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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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PENETAPAN KADAR RUTIN PADA EKSTRAK ETANOL DAUN PIDADA MERAH (Sonneratia caseolaris) DENGAN KLT DENSITOMETER Lestari, Dwi; Syamsul, Eka Siswanto; Mentari, Ika Ayu
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v613.559

Abstract

Red pidada leaves (Sonneratia caseolaris L) which is a species of mangrove plant that can grow in rivers and has been widely used as a natural medicine. Red Pidada leaves are often used by the people of East Kalimantan as a cold powder and wound remover. This study aims to determine the routine content of red pidada leaf extract. The research included extraction by maceration, routine assay using a TLC densitometer, phytochemical screening and validation of methods determined by parameters including: linearity and precision. A mixture of butanol-ethyl acetate-formic acid-asor (5:5:2:1) was chosen as the mobile phase. The results of this research for the maximum routine wavelength are 265 nm. The linearity test obtained from the regression function is y = 151.6 + 80.88x with a correlation coefficient (r) and Vxo of 0.97566 and 0.842% respectively. The concentration of routine in the extract was 1.9215±0.028%
PENGARUH PEMBERIAN INFORMASI OBAT TERHADAP TINGKAT PENGETAHUAN DAN KEPATUHAN PASIEN HIPERTENSI DI WILAYAH KOTA JAKARTA PUSAT Silmi Syauqia Zulfa; Primayanti Nurul Ilmi; Nurfitri Bustamam; Dhigna Luthfiyani Citra Pradana
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.563

Abstract

As many as 59.8% of hypertension patients in Indonesia do not regularly take medication since the patient feels healthy. This study aims to analyze the effect of providing drug information on the level of knowledge and adherence to taking medication in hypertensive patients. The study design was a quasi-experimental pre-test and post-test with medication reminders and education for 14 days. The questionnaires used were the Hypertension Knowledge-Level Scale (HK-LS) for knowledge level, and the Morisky Medication Adherence Scale 8 (MMAS-8) for compliance level. A total of 45 people became research respondents. Based on data analysis, data on the characteristics of elderly patients was obtained, totaling 36 people (80%), 30 people (66.7%) were female, based on educational status in the high school category, the maximum was 66.7%, 53.3% actively works, based on the antihypertensive drug used is amlodipine 10 mg as much as 64.5%. The results of the statistical test using the Wilcoxon test were that providing drug information on the level of knowledge hypertensive patients had (p < 0.05), and there was a significant effect between providing drug information on the level of medication adherence for hypertensive patients (p < 0.05). Based on the study, it was concluded that providing reminders and education can significantly increase medication adherence
UJI ANALISIS KUALITATIF DAN KUANTITATIF KADAR VITAMIN C PADA SEDIAAN KOSMETIK LOTION YANG BEREDAR DI KAB. MAROS DENGAN METODE SPEKTROFOTOMETER Uv-Vis Hashary, A Rufaidah; Arifuddin Yunus; Wati
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.577

Abstract

Cosmetics are an inseparable part of women's lives in particular and are used every day. Lotions are widely used to moisturize the skin and to brighten the skin. Lotion can be used for all skin types for teenagers aged 15 years and over. Vitamin C has various benefits, including as an antioxidant against pollution, sun exposure, brightening the skin, delaying the effects of aging, and increasing collagen formation which makes the skin supple, smooth and bright. The aim of the research was to determine the vitamin C content in cosmetic lotions according to the standards/labels circulating in the Maros district. The research was carried out using qualitative analysis methods in the pharmaceutical chemistry analysis laboratory of STIKes Salewangang Maros where the samples were lotion cosmetic products containing vitamin C at kab. Maros as stated on the product packaging/label and analyzed using a Uv-Vis spectrophotometer. The results of the research obtained showed that all lotion cosmetic preparations contained vitamin C with different percentage levels for each concentration, where lotion samples that did not have a distribution permit obtained high levels of Vitamin C, while lotions that had a distribution permit showed high levels of Vitamin C. not excessive, so it is safe to use for a long time.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN EMULGEL EKSTRAK BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP BAKTERI Propionibacterium acnes Sholaekah, Ayu; Hidayati, Evi Nurul; Sardjiman
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.581

Abstract

         Acne is a condition of sebaceous follicle disruption caused by keratinization disorders (small keratosis), accompanied by the presence of comedones, papules, pustules, and nodules. Starfruit (Averrhoa bilimbi L.) harbors compounds exhibiting antibacterial properties against Propionibacterium acnes, making it a promising candidate for developing an anti-acne emulgel product. The starfruit was extracted via maceration using 70% ethanol solvent over 3x24 hours. Test samples of starfruit extract were prepared at concentrations E1 (10%), E2 (15%), and E3 (20%), while emulgel formulations of the extract were formulated as F1 (10%), F2 (15%), and F3 (20%). Physical evaluations included organoleptic, adhesion, spreadability, homogeneity, pH, emulgel type assessments, and antibacterial tests measuring inhibition zones. Inhibition zone data were analyzed using ANOVA statistics. The method used to observe antibacterial activity in the emulgel formulations employed the good diffusion method by measuring inhibition zone diameters around the holes. The results of antibacterial activity testing of starfruit extract emulgel formulations against Propionibacterium acnes sequentially in F1, F2, F3, K+, K- were 11.96 ± 0.38 mm (strong), 13.84 ± 0.50 mm (strong), 15.03 ± 0.56 mm (strong), 17.64 ± 0.69 mm (strong), and 0 ± 0.00 mm (no antibacterial activity). The evaluation results of the physical quality of starfruit extract emulgel formulations indicated that all three formulas exhibited good physical quality. Based on the study findings, F3 demonstrated superior inhibitory efficacy among the emulgel formulations.
FORMULASI DAN UJI EFEKTIVITAS SEDIAAN MASKER BUBUK ORGANIK DARI EKSTRAK DAUN KELENGKENG(DIMOCARPUS LONGAN) TERHADAP PERTUMBUHAN BAKTERI PROPIONIBACTERIUM ACNE Anisa, Resti; Setiawan, Prayitno; Basir, Nasrawati
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.582

Abstract

Longan leaves (Dimocarpus longan) contain flavonoids, phenols, tannins and saponins which are secondary metabolite compounds that have antibacterial activity. Antibacterials are substances that can interfere with the growth or even kill bacteria by interfering with the metabolism of harmful microbes. The aim of this research is to find out whether the organic powder mask preparation from longan leaf extract is stable and formulated physically and chemically, and to determine the results of the inhibitory power obtained from the organic powder mask preparation from longan leaf extract on the growth of Propionibacterium acne bacteria. This research method is experimental in vitro, with extraction using the Magnetic Stirrer Maceration method with 96% ethanol solvent, preliminary tests are carried out, then an Organic Powder mask formulation is made with concentrations of F1 (3%), F2 (4%), F3 (5% ). Then proceed with the antimicrobial effectiveness test against Propionibacterium acne bacteria The research results showed that there was no difference in the stability of the organic powder mask formulation (p>0.05) before and after the cycling test in organoleptic testing, pH testing, homogeneity, spreadability, dry time testing and particle size testing. Testing the Antibacterial Effectiveness of Propionibacterium acne showed that formula 1 (3%), formula 2 (4%) and formula 3 (5%) were effective against Propionibacterium acne bacteria with an average inhibition zone of 10.26 (medium), 11 respectively. .01 (strong) and 11.28 (strong). It can be concluded that longan leaf extract can be formulated as an organic powder mask preparation and has antibacterial effectiveness against Propionibacterium acne in the strong category at a concentration of 5% with an average diameter of the inhibition zone of 11.28
FORMULASI DAN UJI AKTIVITAS SEDIAAN CLAY MASK DARI EKSTRAK KULIT PEPAYA (CARICA PAPAYA LINN.) DENGAN KOMBINASI EKSTRAK KULIT LEMON (CITRUS LIMON BURM F.) SEBAGAI ANTI AGING Patimah, Kusnul; Hidayati, Evi Nurul; Santoso, Joko
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.588

Abstract

Aging is a change in humans caused by age, psychological and social factors. based on a patient survey at rsud dr. soetomo surabaya in 2017, the group diagnosed with photoaging caused by sun exposure had a prevalence rate of 50.27%. papaya peel and lemon peel contain vitamin c and flavonoids that have properties as natural antioxidants. clay mask preparations are able to remove dirt on the face so that the skin becomes brighter and cleaner. the purpose of this research is to determine the activity and physical quality of the clay mask preparation formulation of papaya fruit peel extract (carica papaya linn.) and lemon peel extract (citrus limon burm f.) as anti-aging. the method in this study is an experimental method with a design in the form of a true experimental post test only control group design. the results of this study obtained the ic50 value of papaya peel extract with a dose of 2 grams of 51.88 ppm and lemon peel extract with a dose of 5 grams of 39.87 ppm, evaluation of clay mask preparations fi obtained brown preparations, homogeneous preparations, ph 5.44, drying time 15.25 minutes; fii obtained brown preparations, homogeneous preparations, ph 5.66, drying time 5.44 minutes; fiii obtained brown preparations, homogeneous preparations, ph 5.50, drying time 20.26 minutes. the conclusion of this study is that papaya peel extract and lemon peel extract have antioxidant activity as anti-aging, the physical quality of clay mask preparations of all formulations has met the standards and the most stable formula is fii. the most preferred formula by volunteers is fii and all formulations do not cause irritation.
UJI POTENSI EKSTRAK ETANOL BAWANG LANANG HITAM (Allium sativum L.) DALAM PENURUNAN KADAR LOGAM BERAT TIMBAL (Pb) SECARA IN VITRO Anggraini, Devina Ingrid; Febryana, Amanda Alerya
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.589

Abstract

Black garlic (Allium sativum L.) is a fermented product made from garlic. This fermentation process has an effect on the chemical compound content of black shallots which has increased, especially in polyphenolic compounds, flavonoids and other antioxidant compounds. Flavonoids are compounds that are able to bind metal ions and reduce metal levels because they contain secondary metabolite compounds that have -OH and -O groups. The aim of this research is to determine the potential of black garlic (Allium Sativum L.) to reduce lead (Pb) metal levels. Determination of the reduction potential of black spring onions reacted with 30 ppm Pb metal and various extracts of 50 ppm, 100 ppm, 150 ppm, 200 ppm, 250 ppm and 300 ppm which were analyzed using Atomic Absorption Spectrophotometry at a wavelength of 283.3 nm. The results of black garlic  extract have the potential to reduce levels of lead metal (Pb) with an EC50 value of 147.96 ppm and a % KV of 0.7296%.
KARAKTERISASI DAN SKRINING FITOKIMIA SIMPLISIA DAN ESKTRAK BUAH BAKAU HITAM (Rhizopora mucronata Poir) Sa'adah, Hayatus; Kavung, Clara Agatha; Supomo
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.608

Abstract

Black mangrove (Rhizopora mucronata Poir) is a species of mangrove plant that lives in mangrove forests which contains secondary metabolites and contains natural antioxidants and antibacterials which are widely used by coastal communities and consumed as food and medicine. The benefits of a natural ingredient with medicinal properties need to be scientifically proven through research. As a first step, characterization of simplicia and extracts was carried out as well as phytochemical screening. Characterization is intended to determine the quality of simplicia and black mangrove fruit extract as well as the content of secondary metabolite compounds. Characterization includes specific and non-specific parameters. In the first stage, black mangrove fruit was extracted by maceration using 96% ethanol solvent and a yield of 23.77% was obtained. Specific characterization test results include organoleptic tests with direct observation results on simplicia in the form of powder. dark brown color, slightly astringent taste, with a distinctive aroma and in the organoleptic test the ethanol extract is a thick extract, blackish brown in color, bitter taste with a characteristic aroma. The average level of dissolved compounds in simplicia water was 7.3% and the extract was 11.33%, while the average level of dissolved compounds in simplicia ethanol was 24% and the extract was 88.33%. The results of non-specific characterization tests include determining the average water content of the simplicia at 15% and the extract at 18%. The average total ash content test for simplicia was 8.3397% and the extract was 10.4976%, while the average acid insoluble ash content test for simplicia was 0.2329% and extract was 0.8144%. The average specific gravity of the extract was 0,98 g/mL and aquadest 0,94 g/mL, results of the microbial contamination test, the total plate number for simplicia was 4.6 x 10-3 colonies/g and the extract was 4.3 x 10-3 colonies/g, while the yeast mold number in simplicia 2.1 x 10-2 colonies/g and in extract 1.3 x 10-2 colonies/g. The results of the phytochemical screening test for simplicia and black mangrove fruit extract were positive for containing metabolite compounds, namely secondary alkaloids, flavonoids, tannins, steroids and terpenoids.
HUBUNGAN TINGKAT KEPATUHAN MINUM OBAT PASIEN HIPERTENSI TERHADAP TEKANAN DARAH PASIEN HIPERTENSI DI RUMAH SAKIT PELABUHAN JAKARTA Vidia Anwar; siti aisyah; doni iswandani; Halim, Marta; fitri putriani
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.626

Abstract

This research was conducted at Hospital X using quantitative descriptive methods with research instruments in the form of the ProMAS questionnaire. The sample collection technique used a purposive sampling method with a total sample of 96 respondents. The analysis used is the Spearman’s rho correlation test. The results showed that respondents who had high compliance were 43 people (44.79%), moderately high compliance was 48 people (50%), and medium low compliance was 5 people (5.21%) with controlled blood pressure of 64 people. and uncontrolled 32 people. Respondents who suffered from hypertension were dominated by women, 55 people (57.3%) with the highest level of education, namely high school graduates/equivalent, 44 people (45.83%). The largest age of respondents who experienced hypertension was 52 - 63 years old, 52 people (54.17%). The conclusion of this study is that there is a significant relationship between adherence to taking antihypertensive medication and the blood pressure of hypertensive patients with the Sig value. (2-tailed) 0.041 < 0.05 with a correlation value of -0.209, which means the level of relationship is weak with the direction of the relationship being negative, meaning that the higher the adherence to taking medication, the lower the blood pressure of hypertensive patients.
HUBUNGAN POLIFARMASI DAN POTENSI DRUG-DRUG INTERACTION (DDI) PADA PASIEN PENYAKIT JANTUNG KORONER (PJK) DI RUMAH SAKIT SWASTA BEKASI Harahap, Nofria Rizki Amalia; Ranti Amanda Putri
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.627

Abstract

Patients with coronary heart disease are at high risk of experiencing medication interactions due to the practice of polypharmacy, which involves taking multiple medications. This can lead to negative treatment outcomes. This study aimed to examine the link between polypharmacy and the potential for drug interactions in patients with coronary heart disease. An observational study utilizing a cross-sectional design was carried out using consecutive sampling. The study included 105 patients. The potential for drug interactions was presented in a table based on each patient's medication profile. The relationship between polypharmacy and the potential for drug interactions was analyzed using the chi-square test. The findings revealed that the majority of patients were male (78.1%) and aged 55-64 years (50.48%). The most common potential drug interactions were clopidogrel with atorvastatin (17.54%), followed by atorvastatin-amlodipine (11.7%) and ticagrelor-acetylsalicylic acid (11.11%). The analysis of the relationship between the number of drugs (polypharmacy) and the number of potential drug interactions resulted in a significant value of 0.000 (<0.05) with an odds ratio of 18.5. This means that patients using polypharmacy are 18.5 times more likely to experience drug interactions compared to those using fewer medications.

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