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CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Published by Universitas Airlangga
ISSN : -     EISSN : 2721544X     DOI : http://dx.doi.org/10.20473/cimrj.v1i2.21472
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
The scope for CIMRJ includes: Allergy, Endocrinology, Gastroenterology, Geriatrics, Hematology, Hepatology, Nephology, Rheumatology, Tropic.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 88 Documents
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COVID-19 Vaccination in Autoimmune Patients: A Literature Review Wardhany, Atiqah Nurul; Awalia; Setiabudi, Rebekah J
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.53033

Abstract

Patients with autoimmune diseases, especially rheumatic diseases, have their own concerns regarding the coronavirus disease 2019 (COVID-19) vaccination. Their concerns are specifically related to the physicological response, side effects, and effectiveness of the COVID-19 vaccination. COVID-19 and autoimmune diseases share some similarities in their clinical manifestations, immune responses, and pathogenic mechanisms. The correlation between COVID-19 vaccination and autoimmune diseases can be attributed to epitope mimicry, where the antigen contained in the vaccine has a structural similarity to self-antigen. The purpose of this literature review was to discuss the various types of vaccines, the side effects of the COVID-19 vaccination, and the effect of autoimmune patients' medication on the administration of the COVID-19 vaccination. According to several articles obtained in this study, most autoimmune patients typically experienced mild to moderate side effects. It was not advised for these patients to stop treatment before receiving the COVID-19 vaccination, as doing so was unlikely to affect the vaccine's effectiveness or the patients' immune response. The condition of the autoimmune patients was what influenced the immune response mediated by antibodies. Therefore, the COVID-19 vaccination must be administered when the patients are in a stable condition. In conclusion, it was determined that there is no restriction preventing autoimmune patients from receiving the COVID-19 vaccination. However, it should be noted that autoimmune patients are not recommended to receive live vaccines.   Highlights: 1. This study reviewed the concerns of autoimmune patients over the side effects of the COVID-19 vaccination on their prescribed medication. 2. It is advisable for autoimmune patients to refrain from obtaining live-attenuated vaccines because of their potential effect on the immune response.
Association between the Duration of Steroid Therapy with Hyperglycemia in Patients with Systemic Lupus Erythematosus (SLE) Widyanrika, Farahdiva Audrey; Mudjanarko, Sony Wibisono; Rochmanti, Maftuchah; Ardiany, Deasy; Permana, Putu Bagus Dharma
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.53043

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease which primary treatment consists of steroid drugs administration. Prolonged steroid administration is often associated with an increase in blood glucose, a condition known as hyperglycemia. Hence, this study aimed to evaluate the association between the duration of steroid therapy with hyperglycemia in patients with SLE treated at a tertiary healthcare center in Surabaya, Indonesia.Methods: A cross-sectional study was conducted under a purposive sampling frame from January to December of 2022 by utilizing secondary data from electronic medical health records in Dr. Soetomo General Academic Hospital, a tertiary healthcare center in Surabaya, Indonesia. The association between variables were analyzed using Fisher's exact test, chi square test, independent T-test, one-way ANOVA, Mann-Whitney, and Spearman's rank correlation.Results: Out of 150 included patients, 2.67% experienced hyperglycemia following steroid therapy for SLE. There were no significant associations between clinical variables and hyperglycemia occurence in SLE patients (p>0.05). Patients that received higher doses of steroid did not experience any significant difference in hyperglycemia (p=0.727 for <6 months; p=0.865 for ≥6 months). Daily steroid dose was also not significantly associated with the severity of SLE manifestations based on the SLEDAI score (p=0.081). Overall, no significant association was identified between the duration of steroid therapy with hyperglycemia among SLE patients in the hospital (p=0.365). Conclusion: The study found no significant correlation between clinical variables, hyperglycemia incidence, daily steroids dosage, methylprednisolone dosage, SLE severity, or steroid use duration in patients with Systemic Lupus Erythematosus.
The Effect of Ajwa Date (Phoenix dactylifera) Extract on the Histopathology of Pancreatic Islets in Mice with Diabetes Mellitus Arna, Nadhifa; Humairah, Ira; Susanto, Joni; Yuliawati, Tri Hartini
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.53610

Abstract

Introduction: It is necessary to develop alternative antidiabetic therapies that are safer and more affordable to overcome the high prevalence of diabetes mellitus in Indonesia. Ajwa dates (Phoenix dactylifera) have a high flavonoid content; hence, this study aimed to investigate their effect on streptozotocin-induced diabetes mellitus mice by examining the number of beta cells and the islets of Langerhans. Methods: Twenty-five mice were divided into five groups: a negative control group (K1), a positive control group (K2), and three treatment groups (P1, P2, and P3). The K2, P1, P2, and P3 groups were induced by 100 mg/kg bw of streptozotocin. Additionally, the P1, P2, and P3 groups received oral treatment using ajwa date methanol extract at different doses of 3, 5, and 7 g/kg bw, respectively. The treatment was administered daily for four weeks. The initial analysis included the homogeneity test and the Shapiro-Wilk test. As the data were non-normally distributed, the analysis proceeded with the Kruskal-Wallis test (p<0.05). Results: The comparative analysis revealed significant differences in the number of beta cells among the groups, with a notable decrease observed in the K2 group and an increase in each treatment group. The measurement of the islets of Langerhans exhibited significant differences among the groups, with p=0.001.  Conclusion: The administration of ajwa date methanol extract can affect the number of beta cells and the islets of Langerhans in mice with diabetes mellitus.   Highlights: 1. This original study examined the antioxidant compounds derived from naturally sourced ajwa date (Phoenix dactylifera) extract. 2. Ajwa date extract has the potential to protect against histological damage, specifically to beta cells and pancreatic islets, in mice induced by streptozotocin.
Effect of High-Calorie Diet and Moderate-Intensity Physical Exercise on Gastric Histopathological Features of Mice Zamzam, Ramadhani Rizki; Irwadi, Irfiansyah; Rahniayu, Alphania
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.54573

Abstract

Introduction: Habit of consuming excess calories and sedentary lifestyle can cause oxidative stress which is known to be involved in the pathophysiological process of various diseases including diseases of the gastrointestinal mucosa. Increased Reactive Oxygen Species (ROS) due to a high-calorie diet can damage lipids, proteins, and DNA oxidation of the mucosa and lead to inflammation, apoptosis, damage of mucosal and its barrier. Moderate-intensity physical exercise is known to have health benefits, improve quality of life, reduce the risk of death, and prevent the occurrence of diseases related to oxidative stress. The aim of this study was to analyze the effect of high-calorie diet and moderate-intensity physical exercise on gastric histopathological features of mice.Methods: This research was a true experimental study with posttest only control group design. Female Balb/C strain were randomly assigned into three groups, the control group/K1 (n=12), high-calorie diet group/K2 (n=12), and high-calorie diet and moderate-intensity physical exercise group/K3 (n=9). High-calorie diet in the form of dextrose (D40) was given ad libitum using sonde in a dose of 3-5% of calories or 0.0325 mL/gBW. The moderate-intensity physical exercise was carried out by swimming three times a week for 15 minutes using 6% gBW loading. After 4 weeks of treatment, the mice were sacrificed and their stomach were sampled and prepared for microscopic analysis.Results: The histopathological examination of the gastric mucosa showed the average number of inflammatory cells was 11.60 for K1, 11.25 for K2, and 14.5222 for K3. The Shapiro-Wilk test revealed that the data on inflammatory cells infiltrations were not normally distributed (p<0.05), so a non-parametric difference test was conducted using the Kruskal-Wallis test. Based on the Kruskal-Wallis test results, it was obtained that p>0.05, which means no significant difference was found between the three study groups.Conclusion: There was no effect of a high-calorie diet and moderate-intensity physical exercise on the gastric histopathological features of mice (Mus musculus) in this study
Comorbid Diseases and Outcomes of Critically Ill COVID-19 Patients Admitted to an Indonesian Intensive Care Unit from May to October 2021 Siahaan, Katrin Wilentina; Somia, I Ketut Agus; Utama, I Made Susila; Dian, Ni Made Dewi; Gayatri, Anak Agung Ayu Yuli; Purnamasidhi, Cokorda Agung Wahyu; Merati, Ketut Tuti Parwati
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.54859

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The spread of COVID-19 has become a worldwide health threat, with 583,038,110 cases and a death toll of 6,416,023. This study attempted to determine the relationship of age, sex, and comorbid diseases with the outcomes of critically ill COVID-19 patients at Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, Indonesia. Methods: This analytic study employed a retrospective approach, analyzing secondary data from medical records using a purposive sampling method. The research included univariate analysis, bivariate analysis using the chi-square test, and multivariate analysis using a general linear model performed with the assistance of IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA). A statistical analysis result with a p-value of less than 0.05 was deemed significant. Results: A total of 264 critically ill COVID-19 patients were hospitalized in the Intensive Care Unit of Prof. Dr. IGNG Ngoerah Central General Hospital from May to October 2021. Comorbid diseases were present in 215 patients. The comorbid diseases that had the greatest impact on increasing mortality were diabetes mellitus, hypertension, kidney disease, and cardiovascular disease (p=0.000–0.006, 95% CI). Conclusion: Age and sex do not have any significant relationship with the outcomes of critically ill COVID-19 patients. Meanwhile, comorbid diseases, such as diabetes mellitus, hypertension, and renal and cardiovascular diseases, pose a significant impact on the mortality rate of critically ill COVID-19 patients.   Highlights: 1. This study investigated patients who were critically ill with COVID-19 to determine the relationship between age, sex, comorbidities, and patient outcomes. 2. The findings of this study may provide additional data on the impact of comorbidities on the severity of COVID-19, which can be valuable to prevent mortality due to the infection.
Serum Serotonin Levels and the Severity Scores and Types of Delirium among Geriatric Patients in Denpasar, Indonesia Kusnawan, I Made Dedy; Astika , Nyoman; Kurniawan, Lely Setyawati; Aryana , I Gusti Putu Suka
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.54860

Abstract

Introduction: Delirium is an acute attention disorder that often occurs in elderly patients. The serotoninergic pathway is the main neurotransmitter pathway involved in the development of delirium. Serotonin, known as 5-hydroxythyramine (5-HT), affects mood, aggressiveness, cognition, depression, pressure, and stress in the brain environment. This may lead to the formation of hypoactive, hyperactive, or mixed delirium processes. This study utilized laboratory data with the aim of investigating whether serotonin levels have a correlation with severity score and delirium type in elderly individuals who experience delirium during hospitalization. Methods: This study was conducted in the field of geriatrics at Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, Indonesia, from April 2022 to October 2023. The sample was gathered consecutively, consisting of 62 hospitalized geriatric patients who suffered from delirium and were willing to participate by signing an informed consent. We excluded post-surgical patients and psychoactive drug users. The data were collected using the Memorial Delirium Assessment Scale (MDAS), the Confusion Assessment Method (CAM), and a serum serotonin test. This study used bivariate analysis, the Kruskal-Wallis test, and Spearman’s correlation (p<0.05). Results: A total sample of 62 individuals was required. There was a significant difference in the mean serotonin levels among different types of delirium (p<0.05). Out of all the documented cases, hypoactive delirium was the most frequently observed (64.5%). Most of the elderly patients experienced severe delirium (54.8%). Serotonin levels had a significantly negative correlation with the MDAS scores (r=-0.95; p<0.001). Conclusion: The research findings indicate a correlation between lower serotonin levels and higher MDAS scores, and vice versa.   Highlights: 1. This study attempted to determine the relationship between serum serotonin levels and delirium severity scores among geriatric patients in Indonesia. 2. There was a significant difference in the mean serotonin levels among elderly individuals with hypoactive, hyperactive, and mixed types of delirium.
Shift Work and Associated Health Consequences: A Review Burooj, Ahmed
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.56842

Abstract

This literature review aims to examine the complex relationship between engaging in shift work and its subsequent health sequelae, while also shedding light on fields of research that require further investigation. Indexing services (i.e., Scopus and PubMed) were used to identify pertinent studies, prioritizing original research, review articles, and meta-analyses from 2018 to 2023. Papers not published in English or where full-text translation was not available, research conducted solely on non-human populations, as well as proposal and opinion papers, were excluded. Papers published before 2018 and those with a sample size of 50 participants or fewer were also omitted. The author conducted a thorough evaluation of each study to ensure its relevance and significance. After deduplication of the search results and implementation of the exclusion criteria, 51 papers were shortlisted for this review. The keywords used for the literature search were “shift work”, “health”, “night shift”, “cardiovascular”, “circadian, cancer”, “disease”, “dose-response relationship”, and “long working hours”. The results showed that shift work significantly impacts various aspects of health, presenting risks in the areas of cardiovascular health, cancer susceptibility, circadian rhythm, immunity, metabolism, reproductive health, and mental well-being. Shift workers have increased risks for diabetes, hypertension, adverse cardiac events, circadian dysrhythmia, metabolic syndrome, mental health disorders, and even certain types of cancer. Shift work exhibits significant associations with sexual and reproductive dysfunction in both sexes, including elevated risks for miscarriages and preterm birth. In conclusion, the findings underscore the need for comprehensive health interventions and further research to understand the intricate relationships between shift work and long-term health consequences.   Highlights: 1. Disruption of circadian rhythm due to shift work contributes to various health issues, including altered melatonin levels, immune dysfunction, and metabolic disturbances. 2. There is a critical need for longitudinal studies to explore interventions and workplace policies that can mitigate the adverse health effects of shift work. 3. Addressing the multifaceted impact of shift work on health requires a holistic approach that considers factors like circadian rhythm optimization, workplace support, and tailored interventions.
Smoking Behaviors, Dietary Patterns, and Dyspepsia among Indonesian Adults in 2022 Aprilawati, Dwi; Davis, Gerald Sebastian; Nuha, Muftihana Hanin; Ollyvia, Zsa Zsa; Fadilla, Aulia Nur; Rahmadanti, Ananda; Aufazhafarin, Nadhifa Tanesha; Kloping, Nabila Ananda; Priyambodo, Pamarga; Watang, Andreas Novaldi; Lumaksono, Nandiwardhana Dhira Pranaya; Munir, Sirazul
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.58592

Abstract

Introduction: The global prevalence of dyspeptic syndrome among adults was estimated to be 1.8–57% in 2014, with an average of 20.8%. In a pilot survey involving 30 respondents, we found 21 acute respiratory infections, 16 dyspeptic syndromes, and 6 hypertension cases. Smoking was observed in 70% of the total respondents. This was the basis for conducting additional research in 2022 to examine the relationship between dyspepsia, smoking behaviors, and dietary patterns among adults in Krajan Hamlet, Malang, Indonesia. Methods: This quantitative study used an analytical observational design with a cross-sectional approach. The sample consisted of 70 adults aged 18–65, selected by random sampling. The collected data were analyzed using the Chi-squared test (p<0.05). Results: The prevalence rate for dyspepsia was 44.3%. Among them, 67.1% were smokers (both frequent and non-frequent), and 32.9% were non-smokers (including former and passive). The active smokers had a smoking duration of >2 years and smoked >10 cigarettes daily. A total of 11.4% of subjects exhibited eating habits of consuming trigger foods that put them at a high risk for dyspepsia. Specifically, 42.0% of subjects had an eating interval of >6 hours, while 87.1% had a meal frequency that led to a high risk of developing dyspepsia. There was a significant relationship between a high-risk diet and dyspeptic syndrome (p=0.037). Conclusion: High-risk diets exhibited a relationship with the prevalence of dyspeptic syndrome. Early detection is crucial in an effort to prevent and reduce the incidence and complications of dyspeptic syndrome.   Highlights: 1. This study investigated the relationship between dyspepsia, smoking behaviors, and dietary patterns, which are often overlooked, particularly among those living in rural areas. 2. The findings of this study are anticipated to raise awareness regarding the detrimental impacts of smoking and unhealthy diets on dyspepsia.
Weight Gain in Type 2 Diabetes Mellitus Patients Receiving Sulfonylurea Medications at a Tertiary Hospital in Surabaya, Indonesia Respati, Ghagat Dresta Putra; Prajitno, Jongky Hendro; Setiawati, Rosy; Wironegoro, Rio
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.52126

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. The prevalence of diabetes in Indonesia is 1.5%, although East Java recorded a 2.1% rate in 2013. T2DM medications, such as sulfonylureas, may lead to hypoglycemia and weight gain. This study aimed to investigate the weight gain effects of sulfonylureas in T2DM patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective cross-sectional study used retrograde anamnesis on 41 T2DM patients receiving sulfonylurea medications for the preceding six months. The data were collected from medical records and interviews with the T2DM patients who received treatment at the Internal Medicine Clinic of Dr. Soetomo General Academic Hospital from January to June 2022. Results: Most patients were 46–65 years old (73.2%), female (51.2%), and had been diabetic for over 15 years (48.8%). The predominant medications administered to the patients were glimepiride (41.4%) and a combination of glibenclamide 5 mg, metformin 500 mg, and acarbose 100 mg (19.5%). Almost all patients took their medications in the morning before meals (92.6%). The average weight gain was 4.6 kg, with the glibenclamide and metformin combination resulting in a 17% incidence. Conclusion: T2DM patients who use sulfonylureas generally gain weight and exhibit specific traits, including being middle-aged, female, and diabetic for multiple years. The most commonly used sulfonylureas are glimepiride for monotherapy and glibenclamide for combination therapy with metformin and acarbose. Future research is required to understand weight gain in T2DM patients treated with sulfonylureas more comprehensively.   Highlights: 1. This study investigated weight changes in type 2 diabetes mellitus (T2DM) patients receiving sulfonylureas, with a special focus on the emergence of weight gain as a new problem in T2DM management. 2. The importance of this study pertains to its findings regarding weight gain in T2DM patients treated with sulfonylureas, offering additional data that aids in preventing adverse effects of the medications.
Bacterial and Fungal Coinfections in COVID-19 Inpatients at a Tertiary Hospital in Surabaya, Indonesia, from November 2020 to February 2022 Shabira, Naura Ghina; Widodo, Agung Dwi Wahyu; Rusli, Musofa
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.53331

Abstract

Introduction: After the first discovery of coronavirus disease 2019 (COVID-19) in 2020, the rapid increase of cases beyond China prompted the declaration of a pandemic. Elevated rates of bacterial-fungal coinfection were observed in hospitalized COVID-19 patients. This study aimed to determine the profiles of bacterial and fungal coinfections in COVID-19 patients diagnosed between November 2020 and February 2022 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective descriptive study obtained data from medical records and used total sampling to assemble 278 COVID-19 patients who met the inclusion criteria. The evaluated variables were subject characteristics, including age, sex, comorbidities, length of stay, ventilator use, bacterial coinfections, fungal coinfections, and bacterial-fungal coinfections. Results: The age group of 55–64 years (26.9%) was predominant among the patients, with males (55.4%) outnumbering females. Hypertension was the most prevalent comorbidity (15.8%). The patients were mostly hospitalized for over ten days (66.2%). Eleven patients (4%) were admitted to the intensive care unit, and five patients (1.8%) required mechanical ventilation. The bacterial coinfections were primarily caused by Streptococcus viridans (56.6%), found in 145 sputum specimens, followed by Klebsiella pneumoniae (23.4%). The predominant isolates in the bacterial-fungal coinfections were Streptococcus viridans and Candida albicans (24.8%), identified in 125 sputum specimens, followed by Klebsiella pneumoniae and Candida albicans (18.4%). Conclusion: COVID-19 patients with bacterial-fungal coinfections present certain characteristics, including being male, middle-aged, hypertensive, and hospitalized beyond ten days. Streptococcus viridans, Klebsiella pneumoniae, and Candida albicans are common etiologies in bacterial-fungal coinfections.   Highlights: 1. This study overviews the distribution of patients and causative pathogens associated with bacterial, fungal, and bacterial-fungal coinfections, which have escalated with the rapid rise of coronavirus disease 2019 (COVID-19) hospitalization. 2. Data on the causative pathogens of bacterial-fungal coinfection in COVID-19 patients can be considered in the development of guidelines for empirical therapy in clinical practice.  

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