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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 121 Documents
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FORMULASI EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill) DAN DAUN SIRIH (Piper betle) SEBAGAI REPELLANT (ANTI NYAMUK) BERBENTUK MAT ELEKTRIK TERHADAP NYAMUK Aedes aegypti Yunus, Arifuddin; Wahyuni, Dwi Fitrah; Nurzak, An Nisaa
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.219

Abstract

The epidemiology and area of the spread of DHF is increasing along with the increasing mobility and population density. One of the efforts made in eradicating mosquito vectors is by using insecticides. This study aimed to examine the effectiveness of the combination of avocado (Persea americana) and betel leaf (Piper betle) ethanol extracts against the death of Aedes aegypti mosquitoes. This study aimed to examine the effectiveness of the combination of avocado (Persea americana) and betel leaf (Piper betle) ethanol extracts against the death of Aedes aegypti mosquitoes. This research design is experimental with post test only control group design. The electric mat that had been soaked with a combination of ethanolic extract of avocado (Persea americana) and ethanolic extract of betel leaf (Piper betle) was divided into 4 concentration groups, namely positive control, negative control, and a combination of extracts with concentrations of 1%, 3% and 5 %. Then tested with 10 Aedes aegypti mosquitoes in each treatment. Then tested with 10 Aedes aegypti mosquitoes in each treatment. The results showed that at a concentration of 5% it was able to kill 10 Aedes aegypti mosquitoes in just 5 minutes compared to concentrations of 1% and 3%. From this study it can be concluded that the greater the concentration of extract used, the faster the duration of time to kill the Aedes aegypti mosquito.
GAMBARAN INTERAKSI OBAT PENYAKIT JANTUNG KORONER DENGAN SINDROM METABOLIK PADA PASIEN RAWAT JALAN DI RS TK II DR. SOEPRAOEN MALANG Aprilianti, Rakhmadani Gadis; Sekti, Beta Herilla; Hidayati, Lilik Nur
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.222

Abstract

Drug interaction is the effect of a drug that is caused when there are two or more drugs that interact and affect the body's response to treatment. The method used in this study is a descriptive study using a cross-sectional observational method with retrospective observations in October - December 2020. Patient data collection was obtained from patient medical records using a purposive sampling technique with inclusion criteria. A total of 89 patients were taken as samples. Data analysis using MEDSCAPE and drugs.com applications. A total of 82 prescriptions have the potential for drug interactions, where the most significant level of drug interaction is moderate level (81.48%, these include aspirin with candesartan and bisoprolol with amlodipine. The most drug interaction is the interaction between aspirin and bisoprolol which is classified as a minor interaction (17.74%). The most frequently used type of drug is bisoprolol (22.18%) and the most frequently used drug class is beta blocker
TREN PENGGUNAAN ANTIBIOTIKA LINI 3 DI RS X BEKASI PERIODE TRIWULAN I TAHUN 2020 DIBANDINGKAN DENGAN TRIWULAN IV TAHUN 2019 Hasanah, Kurniatul
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.227

Abstract

Antibiotics are the most widely used drugs in the treatment of infections caused by bacteria. Resistance of microorganisms to antibiotics, pharmacokinetic and pharmacodynamic factors, drug interactions and side effects and cost factors are needed to be considered in their use. The use of antibiotics needs to be evaluated quantitatively and qualitatively. The study was conducted to determine and evaluate the use of line 3 antibiotics quantitatively in the X Bekasi Hospital in the first quarter of 2020 compared to the fourth quarter of 2019. It was descriptive study with retrospective data collection using total sampling technique. There are 13 types of antibiotics that are included in the line 3 antibiotics used at X Bekasi Hospital. The percentage of use of line 3 antibiotics in the first quarter of 2020 compared to the fourth quarter of 2019 increased by 26.9% for the use of amikacin 250 mg injection but decreased by 100% for the use of amikacin 500 mg injection, increased by 17.8% for the use of meropenem 0.5 g injection but decreased by 16.1% for the use of meropenem 1 g injection, decreased by 100% for the use of imipenem-cilastatin injection, linezolid 600 mg injection and vancomycin 500 mg injection, decreased by 212.5%, 53.6%, 41.2% and 69.2% each for the use of doripenem 500 mg injection, decreased, ceftazidime 1 g injection, cefepime 1 g injection and piperacillin tazobactam injection, and increased 75% for the use of tigecycline 50 mg injection. The use of line 3 antibiotics in X Bekasi Hospital was very large and varied in the fourth quarter of 2019 compared to the first quarter of 2020. A very significant amount was seen in the use of imipenem-cilastatin injection, linezolid 600 mg injection and vancomycin 500 mg injection.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TABAT BARITO (Ficus deltoidea) TERHADAP BAKTERI Bacillus substillis DENGAN TINGKATAN POLARITAS PELARUT Rahayu, Sri; Amaliah, Noor; Patimah, Raudatul
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.229

Abstract

Tabat barito leaf (Ficus deltoidea) is a single leaf of a sole form, the leaf has round tip with a flat edge and a pointed base. These leaves have a smooth surface, coloured green above and brownish yellow beneath. This study aims to determine the antibacterial activity of polar, semi-polar and non-polar compounds contained in Tabat barito leaf extract extracted with solvents of different polarity. The highest bacterial inhibition was also measured against Bacillus substillis which is a gram-positive bacterial. The maceration method uses 3 levels of solvents with different polarities, started with a non-polar solvent (n-hexan), a semi-polar solvent (ethyl acetate) and finally macerated with a polar solvent (methanol). The bacterial activity test was done with diffusion method. The results showed that the Tabat Barito leaf extract contained antibacterial compounds that were non-polar, semi-polar and polar. The highest inhibition of the hexane extract at concentration 15% with a clear zone diameter of 22.33 mm in very strong inhibition category against Bacillus substilis bacteria
TINGKAT PEMAHAMAN TENAGA TEKNIS KEFARMASIAN TERHADAP OBAT PATEN DAN OBAT GENERIK DI KOTA PADANG Verawaty, Verawaty; Dewi, Irene Puspa; Kota, Fanny Millenia
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.230

Abstract

Patent drugs are drugs that still have patent rights and can only be produced by the manufacturer of the patent holder. while generic drugs are drugs whose patents have expired, so that they can be produced by all pharmaceutical companies. The purpose of this study was to determine the level of understanding of the pharmaceutical technical staff of Padang City on patent drugs and generic drugs. This research is a descriptive observational study using data collection instruments in the form of online questionnaires (google forms). The research variable is the respondent's level of understanding of generic and patent drugs. The respondents of this study were Pharmacy Technical Staff of Padang City, aged 20 years, both male and female, as many as 55 respondents. The sampling technique in this study was non-purposive sampling in accordance with the inclusion and exclusion criteria. Determination of the sample size in this study using the Slovin formula with an error rate of 5%. Collecting data by distributing online questionnaires via Google Forms. The data obtained is coded and entered into an Excel worksheet. The results showed that the level of understanding of the pharmaceutical technical staff of Padang City on patent drugs and generic drugs was categorized as sufficient (74.5%).
POTENSI EKSTRAK N-HEKSAN, DIKLOROMETANA, ETIL ASETAT, DAN ETANOL 70% JAMUR DEWA (Agaricus blazei Murill) TERHADAP SEL MCF-7 Misgiati, Misgiati -
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.231

Abstract

God mushroom is a functional food. It has pharmacological activity. This content has activity as an anticancer. The purpose of this study was to conduct a preliminary test to obtain an active ingredient capable of having anticancer activity on MCF-7 cells. The stages of the research are stratified extraction with several solvents. Extraction using maceration. The resulting extract was identified and tested for the anticancer activity of MCF-7 cells. The test uses the TLC method. The stationary phase with silica GF254, the mobile phase is n-hexane: ethyl acetate. Anticancer activity test using the MTT method. The results of the identification of each extract contained terpenoid secondary metabolites. Anticancer activity of MCF-7 cells with IC50 extract of n-hexane 15.0923 µg/ml, dichloromethane extract 17.4213 µg/ml, ethyl acetate extract 10.9132µg/ml with strong cytotoxicity criteria, while for ethanol extract IC50 675, 1236 µg/ml.
ANALISIS EFEKTIVITAS BIAYA METODE KB DAN KUALITAS HIDUP AKSEPTOR DI PUSKESMAS LOA JANAN Wiwid Verri Yanti; Husnul Warnida; Triswanto Sentat
Jurnal Riset Kefarmasian Indonesia Vol 4 No 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.237

Abstract

Family Planning (KB) is a national scale program to reduce birth rates and control population growth in Indonesia. Family planning has three phases. The first phase is the phase of delaying/preventing pregnancy. The second is the phase of spacing out pregnancies, and the third is the phase of terminating/terminating pregnancy/fertility. The use of contraceptives in family planning is an effort to prevent pregnancy. The most common contraceptive methods are the pill, injection, and IUD. The purpose of this study was to determine the cost-effectiveness of the use of oral contraceptive pills, contraceptive injections, and IUD at the Loa Janan Health Center. This study used a sample of 42 acceptors. The average cost of injection contraceptives is (Rp 25,000), pills (Rp 15,000), IUD (Rp 107,000) and the effectiveness of injection contraceptives (0.95%), pills (0.857%), and IUDs (0.867%). The ACER (Average cost-effectiveness ratio) value of injection contraceptives was Rp. 26,315, and 75% of the acceptors had an average quality of life. The ACER value of the pill was Rp. 17,502, and 85.7% of the acceptors had a good quality of life, the ACER value of the IUD was Rp. 123,414, and 60% of the acceptors had a good quality of life. The Pill-Injection's ICER (incremental cost-effectiveness ratio) value is Rp. 107,526. The ICER of IUD-Injection is Rp. -987,951, and the IUD-Pill (Rp.9,200,000). Hence, oral contraceptive gave a good quality of life and is more cost-effective than contraceptive injection and IUDs. Keywords: Cost-Effectiveness Analysis, IUD, injection contraceptive, oral contraceptive, Loa Janan Health Center
OPTIMASI FORMULA BODY BUTTER EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava Linn) DENGAN BASIS COCOA BUTTER DAN MILK BUTTER I Gede Made Suradnyana; I Komang Gede Mahardika; Nyoman Budiartha Siada
Jurnal Riset Kefarmasian Indonesia Vol 4 No 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.242

Abstract

Guava leaf extract is known to contain flavonoids, a class of flavone compounds that have very strong antioxidant activity. The antioxidant activity of guava leaf ethanol extract as measured by the DPPH method showed an IC50 value of 72 µg/ml. Body butter preparations have a better ability to nourish and maintain skin moisture because they contain high oil components. Cocoa butter and milk butter are the bases that are widely used in body butter formulas and are able to maintain skin health. This study aims to determine the area of optimum composition of the combination of cocoa butter and milk butter in body butter preparations of guava leaf ethanol extract (Psidium guajava L.). This study used a factorial design with two factors, namely cocoa butter and milk butter and two levels, namely 2% and 4% for cocoa butter and 2% and 15% for milk butter. The observed responses were pH and spreadibility with data analysis using Design Expert and SPSS software. Based on the results of the research, the optimum area for the combination of cocoa butter and milk butter with the pH equation is Y = 6.00000 – 1.77504(X1) – 4.73345 (X2) + 1.8336(X1X2) and the dispersion equation is Y = 3 ,77692+0,366667(X1) – 0,005128(X2) + 0.033333(X1X2). The optimal composition area of cocoa butter and milk butter has been validated on the combination of 3% cocoa butter and 8,5% milk butter.
EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN PNEUMONIA DI RUMAH SAKIT BHAYANGKARA KUPANG PERIODE JULI – DESEMBER 2019 Muhammad Yusuf; Nielma Auliah; Hana Evangelista Sarambu
Jurnal Riset Kefarmasian Indonesia Vol 4 No 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.243

Abstract

Pneumonia is a disease in Indonesia that has a high mortality rate in 2018. Pneumonia is an inflammation of the lungs caused by microorganisms (bacteria, viruses, fungi, parasites). Pneumonia caused by Mycobacterium tuberculosis is not included. While lung inflammation caused by non-microorganisms (chemicals, radiation, aspiration of toxic substances, drugs, etc.) is called pneumonitis. One of the treatment for pneumonia is antibiotics where the incidence of resistance in patients often occurs due to irrational use, therefore it needs to be monitored and evaluated by health workers. The purpose of this study was to determine the use of antibiotics in pneumonia patients at Bhayangkara Hospital Kupang with the Gyssens method according to the Minister of Health of the Republic of Indonesia No. 8 of 2015. The Gyssens method is an evaluation of the use of antibiotics to assess the accuracy of the use of antibiotics which includes the accuracy of indications, the accuracy of selection based on effectiveness, toxicity, price and spectrum, duration of administration, dose, interval, route and time of administration. The method used is non-experimental with a descriptive research design, the sample taken is 25 medical record data. The results of the research category 0 (precise and rational) were 84% or in other words the use of antibiotics was rational, category IVb (there were antibiotics that were less toxic) was 12% and in category IIb (inappropriate interval antibiotics) was 4%.
PENETAPAN KADAR AIR SIMPLISIA DAUN KEMANGI (Ocimum basilicum L.) BERDASARKAN PERBEDAAN METODE PENGERINGAN Andi Wijaya; Noviana Noviana
Jurnal Riset Kefarmasian Indonesia Vol 4 No 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.246

Abstract

Drying is one of the steps in making basil leaves simplicia. Drying is done to reduce the water content of simplicia. This study aims to determine the effect of the drying method on the water content of simplicia basil leaves. This research is an experimental post-test only group design. The basil leaves were dried using 2 methods, namely the direct sunlight method with a black cloth cover and the oven method at 50°C for 7 hours. The dried simplicia was then determined the water content using the gravimetric method. The water content data were analyzed using the Shapiro-Wilk test to determine the normality of the data, followed by the Independent T-test with a 95% confidence level. The results showed that the average moisture content of the drying method using the oven was 9,58±0.15% and the drying method using sunlight was 11,39±0.15%. These results indicate a significant difference (p≤0,05). This study concludes that different drying methods can affect the water content of basil leaves simplicia

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