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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
 503   504   505   506   507 
Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR) Damayanti; Hari Sukanto; Marsudi Hutomo; Sylvia Anggraeni; Menul Ayu Umborowati; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15739

Abstract

Background: Cutaneous Adverse Drug Reaction (CADR) is a frequent problem in clinical practice since there were new drugs or drug misuse, which leads to high morbidity and mortality rate. It is often difficult to determine the offending drug only from the history. Provocation test, intradermal test or skin prick test are of significant value, but having higher risk to re-precipitate life-threatening reaction. Drug patch test (DPT) is a test, which is performed to CADR patient to determine the culprit drug. The main advantages of DPT are, it gives rarely adverse reaction and any commercialized form of drugs can be used.Methods: This is a retrospective study, aimed to analize the clinical relevance between anamnesis and DPT result in patient with history of CADR. All patient, who were performed with DPT in one year period in Dr. Soetomo General Academic Hospital Surabaya Indonesia, were evaluated in this study. Results: There were 14 patients with history of CADR, who performed DPT; consist of 7 maculopapular eruption cases, 4 Stevens-Johnson Syndrome (SJS) cases, 1 Fixed Drug Eruption (FDE) case, 1 Acute Generalized Exanthematous Pustulosis (AGEP) case and 1 Drug Reaction with Eosinophilia and Systemic Reaction (DRESS) case. There were 9 patients (64.3 %), who got positive result of DPT. The relevance between anamnesis and positive result of DPT were shown in 8 patient (88.9%) of 9 patient with positive DPT result. Conclusion: DPT has important role in identifying the culprit drug in CADR, especially when multiple drugs are involved.
Effect of Insect Growth Regulators “Dimilin25% wp and Match 50 EC” Against House Fly (Musca domestica) Life Stages (Diptera: Muscidae) Ezeddin A. Albayyar; Rafraf Abdul Aziz Abdel Qader
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15740

Abstract

The study was conducted to identify the effect of growth regulators “Match and Dimilin” using different concentrations on the incomplete life stages of the house fly, and calculating the percentages of egg hatching, incapability of larvae pupation and emergence of adult insects in laboratory conditions. All the concentrations showed different percentages in their effect on the life stages of the insect, whereas the effects were increased with the exposure rate increasing. However, the hatching rate for eggs in the concentration of (1000) mg/l reached to (0.00%) for the Match growth regulator, while it reached (20.50%) for the Dimilin regulator at the same concentration. In the larval stages, the percentage of larvae that reached the pupa phase in concentration of (1000) mg/l for both growth regulators was (0.00%), while the emergence rate of adults for the same concentration was reached in growth regulators Match and Dimilin for (25.33%) and (10.33%) respectively
The Protective Effect of Xanthone via Malondialdehyde and Superoxide DismutaseExpression on Mice Sertoli cell Induced by 2-Methoxyethanol Ernawati; Zufra Inayah; Sri Agus Sudjarwo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15741

Abstract

The antioxidants can be used for protective in oxidative stress that is one of the important mechanisms of 2-methoxyethanol (2-ME)-induced testis toxicity. The current study was carried out to evaluate The protective effect of xanthone via Malondialdehyde (MDA) and Superoxide Dismutase (SOD) expression on mice Sertoli cell induced by 2-Methoxyethanolon the Sertoli cell number induced by 2-ME in mice. The study used 35 male mice divided into 5 groups: control group (mice were given daily with water purified by distillation); 2-ME group (mice were given daily with 2-ME 200 mg/kg BW orally once in a day for 35 days); and the treatment group ( mice were given the xanthone 60 mg, 120 mg, and 240 mg/kg BW orally once in a day for 38 days, and on the 3th day, were given 2-ME 200 mg/kg BW one hour after the xanthone administration). After 38 days, the testis tissues were collected to evaluate the histological of Sertoli cell number, and also evaluated the immunohistochemical of MDA and SOD expression on Sertoli cell. The result showed that 2-ME administration significantly increased MDA expression, and decreased both SOD expression and the number of Sertoli cells. However, the treatment of xanthone significantly decreased MDA expression, and increased the expression of SOD of the Sertoli cell in the immunohistochemical. Xanthone also significantly increased the Sertoli cell number in histopathological evaluation. In conclusion, From the results of this study demonstrated that xanthone is able to protect Sertoli cell number in mice treated with 2-ME through decreasing MDA and increasing SOD.
Failure Mode and Effect Analysis: A Technique to Prevent the Risk of SARS-COV-2 Infectionin A Retrocession Unit Esso Eric Valery Latt; Youssef Moutaouakkil; ZidaneQriouet; YassineAtbib; YasminaTadlaoui; Jamal Lamsaouri; YassirBousliman
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15742

Abstract

Securing healthcare workers and patients against the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection/transmission, require the development of new tools and methods. Several laboratories have started recently clinical trials to develop vaccines and drugs, however these solutions require more time to evaluate and validate them. As an alternative and in order to stop the spread of SARS-CoV-2 infection, our objective is to implement preventive and corrective actions to reduce the infectious/transmission risk of SARS-COV-2 during hospital retrocession, using the failure mode effect analysis (FMEA) method. The criticality of each failure mode was assessed by calculating the criticality index (CI). The obtained data showed 12 fault modes with a total criticality index (CI) of 480, two acceptable risks, four significant risks and six critical risks. Ten risks were identified as priorities (CI > 15): four related to patient reception, two related to personnel, two during dispensation, one related to the end of dispensation and the last related to traceability. These risks were corrected by improvement actions proposed by FMEA and then re-evaluated effectively.This study assessed the feasibility and relevance of the use ofFMEA in the hospital retrocession dispensing process related to the infectious/transmission risk of SARS-CoV-2.Finally, FMEA seems to be an effective method to reduce the infectious/transmission risk of SARS-COV-2 during hospital retrocession.
Evaluating the Knowledge of Moroccan Patients Regarding their Oral Anticoagulant Treatment Admitted in Cardiology and Cardiovascular Surgery Units Esso Eric Valery Latt; Youssef Moutaouakkil; Badreddine Moukafih; Yahia Cherrah; Jamal Lamsaouri; Yassir Bousliman
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15743

Abstract

Background. Vitamin K antagonists (VKAs), the most commonly used anticoagulants worldwide. Our aim was to assessing the moroccan patients’ knowledge regarding their VKA treatment after their hospital stay in Cardiology and Cardiovascular Surgery units before being discharged home.Methods. One hundred and twenty-three patients were enrolled in this prospective, monocenter study. Their level of knowledge was assessed by a semi-structured interview between the pharmacist and the patients.Results. 75,61% of patients were able to give the name of the drug they were taking, 76,42 % could explain its effect and finally, 79,67% of patient knew their INR target values. 19,51 % of patients were able to describe the symptoms in case of overdose and what to do in that case. 47,15 % of patients were aware of food interactions and 56,09 % of self-medication risks. Conclusion. Our study, as in previous studies among Patients with chronic diseases, identified some gaps in knowledge. These findings indicate the need for better education of patients regarding their VKA treatment.
The Role of Forensic Expert on the Albanian Juridical Processes Focused on Minor’s Issues Evis Garunja
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15744

Abstract

Adapting the legal framework to social change highlighted the necessity of expert involvement in all stages of juridical proceedings. The expertise of the psychologist during the process constitutes an important guide for a fair and right court decision on cases focused on minors. This figure facilitates a lot the work of judges on a responsible decision for the minor’s future.The article highlights some of the duties, responsibilities, and functions of the psychologist during court proceedings, how they operate in the judicial system today, how this function can be improved to support the minor, and the institutions themselves. The article highlights some of the weaknesses of this role on its reposition as a concrete and substantial part of the judicial structure to produce maximum positive effects, as well as enhancing its opportunities and facilitating process services and the minor’s future orientation in cooperation with other institutions in charge or social services
Physical Burden among Caregiver of Child with Nephrotic Syndrome in Najaf City in Iraq Entesar Abdulameer Fajr
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15745

Abstract

Caregiver of children with Nephrotic syndrome report negative impact on their physical and psychological health. The descriptive (cross-sectional) research is an investigation done to determine the physical burden among caregivers of children with Nephrotic syndrome. During the time from September 23, 2018 to September 1, 2019, an intended (non-random) samples (115) are select from Al-Sadr Medical City in Najaf city. The tool is present to (21) professionals from different academies to be effective, and the reliable of the tool is determine complete by coefficient alpha implicit, and the consistency of this tool is (r = 0.81). Nephrotic syndrome is the greatest cause of burden for patients and caregiver. This may be related to patients, needs that include physical, psychological, and emotional support. This requires much knowledge and more skills from caregivers and developed responsibilities for them. These responsibilities may lead to much burden that includes social and economic burdens. It can be concluded that more than half of the caregiver of child with Nephrotic Syndrome were affect by physical burden at moderate to severe degree.
Gitelman Syndrome in Post-Partum Pre-Eclampsia in Dr. Soetomo Hospital, Surabaya, Indonesia Erix Agus Hasudungan Telaumbanua; Ferdy Royland Marpaung
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15746

Abstract

Gitelman Syndrome (GS) is an autosomal recessive tubular kidney disorder. The disorder is rare with a prevalence estimated to be 1 in 40,000 individuals. We closely observed a 28-year-old female with complaints of stiffness and cramps on both hands and feet for 2 weeks and became worse in 3 days before admittance, nausea (+), vomiting (+), shortness of breath (+). Medical records showed that patient underwent post SC 32nd day because of severe pre-eclampsia + IUGR + Oligohydramnion. Physical examination showed GCS 456, blood pressure 140/80 mmHg, heart rate 96x/minute, respiration rate 24x/minute, temperature 37 oC. Laboratory results showed Hb 9.4 g/dl, MCV 86.8 fL, MCH 29.6 pg, MCHC 34.1 g/dL, WBC 7.83x103/uL, PLT 483x103/uL, potassium 2.8 mmol/L, sodium 138 mmol/L, chloride 95 mmol/L, calcium 8.3 mg/dL, magnesium 1.1 mg/dL, phosphate 3 mg/dL, BUN 8 mg/dL, serum creatinin 0.76 mg/dL, urinary calcium 488.4 mg/24 hours, urinary creatinine 488.4 mg/24 hours, proteinuria +1, and blood gas test suggested mixed metabolic alkalosis and respiratory acidosis. Gitelman Syndrome is characterized by hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria. The diagnosis of GS is generally relatively late because of its difficulty to be clinically categorized; therefore, a more comprehensive diagnosis approach is needed. The diagnosis of Gitelman Syndrome is based on clinical symptoms and laboratorial abnormalities and can be confirmed by genetic testing.
Prevention and Early Detection of Metabolic Syndrome in Household Community, Surabaya Ema Qurnianingsih; Lina Lukitasari; Ira Humairah; Siti Khaerunnisa; Gwenny Ichsan Prabowo; Suhartati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15747

Abstract

Introduction. Metabolic syndrome is a collection of factors believed to increase the risk of atherosclerosis and type 2 diabetes mellitus. The incidence of metabolic syndrome in young adults is increasing, especially in Asian countries. Therefore we need efforts to increase knowledge in society about this disease. Aim. We conducted a socialization program on prevention and early detection of metabolic syndrome in household community to increase public knowledge about this disease.Method. This program was conducted in August 2017 in Wonokromo District, Surabaya. The participants in the activity consisted of 32 people from household community. The activity consisted of blood sampling collection, body weight, and abdominal circumference measurement for risk factor assessment, pre-test, socialization of metabolic syndrome, and post-test.Results. From the results of the pre and post test, we found an increase knowledge of 76.9% participants. The laboratory test results for early detection of metabolic syndrome showed 37.5% of participants had metabolic syndrome. We also found a significant positive correlation between body weight and abdominal circumference (p = 0.000, r = 0.867). There was also a significant negative correlation between body weight and HDL (p = 0.004, r = -0.494), between abdominal circumference and HDL (p <0.05, r = -0.376), and between TG and HDL (p <0.05, r = -4.22).Conclusion. Socialization and early detection of metabolic syndrome can increase knowledge, awareness, and detection of metabolic syndrome in the household community.
The Effect of Atorvastatin in Knee Osteoarthritis Eman Mohammed Jasim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15748

Abstract

The aim of this, randomized, double-blind, placebo-controlled study is to evaluate the effect of using 40mg atorvastatin on the progression of joint structural changes and symptoms over 3months in Iraqi patients with symptomatic knee osteoarthritis.This study was performed at Department of Rheumatology, Baghdad Teaching Hospital during the period from September 2020 to January 2021.A total of 44 patients with knee osteoarthritis were assigned to the placebo group (n=21) and atorvastatin group (n=23)that was received atorvastatin 40mg once daily. Both groups received etoricoxib tablets 60mg as a rescue medicine on need. Both groups were treated continuously for 12 weeks.Serum levels of C-terminal telopeptide of type II collagen CTXII, high sensitive c-reactive protein HS-CRP and Western Ontario and McMaster Universities Osteoarthritis Index WOMAC was measured before and after three months of treatment.Resultsshowed that after three months of treatment, the atorvastatin group showeda significant symptomatic improvement in total WOMAC scoring (P<0.0001) associated with a significant reduction (P<0.001) in serum CTXII, HS-CRP level.These results confirmed that the atorvastatin treatment in patients with knee osteoarthritis has clinical efficacy in reducing symptoms through the improvement of WOMAC index and reduction of serum level of CTXII and HS-CRP. In conclusions: Atorvastatin in a dose of 40mg daily can reduce the symptoms of OA.

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