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TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia
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INDONESIA
Indonesian Journal of Pharmaceutical and Clinical Research
Published by Universitas Sumatera Utara
ISSN : 26156199     EISSN : 26203731     DOI : https://doi.org/10.32734/idjpcr.v1i1.203
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical technology, pharmacology, clinical pharmacy, medical sciences, biological pharmacy and pharmaceutical chemistry. The journal also receives systematic reviews, meta-analysis and review article on new issues in pharmaceutical and clinical sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal. At the initial stage, this journal will be published online twice a year.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 112 Documents
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UJI AKTIVITAS ANTIHIPERLIPIDEMIA EKSTRAK ETANOL DAUN ARA SUNGSANG (Asystasia gangetica) TERHADAP KADAR KOLESTEROL PADA MENCIT PUTIH JANTAN (Mus musculus) Muharni Saputri; Muflihah Fujiko; Dasopang, Eva Sartika; Shinta Naswa; Nova Arianti
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18083

Abstract

Hyperlipidemia can be treated with medication. However, the large side effects cause people to return to herbal medicine. Sungsang fig leaves contain flavonoid, tannin and saponin compounds that can reduce cholesterol levels. The stages of the procedure carried out are making simplisia, followed by cold extraction, namely maceration with ethanol p.a solvent as the solvent of choice. Furthermore, phytochemical screening of sungsang fig leaf extract and simplisia characterization studies were carried out. After that, anti-hyperlipidemia activity was tested in vivo using male white mice to determine the effect of reducing blood cholesterol levels with ethanol extract of sungsang fig leaves. The result of the decrease in cholesterol levels in white male mice from ethanol extract of sungsang fig leaves at a dose of 500 mg/kg BW was 41%. These results are 1.20 times greater than the dose of 125 mg/kg BW and 1.17 times greater than the dose of 250 mg/kg BW. Synergistic compounds to reduce cholesterol levels are flavonoids, tannins and saponins. The decrease in cholesterol levels from ethanol extract of sungsang fig leaves at a dose of 500 mg/kg BW is not significantly different from simvastatin 10 mg.
Unveiling the Mineral Composition: Potassium and Magnesium Levels in Musa Paradisiaca L. Varieties from Medan's Traditional Markets Using Atomic Absorption Spectrophotometry
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18109

Abstract

Bananas are rich in nutrients, particularly vitamin C, starch, sugar, fiber, and serve as an affordable source of vitamins, minerals, and energy for the community. The mineral content in fresh bananas includes zinc, selenium, phosphorus, manganese, iron, copper, and calcium. Consuming bananas for magnesium intake is particularly important. A single fresh banana contains 27 mg of magnesium. This study was conducted in the laboratory of the Faculty of Pharmacy using the Atomic Absorption Spectrophotometry (AAS) method, which is relatively fast and capable of measuring metal concentrations at low and specific levels for each element without requiring separation. The analysis results of potassium and magnesium in Ambon Bananas, Banten Bananas, Barangan Bananas, Kepok Bananas, Lilin Bananas, Mas Bananas, Raja Bananas, and Horn Bananas showed potassium levels of (367.1354 ± 1.4227) mg/100g; (412.7505 ± 0.9358) mg/100g; (386.6516 ± 0.6478) mg/100g; (413.2283 ± 0.6933) mg/100g; (405.5700 ± 0.7744) mg/100g; (417.1851 ± 0.5417) mg/100g; (374.8651 ± 0.6505) mg/100g; and (340.4262 ± 0.7292) mg/100g, respectively. The magnesium levels were found to be (44.2010 ± 0.1073) mg/100g; (57.9526 ± 0.0986) mg/100g; (45.9309 ± 0.0907) mg/100g; (82.8869 ± 0.2170) mg/100g; (79.2840 ± 0.0987) mg/100g; (59.1938 ± 0.0792) mg/100g; (76.8133 ± 0.0939) mg/100g; and (55.1193 ± 0.0734) mg/100g, respectively. The high potassium and magnesium levels found in this quantitative analysis indicate that bananas are highly beneficial for individuals with hypertension. Keywords: Banana, Potassium, Magnesium, Atomic Absorption Spectrophotometry
Pengembangan Formulasi Krim Pelembab Kulit Berbasis Ekstrak Sari Buah Mangga (Mangifera indica L.): Pendekatan Fungsional dan Kosmetika Alami Suci, Nurul; Khairunnisa, Lia; Nasri, Nasri; Kaban, Vera Estefania
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18220

Abstract

This study aimed to develop a formulation of mango fruit juice (Mangifera indica L.) as a moisturizing agent in the form of hand cream. The main component of mango, sucrose, has the ability to attract moisture from the air due to its hydroxyl groups, which helps reduce water evaporation from the skin. Mango juice was obtained by blending the mango pulp using a juicer, followed by the addition of 0.1% sodium metabisulfite as an antioxidant. The extract was then concentrated using a freeze-drying technique at -40°C and 2 atm pressure. The cream formulation developed was an oil-in-water (m/a) emulsion type, with mango fruit juice concentrations of 2.5%, 5%, 7.5%, and 10%. These were compared to cream containing 2% glycerin and a blank formulation. Various tests were conducted to evaluate the physical quality of the cream, including homogeneity, pH, stability, emulsion type, and irritation tests using a moisture-checker. The results showed that mango fruit juice was successfully formulated into a homogeneous m/a cream, with a pH ranging from 5.55 to 7.04, and remained stable for up to 12 weeks of storage. The cream formulated with mango juice was proven to increase skin moisture without causing irritation. The higher the concentration of mango fruit juice, the greater the moisturizing effect. The 2.5% concentration provided a moisturizing effect comparable to cream containing 2% glycerin. The best moisturizing effect was achieved at a 10% concentration, which increased skin moisture by up to 14.4% after 4 weeks of use. This mango juice is effectively used in m/a type creams as a skin moisturizer. Keyword: Mango fruit juice, cream, skin moisturizer
Phytochemical Screening and Determination of Phenolic and Flavonoid Contents in Ethanol Extract of Phyllanthus emblica L. Fruit Syahputra, Hafid
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18235

Abstract

Phyllanthus emblica L. fruit is known for its potent antioxidant activity, closely associated with its phenolic and flavonoid content. This study aims to analyse the secondary metabolite composition and determine the total phenol and flavonoid levels in Phyllanthus emblica fruit. The extraction process was carried out using the maceration method with 96% ethanol as the solvent, followed by a rotary evaporator evaporation. The ethanol extract was subjected to phytochemical screening with colour reagents, and the total phenol and flavonoid contents were assessed using a colourimetric method. TheFolin–Ciocalteu reagent was employed for complex phenolic compounds, with gallic acid as the standard reference. The total flavonoid content was determined using the aluminium chloride method, with quercetin as the standard. The results indicated that the ethanol extract of Phyllanthus emblica fruit contained alkaloids, saponins, flavonoids, tannins, triterpenoids, and glycosides. The study found that the total phenol content was 61.1271±3.86 mg GAE/g extract, while the total flavonoid content was 3.3742±0.06 mg QE/g extract.
ANTIFUNGAL OF SOKA FLOWER (Ixora Chinensis Lam.) ETHANOL EXTRACT AGAINST Candida albicans AND Pityrosporum ovale Keliat, Jane Melita; Sumayyah, Tengku
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.19926

Abstract

Pathogenic fungi are microorganisms that cause infectious diseases in humans and are capable of growing and developing in various environments. The types of fungi that most often cause skin infections are Candida albicans and Pityrosporum ovale. The soka flower plant (Ixora chinensis Lam.), commonly found in Indonesia, is known to have antibacterial properties. The antifungal strength of the soka flower comes from the natural chemicals in its ethanol extract, which stops the growth of Candida albicans and Pityrosporum ovale. The research method was conducted experimentally, which included stages such as the preparation of dry powder, characterization of dry powder, phytochemical screening both on dry powder and the ethanol extract of soka flowers, preparation of the ethanol extract, standardization of the extract, and evaluation of the antifungal activity of the ethanol extract against both types of fungi. The research results indicate that the minimum inhibitory concentration of the ethanol extract of the soka flower against Candida albicans is 5.5 mg/ml with an inhibition zone diameter of 8.8 mm ±0.05, while for Pityrosporum ovale, the minimum inhibitory concentration is 50 mg/ml with an inhibition zone diameter of 10.7 mm ±0.50. The statistical analysis from Kruskal-Wallis tests show a significant difference in the amounts of ethanol extract from soka flowers based on the size of the inhibition zones for Candida albicans and Pityrosporum ovale, with probabilities of 0.000 and 0.001, both of which are below 0.05.
FORMULASI SEDIAAN MASKER GEL PEEL-OFF KOPI ROBUSTA (Coffea canephora) DAN EFEKTIVITASNYA SEBAGAI ANTI PENUAAN DINI Hanum, Tengku Ismanelly; Marianne, Marianne; Sumaiyah, Sumaiyah; Hasibuan, Poppy Anjelisa Zaitun; Hasibuan, Wan Fadilla; Bestari, Khansa Candra
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.19940

Abstract

Robusta coffee (Coffea canephora) contains several components that are good for facial skin, such as flavonoids which act as antioxidants. A peel-off gel mask is a skin care cosmetic preparation in the form of a gel and after being applied to the skin for a certain time until it dries, this preparation will form an elastic transparent film layer, so that it can be peeled off. This research aims to develop Robusta coffee into a peel-off gel mask preparation. off off which has appearance, pH, viscosity, spreadability, drying time, and its effectiveness as an anti-aging agent. The research stages carried out were the formulation of a 10% coprobusta peel-off gel mask, stability testing at room temperature for 12 weeks and the anti-aging effectiveness of the 10% corobusta peel-off gel mask. Stability test parameters include pH, viscosity, spreadability, and drying time. Test the effectiveness of anti-aging using a skin analysis tool with test parameters, namely air content, smoothness, pore size, number of blemishes and wrinkles. The results of this study show that the preparation is stable in all test parameters for 12 weeks of storage at room temperature, does not irritate the skin and has anti-aging activity on facial skin, namely increasing air content, smoother skin, smaller pores, reducing the number of blemishes and wrinkles over time. four weeks of treatment.
POLA PERESEPAN TERAPI ANTIDIABETES ORAL DI PUSKESMAS IMOGIRI BATUL Amalina, Adila Nur; Risa, Mexsi Mutia
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20061

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. The prevalence of diabetes mellitus in Indonesia continues to increase and is included in the top 10 diseases at the health center in Bantul Regency. In addition, diabetes mellitus is also included in the top 5 diseases at the Imogiri I Health Center. The purpose of this study was to find out the description of type II diabetes mellitus drug prescription at the Imogiri I Health Center for the period August - December 2022. This study used a non-experimental descriptive method by collecting retrospective medical records of patients with diabetes mellitus type II. The data obtained were then analyzed in a quantitative descriptive manner presented with percentages in the form of diagrams. The results showed that most patients with type II diabetes mellitus were female (31%) with the most age range being 46-65 years (57%). The description of drug prescribing for type II diabetes mellitus patients at the Imogiri I Health Center consists of the use of diabetes mellitus drugs alone, namely the biguanid group (Metformin) as much as 95% and the sulfonylurea group (Glimepirid) as much as 5%. It can be concluded that the drug most often prescribed to patients with diabetes mellitus type II at the Imogiri I Public Health Center with a single treatment is metformin as much as 95% which belongs to the biguanide group.
UTILISATION OF VIDEO CALLS TO IMPROVE ADHERENCE IN TUBERCULOSIS PATIENTS: PILOT STUDY Nugraha, Dhanang Prawira; Rodiyah, Enik; Monica, Eva
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20557

Abstract

Tuberculosis is the 9th leading cause of death in the world, but it takes at least 6 months to be treated. One of the challenges in tuberculosis treatment is that the treatment time is quite long, and the drugs used are also quite a lot so that it affects patient adherence in taking medication. The objective of this study was to see the effectiveness of video calls in enhancing the adherence of tuberculosis patients. The research method used was experimental pre-post noncontrol design. This study involved 12 tuberculosis patients from the Kepulungan Community Health Centre who were enrolled in the Pulmonary Tuberculosis Control Programme (Program Penanggulangan Tuberkulosis Paru/P2TB) and who met the study's inclusion and exclusion criteria. In the study, video call treatment was the independent variable while adherence was the dependent variable. The sample collection used total sampling and statistical analysis using Wilcoxon test. The findings of this investigation suggest that there is a substantial discrepancy in compliance levels between the pre- and post-video call treatment phases, as evidenced by the augmentation in the mean TB-MAS score from 102.5 to 113.6, accompanied by a p-value of 0.018 (<0.05). This shows that video calls are useful in improving patient adherence in taking antituberculosis drugs.
IDENTIFICATION AND CHARACTERIZATION OF ANCHOVY (Stolephorus commersonnii) PRODUCED IN TANJUNG TIRAM VILLAGE BATU BARA REGENCY Rexi, Daniel; Pintauli, Sondang; Dalimunthe, Aminah; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20636

Abstract

Anchovy is a widely consumed marine food source in Indonesia and has the potential to serve as a vital nutritional resource. This study aimed to analyze the primary nutrient contents of anchovy, including protein, total fat, phosphorus, calcium, and iron levels. Nutritional composition analysis was conducted through laboratory testing using scientifically validated standard methods. The results were analyzed descriptively to provide an overview of the chemical composition of anchovy. The findings revealed that anchovy contains 31.5% protein, indicating its value as a rich source of animal protein. The total fat content was measured at 4.76%, suggesting a relatively low to moderate fat level. Furthermore, phosphorus content was recorded at 227.8 mg/kg, calcium at 2.45%, and iron at 36.1 mg/kg—all essential minerals for physiological functions. Based on these results, anchovy demonstrates strong potential as a highly nutritious local food source that could significantly contribute to meeting the community's nutritional needs.
EFFECT OF CASSAVA TUBER PROCESSING ON Candida albicans GROWTH ON MANIHOT DEXTROSE AGAR Patilaya, Popi; Sumantri, Imam Bagus; Keliat, Jane Melita
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20763

Abstract

This study evaluated the effect of cassava tuber processing on Candida albicans growth on Manihot Dextrose Agar (MDA). The sliced cassava tubers were divided into three groups. G1 was milled and dried in an oven at 60°C. G2 was directly dried in the oven. G3 was milled without drying. Each group was soaked in distilled water (1,000 mL) for 15 min and filtered with a flannel cloth. The filtrate was oven-dried, then pulverized to obtain the cassava powder. The powder (8 g) was combined with dextrose (20 g) and agar (15 g). The mixture was suspended in distilled water (1,000 mL), boiled, and sterilized at 121°C for 15 min. The solution was placed into a petri dish and allowed to form agar media. The media derived from G1, G2, and G3 were considered as F1, F2, and F3. A suspension of C. albicans was cultured on the media and incubated for 48 h. The fungal growth was observed by calculating the viable colonies. The data were analyzed with one-way ANOVA and followed by Duncan’s test at the confidence level of 95%. The results showed that C. albicans grown on media F1, F2, and F3 had colony numbers of 128±2.08 x 105 cfu/mL, 64±5.57 x 105 cfu/mL, and 44±3.51 x 105 cfu/mL, respectively. Statistical analysis indicated a significant difference in the fungal growth on the three media (p < 0.05). This study proved that the processing methods of cassava tubers for MDA significantly affected the growth of C. albicans.

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