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JOURNAL LA MEDIHEALTICO
Published by Newinera Publisher
ISSN : 27211215     EISSN : 27211231     DOI : 10.37899/journallamedihealtico.v6i2.1959
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Homecare, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy & Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 466 Documents
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Comparison of the Effectiveness of Dermapen Using Plasma from Platelets with Dermapen on Pockmarked Skin Surface of Female Wistar Rats (Rattus Norvegicus) Nila, Endang Dwi Wulansari Roh; Wijaya, Johanna Fransiska; Edison, Rizki Edmi
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1090

Abstract

Various treatments can cure pockmarks. First, you have to know the cause of the pockmarks and the strength of the pockmarked skin, making it easier to choose the treatment, one of which is dermapen, which uses Plasma from platelets. Test and compare the effectiveness of the derma pen action using Plasma from platelets with the derma pen action on the pockmarked skin surface of female Wistar rats (Rattus Copernicus). This research is a laboratory experiment to compare the effectiveness of the dermapen action using Plasma from platelets with the dermapen action on the pockmarked skin surface of female Wistar rats (Rattus novergicus) using a post-test with control group design or control samples based on treatment groups to analyze the dermapen action using Plasma from platelets with dermapenic action on the surface of rat skin pockmarks. The results showed that the dermapen treatment group with Plasma from platelets at a dose of 10% was more effective in healing cut wounds in white mice than the dermapen treatment group using Plasma from platelets at doses of 2.5% and 5%, respectively. This is because, at a concentration of 10%, blood plasma metabolite compounds from platelets that are applied to wounds already affect the wound. The effect only inhibits microorganisms at small doses, making it less effective in healing wounds. It is recommended that the minimum dose be 10% so that the metabolite compounds in the Plasma from platelets have a healing effect on wounds.
Compare the Effectiveness of a Peel-Off Mask and Sheet-Mask with Green Tea Extract on Dermapen-Treated Wounds on the Back Surface of Female Wistar Rats Henny Hajaratul Aswat; Lenni Dianna Putri; Andri Hidayat
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1091

Abstract

Microneedling has recently been cited as having high efficacy, safety, and recovery rates post-treatment. This microneedling procedure has shown results that increase patient satisfaction and awareness of doctors who want minimal treatment but still get maximum results for healing uneven skin on the face and acne scarring. The test and analysis of the difference in effectiveness between the use of a peel-off mask and a sheet mask in healing wounds treated with derma pen on the surface of the back skin of female Wistar rats (Rattus norvegicus). This research approach uses experimental quantitative research methods, namely an actual experiment or laboratory experimental design. They used a pre-test – post-test control group design to determine and analyze the differences or comparisons in the effectiveness of using a peel-off mask and a sheet mask for wounds treated with a derma pen on the skin surface. The research subjects were 10 female Wistar rats (Rattus norvegicus). The research procedure was the acclimation of test animals, phytochemical screening, treatment, and observation carried out on mice by administering dermapen wounds. The research data was analyzed using the SPSS program. In this study, Wistar strain white rats (Rattus norvegicus) with peel-off and sheet masks healed their wounds. Dermapen wounds heal after 14 days, as the average rat wound length shows. The peel-off mask group healed 100% on day 13, while the sheet-mask group healed 100% on day 12. Based on this percentage difference, the researchers found that the group with the fastest wound healing used a 12-day green tea sheet mask.
Effectiveness of Oral Providing of Ajwa Date Fruit Extract on Malondialdehyde and Superoxide Dismutase Levels of White Rats Induced by Excessive Physical Activity Jayanti, Herlina; Syahrian, Muhammad Faridz; Mukhtar, Zulfikri
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1092

Abstract

Natural food ingredients are becoming increasingly popular as a treatment. According to studies and investigations, experts increasingly turn to natural remedies to treat disease, including date fruit extract (Phoenix dactylifera). This study tested the effectiveness of oral date palm fruit extract (Phoenix dactylifera) in reducing blood malondialdehyde levels in white rats (Rattus norvegicus) induced by excessive physical activity and increasing blood levels. Intense physical exercise increases white rat blood superoxide dismutase. This research is a laboratory experimental research or an actual experiment. The research design used a pre-test and post-test with a control group design to analyze the effectiveness of oral administration of date palm (Phoenix dactylifera) extract on the MDA and SOD levels of white rat (Rattus norvegicus) samples induced by excessive physical activity. The results of date fruit extract (Phoenix dactylifera) at 5 ml were more effective at reducing MDA and increasing SOD levels in white mice induced by excessive physical activity than at 3 and 4 ml. The experimental group treated with date fruit extract (Phoenix dactylifera) had lower MDA and higher SOD levels than the group given distilled water. Date fruit extract (Phoenix dactylifera) contains flavonoids and tannins. Some bioactive substances are antioxidants. Antioxidants can assist the body fight free radicals from excessive physical exertion.
Test of the Effectiveness of Giving Salmon DNA Serum with Virgin Coconut Oil Extract on the Growth of Skin Tissue from Cut Scars on the Skin of Female Wistar Rats (Rattus Norvegicus) Apriani, Silvi; Angie, Evelyn; Nasution, Syamsul Arifin
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1093

Abstract

Various treatments can cure pockmarks. First, you have to know the cause of the pockmarks and the strength of the pockmarked skin, making it easier to choose the treatment, one of which is dermapen, which uses plasma from platelets. Test and compare the effectiveness of the derma pen action using platelet plasma with the derma pen action on the pockmarked skin surface of female Wistar rats (Rattus novergicus). This research is a laboratory experiment to compare the effectiveness of the dermapen action using plasma from platelets with the dermapen action on the pockmarked skin surface of female Wistar rats (Rattus novergicus) using a post-test with control group design or control samples based on treatment groups to analyze the dermapen action using plasma from platelets with dermapenic action on the surface of rat skin pockmarks. The results showed that the dermapen treatment group with plasma from platelets at a dose of 10% was more effective in healing cut wounds in white mice than the dermapen treatment group using plasma from platelets at doses of 2.5% and 5%. This is because, at a concentration of 10%, blood plasma metabolite compounds from platelets that are applied to wounds already affect the wound. The effect only inhibits microorganisms at small doses, making it less effective in healing wounds. It is recommended that the minimum dose be 10% so that the metabolite compounds in the plasma from platelets have a healing effect on wounds.
Knowledge and Application of Pharmacist Ethical Practices in Surakarta City Denise Pasesa, Rara; Da'i , Muhammad
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1097

Abstract

This study aims to determine the knowledge and application of pharmacist ethical practices in the city of Surakarta. This research is a type of descriptive research. This research was conducted in all pharmacies and hospitals in the Surakarta City area. Data collection will take place in November 2023-January 2024. The population in this study was 489 and the error rate was 5%, so the sample taken was 205 people. The selection of respondents in this study was carried out by non-probability sampling techniques with a sampling technique, namely purposive sampling. The instrument used in this study was a questionnaire. Data analysis of this study was carried out by descriptive analysis on SPSS software. Based on the results of the study, pharmacists were dominated by good knowledge as many as 132 respondents (64%) while for the application of pharmacist ethical practices in Surakarta City was dominated by the application of ethics as many as 122 respondents (60%). This study concludes that pharmacists in Surakarta City have good knowledge of ethical practices and sufficient application of ethical practices.
The Effect of Binahong Leaf Extract on Reducing Cholesterol and Histopathological Features in the Liver Trisnawati, Risca; Djuang, Michelle Hendriani; Hutapea, Johnson
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1098

Abstract

Being overweight or obese raises your risk of elevated cholesterol, triglycerides, and fatty liver. The liver is crucial to metabolic regulation. Essential to preserve liver health. Maintaining your diet, exercising, and eating antioxidants are all options. Many plants contain antioxidants, like Binahong (Anredera cordifolia). This study examines how Binahong leaf extract reduces cholesterol and improves liver function in high-fat-fed Wistar rats (Rattus norvegicus) and their liver histology. An actual experiment or laboratory experimental study is quantitative. 24 Wistar rats were sampled. Binahong leaf extract was the independent variable, cholesterol levels liver histological features were the dependent variable, and a high-fat diet was the precondition. The test animals were put into four groups: control, groups 2, 3, and 4 with Binahong leaf extract at 30mg/BW, 50mg/BW, and 70mg/BW. SPSS normality, homogeneity, and ANOVA tests. If p > 0.05, research results are generally distributed with 0.200 significance. Significant homogeneity was 0.176 > 0.05. Effective One-Way ANOVA test results (0.000 or <0.05). Post Hoc LSD test analysis yielded important values of 0.000.0001 and 0.024 < 0.05. The phytochemical test found flavonoids, alkaloids, saponins, steroids, and tannins in Binahong leaf extract. Binahong leaf extract at 70 mg/BW reduced cholesterol, body weight, and LDL in hypercholesterolemic male white mice best. The study found that Binahong leaf extract's secondary metabolites—flavonoids, alkaloids, saponins, steroids, and tannins—reduce cholesterol, LDL, and body weight in Wistar strain white rats (Rattus Norvegicus) with hypercholesterolemia.
The Effect of Giving Celery Extract on Testicular Function of Wistar White Rats Exposed to Lead Acetate Mefriyanti, Evi; Lumbantobing, Andrico Napolin; Akbar, Khainir
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1099

Abstract

The population is unaware of lead poisoning risks. Lead can cause tissue function and metabolism issues. Celery (Apium graveolens L), an antioxidant, is widely used in medicine and as a multivitamin. This study examines how celery extract affects SOD levels and testicular Caspase-3 expression in lead-exposed Wistar white rats (Rattus norvegicus). The accurate experiment-based quantitative research. 27 Wistar white rats (Rattus norvegicus) were sampled. This study examined celery extract as an independent variable and SOD and caspase-3 expression as dependent variables. Three treatment groups were presented: Control Group, Treatment Group 1 with 200 mg/kg BW celery extract, and Treatment Group 2 with 400 mg/kg BW. The Paired T-test and normality test were performed. SPSS 26.0 processed statistical data. The study indicated that celery extract increased SOD levels, but not as much as without lead introduction. Also, the caspase-3 decrease was not significant. In normality tests, SOD and caspase-3 were p > 0.05. Similarly, the Paired T-test showed 0.000 < 0.05 for SOD caspase-3 levels. Celery leaf extract (Apium graveolens Linn) at 200 and 400 mg/kg BW provided active components like alkaloids, flavonoids, saponins, tannins, and steroids, which were beneficial. The body benefits from its antioxidant properties.
Different Effects of Hylocecarus Polyrhizus and Hylocecarus Undatus Extract on Reducing Total Cholesterol of Male Rattus Norvegicus Wistar Strain Fahriani, Elviza; Mylano, Tri Adi; Hutapea, Johnson
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1100

Abstract

A chronic ailment that is caused by excessive food consumption and a lack of physical activity, obesity is a condition that may be prevented. The tropical dragon fruit can control cholesterol levels, support the immune system, and give a natural colorant for culinary applications. In a true experimental research, sample with rats were fed red and white dragon fruit extracts to determine the amounts of cholesterol in their bodies. Spectrophotometry was used to determine the rats' blood lipid profiles, cholesterol levels, and body weight after they were fed a meal that was high in fat and contained duck egg yolk. For this study, extracts from red and white dragon fruits were administered to male Wistar rats to determine their effects on cholesterol levels. After fourteen days, both groups had a reduction in high cholesterol levels, with group 4 exhibiting the most significant drop in cholesterol levels. Additionally, the extracts decreased the levels of MDA while simultaneously increasing the levels of SOD. The most significant rise was seen in group 4, given white dragon fruit extract at 140 mg/200 gr BW daily. SPSS was utilized to analyze the effects of dragon fruit on blood cholesterol levels in experimental animals, employing the LSD technique and one-way ANOVA.
Antioxidant In Reducing MDA Conditions and Increasing SOD Conditions in White Rats (Rattus norvegicus) Wistar Strain Given a High Cholesterol Diet and Induced More Physical Activity Riana, Nova; Putri, Lenni Dianna; Novriani, Erida
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1101

Abstract

Sedentary lifestyles increase the risk of morbidity and infectious illnesses. Physical exercise can improve immune function but can lead to increased oxidants and reactive oxygen species (ROS), damaging cells and tissues. Crucial in mitigating the cellular damage caused by free radicals are antioxidants, including non-enzymatic antioxidants such as glutathione, vitamins C and E, and others. Moderate to high-intensity physical exercise can result in an increase in ROS and a reduction in SOD. Grape seeds are rich in antioxidants, which have been shown to neutralize free radicals and protect against inflammation, bacteria, ulcers, and cancer. These antioxidants, including phenols and proanthocyanidins, are beneficial to health and have applications in various industries, including energy production, cosmetics, and pharmaceuticals. Research is also being conducted to explore their antioxidant effects on MDA levels. Grape seed extract was tested for its impact on malondialdehyde (MDA) levels in the blood of male Wistar strain white rats. Rats' MDA levels decreased following four weeks of treatment. Rat cages, digital scales, an MDA test kit, and SPSS were some of the equipment used in the study. Grape seed extract effectively reduces MDA levels in rats with hypercholesterolemia, resulting in weight loss and a lee index below 0.3, and increases SOD levels, indicating potential for human use.
Neurological Deafness Prevalence Based on Diabetes Mellitus and Gender Wirayudha, Yan; Kurniati, Yuni Prastyo; Nugraheni, Fladea Eka
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1115

Abstract

Neurological deafness or sensorineural hearing loss is a hearing loss caused by damage to the cochlea, vestibulocochlear nerve (N.VIII), or the nerve pathways that connect the ear to the brain. Indonesia is part of 4 countries in Asia that have a high prevalence of sensorineural hearing loss, namely 4.6%. Neurological deafness is caused by several factors, including age, genetic factors, and environmental factors. Some studies also show that hypertension, diabetes, and hypercholesterolemia can predispose to neural deafness. One of the complications caused by diabetes mellitus is hearing loss caused by microangiopathy. Gender has also been linked as a risk factor that causes neural deafness. This study aims to determine the relationship between diabetes mellitus and gender with the incidence of neurological deafness in adult patients in the city of Surakarta. This study used secondary data from adult neurologically deaf patients aged >18 years who had diabetes mellitus. This research design uses cross sectional. The total sample size was 67 respondents. The data obtained were analyzed using the chi-square test and logistic regression test. The results of this study stated that there was a relationship between diabetes mellitus and the incidence of neural deafness (p=0.000), there was a relationship between gender and the incidence of neural deafness, namely male gender (p=0.025). A significant relationship was found between diabetes mellitus and gender and the incidence of neurological deafness in adult patients in the city of Surakarta.

Page 20 of 47 | Total Record : 466

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