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Indonesian Journal of Global Health research
Published by Global Health Science Group
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr.v2i2
Core Subject : Health, Education,
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health
Indonesian Journal of Global Health Research (IJGHR) menyediakan forum untuk berbagi publikasi penelitian ilmiah, perawatan kesehatan yang tepat waktu dan terkini serta mempromosikan pengembangan keperawatan, kesehatan masyarakat, masyarakat, lingkungan, dan kesehatan kerja. Jurnal ini menerbitkan makalah penelitian asli ilmu kesehatan. Prioritas tinggi akan diberikan pada artikel tentang kesehatan masyarakat, keperawatan, remaja, masyarakat, kesehatan lingkungan dan pekerjaan, dan sebagainya. Kategori berikut diterimapenelitian asli. Topik-topik yang berkaitan dengan jurnal ini termasuk tetapi tidak terbatas pada: kesehatan masyarakat, promosi kesehatan, kesehatan lingkungan, kesehatan kerja, aspek klinis yang berkaitan dengan kesehatan, layanan kesehatan, kebijakan dan manajemen kesehatan, kesehatan sekolah, kesehatan makanan, kesehatan jarak jauh, kesehatan pedesaan , kesehatan masyarakat, kesehatan mental, kesehatan remaja, kesehatan industri, kesehatan sirkumpolar, pemerataan dalam kesehatan, perawatan kesehatan reproduksi, kesehatan perkotaan, geografi kesehatan, kesehatan wanita, pediatri dan kesehatan anak.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 2,081 Documents
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The Role of Toll-Like Receptor-2 in the Pathogenesis of Pulmonary Tuberculosis Sudarto, Sudarto; Hafy, Zen; Saleh, Irsan; Liberty, Iche Andriyani; Ahmad, Zen; Lubis, Fadhyl Zuhry; Hu, Owen; Salutondok, Welly
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6797

Abstract

Pulmonary tuberculosis (PTB), primarily caused by Mycobacterium tuberculosis (M.tb), remains a major global health burden. Toll-like receptor 2 (TLR-2), a critical component of the innate immune system, plays a key role in the host-pathogen interaction by recognizing specific components of the mycobacterial cell wall and initiating downstream inflammatory pathways. However, the dual role of TLR-2 in both protective immunity and immune evasion by M.tb contributes to the complexity of TB pathogenesis. This study aims to investigate the role of Toll-Like Receptor-2 (TLR-2) in the pathogenesis of pulmonary tuberculosis, including its immunological mechanisms, relationships with disease severity, and the potential of TLR-2 as a diagnostic and therapeutic target. This literature review systematically analyzed molecular mechanisms involving TLR-2 signaling in pulmonary TB using peer-reviewed primary and secondary sources from experimental and clinical studies. Emphasis was placed on signal transduction (NF-κB and MAPK), cytokine profiles, antigen presentation, and the impact of TLR-2 gene polymorphisms on TB susceptibility. Activation of TLR-2 through ligands such as lipoproteins, lipoarabinomannan (LAM), and PE/PPE proteins initiates immune responses via MyD88-dependent pathways, leading to the release of proinflammatory cytokines (TNF-α, IL-6, IL-12). TLR-2 also enhances the function of macrophages and dendritic cells, promoting Th1-mediated immunity. However, chronic or excessive stimulation of TLR-2 can suppress antigen processing, promote IL-10 expression, inhibit phagolysosome fusion, and facilitate M. tb survival within host macrophages. Polymorphisms in the TLR-2 gene (e.g., rs3804099) have been associated with increased susceptibility and variable clinical outcomes in PTB. TLR-2 plays a paradoxical role in pulmonary tuberculosis by mediating both protective immunity and facilitating immune evasion by M.tb. Understanding the balance of TLR-2 signaling and genetic variation is crucial for developing immunomodulatory therapies and personalized interventions in TB management.
Correlation Between Lead Levels and Percentage of Basophilic Stippling in the Blood of Silver Men Azzahra, Ratu; Dhanti, Kurnia Ritma; Djalil, Asmiyenti Djaliasrin; Sulistiyowati, Retno
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6818

Abstract

The phenomenon of silver men has become increasingly prevalent in recent years. The direct application of metallic paint to the body and the nature of their activities are major factors contributing to potential lead expsure. Elevated blood lead levels can disrupt hematopoiesis, leading to various blood abnormalities, including the presence of basophilic stippling. Basophilic stippling is a distinctive marker indicative of heavy metal toxicity, particularly lead poisoning. This study aims to examine the correlation between blood lead levels and the presence of basophilic stippling in the blood of silver men in Purbalingga Regency and Purwokerto Sub-district. This study employed an observational analytical design with a cross-sectional approach. The research sample consisted of blood specimens from 14 silver men, selected using accidental sampling. Blood samples (3 mL) were collected from the respondents arms into EDTA tubes. Blood lead levels were analyzed using Atomic Absorption Spectrophotometry (AAS), while basophilic stippling was examined through Giemsa-stained blood smears observed under a microscope. The collected data were analyzed using Pearsons correlation test. The Pearson correlation test yielded a p-value of 0.045 (p 0.05) and a correlation coefficient of 0.542, indicating a strong positive correlation. There is a strong correlation between blood lead levels andthe presence of basophilic stippling in silver men. An increase in blood lead levels is accompanied by the occurrence of basophilic stippling, highlighting the potential toxic effects of lead exposure in this population.
The Effect of Nurse Driven Protocol Implementation on the Incidents of Catheter Acquired Urinary Tract Infection in Geriatric Patients Tiodora, Tiodora; Sahar, Junaiti; Kuntarti, Kuntarti
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6841

Abstract

The aging process affects the immune system, making the elderly more vulnerable to bacterial and viral infections. Urinary tract infection (UTI) is the second most common infection among geriatric patients. UTIs caused by urinary catheter use, known as Catheter Acquired Urinary Tract Infections (CAUTI), are the leading cause of nosocomial infections, with 80% linked to catheter use. Preventing catheter use beyond 72 hours can reduce CAUTI incidence. The use of Nurse Driven Protocols (NDP) is one of the interventions recommended by the CDC to reduce catheter-related risk factors. This articles aiming to discuss the impact of NDP implementation on the incidence of CAUTI in geriatric patients. This study was conducted using the PRISMA checklist. Literature searches were conducted through several databases, including ProQuest. Science Direct, Scopus, and ClinicalKey Nursing, within the last five years (2020–2024). From 110 identified articles, five met the inclusion criteria, and two were analyzed in depth. The implementation of Nurse Driven Protocols (NDP) significantly reduced the incidence of CAUTI by ensuring catheters are only used when absolutely necessary and removed as soon as no longer indicated. Routine 24-hour assessments enable nurse to independently evaluate catheter use based on clear clinical criteri , such as the HOUDINI system. NDP empowers nurse to conduct independent evaluations and make decisions regarding catheter use, effectively preventing CAUTI and improving the quality of patient care.
The Relationship between Smoking and Physical Activity with Cognitive Impairment among the Elderly Harahap, Rukia Riskita Dewi; Sabri, Rika; Mahathir, Mahathir
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6849

Abstract

The rising number of elderly individuals presents challenges, especially concerning their health and well-being. Without proper intervention, these issues can escalate into more complex problems, including cognitive impairment. To minimize the risk of cognitive impairment that can lead to dementia, it's crucial to reduce risk factors like quitting smoking and engaging in regular physical activity. This study aimed to explore the relationship between smoking, physical activity, and cognitive impairment in the elderly. A retrospective research method was employed, utilizing simple random sampling. The study included 142 elderly participants who met the inclusion criteria. To assess cognitive levels, the Mini Mental State Examination (MMSE) was used. This instrument demonstrated strong validity and reliability, with a Cronbach's Alpha of α=0.827. For measuring physical activity, the Physical Activities Scale For the Elderly (PASE) instrument was utilized, also showing good validity and reliability with a Cronbach's Alpha of α=0.768. Data analysis was conducted using the chi-square statistical test, which revealed a significant relationship between smoking, physical activity, and cognitive impairment in the elderly (p < 0.05). The research findings indicated that the majority of respondents (57.04%) experienced mild cognitive impairment. Additionally, 54.23% of respondents had a history of smoking, and 65.49% exhibited poor physical activity.
The Effect of Physical Exercise on Cognitive Impairment in Patients with Diabetes Mellitus Anastania, Yeane; Dahlia, Debie; Yona, Sri; Kurnia, Dikha Ayu
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6868

Abstract

Diabetes mellitus has been proven to be associated with cognitive decline and an increased risk of dementia. Exercise, both physical activity and brain training, as a non-pharmacological intervention, has the potential to improve cognitive function. Objective to investigate the effect of physical activity on cognitive impairment in patients with diabetes mellitus. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) method was used to select articles. The JBI critical appraisal checklist was used for quality assessment. Articles were searched through PubMed, Medline, and ScienceDirect databases from 2014 to 2024, using full-text articles. Out of 507 articles identified, 13 articles were included in the review, selected through a screening process based on predefined inclusion and exclusion criteria, and all demonstrated that physical activity, cognitive training, combined training, and training with lifestyle modifications can improve cognitive function in patients with type 2 diabetes mellitus. Exercise programs such as aerobic exercise, combined training, or other more specific exercises have been proven to improve cognitive function and metabolic indicators in patients with diabetes mellitus, such as HbA1c levels and insulin resistance. However, the majority of study participants were older adults.
Initiation of the Development of a Bedside Handover Guideline in the Emergency Department of Hospital X Joaquin, Hinoveva Natalia; Handiyani, Hanny; Wilda, Andi Amalia; Harpendewisasmita, Harpendewisasmita
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6869

Abstract

Emergency Department (ER) services are highly complex and carry significant risks to patient safety. Effective communication during the handover process is critical to improving patient safety and care quality. Bedside handover is a strategic form of communication between healthcare workers, ensuring that vital patient information—such as vital signs and urgent care needs—is conveyed accurately and directly, with involvement from both patients and families. The ISBAR communication tool provides a clear structure that helps reduce the risk of miscommunication. Objective to develop a guideline that serves as a consistent reference for nurses in performing bedside handover, fostering a culture of safety and high-quality care at Hospital X. Method: This study used a case report approach with both qualitative and quantitative methods to examine the nursing service system at Hospital X. Data were collected through interviews, document reviews, observations, and questionnaires, and analyzed using the nursing management function approach: planning, organizing, directing, and controlling. Questionnaires were distributed to unit leaders, unit coordinators, and all staff nurses working in Room X, with a total of 48 respondents with total sampling. In the Unfreezing Phase, many ER nurses resisted the bedside handover method, perceiving it as time-consuming and burdensome. Observations revealed continued reliance on traditional handover methods. In the Changing Phase, a Plan of Action (POA) was developed, including drafting supervision guidelines, conducting socialization, and evaluating bedside handover implementation. In the Refreezing Phase, bedside handover was expected to become standard practice, though implementation was limited by time constraints. The implementation of bedside handover in the ER, guided by Lewin’s Change Theory and structured through ISBAR, is a strategic step to ensure care continuity and improve patient safety.
Patient Satisfaction and Associated Factors among Patients of Dental Profession Students, Indonesia: A Cross Sectional Study Fitrianto, Fakhrul; Prasetio, Diki Bima; Failasufa, Hayyu; Kusniati, Retno
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6104

Abstract

Patient satisfaction regarding oral health services is defined as the difference between the patient's view of the services they receive and their expectations of these services. Communication is one of the factors that contribute to increasing the level of patient satisfaction. Meanwhile, communication problems are often a patient complaint as 35%-40% of patients are not satisfied when consulting with a doctor. Analyzing the relationship between patient satisfaction and the provision of communication, information, and education carried out by dental profession students at the Dental and Oral Hospital of Muhammadiyah University, Semarang. Method: This type of research is observational with cross sectional design. The population is 101 consisting of dental professional student patients. The sampling technique uses accidental sampling. The independent variables are the provision of IEC, age, gender, and level of professional students and the dependent variable is patient satisfaction. The questionnaire to measure patient satisfaction and the provision of IEC was taken from previous studies and has been proofread. Validity testing was conducted using expert judgment, with heterotrait-monotrait (HTMT) ratios below 0.9, and the reliability test using Cronbach's alpha yielded a result of 0.7. Ethical approval has been obtained and data collection involves informed consent and questionnaire interviews. Data analysis was carried out with univariate and bivariate using rank spearman correlation and Chi-square. There is a relationship between the provision of IEC with patient satisfaction (p = 0.000). there is no relationship between age (p = 0.840), gender (p = 1.000) and the level of professional students (0.260) with patient satisfaction. the results of patient satisfaction at RSGM Unimus assessed by patients have very satisfactory results. Maintaining and improving patient satisfaction is needed by RSGM to achieve maximum service quality. There is a relationship between the provision of communication, information, and education with patient satisfaction.
Analysis of Risk Factors for Chronic Kidney Failure Sudarmiyati, Nunuk; Pakki, Irfansyah Baharuddin; Ramdan, Iwan Muhamad
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6649

Abstract

The background of this study focused on the increasing incidence of chronic renal failure at Kudungga Sangatta Hospital, East Kutai Regency, which is a serious concern in an effort to improve the quality of public health services. The general objective was to analyze the risk factors of chronic renal failure in Kudungga Sangatta Hospital, East Kutai Regency. This type of research is an analytic observational research with case control design or case control study. The non-random sampling method is purposive sampling as many as 140 people, as for data collection techniques, namely, the preparation stage (preparing a research permit, and conducting a preliminary study), after that there is an implementation stage (collecting respondent data, sorting samples according to sample criteria in two sample groups, filling out questionnaire data, and collecting research instruments). The data analysis techniques in the study were editing, coding, shorting, data entry, and data cleaning. Age was significantly associated with the incidence of acute renal failure (P < 0.001). Family history of hypertension is significantly associated with the incidence of acute renal failure (P < 0.001, OR = 69.750). Family history of diabetes mellitus was not significantly associated with the incidence of acute renal failure (P = 0.806). Taking Analgesic and NSAID drugs were not significantly associated with the incidence of acute renal failure (P > 0.05). The conclusion is that there is a relationship between age and family history of hypertension with the incidence of chronic renal failure and there is no relationship between family history of diabetes mellitus, and using analgesic drugs and NSAIDs is not significantly related to the incidence of acute renal failure at Kudungga Sangatta Hospital, East Kutai Regency.
Analysis of Factors Associated with the Incidence of Dengue Hemorrhagic Fever (DBD) Astuti, Astuti; Pakki, Irfansyah Baharuddin; Ramdan, Iwan Muhamad
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6650

Abstract

Dengue fever is still a public health problem worldwide, especially in tropical and subtropical regions. Data from around the world shows that Asia ranks first in the number of Dengue Fever sufferers each year. The purpose of this study was to determine the factors that affect the incidence of Dengue Fever (DHF) in the work area of BLUD Puskesmas Sangatta Utara, Kecamatan Sangatta Utara, Kabupaten Kutai Timur. This study used a case-control design, with 115 positive cases of DHF and 115 control cases in the work area of BLUD Puskesmas Sangatta Utara, East Kutai Regency, making a total of 230 samples. The data collection techniques included a preparation stage (obtaining research permits and conducting a preliminary study), followed by an implementation stage (collecting respondent data, sorting samples according to criteria into two groups, filling out questionnaires, and collecting research instruments). This study found a significant association with the incidence of DHF in the following variables: knowledge (p < 0.001) OR 0.061, daytime activity (p < 0.001) OR 2.878, mosquito nest eradication efforts (p < 0.001) OR 0.118, and the habit of hanging used clothes in the house (p < 0.001) OR 8.576. It can be concluded that the habit of hanging used clothes in the house is the most dominant variable associated with the incidence of DHF in the work area of BLUD Puskesmas Sangatta Utara (Odds Ratio Exp(β) = 89.297).
Molecular Biomarkers in Pneumonia: Therapeutic Potential of Traditional Plant Medicine Awairaro, Tirsa Persila; Mukhtar, Diniwati; Budiman, Dicky; Marsiati, Himmi
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6671

Abstract

Pneumonia causes 2.56 million global deaths annually, with current therapies limited by antimicrobial resistance and adverse effects. Traditional medicinal plants offer multi-target potential through anti-inflammatory, antioxidant, and immunomodulatory mechanisms. This review synthesizes knowledge on molecular biomarkers in pneumonia pathogenesis and evaluates therapeutic potential of medicinal plants, particularly Coleus amboinicus. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science covering publications from January 2000 to June 2025. Inclusion criteria encompassed studies investigating molecular biomarkers, pneumonia therapeutic pathways, or medicinal plants with respiratory therapeutic properties. Narrative synthesis was employed due to study heterogeneity. Of 1,247 articles identified, 10 studies met inclusion criteria and were utilized in the analysis. Key inflammatory biomarkers included IL-6, TNF-α, and IL-1β, increasing from 5.05 mg/dL (controls) to 25.30 mg/dL in bacterial pneumonia. Neutrophil extracellular trap (NET) formation emerged as a central mechanism (47.36% of protein targets). Coleus amboinicus demonstrated 139 bioactive compounds with broad-spectrum antimicrobial activity and antioxidant properties (DPPH EC₅₀ 32.67-152.8 µg/mL). Traditional medicinal plants, particularly Coleus amboinicus, modulate key molecular pathways in pneumonia through sophisticated multi-target mechanisms, supporting integration of biomarker-guided approaches in contemporary respiratory care.

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