C memiliki nilai IC50 sebesar 8,539 ppm (sangat kuat). Kata Kunci: Antioksidan, Clerodendrum paniculatum L., DPPH, Spektrofotometri Vis.
Evaluation of Antiinflammatory Activity of Marine Omega-3 in Rats Faizah, Ana Khusnul; Kresnamurti, Angelica
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (806.788 KB) | DOI: 10.32734/idjpcr.v2i2.2666

Abstract

Marine omega-3 from fish contains high EPA dan DHA which may have an analgesic and anti-inflammatory effects. The objective of study is to analyze the anti-inflammatory effect of marine omega-3 in rats. The method of this study is pre-post control experimental. The acute anti-inflammatory effect of marine omega-3 were investigated through carrageenan induced paw edema in rats. Thirty minutes before the procedure, the experimental groups were treated with fish oil 40 and 60 mg/kg; sodium diclofenac (5 mg/kg) as positive control groups and span 80-tween 80 as negative control groups. The degree of paw edema was measured by caliper. The marine omega-3 showed anti-inflammatory effect in a dose-dependent manner. The results of 60 mg/kg of marine omega-3 was significantly different compared with the negative. Overall, the marine omega-3 has acute anti-inflammatory activity in rats.
Comparison of Antioxidant Activity of Ethanol Extract of Fruit and Okra Leaves (Abelmoschus esculentus L. Moench) with DPPH and ABTS Methods Hendri Faisal; Handayani, Sri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (863.022 KB) | DOI: 10.32734/idjpcr.v2i2.2815

Abstract

Excessive free radical activity in the human body can be characterized by pathological conditions such as cardiovascular disease, pre-natal complications, arthritis, cataracts, parkinsonism, alzheimer's, and aging. One way to prevent the formation of free radicals is to use nutrients that act as antioxidants. Natural antioxidants found in fruits and vegetables are effective free radicals and are considered non-toxic when compared with synthetic antioxidants, one of which is the okra plant Abelmoschus esculentus L.The purpose of this study is to determine differences in the antioxidant activity ethanol extract of fruit and okra leaves with DPPH method and ABTS method. The method used in this study is the maceration extraction method with 70% ethanol solvent to obtain fruit extracts and okra leaves. The antioxidant activity test was carried out by the DPPH (1,1-diphenyl-2-picrylhydrazi) method by measuring the absorption of a mixture of sample extracts and DPPH by UV-Visible spectrophotometry at a wavelength of 520 nm and by the ABTS method ((2,2-azinobis- (3 -Ethylbenzothiazoline-6-Sulfonic Acid) by measuring the absorption of a mixture of sample extracts and ABTS by UV-Visible spectrophotometry at a wavelength of 734 nm. measurement of antioxidant activity of okra fruit ethanol extract by ABTS method has very strong antioxidant activity (IC50 24.50 ppm)
In Vitro Test of Anticalculi Effect from Ethyl Acetate Fraction of Chives Leaf (Allium schoenoprasum L.) Iksen; Sinaga, Siti Morin; Kevin, Kevin; Hutabalian, Marshinta Romarta Uly
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.469 KB) | DOI: 10.32734/idjpcr.v2i2.3030

Abstract

Abstract. The purpose of this study was to analyze the ability of chives leaves of ethyl acetate fraction to dissolve calcium in human kidney stones. This research starts from making the ethyl acetate fraction, calibration curve for calcium and measuring dissolved calcium levels in kidney stones by using atomic absorption spectrophotometry. The results showed that the ethyl acetate fraction with a concentration of 2.5% had the greatest anti-calculi capability of 92.02%. The conclusion of this study is that the ethyl acetate fraction of chives leaf has the potential to be anticalculi in the treatment of kidney stones. Abstrak. Tujuan dari penelitian ini adalah untuk menganalisis kemampuan fraksi etil asetat daun kucai untuk melarutkan kalsium pada batu ginjal manusia. Penelitian ini dimulai dari pembuatan fraksi etil asetat, pembuatan kurva kalibrasi kalsium serta pengukuran kadar kalsium terlarut pada batu ginjal dengan menggunakan spektrofotometri serapan atom. Hasil penelitian menunjukkan bahwa fraksi etil asetat dengan konsentrasi 2,5 % memiliki kemampuan antikalkuli yang terbesar yakni 92,02%. Kesimpulan penelitian ini adalah bahwa fraksi etil asetat daun kucai berpotensi sebagai antikalkuli pada pengobatan batu ginjal.
Formulation and Characterization of Nanoemulsion of Tread leave Ethanol Extract (Catharanthus roseus (L.) G. Don) as Antihyperglycemic Mariadi; Prasetyo, Bayu Eko; Adela, Hanny; Wiladatika, Winda
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (881.744 KB) | DOI: 10.32734/idjpcr.v2i2.3204

Abstract

Nanoemulsion technology has been widely developed and applied on natural extract to enhance bioavailability and drug effects. The tread plant (Catharanthus roseus (L.) G. Don) is commonly known in traditional medicine for lowering blood sugar levels. This study aimed to make and characterize nanoemulsion of tread leaf extract as antihyperglycemic using sesame oil and olive oil as carriers. Nanoemulsion formulations were made using ethanol extract of tread leaves, and additives such as Tween 80, isopropyl myristate in varying ratios and some of vegetable oils. The nanoemulsion was physically evaluated tests including the pH, the type of emulsion, homogeneity and size distribution which measured by the Particle Size Analyzer (PSA). Antihyperglycemic testing was carried out on 4 groups of male mice (5 mice/ group) induced with glucose and treated with extract, nanoemulsion, and distilled water. The results showed that the nanoemulsion preparation had a pH of 6.4 to 6.5; o/w type of emulsion and it was stable on storage for 1 month. The particle size distribution of the nanoemulsion was 85.8% with size <500 nm. Nanoemulsion could reduce the blood glucose levels in mice to normal level after 60 minutes. It also showed the decreae for 43-46% of the blood glucose level after 2 hours. The Nanoemulsion of tread leaf extract has a faster ability and a greater percentage in reducing blood glucose levels compared to extract and control. Keywords: Nanoemulsion, Catharanthus roseus, sesame oil, olive oil, Antihyperglikemic

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