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HAYATI Journal of Biosciences
ISSN : 19783019     EISSN : 20864094     DOI : -
HAYATI Journal of Biosciences (HAYATI J Biosci) publishes articles and short communication in tropical bioscience fields such as development, biotechnology, biodiversity and environmental issues. HAYATI J Biosci covers wide range of all life forms topics including virus, microbes, fungi, plants, animal and human. HAYATI J Biosci has been also indexed/registered in Crossref, DOAJ, CABI, EBSCO, Agricola and ProQuest.
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Articles 1,091 Documents
Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques Lis Rosmanah; Uus Saepuloh; Sela Septima Mariya; Irma Herawati Suparto; Wasmen Manalu; Adi Winarto; Huda Shalahudin Darusman
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.145-152

Abstract

Amyloid plaques and Neurofibrillary Tangles (NFTs) are known to be key pathological features of Alzheimer disease. To gain a better understanding of this disease, studies were carried out on the Indonesian primates, the long-tailed macaques, using a spontaneous Alzheimer's disease model. Examining and identifying genetic markers involved in plaque formation and NFTs in long-tailed macaques is necessary to reveal their physiological processes. In this study, the expression of genes involved in the development of amyloid plaque (Amyloid Precursor Protein (APP)) and those that control the phosphorylation of tau protein (CDK5 and AKT1) was examined in the long-tailed macaque brain. This study showed that APP, CDK5, and AKT1 may potentially be developed as genetic markers of Alzheimer's disease. Long-tailed macaques exhibited the development of amyloid plaque in the aging brain based on the analysis of the gene expression profile of its biomarker. Furthermore, long-tailed macaques can be optimized for neurodegenerative models.
Photosynthetic Rate Prediction Model of Golden Melon Plant (Cucumis melo L.) at Vegetative Phase in Greenhouse using Artificial Neural Networks Erniati; Herry Suhardiyanto; Rokhani Hasbullah; Supriyanto
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.30-38

Abstract

The most critical parameter affecting plant growth is the photosynthetic rate. The parameter can be determined by measuring the rate of CO2 assimilation that occurs in plants. Developing a photosynthetic rate model can recommend proper cultivation maintenance in melon plants. Hence, the involvement of input parameters in the developed model affects the accuracy of the prediction. This study aims to develop an artificial neural networks (ANNs) prediction model of the photosynthetic rate of melon plants in the vegetative phase in the greenhouse based on seven environmental and growth parameters and find the best model structure. Model development uses artificial neural networks with several stages: data collection and pre-processing, model development with different input variations, model validation, and selection of the best scenario to predict photosynthetic rate. The results showed that five out of seven input parameters, i.e., air temperature, sunlight intensity, CO2 concentration, air humidity, and plant rows, in the model structure of five inputs, six hidden and one output were the best model scenarios with coefficient of determination (R2) and root mean square error (RMSE) of 0.986 and 0.420, respectively.
Isolation, Identification and Assessment of Efficient Cellulase Producing Bacteria from the Termite Guts Sirikhwan Tinrat; Lueacha Tabtimmai; Saranya Sedtananun; Chakrit Tachaapaikoon; Kiattawee Choowongkomon
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.182-191

Abstract

The present study is concerned with the screening the cellulase-producing bacteria from termite gut, assessed potential cellulase-producing bacteria and partial characterization (optimum parameters) of cellulase from isolated bacteria. The result showed that 15 out of 48 isolated strains was positive for degrading the carboxy methyl cellulose (CMC) in agar by congo-red method. After screening by DNS assay, three selected bacteria exhibited high cellulase activity that were identified as Citrobacter amalonaticus CM 1-3, Bacillus cereus CM 5-1 and Streptococcus salivarius CE 5-1 using 16S rRNA sequence analysis. All bacterial strains utilized CMC and showed the highest cellulase activity. Cellulase characterization of C. amalonaticus CM 1-3 and S. salivarius CE 5-1 was revealed optimum activity at 35°C, pH 7.0 and for 48 h. Bacillus cereus CM 5-1 represented its potential use in industrial processes due to thermostable cellulase production. The crude cellulase of this strain was purified by (NH4)2SO4 precipitation with 1.58 purification fold and 74.38% overall recovery. The optimal temperature and pH for cellulase activity of B. cereus CM 5-1 were at 40°C and pH 7.0. Thus, this study provided additional information about the diversity and partial characteristic cellulase of cellulolytic bacteria from termite gut for future industrial applications.
Exogenous Zinc Application and Generative Traits of Three Local Shallot Varieties Remi Widana Putri; Elkawakib Syam'un; Fachirah Ulfa
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.94-101

Abstract

Increasing shallot (Allium ascalonicum L.) production can be done by application of botanical or true shallot seeds (TSS). Meanwhile, it is well understood that botanical seeds are difficult to produce due to shallots' low flowering capacity. This study aimed to evaluate the generative traits of three local shallot varieties affected by various doses of zinc (Zn). This study was structured using a split-plot design, where the main plots were varieties (Lokana, Rubaru, and Ambassador 3 Agrihorti). In addition, the sub-plot treatment, the dose of zinc (0, 0.5, 1, and 1.5 kg ha-1), was repeated three times. There is an effect of the main factor (variety) where Rubaru and Ambassador 3 Agrihorti show the fastest umbel emergence. In addition, our data show the interaction effects on the age of sheat breaking, flower blooming (DAP), morphology traits of generative organs, and leaf traits. In detail, Lokana with a Zn dose of 1.5 ha-1 shows the best results on the length and diameter of the umbel stalk; Rubaru with Zn 1 kg ha-1 on the age of broken sheath and chlorophyll index; and the Ambassador 3 Agrihorti with Zn 0.5 kg ha-1 on the number of flowers. On the one hand, it can be concluded that each variety responded differently to the dose of Zn. Concerning seed production, on the other hand, the Ambassador 3 Agrihorti with Zn 0.5 kg ha-1 has better potential to be developed for TSS, as seen from the number of flowers per umbel, a higher percentage of flowering plants and a relatively fast flowering time than other varieties.
Antioxidative Parameters Improvements on Nutritional Approach: A Study on Hypoxic Multiple Organs of Sprague-Dawley Andreanyta Meliala; Paramita Narwidina; Yogi Tri Sumarno
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.59-70

Abstract

In various organs, such as the heart, kidneys, and colon, hypoxia enhances the generation of reactive oxygen species (ROS). However, the effects of reoxygenation, as occurs in intermittent hypoxia (IH) to achieve full recovery of hypoxic organs, are not yet clear. The acclimatization response can boost blood oxygen transport capacity, while hypoxia ROS can impact erythrocytes and plasma behavior, resulting in poor peripheral blood flow. This study aimed to study the antioxidant impact of puree Ficus carica (PFC) in rats with IH-induced oxidative stress. Twenty-nine Sprague-Dawley rats were randomly divided into five groups: group N (control, untreated and not exposed to IH, and Group HC was exposed to hypoxia and received distilled water. Group HPF-6.25, HPF-12.5, and HPF-25 (n = 6) received PFC with doses 6.25; 12.5; and 25 ml/kg/d, respectively for 4 weeks before IH exposure. At the end of 4 weeks, all animals except controls were exposed to IH (10% O2 and 90% N2; 4 hours/day for one week). Hematological parameters were measured with several oxidative stress indicators. Hypoxic rats exhibited substantially higher hemoglobin, hematocrit, and mean corpuscular hemoglobin concentrations. All groups exposed to IH showed increased malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity in the heart, kidneys, and colon. The increasing MDA and decreasing SOD compared to controls and pre-treatment using PFC had a dose-dependent protective effect on the heart, kidneys, and colon.
Antigout Activity of The Spatholobus littoralis Hassk. Extract Fractions Against Xanthine Oxidase: Its Metabolite Profile and Inhibition Kinetics Rut Novalia Rahmawati Sianipar; Komar Sutriah; Dyah Iswantini; Trivadila; Suminar Setiati Achmadi
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.1-20

Abstract

The Spatholobus littoralis Hassk. (S. littoralis Hassk.) is a native plant in Indonesia and has been widely used in traditional Dayaknese medicine for non-communicable degenerative diseases. One of these illnesses, known as gout, is caused by excessive uric acid in the blood, which is the catalytic byproduct of a xanthine oxidase (XO) enzyme. In this work, we investigated the inhibition kinetics of XO and identified bioactive compounds from the stem extract fractions of S. littoralis Hassk. using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Fractionation was carried out to obtain n-hexane, dichloromethane, and 1-butanol fractions from the water and 70% ethanol extracts. Fraction of 1-butanol from 70% ethanol and water extract displayed potent inhibitors of XO with IC50 value 116.91±3.51 and 137.15±5.00 mg/L, respectively. Lineweaver-Burk plot analysis showed that the 1-butanol fraction from the two extracts inhibited XO competitively. The 1-butanol fraction from the two extracts has been further identified as a bioactive fraction. The majority of the compounds in the two active fractions were phenolics. These findings revealed that the 1-butanol fraction from the two extracts is promising as an antigout treatment in the future.
Microscopical Evaluation and TLC Analysis of Pluchea indica (L.) Less: Leaf, Stem, and Root Ni Putu Ermi Hikmawanti; Fadlina Chany Saputri; Arry Yanuar; Ratih Asmana Ningrum; Abdul Mun'im; Hayati Hayati
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.71-81

Abstract

Pluchea indica (L.) Less is traditionally utilized to treat postpartum women in Indonesia. The plant has many pharmacological properties, so that it can be further developed as herbal medicine. In that development process, plant authentication is needed to ensure the quality of raw materials. A simple microscopical and thin-layer chromatography (TLC) analysis might be a way to authenticate the plant, but it has never been reported. So, this study evaluates the microscopical and TLC analysis for P. indica authentication in standardized herbal medicines production. Plant microscopic observation, fluorescence analysis, and polyphenol screening were conducted. n-Hexane, ethyl acetate, and methanol extracts of plant organs were then analyzed by TLC. Here, we reported that in microscopical analysis the simplicia of P. indica contains trichomes and tannin-containing cells. In addition, chlorogenic acid as a marker was present in TLC analysis by ethyl acetate-water-formic acid-acetic acid (8.5:1.5:1:1, v/v). The results of this evaluation might provide additional information in the identification, authentication, and quality control of P. indica as a raw material for herbal medicine.
Development of Few Significant SNP Markers from Transcriptomic Data for Selection of Sengon (Falcataria falcata (L.) Greuter and R. Rankin) Resistant to Boktor Stem Borer and Gall Rust Disease Nugroho, Aditya; Anita, Vilda Puji Dini; Matra, Deden Derajat; Siregar, Iskandar Zulkarnaen; Siregar, Ulfah Juniarti
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.110-125

Abstract

Sengon (Falcataria falcata (L.) Greuter and R. Rankin) plantations in Indonesia are threatened by attacks from Boktor stem borers and gall rust disease. Controlling pests and diseases is difficult therefore, planting resistant trees obtained from tree selection programs is necessary. Currently, genomic breeding often incorporates GWAS, which uses thousands of SNP markers to identify markers with significant associations with the traits studied. This study aimed to bypass such expensive studies by identifying and developing SNP markers from sequences of putative resistance genes to Boktor stem borer and gall rust disease, identified from sengon transcriptomic data analysis. A total of 496,194 putative SNP sites were identified from transcriptomic sequences using the SAMtools and BFCtools programs, of which 119 SNP sites were associated with resistance genes. Of the 101 non-synonymous SNPs selected, only 12 were located in the conserved domain of each gene and were used for primer design. Of the 13 primers designed, only 10 were successfully amplified. Validation of 10 developed SNP markers on 100 sengon accessions using the HRM method confirmed a significant association between SNP markers and resistance traits, with a -log 10 (P-value) between 10.49 and 16.63. A few SNPs markers developed from putative resistance gene sequences are associated with resistance traits in sengon. Therefore, the SNP markers could be applied in selection programs for sengon trees resistant to Boktor stem borers and gall rust disease.
Haplotype Diversity in the Mitochondrial COI Gene of Barred Rainbowfish (Chilaterina fasciata) from Mamberamo River of Western New Guinea, Indonesia Widya Pintaka Bayu Putra; Arif Wibowo; Anang Hari Kristanto
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.126-132

Abstract

A Barred rainbowfish (Chilatherina fasciata) is one of the native fish species found in Western New Guinea of Indonesia. This study aimed to observe the levels of haplotype diversity in the partial Cytochrome-c oxidase subunit I (COI) gene of Barred rainbowfish. For the DNA analysis, thirty (30) Barred rainbowfishes were caught from the Mamberamo River. Three (3) molecular packages of BioEdit, MEGA, and DNAsp were used to analyze twenty (30) forward sequences of the COI gene (502 bp). The research showed four (4) haplotypes for the examined population, a total of seven (7) mutations, and low genetic diversity detected in the partial COI gene with the haplotype diversity (Hd) = 0.405 and nucleotide diversity (pi) = 0.003. Meanwhile, the Fu's and Tajima's tests were 1.21 and -0.69, respectively. The UPGMA tree with 1,000 × bootstrap replications revealed that Barred rainbowfishes are grouped into similar clusters with Melanotaenia vanheurni, Chilatherina alleni, and Chilatherina bleheri. In conclusion, haplotype 3 (77%) was detected as the common haplotype for Barred rainbowfishes at the Mamberamo River of Western New Guinea.
Synergism of Consortium of Heterotrophic Bacterial Strains with Pistia stratiotes L. and Salvinia molesta D. Mitch as Biophytoremediator for Heavy Metal Removal in Domestic Wastewater Lud Waluyo; Nyono; Sukarsono; Atok Miftachul Hudha; Abdulkadir Raharjanto
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.21-29

Abstract

High levels of organic matter and heavy metals in domestic wastewater can increase the pollution of water bodies. The water pollution results correspond to the degree of public health. Waste must be controlled and processed first using management methods such as biophytoremedyator to decrease the rate of pollution because its advantages do not negatively impact public health and the environment. Biophytoremediation offers a better alternative method to repair environmental conditions by combining microorganisms and plants. This study aimed to analyze the effect of heterotrophic bacterial strains with Pistia stratiotes L. and Salvinia molesta D. Mitch for heavy metal removal in domestic wastewater. It also investigated the influence of heterotrophic bacterial strains with Pistia stratiotes L. and Salvinia molesta D. Mitch which were also carried out to observe the BOD and COD levels. The results showed decreased heavy metal levels from the three treatment groups. The consortium treatment group of heterotrophs and Salvinia molesta D. Mitch bacteria strains reduced heavy metal levels faster than the other groups by 59%. In addition, it is also able to reduce BOD and COD levels. This study has shown the significant effect of combining heterotrophic bacterial (HB) strains with Pistia stratiotes L. or Salvinia molesta D. Mitch for heavy metal removal in domestic wastewater.

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