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TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia
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INDONESIA
Indonesian Journal of Pharmaceutical and Clinical Research
Published by Universitas Sumatera Utara
ISSN : 26156199     EISSN : 26203731     DOI : https://doi.org/10.32734/idjpcr.v1i1.203
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical technology, pharmacology, clinical pharmacy, medical sciences, biological pharmacy and pharmaceutical chemistry. The journal also receives systematic reviews, meta-analysis and review article on new issues in pharmaceutical and clinical sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal. At the initial stage, this journal will be published online twice a year.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 118 Documents
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Proximate Composition of Anadara granosa and Paphia undulata Permata, Yade Metri; Liesna, Anggi Tri; Rangkuti, Fahmi Muhammad; Insyra, Kharisma; Dayanti, Yasmin
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.9196

Abstract

The sea region of Indonesia is particularly abundant in natural resources. One of the economically viable aquatic commodities is shellfish. The public has a high demand for the shellfish Anadara granosa and Paphia undulata. The goal of this study was to ascertain the protein, carbohydrate, fat, water, and ash content of Anadara granosa and Paphia undulata. The study's sample was intentionally drawn from the sea waters off the coast of Belawan, North Sumatera. Following the SNI technique, the proximal level measurement method was used. According to the examination of proximate levels, there is a 10–12% protein content, 0.14–0.15% carbohydrate content, 1% lipid content, 70%–80% water content, and 2% ash content. It can be concluded that, as functional foods, Anadara granosa and Paphia undulata include nutrients that are good for your health.
Prevalence, management and complications of diabetic patients in pabna city Parvez, G M Masud; Rumayesha; Parvin, Mst. Shanzida; Afrin, Aziza; Azad, Abul Kalam; Aktar, Mst. Mahabuba; Rabbi, Md. Fazle; Rashid, Sumaiya; Farjana, Akila; Naznin, Most. Anika; Sultana, Razia; Parvin, Shumaia; Kader, Md. Abdul
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.10411

Abstract

Diabetes is one of the leading causes of death and its prevalence is increasing day by day. This survey was conducted by direct interviewing to the diabetic patients. In this study, the interviewees were the diabetic affected patients of Pabna district. About 1100 persons were interviewed among them 37.55% were male and 62.45% were female. Most of the patients have onset of diabetes at 41-50 years age. Most of our observed patients have suffered from diabetes between 1-5 years (62.64%) followed by 6-10 years (25.18%). Here 3.18% patients have BMI ≤18.5, 47.55% have between 18.5-24.9, 39.55% have BMI 25.5-29.9 and 9.73% have BMI ≥30. Here 93.45% diabetic patients have blood glucose level of >7 mmol/L. The diabetic patients also suffered from retinopathy 50.36%, neuropathy 19.73%, nephropathy 23.55% and foot problem 43.36%. About 63.27% are taking diet, 56.91% are taking exercise and 93.91% are taking drug for treating diabetes. It was found that the patients are suffering from different other diseases. The patients need to be aware about the potential risk of other diseases.
Herbal Medicines and Recent Development on Novel Herbal Drug Delivery System Ahmed, Aziz; Shuaib, Mohd; Shirsat, Mrunal K.; Sharma, Deeksha
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.11702

Abstract

The World Health Organization (WHO) defines herbal medicine as a technique that uses herbs, herbal ingredients, herbal preparations, and finished herbal products. Herbal remedies contain a variety of chemical components known as phytochemicals, which fall into a number of categories including saponins, flavonoids, glycosides, tannins, alkaloids, and terpenoids. Due to the presence of these phytochemicals, herbal medications can be used to treat a variety of ailments and diseases, including gastrointestinal problems, skin infections, arthritis, migraines, and weariness. Herbal medicines have less major adverse effects than conventional pharmaceuticals and are less expensive. New herbal formulations can include transfersomes, ethosomes, microspheres, phytosomes, liposomes, polymeric nanoparticles, and nanocapsules. In comparison to traditional herbal medicines, the novel herbal drug delivery systems offer many advantages, including increased solubility and bioavailability, protection from side effects, enhanced pharmacological action, increased stability, better delivery to tissue macrophages, consistent delivery, and protection against the physical and chemical breakdown of active ingredients. To incorporate standardised herbal extract or aqueously soluble active ingredients into phospholipids to build lipid companionable molecular complexes, phytosome has been described as a patented innovative herbal technology produced by a leading manufacturer of medicines and nutraceuticals. The use of herbal medicines can be expanded in order to increase their efficacy by incorporating them into more sophisticated medications.
The Lipid Profile and Aorta Histopathology On Hyperlipidemic Rat by Saurauia vulcani Korth. Leaves Extract Octora, Debi Dinha; Rosidah; Silalahi, Jansen; Satria, Denny
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.6521

Abstract

Abstract. Dyslipidemia is a pathological condition characterized by increased levels of total cholesterol, triglycerides and LDL and decreased levels of HDL. Dyslipidemia causes cardiovascular disease risk factors by increasing cholesterol levels, increasing triglyceride levels, lowering HDL levels, and increasing LDL levels, as well as decreasing the proliferation of cardiac aortic cells in dyslipidemic rats. The pirdot plant (Saurauia vulcani Korth.) has long been known by the Simalungun, Toba and Karo communities to have the potential to treat various diseases caused by disruption of lipid processes in the body. Pirdot leaves contain bioactive compounds of flavonoids, tannins and saponins that have the potential to improve lipid profiles and prevent cardiovascular disease. This study aims to determine the activity of EEDP on the lipid profile of dyslipidemic rats. Pirdot leaf simplicia powder was extracted by maceration with 96% ethanol solvent and the extract was used on 30 dyslipidemic rats which were divided into 6 groups. Group 1 (Na-CMC), group 2 (Atorvastatin), group 3, 4, 5, 6 EEDP doses of 50, 100, 200, 400 mg/kg BW were administered orally for 21 days. At the end of the treatment, the levels of total cholesterol (TC) and aortic cell proliferation were measured. The results showed that Saurauia vulcani Korth had water content (6.23%), water soluble extract (10.50%), simplicia content soluble in ethanol (14.77%), total ash content (7.05%) and acid insoluble ash content (0.48%). From the antidyslipidemic study it was shown that EEDP 400 mg/kg BW improved blood lipand to increase aortic cell proliferation dyslipidemic rats was 69.84±0.27. Based on the explanation above, it is concluded that EEDP has an antidyslipidemic effect.
Comparison of antihypertensive drug utilization in community health centre and type B teaching hospital Sitorus , Tromphin; Simatupang, Abraham
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.11982

Abstract

Antihypertensive medicine is one of the many complex factors contributing to the sustained rise in hypertension prevalence, which remains a global health concern. The Social Security Agency on Health, or Badan Penyelenggara Jaminan Social (BPJS) Kesehatan, in Indonesia is an integrated healthcare system that provides universal healthcare to its citizens. This retrospective cross-sectional study examined the use of antihypertensive medications covered by BPJS between January and December 2021 at the Rawabuntu Primary Health Centre and the Universitas Kristen Indonesia (UKI) type B public hospital. The necessary data was extracted from the medical files of 192 hypertensive patients. The patients' characteristics were analysed descriptively. The rationality of antihypertensive medication use was evaluated in accordance with Association of Indonesian Hypertension Physicians-approved guidelines. The majority of patients in both categories were female (52.1 percent at the Rawabuntu Primary Health Centre and 60 percent at the teaching facility). In both healthcare facilities, the correct indication, patient, and dosage were administered 100 percent of the time, according to this study. While only 66.7% and 85.4% of patients at the Rawabuntu Primary Health Centre and UKI hospital received the correct drug category, respectively. The rational use of antihypertensive medications was substantially lower at the Primary Health Centre than it was at the UKI Hospital (p = 0.001).
Cytotoxic and Apoptotic Activities of Vernonia amygdalina Extract in HepG2 Cell Line Harefa, Herman Syukur; Hasibuan, Poppy Anjelisa Zaitun; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.6350

Abstract

Liver cancer is a malignant tumor originating from the development of chronic hepatitis or cirrhosis and is responsible for damage to the shape and function of the liver. The loss of the ability of conventional chemotherapy to inhibit the growth of cancer cells is a major focus in the world. Natural ingredients are the solution to this problem, for example the use of Vernonia amygdalina leaves. Vernonia amygdalina contains flavonoids, cardiac glycosides, and steroids/triterpenoids which are reported to have anticancer properties. This study aims to examined the activity of these plants as anticancer liver through cytotocix and apoptotic activity. Vernonia amygdalina ethanol extract (VAEE), Vernonia amygdalina ethyl acetate extract (VAEAE), and Vernonia amygdalina n-hexane extract (VAHE) were obtained from a multistage maceration process. The extracts were tested for cytotoxic activity by the MTT method on HepG2 cells. VAEAE had the best inhibitory concentration 50 (IC50) value of 19.91 ± 0.24 µg/mL. Apoptosis test was performed using double staining method. Subjective observations were made using a fluorescence microscope. It was seen that Vernonia amygdalina ethyl acetate extract was able to trigger apoptosis in HepG2 cells.
Formulation and Evaluation of Body Scrub Cream Containing Ethanol Extract of Black Cumin Seeds (Nigella sativa L.) and Coffee Grounds (Coffea arabica L.) as Anti-aging Hasibuan, Poppy Anjelisa Zaitun; Sumaiyah, Sumaiyah; Siregar, Dedek Harianti
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.8256

Abstract

Cosmetics are now mandatory for most women. Various natural ingredients have now been used as basic ingredients for beauty treatments. This study aimed to formulate and determine the effectiveness of body scrub cream preparations containing ethanolic extract of N. sativa and coffee grounds as antiaging. The skin antiaging was divided into five formulas: F0 (cream base), F1 (coffee ground 5%), F2 [coffee ground 5% + Ethanol Extract of N. sativa (EENS) 2%], F3 (coffee ground 5% + EENS 3.5%) and F4 (coffee ground 5% + EENS 5%). The body scrub cream preparations were subjected to organoleptic, homogeneity, emulsion type, and pH evaluation. The irritation test and antiaging activity were evaluated by using a skin analyzer. The body scrub was stable in 12-week storage. The result showed that there was no irritation on the volunteers’ skin. The body scrub cream with the highest antiaging activity was the F4 formula. It showed 9.6% for increasing skin moisture, 17.68% for increasing skin smoothness, 11.42% in reducing the size of pores and 12.84% in reducing the number of spots.
Teratogenic Toxicity of Ethanol Extract of Mahkota Dewa Fruit Flesh (Phaleria macrocarpa (Scheff.) Boerl) Julianti, Maelani; Yuandani; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.8733

Abstract

Mahkota Dewa is known as one of the medicinal plants in Indonesia. It contains bioactive compounds and potentially has pharmacological activity. This study aimed to determine the possible toxic effects of Mahkota DewaThe ethanol extract of Mahkota Dewa fruit flesh was given to rats. Group I (control 0.5% Na-CMC), groups II, III and IV as a treatment group (Mahkota Dewa at doses of 100, 500 and 1000 mg/kg bw, respectively). Group V as a control satellite (Na-CMC 0, 5%) and group VI as a satellite of the ethanol extract at a dose of 1000 mg/kg bw., Each groups were treated on day 6 to 15 of gestational. On the 19th day getation, the rats were dissected and observed the skeletal malformations. The data were analyzed using one-way ANOVA followed by a post-hoc tukey. The results toxicity showed that no fetuses had external malformations. On fetal skeletal appearance, all skeletal bone preparations were normal. Based on the study, the ethanolic extract of Mahkota Dewa Fruit Flesh did not cause a teratogenic effect on the fetus during the organogenesis period at doses of 100 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw  
Evaluation of Ethanol Extract of Red Algae (Kappaphycus Alvarezii Doty): Total Phenolic and Flavonoid Content . S, Aminah; Arianto, Anayanti; Dalimunthe, Aminah
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.8871

Abstract

This study aims to determine the characterization of red algae simplicia and the amount of yield obtained from the manufacture of red algae ethanol extract using the soxhletation method. Red algae were taken from Banggai Islands Regency, South Sulawesi and processed into dry simplicia and characterized by macroscopic examination, determination of water content, content of water soluble extract and ethanol, total ash content and acid insoluble ash content. Simplicia was extracted using 96% ethanol solvent by soxhletation method and calculated the amount of yield obtained. Macroscopic observation of red algae simplicia obtained a brown coarse powder accompanied by a distinctive taste and odor. Determination of the water content of simplicia obtained 7.21%, water soluble extract content 31.54%, ethanol soluble extract content 17.27%, total ash content 33, 96% and 11.42% acid insoluble ash content. The ethanolic extract of red algae using the soxhletation method was obtained as much as 68.92 grams with a total extract yield of 13.78%. Based on the results of the study, it can be concluded that the simplicia characterization of red algae meets the requirements and has a large extract yield.
Immunomodulatory Effects of Phaleria macrocarpa Leaf Extract in Normal And Cyclophosphamides Induced in Wistar Rats Febriady, Andy; Harahap, Urip; Yuandani, Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.11271

Abstract

Abstract. Cyclophosphamide is an antineoplastic drug belonging to the alkylating agents commonly used in treating cancer. However, the use of cyclophosphamide causes a decrease in the body's immune system by reducing lymphocyte proliferation. The curent study was conducted to evaluate the immunomodulatory effect of ethyl acetate extracts of the leaf of the P. macrocarpa (EEADMD) and the ethanol extracts of the leaf of the P. macrocarpa (EEDMD) in normal and cyclophosphamide induced rats. This study used rats classified into two major groups: normal rats and rats induced by cyclophosphamide which were then given P. macrocarpa leaf extract until day 14. On day 4, the test animals were infected with 1% Staphylococcus aureus suspension in. Induced with cyclophosphamide 70 mg/kg BW was carried out on the 8th and 13th days, and then the immunomodulatory activity was tested using total leukocyte analysis, leukocyte differential, and delayed type hypersensitivity response. The results showed that EEDMD 400 mg/kg BW  in normal rats and EEDMD 100 mg/kg BW in cyclophosphamide induced rats could increase total leukocytes and leukocyte differential with a significant difference to the negative group (p <0.05). The results of the delayed hypersensitivity response test of EEADMD and EEDMD at a dose of 100 mg/kg BW with cyclophosphamide induction and normal rats could give an increase in rat paw volume with a significant difference to the negative group (p <0.05). This study shows that EEADMD and EEDMD have an immunomodulatory effect on increasing total and differential leukocytes and leukocyte differential and delayed type hypersensitivity response.

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