cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Sony Eka Nugraha
Contact Email
Idkpcr@usu.ac.id
Phone
+62823 7049 2800
Journal Mail Official
idjpcr@usu.ac.id
Editorial Address
TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia
Location
Kota medan,
Sumatera utara
INDONESIA
Indonesian Journal of Pharmaceutical and Clinical Research
Published by Universitas Sumatera Utara
ISSN : 26156199     EISSN : 26203731     DOI : https://doi.org/10.32734/idjpcr.v1i1.203
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical technology, pharmacology, clinical pharmacy, medical sciences, biological pharmacy and pharmaceutical chemistry. The journal also receives systematic reviews, meta-analysis and review article on new issues in pharmaceutical and clinical sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal. At the initial stage, this journal will be published online twice a year.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 118 Documents
 7   8   9   10   11 
Relationship between Patient Knowledge and Attitude Level in the Use of Antibiotic at Tanjung Paku Community Health Center Solok City: Hubungan Tingkat Pengetahuan dan Sikap Pasien dalam Penggunaan Antibiotik di Puskesmas Tanjung Paku Kota Solok Armal, Khairil; Azkia, Nisa; Afriani, Tika
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 2 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i2.13711

Abstract

Low levels of knowledge about the proper use of antibiotics can lead to incorrect usage, which raises the possibility of antibiotic side effects. The goal of this study is to evaluate patient attitudes and knowledge regarding the use of antibiotics at the community health center in Tanjung Paku Solok City. A questionnaire acted as the data collection tool in a cross-sectional study with a descriptive approach and accidental sampling as the sample process. 60 patients who met the inclusion criteria were included in the sample. The Chi Square test, partial T test, simultaneous F test, and multiple linear regression test were used to examine the results. The results revealed that in good category for knowledge is 57 people (95%), in enough category is 3 people (5%), and there is no one in less category. While the results for good category in attitude is 48 people (80%), in enough category is 12 people (20%) and there is no one in less category. It can be stated that the patients of community health center in Tanjung Paku Solok City has knowledge and attitude category in the use of antibiotic is good. The results of the analysis between knowledge and attitude is having a significant relationship (Sig. = 0.039) but has less influence value, and there is no relationship between variables with the sociodemography (age, gender, lastest education, and occupation). And respondent achievement level (TCR) showed that 80% were good at knowledge statements and 70% were good at attitude statements.
Uji Toksisitas Akut Ekstrak Etanol Daun Sirsak (Annona muricata L.) Terhadap Ginjal Mencit salim, Emil; Dewi, Puteri Nigie Kemala; Ginting, Herawaty
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 2 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i2.13724

Abstract

Soursop leaf ethanol extract was reported to have immunomodulatory, antidiabetic, anti-inflammatory, lowering uric acid and cholesterol levels properties. Based on these reports, soursop leaf ethanol extract has the potential to be developed into a standardized herbal medicine. To ensure safety, this extract must undergo toxicity studies before marketing. This study examined soursop leaf ethanol extract acute toxicity. LD50 was estimated using the Reed and Muench method, and the effect of the extract on the kidneys was observed. This study used 50 mice—25 males and 25 females—divided into 5 groups. The control group received sodium carboxymethyl cellulose (CMC-Na) 0.5% w/v, and the treatment groups received ethanol extract of soursop leaves at doses of 500, 1000, 1500, and 2000 mg/kg bw orally on the first day, then body weight and number of deaths were calculated and the toxic symptoms were observed over 14 days. After 14 days, the surviving mice were sacrificed to examine the relative organ weights, macropathology and histopathology of the mice kidneys. Male and female mice in the 1500 and 2000 mg/kg bw dose groups showed toxic symptoms. There was no significant difference in relative organ weight at 14 days between groups. The results of organ macropathology showed no colour differences in all groups. Based on histopathological examination, mild damage to the kidney organs can be seen at doses of 1500 and 2000 mg/kg bw and the LD50 result was 1819 mg/kg bw. In conclusion, soursop leaf ethanol extract has a mild toxic effect on mice.
The Effect of Fermentation Time Variation on Antioxidant Activity of Fermented Robusta Coffee Leaves (Coffea canephora Pierre ex A.Froehner) Brew Lisda Rimayani Nasution; Devi Agripina Saragi; Yade Metri Permata
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 2 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i2.14255

Abstract

Antioxidants are electron-donor compounds that can delay, slow down and prevent free radical reactions. Fermentation is a chemical change that occurs due to the activity of microorganisms which can increase the amount of phenols in tea thereby increasing its antioxidant activity. Fermentation is carried out with the help of a Symbiotic Culture of Bacteria and Yeast (SCOBY) culture, which is commonly used in the production of kombucha. Kombucha is a fermented tea drink produced from leaves that contain high phenols such as robusta coffee leaves (Coffea canephora Pierre ex A.Froehner). Factors that affect the fermentation process are pH and fermentation time. This study aimed to explain the effect of fermentation time on the antioxidant activity of fermented robusta coffee leaves brew. Brewed robusta coffee leaves were made by brewing robusta coffee leaves simplicia powder, adding kombucha liquid starter, then fermented for 0; 3; 7; 14; and 21 days, then pH and antioxidant activity was measured using UV-Visible spectrophotometer using the 2,2-dipheny-1,1-picrylhydrazyl (DPPH) at a wavelength of 516 nm. This study showed that 0; 3; 7; 14; and 21 days fermented robusta coffee leaves brew have pH of 6,07; 4,62; 4,07; 3,21; and 2,74, and IC50 values is 285,1645 μg/ml; 219,7012 μg/ml; 192,2325 μg/ml; 187,0434 μg/ml; and 173,9249 µg/ml. There is an effect of fermentation time variation on the antioxidant activity of fermented robusta coffee leaves brew. Keyword: Antioxidant, Fermentation, pH, Robusta coffee leaves, Time variation
Preparation and Evaluation of Polyherbal Face Pack Ashok Kumar BS; Mouna A; Lakshman K; Nandeesh R
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 2 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i2.14707

Abstract

It is believed that Queen Cleopatra, the Egyptian goddess of beauty, used donkey milk in her baths to maintain her youthful appearance. Herbs are known to benefit the skin by providing a natural glow and softness, cleansing dead cells, and promoting the regeneration of new cells. This study aims to prepare polyherbal face packs (F1-F4) using natural ingredients such as turmeric, neem, orange peel, multani mitti, gram flour, rose petals, sandalwood, rice flour, and aloe Vera. The polyherbal face packs (F1-F4) were evaluated based on organoleptic properties, physicochemical parameters (loss on drying, ash content, and pH), rheological properties (angle of repose, Hausner’s ratio, Carr’s index, bulk and tapped density) and spreadability. The evaluation results showed that the all polyherbal face packs had favourable physicochemical and rheological properties and spreadability. This study successfully prepared and evaluated polyherbal face packs (F1-F4) using a combination of natural ingredients known for their skin benefits, such as turmeric, neem, orange peel, multani mitti, gram flour, rose petals, sandalwood, rice flour, and aloe vera. The face packs were subjected to a comprehensive set of tests to assess their suitability for cosmetic use.
Phytochemical Screening and Antibacterial activity of Polyphenol rich Extract of Passion Fruit Pericarp (Passiflora edulis Sims) on Propionibacterium acnes Nugraha, Sony Eka; Syahputra , Rony Abdi; Nabila, Nabila
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.17765

Abstract

Indonesia's primary hub for cultivating purple passion fruit is North Sumatera. The passion fruit was transformed into a beverage product, which led to the creation of passion fruit pericarp trash. The potential medicinal properties of the passion fruit pericarp, particularly its antibacterial impact, need to be further explored. This study aimed to assess the phytochemical composition and antibacterial properties of an ethanol extract derived from the pericarp of purple passion fruit against Propionibacterium acnes. The extraction was performed using the percolation method with 96% ethanol. The antibacterial activity against Propionibacterium acnes was assessed using the agar diffusion method with paper discs. The phytochemical screening of the simplicia and ethanol extract revealed the existence of flavonoid, glycoside, saponin, tannin, and steroid/triterpenoid compounds. The ethanol extract exhibited significant antibacterial activity against Propionibacterium acnes at a dosage of 300 mg/ml, demonstrating a dose-dependent impact.
Antidiabetic Activity of Ethanol Extract from Red Spinach Leaves (Amaranthus tricolor L.) on Mice Salim, Emil; Wulandari, Siti
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.17767

Abstract

This study aims to determine the antidiabetic activity of ethanol extract of red spinach leaves (Amaranthus tricolor L.) on male mice. The study was conducted experimentally using 25 male mice divided into 5 treatment groups, namely the negative control group (CMC Na 0.5%), positive control (glibenclamide 0,65 mg/kg BW), and 3 others groups given ethanol extract of red spinach leaves at doses of 100, 200 and 400 mg/kg BW. Mice were induced with streptozotocin (STZ) dose of 100 mg/kgbw intraperitoneally. After 72 hours, diabetic mice were treated for 15 days orally and blood glucose levels were checked every 5 days.using a glucotest device. The results showed that Ethanol extract od Red Spinach Leaves (EERSL) doses of 100 and 400 mg/kg BW were not significantly different from the negative control CMC Na (p>0.05) in reducing blood glucose levels. EERSL doses 200 mg/kgbw and positive control glibenclamide significantly reduce blood glucose levels campared to negative control CMC Na (p<0.05). Ethanol extract of red spinach leaves has antidiabetic activity on male mice at a dose of 200 mg/kg BW, whose effect is not significantly different compared to the glibenclamide.
Antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea by CUPRAC and FRAP methods Satria, Denny; Rifda Amaliya Ma’ruf; Syukur Berkat Waruwu; Urip Harahap; Hari Purnomo4
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.17768

Abstract

An imbalance in the number of free radicals produced in the body can result in oxidative stress. Excessive oxidative stress can lead to chronic inflammation, which in turn can lead to most chronic diseases. Inflammation is related to oxidation through increased reactive oxidative stress, which can target modulators associated with inflammation, such as inflammatory cytokines. Antioxidants can inhibit or stop oxidation by protecting the body and neutralizing free radicals. 1.3-bis(p-hydroxyphenyl)urea is a modification of p-aminophenol and has hepatotoxic side effects such as those caused by acetaminophen. This compound can relieve pain, is anti-inflammatory, and has fewer side effects. This research was conducted to evaluate the antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method and the FRAP (Ferric Reducing Antioxidant Power) method. The results of the CUPRAC method research show that the 1.3-bis(p-hydroxyphenyl)urea compound has an IC50 value of 4.40 ± 0.07 μg/mL. Meanwhile, the FRAP method was 29.36 ± 1.20 μg/mL. Apart from suppressing inflammation, this compound has the potential to be an antioxidant compound.
Development of Oral Thin Film Strip Contained Ethanol Extract of Clove Leaves (Syzygium aromaticum (L.) Merr. & Perry) Bayu Eko Prasetyo; Mariadi; Emil Salim
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.17919

Abstract

Halitosis or bad breath can occur due to poor oral hygiene care, dental caries or infections in the oral cavity. The use of mouth fresheners is one of the solution product to overcome the problem. Oral Thin Film Strip (OTFS) is an alternative mouth freshener. The preparation of OTFS was carried out using the solvent casting method. Five film formula were made with varying concentrations of gelatin and HPMC, namely F1 (0:3), F2 (1:3), F3 (1:1), F4 (3:1), and F5 (3:0). Evaluation of the preparation included organoleptic test, weight uniformity, thickness, disintegration time, pH, and folding resistance. Stability testing was carried out for 3 months at 25±2°C and 40±2°C. Antibacterial activity test against Streptococcus mutans (S. mutans) on the preparation was done using disc diffusion method. The OTFS preparation produced gave a homogeneous colour, aroma and taste of the extract. The resulting preparation had weight between 0.345-0.180 grams, thickness between 0.148-0.247 mm, disintegration time of 44-60 seconds, a pH between 6.06-6.33, and a film folding resistance between 339.83-673.67 times. The preparation was stable in storage for 3 months at a temperature of 25±2℃ and 40±2℃. The preparation showed antibacterial activity against S. mutans with zone of inhibition between 8.0-9.1 mm. Clove leaf ethanol extract can be formulated into OTFS preparations with good physical characteristics, stable in 3 months storage and had antibacterial activity against S. mutans so that it has the potential to overcome bad breath.
Wound Healing Herbal Formulation from Essential Oil of Lemongrass (Cymbopogon citratus) Wisdawati, Wisdawati; Razak, Rais
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.14759

Abstract

Untreated wound may lead to the infection. In some countries, plants are used to cure wound traditionally. Lemongrass (Cymbopogon citratus) has various bioactive compounds, including citronellol, limonene and geraniol that perform some pharmacological activities. In this study, the essential oil of lemongrass was designed into ointment formulation since lemongrass has been reported to have a wound healing effect in mice. The wound healing ointment made from different concentration of the essential oil of Cymbopogon citratus (F1: EOCC 5%, F2: EOCC 10% and F3: EOCC 15%) using a water-removable base and the characteristic as well as the stability (texture, color, smell, homogeneity, and pH) after been stored for 14 days was also evaluated. The result showed that all formulation (F1, F2, and F3) of wound healing formulation revealed good texture, consistency, odor, color, homogeneity and compatible to the skin until 14 days of storage. However, F3 (EOCC 15%) has a strong lemongrass smell compare to the other formulations.
Isolation and identification of diosgenin and flavonoids compound from ethanol extract of Dioscorea hispida Dennst. tuber syahputra, hafid; Masfria; Amana, Meuthia Rizka; Rivai, Muhammad
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.15994

Abstract

The tuber of Dioscorea hispida Dennst. has potential for development as a synthetic pharmaceutical ingredient due to the presence of secondary metabolites such as diosgenin and flavonoids, which exhibit biological activity within the body. Further exploration of this potential requires the isolation and identification of these compounds. Diosgenin was isolated from the ethanol extract using thin-layer chromatography, while flavonoids were isolated from the ethyl acetate fraction using paper chromatography. The pure isolates of both compounds were identified using UV-Vis spectrophotometry and FT-IR spectroscopy. The UV-Vis spectrophotometric analysis of diosgenin revealed maximum absorption wavelengths at 205 and 453 nm. Flavonoid isolates exhibited maximum absorption wavelengths of 264 nm for the first isolate, 265 nm for the second, 276 nm for the third, and 272 nm for the fourth. FT-IR spectroscopic analysis of the diosgenin isolate indicated the presence of functional groups such as -OH, aromatic C=C, and aromatic C-O, while the flavonoid isolate showed the presence of O-H, aromatic C-H, aliphatic C-H, C=O, C=C, and C-O. These identification results confirm that the isolates obtained indeed contain diosgenin and flavonoids.

Page 9 of 12 | Total Record : 118

 7   8   9   10   11 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 2 (2023): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 1 (2018): Indonesian Journal of Pharmaceutical and Clinical Research More Issue