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TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia
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INDONESIA
Indonesian Journal of Pharmaceutical and Clinical Research
Published by Universitas Sumatera Utara
ISSN : 26156199     EISSN : 26203731     DOI : https://doi.org/10.32734/idjpcr.v1i1.203
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical technology, pharmacology, clinical pharmacy, medical sciences, biological pharmacy and pharmaceutical chemistry. The journal also receives systematic reviews, meta-analysis and review article on new issues in pharmaceutical and clinical sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal. At the initial stage, this journal will be published online twice a year.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 112 Documents
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Formulasi NLC-Stick Ekstrak Bunga Telang (Clitoria ternatea L.) Dengan Variasi Konsentrasi Shea Butter dan Asam Stearat Damanik, Virna Helena; Pratiwi, Liza; Wijianto, Bambang
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.16719

Abstract

NLC of telang flower extract has an effect as a sunscreen to protect the skin from sunlight. Stick preparation in NLC formulation can facilitate the use of sunscreen. This study aims to determine and compare variations in the concentration of Shea Butter (as a Base) and stearic acid (as a Harding Agent) and obtain the results of physical evaluation of variations in the concentration of Shea butter and Stearic Acid. NLCs of telang flower extract were formulated into formulas with varying concentrations of shea butter and stearic acid in the ratio of 80:20; 50:50; 20:80. Furthermore, the physical properties of NLC-Stick of bay flower extract were evaluated, including organoleptic test, homogeneity test, pH test, melting time test, and spreadability test. The results showed that the optimal variation of shea butter and stearic acid concentration was 50:50. The optimum formula of NLC-Stick of telang flower extract has a colour like the active substance, solid shape, soft aroma, homogeneous, pH of 4.56 ± 0.3, melting time test of 21 minutes, and spreadability test of 3 cm. NLC-Stick with varying concentrations of shea butter:stearic acid (50:50) has a physical evaluation that meets the stick requirements.
Formulasi dan Uji Aktivitas Anti-aging Sediaan Hand Cream yang Mengandung Ekstrak Etanol Kulit Buah Nanas (Ananas comosus (L.) Merr.) Sumaiyah; Gulo, Jevon Three Kartika
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17790

Abstract

Hand skin that is often exposed to the sun easily loses moisture and is more rough. Hand cream is a care product that is applied to the palms and backs of the hands that can help restore hydration and skin function due to dry and rough skin. Pineapple peel contains flavonoids, vitamin C, and bromelain enzymes that has potential to be formulated into anti-aging preparations. This research aims to formulate ethanol extract of pineapple peel (Ananas comosus (L.) Merr.) into hand cream and to test the effectiveness as anti-aging agent. This research included making extracts by percolation method using 70% ethanol solvent, testing the antioxidant activity of pineapple peel extract using DPPH method, and hand cream formulations with the addition of pineapple peel extract with respective concentration of 0% (F0), 5% (F1), 7.5% (F2), and 10% (F3). Evaluation of hand cream preparations included organoleptic test, homogeneity, emulsion type, pH, viscosity, and physical stability at room temperature storage for 12 weeks and cycling test. Anti-aging effectiveness testing was carried out during the 4 weeks treatment period, by measuring parameters such as moisture, pores, blemishes and wrinkles on the skin of the backs of volunteers' hands which were measured once a week using a skin analyzer. The results of the antioxidant activity test of the ethanol extract of pineapple peel were included in the strong category with an IC50 value of 88.21 µg/mL. The hand cream preparation produced was homogeneous, O/W emulsion type, pH value 5.09-6.56, viscosity value 4086.76-6104.96 cPs, stable during 12 weeks of storage at room temperature and stable in the cycling test for 4 weeks. Hand cream preparations with a concentration of 10% have better effectiveness than 0%, 5% and 7.5% which results in an average percent moisture recovery of 77.60%, pores 62.92%, blemishes 55.65%, and wrinkles 45.92%.
Body Scrub Salt Formulation from Cinnamomum burmannii (C. Ness & T. Ness) Blume Extract as an Antibacterial Against Staphylococcus aereus Surbakti, Chemayanti; Nobelia, Christine Ruth; Hanum, T. Ismanelly
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17847

Abstract

Skincare is currently a major focus in the beauty industry with skin exfoliation being an important step. One product used to exfoliate the skin is a body scrub, which contains ingredients such as himalayan salt and cinnamon bark extract. Himalayan salt helps remove dead skin cells and moisturizes the skin, while cinnamon extract has antimicrobial properties that can protect the skin from bacteria. This study aims to formulate and test the effectiveness of body scrub with skin analyzer and antibacterial activity against Staphylococcus aureus. This research uses an experimental method with several stages, namely plant material collection, plant identification, powder making, extract making, preparation making, evaluation and stability, effectiveness test with skin analyzer and antibacterial activity against Staphylococcus aureus. The 10% body scrub has better effectiveness than 0%; 2.5% and 5% which obtained a percent increase in skin moisture (71.62%), a decrease in the number of blemishes on the skin (70.73%) and a decrease in pore size on the skin (76.38%) for 4 weeks of treatment. In testing antibacterial activity, the 10% concentration was also considered the optimal concentration because it had the greatest inhibition of 14.20 ± 0.59 mm. The results concluded that Himalayan salt and cinnamon bark extract can be formulated into a body scrub dosage form that meets the stability requirements and has the effectiveness in moisturizing, smoothing, and brightening the skin. The formula that has the most effective antibacterial activity is a body scrub containing extracts with a concentration of 10% against Staphylococcus aureus bacteria.
Antibacterial Activity Test of Malacca Leaf Extract (Phyllanthus emblica) Against Staphylococcus aureus and Staphylococcus epidermidis Bacteria Ridwanto, Ridwanto; Aprilia, Hijjatun; Rani, Zulmai; Putri Aisyia Fauzi, Ziza; Kaban, Vera Estefania; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17912

Abstract

Antibacterials are substances that can interfere with the growth or even kill bacteria and have the side effect of antibacterial resistance. One effort to reduce resistance is choosing to use natural bacterial ingredients. One plant that can potentially contain antibacterial activity is malacca leaves (Phyllanthus emblica). The contents of this plant include flavonoids, alkaloids, tannins, saponins, and steroids/triterpenoids. This research aimed to prove the antibacterial activity test of malacca leaf extract. The stages in this research included phytochemical screening and testing the antibacterial activity of ethanol extract from Malacca leaves for Staphylococcus aureus and Staphylococcus epidermidis bacteria using the diffusion method using paper discs. The characteristics of malacca leaf simplicia obtained were water content of 4.6%, water-soluble content of 28%, ethanol-soluble essence content of 23.33%, total ash content of 2.00%, and insoluble ash content of 0.5%. The results of phytochemical screening showed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The antibacterial test results of malacca leaf extract at concentrations of 500 mg/ml, 400 mg/ml, 300 mg/ml, and 200 mg/ml have an antibacterial effect against Staphylococcus aureus and Staphylococcus epidermidis, and there is no difference in the effectiveness of the inhibitor against gram-positive and negative grams.
FORMULASI DAN UJI ANTIOKSIDAN EKSTRAK ETANOL DAUN BINAHONG (Anredera Cordifolia) SEBAGAI GEL PELEMBAP Ginting, Ernawaty; nadia, syarifah; Nurul Karima; rossela; Ovalina Sylvia Br Ginting
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.17967

Abstract

Dry skin is often caused by air pollution and sun exposure. Binahong leaves (Anredera Cordifolia) contain flavonoids that can keep the skin moisturized. The gel formulation of binahong leaf extract was chosen because it has good penetration, making it an effective solution for dry skin.This study began by macerating the simplicia of binahong leaves (Anredera Cordifolia) with ethanol p.a (1:10), then formulated into gel preparations with concentrations of 2.5%, 3% and 3.5% with CMC, TEA, nipagin, glycerin and propylene glycol as gel preparation ingredients. Then the physical quality of the preparation was checked which included organoleptic test, pH test, homogeneity test, stability test, dispersion test, adhesion test, irritation test, liking test and viscosity test. In addition, moisture tests and antioxidant tests were carried out using the DPPH method. The gel formulation made has met the physical quality requirements of the preparation, namely all preparations are homogeneous, stable and do not irritate the skin. The pH value is 4.5-4.8, the spread power is 5.5-6.8 cm, the adhesion value is 15-24 seconds and the viscosity value is 12,400-22,299 m.Pas. The amount of antioxidants in formulation 3 was 84.61 mcg/mL ± 0.05 with the strong category and the recovery percentage was 66.94% with a very humid scale. The amount of antioxidants in formulation 2 was 118.56 mcg/mL ± 0.00 with the medium category and the percent recovery was 54.39% with a humid scale. The number of antioxidants in formulation 1 was 163.98 mcg/mL ± 5.71 with the weak category and the recovery percentage was 44.50% with the dry scale. Formulation 3 with a concentration of 3.5% has the highest antioxidants and recovery.
Potensi Antioksidan Dari Ekstrak Etanol Kulit Buah Asam Jawa (Tamarandus Indica L.) sebagai Anti Aging Dalam Sediaan Kosmetik Gel Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai; Andjelie, Tiara; Zulhij, Fizrya
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17992

Abstract

Skin aging can be caused by intrinsic factors which are aging processes that take place naturally and extrinsic factors caused by environmental influences such as sunlight, air, chemicals and the surrounding environment. Prevention of premature aging can be done by giving anti-oxidants, especially herbal skin care products and anti-oxidant cosmetic preparations. plants and spices. One plant that functions as an anti-oxidant is tamarind fruit (Tamarindus indica L.) is a plant with the family Mimosaceae. The method used in this study is a preparation made based on the standard formula of Na-CMC gel base according to Muttiin (2021), a gel standard formula based on Sodium Carboxymethyl cellulose (Na-CMC) based on % w/w. The results of research on the physical characteristics of gel preparations concluded that the gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) has met the physical quality standards of facial gel preparations. Gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) can provide anti-aging effects which can improve skin condition in the first week.
a Molecular Docking Meniran (Phyllanthus niruri L.) Terhadap Penghambatan Enzim Tyrosine Kinase Sebagai Antikanker: Molecular Docking Kartika, Widya Ayu
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.17993

Abstract

ABSTRAK Tumbuhan meniran (Phyllanthus niruri L.) merupakan tumbuhan genus Phyllanthus. Diketahui tumbuhan genus Phyllantus memiliki kandungan senyawa corilagin, geranin, asam galat, filantin, hipofilantin, asam elagat, filtetralin, nirantin, katekin, kuersetin, astragalin, yang merupakan salah satu turunan tannin yang dapat berfungsi sebagai antivirus dan antikanker. Jenis peneliian ini merupakan penelitian melalui pendekatan Computer-Aided Drug Design (CADD) atau in silico yang berbasis komputer dengan tujuan untuk memperoleh ikatan interaksi yang optimal antara protein dan ligan sehingga dapat menghasilkan agen penghambat perkembangan sel kanker. Berdasarkan hasil simulasi molecular docking, senyawa geranin memiliki afinitas paling baik dibandingkan senyawa lainnya yaitu -9,4 kcal/mol sedangkan dibanding dengan nativ ligand-nya yaitu -8,3 atau dengan kata lain senyawa geranin yang berasal dari tumbuhan meniran ( Phillanthus niruri L. ) dapat bereaksi sebagai obat apabila berikatan dengan reseptor target pada kanker. Kesimpulan dari penelitian ini dapat dilihat berdasarkan hasil visualisasi docking juga menunjukkan beberapa ikatan berupa ikatan hydrogen conventional yang mendominasi dan beberapa ikatan hydropobic. Interaksi yang terjadi pada sisi aktif protein target tersebut, mengindikasikan bahwa senyawa tersebut memiliki kemampuan dalam menembus dinding sel dengan kata lain senyawa tersebut dapat bereaksi sebagai obat apabila berikatan dengan molekul reseptor target pada penyakit kanker. Kata kunci : Antikanker, Geranin, In silico, Meniran, Moleculer Docking
Identifikasi Drug Related Problems Pada Pasien Penyakit Ginjal Kronis Di Rumah Sakit Prof. dr. Chairuddin Panusunan Lubis Tahun 2023 Rudang, Singgar Ni; Rambe, Rima Elfitra; Annisa, Sheyla
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.18031

Abstract

Chronic kidney disease (CKD) is an abnormality of kidney structure or function, present for ≥ 3 months, with implications for health. The high number of medications used by CKD patients can increase the potential for Drug-Related Problems (DRPs) which can interfere with desired health outcomes. This study aimed to determine the occurrence of DRPs in chronic kidney disease patients admitted to Prof. dr. Chairuddin Panusunan Lubis Hospital in 2023. This study was a descriptive retrospective cross-sectional study conducted. Data were obtained from the medical records of CKD inpatients in 2023 (n=51). The sampling technique used was total sampling. The occurrence of DRPs was identified based on the Pharmaceutical Care Network Europe (PCNE) V9.1 classification, which includes problems categories (P1-P3) and causes (C1-C6). There were 28 females (54.90%) and 23 males (45.10%), with an average age of 46.8±11.5 years. The highest stage of CKD was stage 5 (78.43%). The most common comorbid condition was anemia (84.31%), with the most frequently used medication being antihypertensives in the Calcium Channel Blocker class (88.24%). Among the 51 medical records, 21 (41,17%) showed the occurrence of DRPs, consisting of 26 Problems (P) categorized under P1. Treatment effectiveness (46,15%) and P2. Treatment safety (53,85%), and 26 Causes (C) categorized under C1. Drug selection (57,69%) and C3. Dose selection (42,31%). Drug-Related Problems (DRPs) occurred in chronic kidney disease patients admitted to Prof. dr. Chairuddin Panusunan Lubis Hospital in 2023.
Optimasi Dan Formulasi Minuman Instan Granul Bunga Kecombrang (Etlingera Elatior (Jack) R.M.Sm) Dengan Kombinasi Xylitol, Madu Dan Sukrosa Zulhij, Fizrya; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18034

Abstract

Kecombrang merupakan tumbuhan dari keluarga Zingiberaceae, tumbuh di banyak tempat di Indonesia. Tujuan penelitian ini adalah untuk mengetahui hasil formula optimum granul instan serbuk bunga kecombrang (Etlingera elatior) dengan kombinasi Xylitol, Madu dan Sukrosa dari Simplex Lattice Design, untuk mengetahui hasil sediaan granul instan yang dilihat dari persyaratan sebagai granul instan. Metode yang digunakan adalah eksperimental. Granul instan diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi dan diuji karakteristik fisiknya. Data yang diperoleh kemudian di input kedalam aplikasi dan di dapatkan prediksi formula optimum dari aplikasi, selanjutnya prediksi formula optimum di formulasi lalu dibandingkan antara prediksi software Design Expert® versi 13 dengan menggunakan Uji-t one sample pada software SPSS®. Hasil penelitian menunjukkan granul dengan kombinasi Xylitol, Madu dan Sukrosa pada granul instan serbuk bunga kecombrang (Etlingera elatior) mendapatkan hasil formula yang optimum menggunakan metode simplex lattice design dengan konsentrasi Xylitol (9.6%), Madu (6%) dan Sukrosa (5.4%). Sediaan granul serbuk bunga kecombrang tidak memenuhi persyaratan sebagai granul instan yang dimana pada uji waktu alir mendapatkan hasil t>4-10 gr/detik, kelembaban granul MC>4%.
OPTIMASI DAN FORMULASI GRANUL DAUN SINGKONG (Manihot esculenta Crantz) DENGAN KOMBINASI MANITOL, SUKROSA DAN MADU silalahi, zahra salsabila; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18035

Abstract

Tanaman daun singkong (Manihot esculenta Crantz) merupakan salah satu tumbuhan obat yang digunakan secara turun temurun. Secara farmakologi daun singkong mempunyai aktivitas sebagai antiinflamasi, antibakteri, antioksidan. Pada penelitian ini metode yang digunakan adalah eksperimental. Formula granul diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi di formulasi secara konvensional dan diuji karakteristik fisiknya. Hasil penelitian ini menunjukkan bahwa formula optimum granul yang diperoleh yaitu dengan konsentrasi manitol 14%, sukrosa 5,4% dan madu 2,6%. Hasil uji evaluasi yang diperoleh indeks tap 10%, waktu alir 3.58 detik dan sudut diam 24.42o. Hasil pengujian menggunakan Uji-t one sample pada software SPSS Statistic® didapati bahwa nilai p>0,05 sehingga data dinyatakan tidak berbeda signifikan .Hasil pengujian antibakteri menunjukkan bahwa formula optimum memiliki daya hambat yang kuat.

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