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JOURNAL LA MEDIHEALTICO
Published by Newinera Publisher
ISSN : 27211215     EISSN : 27211231     DOI : 10.37899/journallamedihealtico.v6i2.1959
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Homecare, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy & Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 466 Documents
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Folate Metabolism and Its Implications in Pregnancy Puspitasari, Maya Khaerunnisa; Irianti, Setyorini; Pramatirta, Akhmad Yogi; Wirawan, Wahyudi; Islamy, Nurul; Maelissa, Merlin Margreth; Lumentut, Anastasia Mariane
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1885

Abstract

The impact of folate nutritional status on a variety of pregnancy outcomes has been acknowledged for a considerable period of time. Folate is increasingly recognized not just as a nutrient required to prevent megaloblastic anemia during pregnancy, but also as a vitamin necessary for reproductive health. Folate plays an important role in several metabolic processes including DNA synthesis and methylation. Changes in folate status can affect the stability and integrity of DNA or affect the methylation patterns of some tissues. Folate is required for cell division and cell maintenance, as it acts as a co-enzyme in the transfer and processing of carbon units and plays an important role in the synthesis of nucleotides (thymidine) that are essential for de novo construction or DNA repair. The purpose of this article is to examine the function of folic acid in human health especially in pregnancy and to evaluate the benefits, concerns, and epigenetic effects of maternal FA in light of recent discoveries that are crucial for the development of future research.
Acute Fatty Liver in Pregnancy Wirawan, Wahyudi; Setiawan, Dani; Maelissa, Merlin Margreth; Islamy, Nurul; Lumentut, Anastasia Mariane; Puspitasari, Maya Khaerunnisa
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1890

Abstract

Acute fatty liver in pregnancy (AFLP) is a rare, life-threatening condition that typically occurs in the third trimester, characterized by fat accumulation in the liver. It is associated with high maternal and fetal morbidity, although mortality rates have decreased with improved obstetric care. AFLP's exact cause remains unclear, though it is linked to impaired fatty acid metabolism in the liver. Key risk factors include multiple pregnancies, male fetuses, and metabolic disorders. The condition presents with non-specific symptoms like nausea, jaundice, and abdominal pain, with progression to liver failure and encephalopathy in severe cases. Early diagnosis is critical, and the Swansea Criteria have proven useful. Management focuses on early delivery and supportive care, with cesarean section preferred due to the risk of fetal distress. Liver transplantation may be necessary for severe cases. While maternal and fetal survival rates have improved, the condition still poses significant challenges, emphasizing the need for prompt diagnosis and treatment.
The Effect of Black Rice Extract on Lipid Profile Changes in Hypercholesterolemic Mus musculus Awalia, Awalia; Makmun, Armanto; Bamahry, Aryanti R.; Rasfayanah, Rasfayanah; Mangarengi, Yusriani
Journal La Medihealtico Vol. 6 No. 1 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i1.1947

Abstract

Increased levels of lipid profiles in the blood affect the occurrence of coronary heart disease. Several large studies have shown that several natural food ingredients rich in antioxidants are associated with a lower incidence of cardiovascular disease. prevent the occurrence of several degenerative diseases. The research design used was a research design with a control group (pretest-posttest control group design). The research design used was a pretest-posttest control group design with 27 mice (mus musculus). They were divided into 3 groups: the negative control group (placebo), the positive control group (simvastatin), and the treatment control group (black rice). The intervention was carried out for 21 days. Data analysis was carried out using the paired T test and one way ANOVA test. Giving black rice extract can significantly improve lipid profile levels in mice, especially increasing HDL cholesterol levels by (10.44%) and decreasing triglyceride levels by (12.89%) as well as Simvastatin administration can also improve lipid profile levels significantly, especially decreased total cholesterol levels by (24.67%) and decreased LDL cholesterol by (32.08%). Based on the one way ANOVA test, P values were obtained successively in the administration of black rice extract, namely total cholesterol (p=<0.001), HDL cholesterol (p=<0.001), LDL cholesterol (p=<0.001), and triglycerides (p=<0.001). Likewise, in the administration of simvastatin, the lipid profile levels were obtained (p = <0.001). The conclusion of this study was that there was a significant effect of giving black rice extract on the lipid profile of hypercholesterolemia mice which was as effective as simvastatin.
The Relationship Between Social Support and Work Stress with Burnout in Emergency Installation and Intensive Care Unit Ntobuo, Fendi; Syamsuddin, Lenny; Rahim, Putri
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1950

Abstract

The purpose of this study is to investigate the connection between burnout from work stress and social support. The nurses at the ICU and emergency room at Dr. Hasri Ainun Habibie. This study takes a quantitative approach and employs a correlational study design. Total sampling was used to collect the samples. There were 40 responders, 24 of whom were ER nurses and 16 of whom were ICU nurses. This study used the multiple correlation approach. According to the study's findings, there is a significant negative relationship between social support and burnout (correlation coefficient value = -73.1%), a positive and significant relationship between job stress and burnout (correlation coefficient value = 41.4%), and a relationship between social support and job stress with burnout (correlation coefficient value = 46.4%). The ER and ICU nurses at Dr. Hasri Ainun Habibie report a jointly significant association between social support and job stress burnout, as indicated by the coefficient of determination value (R square) of 53.5%.
The Relationship between Patient Perception of Service Quality and Polyclinic Revisit Interest Nurhadiyastuti, Ameilia; Indriyani, Yeni; Agustina, Cynthia; Setyawan, Agus
Journal La Medihealtico Vol. 6 No. 1 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i1.1956

Abstract

The quality of health services encompasses several factors, such as service speed, diagnostic accuracy, facility comfort, the friendly attitude of medical personnel, and patient satisfaction with the services provided. Patient perceptions of service quality play a vital role in building trust and loyalty toward healthcare institutions. According to the 2024 annual report of Ir. Soekarno Regional General Hospital, while there has been a decline in overall patient visits, the number of returning patients has increased. This study aimed to examine the relationship between patient perceptions of service quality and the interest in outpatient re-visits at Ir. Soekarno Regional General Hospital, Sukoharjo Regency. The research used a descriptive quantitative approach with a cross-sectional design. A total of 146 respondents were selected using accidental sampling, determined through the Lemeshow formula based on specific inclusion and exclusion criteria. Data was collected through a questionnaire using a Likert scale, and analysis was performed using Chi-Square tests. The results indicate a significant relationship between the physical dimension (p=0.005) and interest in repeat visits. However, other dimensions such as reliability (p=0.628), personal interaction (p=1.000), problem solving (p=1.000), and policy (p=0.119) showed no significant relationship with outpatient re-visit interest. Overall, the perceived service quality was considered less than optimal, as only the physical dimension influenced repeat visit interest, while other aspects did not. Therefore, it is recommended that the hospital maintain its current physical facilities while focusing on improvements in other service dimensions to enhance patient satisfaction and loyalty.
Implementation of Leadership Commitment to Employee Performance Quality Using the Six Building Blocks Method Agustina, Cynthia; Indriyani, Yeni; Nurhadiyastuti, Ameilia; Setyawan, Agus
Journal La Medihealtico Vol. 6 No. 1 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i1.1957

Abstract

Hospital leadership commitment plays a crucial role in planning environmental health initiatives by allocating the necessary resources. Although the achievement of Minimum Service Standards at Ir. Soekarno Regional General Hospital is considered outstanding, challenges remain, such as expired training certifications, unmet opportunities for training renewal, and procedural non-compliance by some staff members. Therefore, leadership must enhance employee career development to foster organizational commitment and improve the quality of service delivery. This study aims to analyze leadership commitment in improving employee performance at Ir. Soekarno Regional General Hospital using the six building blocks method. The research design is qualitative, utilizing semi-structured interviews with both leadership and employees. Informant sampling was conducted through purposive sampling, with data verification carried out using source and technique triangulation. The findings reveal that the leadership has established organizational commitment through policy support, optimization of information systems, training budgets, and active employee participation in decision-making. However, the application of the six building blocks method in the context of employee performance based on leadership commitment remains suboptimal, particularly in the health workforce component. While physical health support for employees is adequately addressed, mental health support in the workplace is still lacking. Therefore, more intensive dissemination of policies and mental health programs is necessary, particularly for staff in underrepresented units.
In Silico Study of Gamma-Mangostin Compound from Garcinia Mangostana L. Fruit Skin and Activity Test as an Alpha Amylase Inhibitor Kurniawan, Kurniawan; Marfu'ah, Nurul; Fazriah D., Gita
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1889

Abstract

The aim of this study is to determine the interaction between the gamma-mangostin compound and the α-amylase enzyme using molecular docking modeling and in vitro. The results of molecular docking showed that all compounds could interact with the active site of the α-amylase enzyme. The gamma-mangostin compound has a fairly negative binding affinity. The binding affinity score of the compound was then compared with the control, namely the carbohydrate inhibitor acarbose. The results showed that the binding affinity quite close to the control, namely -9.1 kcal/mol, while the control was -16.4 kcal/mol, but the score was not negative enough. Interaction of the target protein with the alpha amylase compound to determine the amino acid residues on the active side of the protein. The results showed that there were hydrogen, alkyl and van der waals bonds on the active side of the protein that were the same as the control. In silico and in vitro, the gamma-mangostin compound has the potential to reduce blood sugar levels with an α-amylase inhibitor, in vitro with percentage of 43.33% approaching the positive control, namely acarbose, which is 56.25% at a concentration of 200 ppm and an IC50 value of 166.06 ppm.
Endocrine Control of Fetal Growth, the Delivery Process, and the Physiology of Childbirth Maelissa, Merlin Margreth; Siddiq, Amillia; Islamy, Nurul; Puspitasari, Maya Khaerunnisa; Lumentut, Anastasia Mariane; Wirawan, Wahyudi
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1903

Abstract

Childbirth is a complex physiological process characterized by the expulsion of the fetus from the uterus, marked by uterine contractions and cervical changes. The timing of labor is crucial for favorable pregnancy outcomes and is regulated by the neuroendocrine maturation of the fetus. Hormones like estrogen, progesterone, and human placental lactogen play key roles in fetal growth regulation, with fluctuations influencing birth weight and placental development. Progesterone inhibits labor by relaxing the uterus, while estrogen promotes labor by stimulating uterine contractions and cervical changes. The transition from uterine quiescence to active labor involves multiple stages, from myometrial relaxation to enhanced contractility. Labor progresses through phases, starting with quiescence, followed by the onset of rhythmic contractions, active labor, and concluding with involution. Uterine stretching and the role of fetal lung maturation also contribute to labor initiation, as fetal lung surfactant activates macrophages, leading to inflammation and progesterone withdrawal. This process synchronizes labor timing with fetal lung development. In conclusion, labor is influenced by a combination of endocrine and mechanical factors, including prostaglandins, cytokines, and hormones such as oxytocin and CRH. Proper endocrine regulation ensures timely labor, while disruptions in this system, such as premature or prolonged pregnancies, can lead to increased fetal morbidity and mortality.
Effectiveness of Topical Tranexamic Acid in the Treatment of Melasma Pandanwangi, Siti; Setriyadi, Dedy; Dzulhijjah, Hawa
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1923

Abstract

Melasma is a chronic skin hyperpigmentation condition that often occurs in women of reproductive age, especially in areas exposed to sunlight. One of the therapeutic agents that has attracted attention is tranexamic acid (TXA), which was originally used as an antifibrinolytic agent, but is now known to have an effective mechanism of action in reducing hyperpigmentation. TXA works through plasminogen inhibition, tyrosinase activity, and angiogenesis, as well as providing anti-inflammatory effects. This study uses the PRISMA systematic review method, involving the analysis of 30 relevant articles out of a total of 289 articles identified. The results showed that topical TXA in various formulations, such as creams, gels, or liposomal serums, provided a significant reduction in the Melasma Area and Severity Index (MASI) score. The combination of TXA with other modalities, such as microneedling, laser, and vitamin C, showed more effective results than monotherapy. Topical TXA is an effective and safe therapeutic agent for melasma, especially in the case of refractory or combination therapies. Further research is needed to evaluate the long-term effectiveness and innovation of new formulations in improving the penetration and efficacy of TXA.
Effectiveness of Oral Tranexamic Acid in the Treatment of Melasma: A Systematic Review Zuniarto , Ahmad Azrul; TW, Siti Pandawangi; Kinanti, Vidya Putri
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1929

Abstract

Melasma is a skin condition characterized by hyperpigmented patches, generally appearing on facial areas such as the cheeks, forehead, and upper lip. This condition is more common in women, especially during pregnancy or when using hormonal contraceptives. The factors that cause melasma include sun exposure, hormonal changes, and genetic factors. The purpose of this study is to examine the effectiveness and safety of the use of oral Tranexamic acid (TXA) in the treatment of melasma based on recent studies. The method used by literature search in journals published between 2022–2024 used keywords related to oral TXA and melasma. Studies that met the inclusion criteria were evaluated to compare the outcomes of oral TXA therapy based on dose, duration, and side effects. The results showed that oral TXA was proven to be effective in reducing the Melasma Area Severity Index (MASI) score with a dose of 500–1500 mg/day for 8–12 weeks. A significant decrease in MASI scores was achieved at week 12, showing consistent results across multiple studies. The most commonly reported side effects are gastrointestinal disorders, such as nausea and abdominal pain. Oral TXA does not cause serious side effects at doses up to 4 g/day. Tranexamic acid (TXA) in oral form is an effective and safe therapy in managing melasma. However, further research is needed to determine the ideal duration of treatment and strategies in preventing melasma recurrence.

Page 35 of 47 | Total Record : 466

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